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Protein

Low-affinity glucose transporter HXT1

Gene

HXT1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Low-affinity glucose transporter. HXT1 is as well involved in the transport of mannose.

Miscellaneous

Glucose transport is thought to be mediated by two kinetically distinct systems, a glucose-repressible high-affinity system and a constitutive low-affinity system.
Present with 23300 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • carbohydrate:proton symporter activity Source: GO_Central
  • fructose transmembrane transporter activity Source: SGD
  • galactose transmembrane transporter activity Source: SGD
  • glucose transmembrane transporter activity Source: SGD
  • mannose transmembrane transporter activity Source: SGD
  • pentose transmembrane transporter activity Source: SGD

GO - Biological processi

  • glucose import Source: GO_Central
  • glucose transmembrane transport Source: SGD
  • mannose transmembrane transport Source: SGD

Keywordsi

Biological processSugar transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31140-MONOMER
ReactomeiR-SCE-189200 Cellular hexose transport
R-SCE-8856825 Cargo recognition for clathrin-mediated endocytosis

Protein family/group databases

TCDBi2.A.1.1.108 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Low-affinity glucose transporter HXT1
Gene namesi
Name:HXT1
Synonyms:HOR4
Ordered Locus Names:YHR094C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHR094C
SGDiS000001136 HXT1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 60CytoplasmicSequence analysisAdd BLAST60
Transmembranei61 – 81Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini82 – 116ExtracellularSequence analysisAdd BLAST35
Transmembranei117 – 137Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini138 – 143CytoplasmicSequence analysis6
Transmembranei144 – 164Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini165 – 174ExtracellularSequence analysis10
Transmembranei175 – 195Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini196 – 201CytoplasmicSequence analysis6
Transmembranei202 – 222Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini223 – 236ExtracellularSequence analysisAdd BLAST14
Transmembranei237 – 257Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini258 – 340CytoplasmicSequence analysisAdd BLAST83
Transmembranei341 – 357Helical; Name=7Sequence analysisAdd BLAST17
Topological domaini358 – 363ExtracellularSequence analysis6
Transmembranei364 – 381Helical; Name=8Sequence analysisAdd BLAST18
Topological domaini382 – 388CytoplasmicSequence analysis7
Transmembranei389 – 409Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini410 – 431ExtracellularSequence analysisAdd BLAST22
Transmembranei432 – 452Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini453 – 469CytoplasmicSequence analysisAdd BLAST17
Transmembranei470 – 490Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini491ExtracellularSequence analysis1
Transmembranei492 – 512Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini513 – 570CytoplasmicSequence analysisAdd BLAST58

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000503911 – 570Low-affinity glucose transporter HXT1Add BLAST570

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei23PhosphoserineCombined sources1
Modified residuei38PhosphoserineCombined sources1
Modified residuei44PhosphoserineCombined sources1
Glycosylationi228N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP32465
PaxDbiP32465
PRIDEiP32465

PTM databases

iPTMnetiP32465

Expressioni

Developmental stagei

Expression is maximal during lag and early exponential phases of growth, decreasing upon further entry into exponential growth.

Inductioni

Repressed at high glucose concentrations.

Interactioni

Protein-protein interaction databases

BioGridi36528, 123 interactors
DIPiDIP-5593N
IntActiP32465, 38 interactors
MINTiP32465
STRINGi4932.YHR094C

Structurei

3D structure databases

ProteinModelPortaliP32465
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00910000144141
HOGENOMiHOG000202870
InParanoidiP32465
KOiK08139
OMAiKNEHERE
OrthoDBiEOG092C1Q5W

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR003663 Sugar/inositol_transpt
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
PRINTSiPR00171 SUGRTRNSPORT
SUPFAMiSSF103473 SSF103473, 2 hits
TIGRFAMsiTIGR00879 SP, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 1 hit
PS00217 SUGAR_TRANSPORT_2, 1 hit

Sequencei

Sequence statusi: Complete.

P32465-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSTPDLISP QKSNSSNSYE LESGRSKAMN TPEGKNESFH DNLSESQVQP
60 70 80 90 100
AVAPPNTGKG VYVTVSICCV MVAFGGFIFG WDTGTISGFV AQTDFLRRFG
110 120 130 140 150
MKHHDGSHYL SKVRTGLIVS IFNIGCAIGG IVLAKLGDMY GRRIGLIVVV
160 170 180 190 200
VIYTIGIIIQ IASINKWYQY FIGRIISGLG VGGITVLSPM LISEVAPSEM
210 220 230 240 250
RGTLVSCYQV MITLGIFLGY CTNFGTKNYS NSVQWRVPLG LCFAWALFMI
260 270 280 290 300
GGMMFVPESP RYLVEAGRID EARASLAKVN KCPPDHPYIQ YELETIEASV
310 320 330 340 350
EEMRAAGTAS WGELFTGKPA MFQRTMMGIM IQSLQQLTGD NYFFYYGTIV
360 370 380 390 400
FQAVGLSDSF ETSIVFGVVN FFSTCCSLYT VDRFGRRNCL MWGAVGMVCC
410 420 430 440 450
YVVYASVGVT RLWPNGQDQP SSKGAGNCMI VFACFYIFCF ATTWAPIAYV
460 470 480 490 500
VISECFPLRV KSKCMSIASA ANWIWGFLIS FFTPFITGAI NFYYGYVFMG
510 520 530 540 550
CMVFAYFYVF FFVPETKGLS LEEVNDMYAE GVLPWKSASW VPVSKRGADY
560 570
NADDLMHDDQ PFYKSLFSRK
Length:570
Mass (Da):63,261
Last modified:October 1, 1993 - v1
Checksum:i311CBB35AE80D19E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti70Missing in AAA34700 (PubMed:2046678).Curated1
Sequence conflicti469S → T in AAA34700 (PubMed:2046678).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07079 Genomic DNA Translation: AAB59311.1
M82963 Genomic DNA Translation: AAA34700.1
U00060 Genomic DNA Translation: AAB68933.1
BK006934 Genomic DNA Translation: DAA06789.1
PIRiS38798
RefSeqiNP_011962.1, NM_001179224.1

Genome annotation databases

EnsemblFungiiYHR094C; YHR094C; YHR094C
GeneIDi856494
KEGGisce:YHR094C

Similar proteinsi

Entry informationi

Entry nameiHXT1_YEAST
AccessioniPrimary (citable) accession number: P32465
Secondary accession number(s): D3DL45
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: May 23, 2018
This is version 171 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Protein nomenclature information
    List of publications dealing with protein nomenclature and links to specialized websites
  2. Pathways
    Controlled vocabulary of metabolic pathways

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