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P32463

- ACPM_YEAST

UniProt

P32463 - ACPM_YEAST

Protein

Acyl carrier protein, mitochondrial

Gene

ACP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Carrier of the growing fatty acid chain in fatty acid biosynthesis By similarity. May be involved in the synthesis of very-long-chain fatty acids. Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain By similarity.By similarity

    Pathwayi

    GO - Molecular functioni

    1. ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process Source: SGD

    GO - Biological processi

    1. lipoate biosynthetic process Source: SGD
    2. oxidation-reduction process Source: UniProtKB-KW

    Keywords - Biological processi

    Electron transport, Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Respiratory chain, Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31954-MONOMER.
    UniPathwayiUPA00094.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acyl carrier protein, mitochondrial
    Short name:
    ACP
    Alternative name(s):
    NADH-ubiquinone oxidoreductase 9.6 kDa subunit
    Gene namesi
    Name:ACP1
    Ordered Locus Names:YKL192C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XI

    Organism-specific databases

    CYGDiYKL192c.
    SGDiS000001675. ACP1.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell
    2. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3636MitochondrionSequence AnalysisAdd
    BLAST
    Chaini37 – 12589Acyl carrier protein, mitochondrialPRO_0000000566Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei82 – 821O-(pantetheine 4'-phosphoryl)serineBy similarity

    Post-translational modificationi

    4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group By similarity.By similarity

    Keywords - PTMi

    Phosphopantetheine, Phosphoprotein

    Proteomic databases

    MaxQBiP32463.
    PaxDbiP32463.
    PeptideAtlasiP32463.

    Expressioni

    Gene expression databases

    GenevestigatoriP32463.

    Interactioni

    Subunit structurei

    Complex I is composed of about 30 different subunits.

    Protein-protein interaction databases

    BioGridi33929. 22 interactions.
    DIPiDIP-3990N.
    IntActiP32463. 2 interactions.
    MINTiMINT-494746.
    STRINGi4932.YKL192C.

    Structurei

    3D structure databases

    ProteinModelPortaliP32463.
    SMRiP32463. Positions 66-118.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 acyl carrier domain.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0236.
    GeneTreeiENSGT00390000002127.
    HOGENOMiHOG000178184.
    KOiK03955.
    OMAiTASFAND.
    OrthoDBiEOG757D9J.

    Family and domain databases

    Gene3Di1.10.1200.10. 1 hit.
    HAMAPiMF_01217. Acyl_carrier.
    InterProiIPR003231. Acyl_carrier.
    IPR009081. Acyl_carrier_prot-like.
    IPR006162. PPantetheine_attach_site.
    [Graphical view]
    PfamiPF00550. PP-binding. 1 hit.
    [Graphical view]
    ProDomiPD000887. PD000887. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF47336. SSF47336. 1 hit.
    TIGRFAMsiTIGR00517. acyl_carrier. 1 hit.
    PROSITEiPS50075. ACP_DOMAIN. 1 hit.
    PS00012. PHOSPHOPANTETHEINE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P32463-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFRSVCRISS RVAPSAYRTI MGRSVMSNTI LAQRFYSANL SKDQVSQRVI    50
    DVIKAFDKNS PNIANKQISS DTQFHKDLGL DSLDTVELLV AIEEEFDIEI 100
    PDKVADELRS VGETVDYIAS NPDAN 125
    Length:125
    Mass (Da):13,943
    Last modified:October 1, 1993 - v1
    Checksum:iA0C64C5B796A5DDF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X69765 Genomic DNA. Translation: CAA49419.1.
    Z28192 Genomic DNA. Translation: CAA82036.1.
    AY558392 Genomic DNA. Translation: AAS56718.1.
    BK006944 Genomic DNA. Translation: DAA08974.1.
    PIRiS33960.
    RefSeqiNP_012729.1. NM_001179758.1.

    Genome annotation databases

    EnsemblFungiiYKL192C; YKL192C; YKL192C.
    GeneIDi853642.
    KEGGisce:YKL192C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X69765 Genomic DNA. Translation: CAA49419.1 .
    Z28192 Genomic DNA. Translation: CAA82036.1 .
    AY558392 Genomic DNA. Translation: AAS56718.1 .
    BK006944 Genomic DNA. Translation: DAA08974.1 .
    PIRi S33960.
    RefSeqi NP_012729.1. NM_001179758.1.

    3D structure databases

    ProteinModelPortali P32463.
    SMRi P32463. Positions 66-118.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33929. 22 interactions.
    DIPi DIP-3990N.
    IntActi P32463. 2 interactions.
    MINTi MINT-494746.
    STRINGi 4932.YKL192C.

    Proteomic databases

    MaxQBi P32463.
    PaxDbi P32463.
    PeptideAtlasi P32463.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YKL192C ; YKL192C ; YKL192C .
    GeneIDi 853642.
    KEGGi sce:YKL192C.

    Organism-specific databases

    CYGDi YKL192c.
    SGDi S000001675. ACP1.

    Phylogenomic databases

    eggNOGi COG0236.
    GeneTreei ENSGT00390000002127.
    HOGENOMi HOG000178184.
    KOi K03955.
    OMAi TASFAND.
    OrthoDBi EOG757D9J.

    Enzyme and pathway databases

    UniPathwayi UPA00094 .
    BioCyci YEAST:G3O-31954-MONOMER.

    Miscellaneous databases

    NextBioi 974537.
    PROi P32463.

    Gene expression databases

    Genevestigatori P32463.

    Family and domain databases

    Gene3Di 1.10.1200.10. 1 hit.
    HAMAPi MF_01217. Acyl_carrier.
    InterProi IPR003231. Acyl_carrier.
    IPR009081. Acyl_carrier_prot-like.
    IPR006162. PPantetheine_attach_site.
    [Graphical view ]
    Pfami PF00550. PP-binding. 1 hit.
    [Graphical view ]
    ProDomi PD000887. PD000887. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF47336. SSF47336. 1 hit.
    TIGRFAMsi TIGR00517. acyl_carrier. 1 hit.
    PROSITEi PS50075. ACP_DOMAIN. 1 hit.
    PS00012. PHOSPHOPANTETHEINE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "DNA sequence analysis of the YCN2 region of chromosome XI in Saccharomyces cerevisiae."
      Cheret G., Mattheakis L.C., Sor F.
      Yeast 9:661-667(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: S288c / GRF88.
    2. "Complete DNA sequence of yeast chromosome XI."
      Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
      , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
      Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiACPM_YEAST
    AccessioniPrimary (citable) accession number: P32463
    Secondary accession number(s): D6VX08
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: October 1, 1993
    Last modified: October 1, 2014
    This is version 138 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 60500 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    4. Yeast chromosome XI
      Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

    External Data

    Dasty 3