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Protein

Low-affinity glucose transporter HXT3

Gene

HXT3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Low-affinity glucose transporter.

GO - Molecular functioni

  • fructose transmembrane transporter activity Source: SGD
  • glucose transmembrane transporter activity Source: SGD
  • mannose transmembrane transporter activity Source: SGD
  • sugar:proton symporter activity Source: GO_Central

GO - Biological processi

  • glucose import Source: GO_Central
  • hexose transport Source: SGD
  • transmembrane transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29899-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Low-affinity glucose transporter HXT3
Gene namesi
Name:HXT3
Ordered Locus Names:YDR345C
ORF Names:D9651.14
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR345C.
SGDiS000002753. HXT3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 57CytoplasmicSequence analysisAdd BLAST57
Transmembranei58 – 78Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini79 – 113ExtracellularSequence analysisAdd BLAST35
Transmembranei114 – 134Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini135 – 140CytoplasmicSequence analysis6
Transmembranei141 – 161Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini162 – 171ExtracellularSequence analysis10
Transmembranei172 – 192Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini193 – 198CytoplasmicSequence analysis6
Transmembranei199 – 219Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini220 – 233ExtracellularSequence analysisAdd BLAST14
Transmembranei234 – 254Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini255 – 337CytoplasmicSequence analysisAdd BLAST83
Transmembranei338 – 354Helical; Name=7Sequence analysisAdd BLAST17
Topological domaini355 – 360ExtracellularSequence analysis6
Transmembranei361 – 378Helical; Name=8Sequence analysisAdd BLAST18
Topological domaini379 – 385CytoplasmicSequence analysis7
Transmembranei386 – 406Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini407 – 428ExtracellularSequence analysisAdd BLAST22
Transmembranei429 – 449Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini450 – 466CytoplasmicSequence analysisAdd BLAST17
Transmembranei467 – 487Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini488ExtracellularSequence analysis1
Transmembranei489 – 509Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini510 – 567CytoplasmicSequence analysisAdd BLAST58

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000503931 – 567Low-affinity glucose transporter HXT3Add BLAST567

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9PhosphoserineBy similarity1
Modified residuei13PhosphoserineBy similarity1
Modified residuei14PhosphoserineBy similarity1
Modified residuei23PhosphoserineCombined sources1
Modified residuei26PhosphoserineBy similarity1
Glycosylationi225N-linked (GlcNAc...)Sequence analysis1
Glycosylationi416N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP32466.
PRIDEiP32466.

PTM databases

iPTMnetiP32466.

Expressioni

Inductioni

Repressed at high glucose concentrations.

Interactioni

Protein-protein interaction databases

BioGridi32401. 49 interactors.
DIPiDIP-4178N.
IntActiP32466. 4 interactors.
MINTiMINT-492422.

Structurei

3D structure databases

ProteinModelPortaliP32466.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00850000132516.
HOGENOMiHOG000202870.
InParanoidiP32466.
KOiK08139.
OMAiIGMVCCY.
OrthoDBiEOG092C1Q5W.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32466-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSTPDLISP QKSSENSNAD LPSNSSQVMN MPEEKGVQDD FQAEADQVLT
60 70 80 90 100
NPNTGKGAYV TVSICCVMVA FGGFVFGWDT GTISGFVAQT DFLRRFGMKH
110 120 130 140 150
KDGSYYLSKV RTGLIVSIFN IGCAIGGIIL AKLGDMYGRK MGLIVVVVIY
160 170 180 190 200
IIGIIIQIAS INKWYQYFIG RIISGLGVGG IAVLSPMLIS EVAPKEMRGT
210 220 230 240 250
LVSCYQLMIT LGIFLGYCTN FGTKNYSNSV QWRVPLGLCF AWALFMIGGM
260 270 280 290 300
TFVPESPRYL VEAGQIDEAR ASLSKVNKVA PDHPFIQQEL EVIEASVEEA
310 320 330 340 350
RAAGSASWGE LFTGKPAMFK RTMMGIMIQS LQQLTGDNYF FYYGTTVFNA
360 370 380 390 400
VGMSDSFETS IVFGVVNFFS TCCSLYTVDR FGRRNCLLYG AIGMVCCYVV
410 420 430 440 450
YASVGVTRLW PNGEGNGSSK GAGNCMIVFA CFYIFCFATT WAPIAYVVIS
460 470 480 490 500
ETFPLRVKSK AMSIATAANW LWGFLIGFFT PFITGAINFY YGYVFMGCMV
510 520 530 540 550
FAYFYVFFFV PETKGLTLEE VNDMYAEGVL PWKSASWVPT SQRGANYDAD
560
ALMHDDQPFY KKMFGKK
Length:567
Mass (Da):62,558
Last modified:October 1, 1993 - v1
Checksum:iF6CA1F7B70204526
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07080 Genomic DNA. Translation: AAA34672.1.
U51032 Genomic DNA. Translation: AAB64781.1.
BK006938 Genomic DNA. Translation: DAA12185.1.
PIRiS31294.
RefSeqiNP_010632.1. NM_001180653.1.

Genome annotation databases

EnsemblFungiiYDR345C; YDR345C; YDR345C.
GeneIDi851946.
KEGGisce:YDR345C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07080 Genomic DNA. Translation: AAA34672.1.
U51032 Genomic DNA. Translation: AAB64781.1.
BK006938 Genomic DNA. Translation: DAA12185.1.
PIRiS31294.
RefSeqiNP_010632.1. NM_001180653.1.

3D structure databases

ProteinModelPortaliP32466.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32401. 49 interactors.
DIPiDIP-4178N.
IntActiP32466. 4 interactors.
MINTiMINT-492422.

PTM databases

iPTMnetiP32466.

Proteomic databases

MaxQBiP32466.
PRIDEiP32466.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR345C; YDR345C; YDR345C.
GeneIDi851946.
KEGGisce:YDR345C.

Organism-specific databases

EuPathDBiFungiDB:YDR345C.
SGDiS000002753. HXT3.

Phylogenomic databases

GeneTreeiENSGT00850000132516.
HOGENOMiHOG000202870.
InParanoidiP32466.
KOiK08139.
OMAiIGMVCCY.
OrthoDBiEOG092C1Q5W.

Enzyme and pathway databases

BioCyciYEAST:G3O-29899-MONOMER.

Miscellaneous databases

PROiP32466.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHXT3_YEAST
AccessioniPrimary (citable) accession number: P32466
Secondary accession number(s): D6VSX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: November 30, 2016
This is version 148 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Glucose transport is thought to be mediated by two kinetically distinct systems, a glucose-repressible high-affinity system and a constitutive low-affinity system.
Present with 37200 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.