P32464 (HYM1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein HYM1

Gene names

Name:	HYM1
Ordered Locus Names:	YKL189W

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	399 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Miscellaneous	Present with 1280 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the Mo25 family.

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	budding cell apical bud growth Inferred from mutant phenotype PubMed 12972564. Source: SGD cytokinesis, completion of separation Inferred from mutant phenotype PubMed 11259593. Source: SGD regulation of cell shape Inferred from genetic interaction PubMed 11259593. Source: SGD regulation of transcription, DNA-dependent Inferred from mutant phenotype PubMed 12972564. Source: SGD
Cellular_component	cellular bud Inferred from direct assay PubMed 12972564. Source: SGD incipient cellular bud site Inferred from direct assay PubMed 12972564. Source: SGD mating projection tip Inferred from direct assay PubMed 12972564. Source: SGD
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
KIC1	P38692	5	EBI-8859,EBI-12253
SOG2	Q08817	3	EBI-8859,EBI-30849

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 399	399	Protein HYM1		PRO_0000209836

Sequences

	Sequence		Length	Mass (Da)
	P32464 [UniParc]. Last modified October 1, 1993. Version 1. Checksum: F48860754C892BA9	FASTA	399	45,853
	10 20 30 40 50 60 MFKKYKNQDL DMAFWWKKNP KTPSDYARLI IEQLNKFSSP SLTQDNKRKV QEECTKYLIG 70 80 90 100 110 120 TKHFIVGDTD PHPTPEAIDE LYTAMHRADV FYELLLHFVD LEFEARRECM LIFSICLGYS 130 140 150 160 170 180 KDNKFVTVDY LVSQPKTISL MLRTAEVALQ QKGCQDIFLT VGNMIIECIK YEQLCRIILK 190 200 210 220 230 240 DPQLWKFFEF AKLGNFEIST ESLQILSAAF TAHPKLVSKE FFSNEINIIR FIKCINKLMA 250 260 270 280 290 300 HGSYVTKRQS TKLLASLIVI RSNNALMNIY INSPENLKLI MTLMTDKSKN LQLEAFNVFK 310 320 330 340 350 360 VMVANPRKSK PVFDILVKNR DKLLTYFKTF GLDSQDSTFL DEREFIVQEI DSLPRIISST 370 380 390 TEVSNNNASS SNVASITSPS SVMNNQSSIL THSTSPDSR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"DNA sequence analysis of the YCN2 region of chromosome XI in Saccharomyces cerevisiae." Cheret G., Mattheakis L.C., Sor F. Yeast 9:661-667(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: S288c / GRF88.
[2]	"Sequencing and analysis of 51.6 kilobases on the left arm of chromosome XI from Saccharomyces cerevisiae reveals 23 open reading frames including the FAS1 gene." Wiemann S., Voss H., Schwager C., Rupp T., Stegemann J., Zimmermann J., Grothues D., Sensen C., Erfle H., Hewitt N., Banrevi A., Ansorge W. Yeast 9:1343-1348(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Complete DNA sequence of yeast chromosome XI." Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C. , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W. Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[4]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[5]	"Roles for the Saccharomyces cerevisiae SDS3, CBK1 and HYM1 genes in transcriptional repression by SIN3." Dorland S., Deegenaars M.L., Stillman D.J. Genetics 154:573-586(2000) [PubMed] [Europe PMC] [Abstract] Cited for: GENE NAME.
[6]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X69765 Genomic DNA. Translation: CAA49422.1. X74151 Genomic DNA. Translation: CAA52249.1. Z28189 Genomic DNA. Translation: CAA82032.1. BK006944 Genomic DNA. Translation: DAA08977.1.
PIR	S34681.
RefSeq	NP_012732.1. NM_001179755.1.
3D structure databases
ProteinModelPortal	P32464.
SMR	P32464. Positions 21-355.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-5425N.
IntAct	P32464. 11 interactions.
MINT	MINT-475734.
STRING	4932.YKL189W.
Proteomic databases
PaxDb	P32464.
PeptideAtlas	P32464.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YKL189W; YKL189W; YKL189W.
GeneID	853646.
KEGG	sce:YKL189W.
Organism-specific databases
CYGD	YKL189w.
SGD	S000001672. HYM1.
Phylogenomic databases
eggNOG	NOG307443.
GeneTree	ENSGT00390000004360.
HOGENOM	HOG000234711.
KO	K08272.
OMA	MCADFLE.
OrthoDB	EOG4G7G7D.
Gene expression databases
Genevestigator	P32464.
GermOnline	YKL189W. Saccharomyces cerevisiae.
Family and domain databases
Gene3D	1.25.10.10. 1 hit.
InterPro	IPR011989. ARM-like. IPR016024. ARM-type_fold. IPR013878. Mo25. [Graphical view]
PANTHER	PTHR10182. PTHR10182. 1 hit.
Pfam	PF08569. Mo25. 1 hit. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 1 hit.
ProtoNet	Search...
Other
NextBio	974548.

Entry information

Entry name

HYM1_YEAST

Accession

Primary (citable) accession number: P32464
Secondary accession number(s): D6VX11

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
Last sequence update:	October 1, 1993
Last modified:	May 1, 2013
This is version 104 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program