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Protein

Acyl carrier protein, mitochondrial

Gene

ACP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity). May be involved in the synthesis of very-long-chain fatty acids. Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain (By similarity).By similarity

Pathwayi

GO - Molecular functioni

  1. ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process Source: SGD

GO - Biological processi

  1. lipoate biosynthetic process Source: SGD
  2. oxidation-reduction process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Electron transport, Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Respiratory chain, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31954-MONOMER.
UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl carrier protein, mitochondrial
Short name:
ACP
Alternative name(s):
NADH-ubiquinone oxidoreductase 9.6 kDa subunit
Gene namesi
Name:ACP1
Ordered Locus Names:YKL192C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome XI

Organism-specific databases

CYGDiYKL192c.
EuPathDBiFungiDB:YKL192C.
SGDiS000001675. ACP1.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-SubCell
  2. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3636MitochondrionSequence AnalysisAdd
BLAST
Chaini37 – 12589Acyl carrier protein, mitochondrialPRO_0000000566Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei82 – 821O-(pantetheine 4'-phosphoryl)serineBy similarity

Post-translational modificationi

4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group (By similarity).By similarity

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

Proteomic databases

MaxQBiP32463.
PaxDbiP32463.
PeptideAtlasiP32463.

Expressioni

Gene expression databases

GenevestigatoriP32463.

Interactioni

Subunit structurei

Complex I is composed of about 30 different subunits.

Protein-protein interaction databases

BioGridi33929. 23 interactions.
DIPiDIP-3990N.
IntActiP32463. 2 interactions.
MINTiMINT-494746.
STRINGi4932.YKL192C.

Structurei

3D structure databases

ProteinModelPortaliP32463.
SMRiP32463. Positions 66-118.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 acyl carrier domain.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0236.
GeneTreeiENSGT00390000002127.
HOGENOMiHOG000178184.
InParanoidiP32463.
KOiK03955.
OMAiTASFAND.
OrthoDBiEOG757D9J.

Family and domain databases

Gene3Di1.10.1200.10. 1 hit.
HAMAPiMF_01217. Acyl_carrier.
InterProiIPR003231. Acyl_carrier.
IPR009081. Acyl_carrier_prot-like.
IPR006162. Ppantetheine_attach_site.
[Graphical view]
PfamiPF00550. PP-binding. 1 hit.
[Graphical view]
ProDomiPD000887. PD000887. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47336. SSF47336. 1 hit.
TIGRFAMsiTIGR00517. acyl_carrier. 1 hit.
PROSITEiPS50075. ACP_DOMAIN. 1 hit.
PS00012. PHOSPHOPANTETHEINE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P32463-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFRSVCRISS RVAPSAYRTI MGRSVMSNTI LAQRFYSANL SKDQVSQRVI
60 70 80 90 100
DVIKAFDKNS PNIANKQISS DTQFHKDLGL DSLDTVELLV AIEEEFDIEI
110 120
PDKVADELRS VGETVDYIAS NPDAN
Length:125
Mass (Da):13,943
Last modified:October 1, 1993 - v1
Checksum:iA0C64C5B796A5DDF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69765 Genomic DNA. Translation: CAA49419.1.
Z28192 Genomic DNA. Translation: CAA82036.1.
AY558392 Genomic DNA. Translation: AAS56718.1.
BK006944 Genomic DNA. Translation: DAA08974.1.
PIRiS33960.
RefSeqiNP_012729.1. NM_001179758.1.

Genome annotation databases

EnsemblFungiiYKL192C; YKL192C; YKL192C.
GeneIDi853642.
KEGGisce:YKL192C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69765 Genomic DNA. Translation: CAA49419.1.
Z28192 Genomic DNA. Translation: CAA82036.1.
AY558392 Genomic DNA. Translation: AAS56718.1.
BK006944 Genomic DNA. Translation: DAA08974.1.
PIRiS33960.
RefSeqiNP_012729.1. NM_001179758.1.

3D structure databases

ProteinModelPortaliP32463.
SMRiP32463. Positions 66-118.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33929. 23 interactions.
DIPiDIP-3990N.
IntActiP32463. 2 interactions.
MINTiMINT-494746.
STRINGi4932.YKL192C.

Proteomic databases

MaxQBiP32463.
PaxDbiP32463.
PeptideAtlasiP32463.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYKL192C; YKL192C; YKL192C.
GeneIDi853642.
KEGGisce:YKL192C.

Organism-specific databases

CYGDiYKL192c.
EuPathDBiFungiDB:YKL192C.
SGDiS000001675. ACP1.

Phylogenomic databases

eggNOGiCOG0236.
GeneTreeiENSGT00390000002127.
HOGENOMiHOG000178184.
InParanoidiP32463.
KOiK03955.
OMAiTASFAND.
OrthoDBiEOG757D9J.

Enzyme and pathway databases

UniPathwayiUPA00094.
BioCyciYEAST:G3O-31954-MONOMER.

Miscellaneous databases

NextBioi974537.
PROiP32463.

Gene expression databases

GenevestigatoriP32463.

Family and domain databases

Gene3Di1.10.1200.10. 1 hit.
HAMAPiMF_01217. Acyl_carrier.
InterProiIPR003231. Acyl_carrier.
IPR009081. Acyl_carrier_prot-like.
IPR006162. Ppantetheine_attach_site.
[Graphical view]
PfamiPF00550. PP-binding. 1 hit.
[Graphical view]
ProDomiPD000887. PD000887. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47336. SSF47336. 1 hit.
TIGRFAMsiTIGR00517. acyl_carrier. 1 hit.
PROSITEiPS50075. ACP_DOMAIN. 1 hit.
PS00012. PHOSPHOPANTETHEINE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequence analysis of the YCN2 region of chromosome XI in Saccharomyces cerevisiae."
    Cheret G., Mattheakis L.C., Sor F.
    Yeast 9:661-667(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: S288c / GRF88.
  2. "Complete DNA sequence of yeast chromosome XI."
    Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
    , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
    Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiACPM_YEAST
AccessioniPrimary (citable) accession number: P32463
Secondary accession number(s): D6VX08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: April 29, 2015
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 60500 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.