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Protein

Acyl carrier protein, mitochondrial

Gene

ACP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity). May be involved in the synthesis of very-long-chain fatty acids. Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain (By similarity).By similarity

Miscellaneous

Present with 60500 molecules/cell in log phase SD medium.1 Publication

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

GO - Molecular functioni

  • acyl binding Source: GO_Central
  • acyl carrier activity Source: SGD
  • phosphopantetheine binding Source: GO_Central

GO - Biological processi

  • lipid A biosynthetic process Source: GO_Central
  • lipoate biosynthetic process Source: SGD
  • oxidation-reduction process Source: UniProtKB-KW

Keywordsi

Biological processElectron transport, Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Respiratory chain, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31954-MONOMER
ReactomeiR-SCE-389661 Glyoxylate metabolism and glycine degradation
UniPathwayiUPA00094

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl carrier protein, mitochondrial
Short name:
ACP
Alternative name(s):
NADH-ubiquinone oxidoreductase 9.6 kDa subunit
Gene namesi
Name:ACP1
Ordered Locus Names:YKL192C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKL192C
SGDiS000001675 ACP1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 36MitochondrionSequence analysisAdd BLAST36
ChainiPRO_000000056637 – 125Acyl carrier protein, mitochondrialAdd BLAST89

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei82O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Post-translational modificationi

4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group (By similarity).By similarity

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

Proteomic databases

MaxQBiP32463
PaxDbiP32463
PRIDEiP32463

Interactioni

Subunit structurei

Complex I is composed of about 30 different subunits.

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi33929, 25 interactors
DIPiDIP-3990N
IntActiP32463, 8 interactors
MINTiP32463
STRINGi4932.YKL192C

Structurei

3D structure databases

ProteinModelPortaliP32463
SMRiP32463
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 122CarrierPROSITE-ProRule annotationAdd BLAST80

Sequence similaritiesi

Belongs to the acyl carrier protein (ACP) family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

GeneTreeiENSGT00390000002127
HOGENOMiHOG000178184
InParanoidiP32463
KOiK03955
OMAiLAIEYVY
OrthoDBiEOG092C5SMT

Family and domain databases

Gene3Di1.10.1200.10, 1 hit
HAMAPiMF_01217 Acyl_carrier, 1 hit
InterProiView protein in InterPro
IPR036736 ACP-like_sf
IPR003231 Acyl_carrier
IPR009081 PP-bd_ACP
IPR006162 Ppantetheine_attach_site
PfamiView protein in Pfam
PF00550 PP-binding, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD000887 PD000887, 1 hit
SUPFAMiSSF47336 SSF47336, 1 hit
TIGRFAMsiTIGR00517 acyl_carrier, 1 hit
PROSITEiView protein in PROSITE
PS50075 CARRIER, 1 hit
PS00012 PHOSPHOPANTETHEINE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P32463-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFRSVCRISS RVAPSAYRTI MGRSVMSNTI LAQRFYSANL SKDQVSQRVI
60 70 80 90 100
DVIKAFDKNS PNIANKQISS DTQFHKDLGL DSLDTVELLV AIEEEFDIEI
110 120
PDKVADELRS VGETVDYIAS NPDAN
Length:125
Mass (Da):13,943
Last modified:October 1, 1993 - v1
Checksum:iA0C64C5B796A5DDF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69765 Genomic DNA Translation: CAA49419.1
Z28192 Genomic DNA Translation: CAA82036.1
AY558392 Genomic DNA Translation: AAS56718.1
BK006944 Genomic DNA Translation: DAA08974.1
PIRiS33960
RefSeqiNP_012729.1, NM_001179758.1

Genome annotation databases

EnsemblFungiiYKL192C; YKL192C; YKL192C
GeneIDi853642
KEGGisce:YKL192C

Similar proteinsi

Entry informationi

Entry nameiACPM_YEAST
AccessioniPrimary (citable) accession number: P32463
Secondary accession number(s): D6VX08
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: March 28, 2018
This is version 166 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health