Reviewed, UniProtKB/Swiss-Prot P32463 (ACPM_YEAST)

Names and origin

Protein names

Recommended name:
    Acyl carrier protein, mitochondrial
      Short name=ACP
Alternative name(s):
    NADH-ubiquinone oxidoreductase 9.6 kDa subunit

Gene names

Name:	ACP1
Ordered Locus Names:	YKL192C

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	125 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Carrier of the growing fatty acid chain in fatty acid biosynthesis By similarity. May be involved in the synthesis of very-long-chain fatty acids. Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain By similarity.
Pathway	Lipid metabolism; fatty acid biosynthesis.
Subunit structure	Complex I is composed of about 30 different subunits.
Subcellular location	Mitochondrion.
Post-translational modification	4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group By similarity.
Miscellaneous	Present with 60500 molecules/cell in log phase SD medium. Ref.4
Sequence similarities	Contains 1 acyl carrier domain.

Ontologies

Keywords
Biological process	Electron transport Fatty acid biosynthesis Lipid synthesis Respiratory chain Transport
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	Phosphopantetheine
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW lipoic acid biosynthetic process Inferred from mutant phenotype. Source: SGD transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrion Inferred from direct assay. Source: SGD respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	acyl carrier activity Inferred from electronic annotation. Source: InterPro cofactor binding Inferred from electronic annotation. Source: InterPro phosphopantetheine binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 36	36	Mitochondrion Potential
	Chain	37 – 125	89	Acyl carrier protein, mitochondrial		PRO_0000000566
Amino acid modifications
	Modified residue	82	1	O-(pantetheine 4'-phosphoryl)serine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P32463-1 [UniParc]. Last modified October 1, 1993. Version 1. Checksum: A0C64C5B796A5DDF	FASTA	125	13,943
	10 20 30 40 50 60 MFRSVCRISS RVAPSAYRTI MGRSVMSNTI LAQRFYSANL SKDQVSQRVI DVIKAFDKNS 70 80 90 100 110 120 PNIANKQISS DTQFHKDLGL DSLDTVELLV AIEEEFDIEI PDKVADELRS VGETVDYIAS NPDAN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"DNA sequence analysis of the YCN2 region of chromosome XI in Saccharomyces cerevisiae." Cheret G., Mattheakis L.C., Sor F. Yeast 9:661-667(1993) [PubMed: 8394042] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: S288c / GRF88.
[2]	"Complete DNA sequence of yeast chromosome XI." Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C. , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W. Nature 369:371-378(1994) [PubMed: 8196765] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[3]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed: 17322287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[4]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X69765 Genomic DNA. Translation: CAA49419.1. Z28192 Genomic DNA. Translation: CAA82036.1. AY558392 Genomic DNA. Translation: AAS56718.1.
PIR	S33960.
RefSeq	NP_012729.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:3990N.
IntAct	P32463. 6 interactions.
STRING	P32463.
Proteomic databases
PeptideAtlas	P32463.
Genome annotation databases
Ensembl	YKL192C; YKL192C; YKL192C; Saccharomyces cerevisiae. [Genome view]
GeneID	853642.
KEGG	sce:YKL192C.
NMPDR	fig|4932.3.peg.3706.
Organism-specific databases
CYGD	YKL192c.
SGD	S000001675. ACP1.
Phylogenomic databases
HOGENOM	P32463.
OMA	DSDFTKD
OrthoDB	EOG9R7WTJ
Gene expression databases
ArrayExpress	P32463.
Genevestigator	P32463.
GermOnline	YKL192C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR003231. Acyl_carrier. IPR009081. Acyl_carrier_prot-like. IPR006163. Phsphopanteth_bd. IPR006162. PPantetheine_attach_site. [Graphical view]
Pfam	PF00550. PP-binding. 1 hit. [Graphical view]
TIGRFAMs	TIGR00517. acyl_carrier. 1 hit.
PROSITE	PS50075. ACP_DOMAIN. 1 hit. PS00012. PHOSPHOPANTETHEINE. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	974537.

Entry information

Entry name

ACPM_YEAST

Accession

Primary (citable) accession number: P32463

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
Last sequence update:	October 1, 1993
Last modified:	November 24, 2009
This is version 97 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)