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Protein

Ureidoglycolate lyase

Gene

DAL3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as secondary nitrogen source when primary sources are limiting.1 Publication

Caution

This enzyme was also named ureidoglycolate hydrolase in the literature. However, this is the recommended name of another enzyme (EC 3.5.1.116) acting on ureidoglycolate. To make the distinction between ammonia- or urea-releasing activities from ureidoglycolate, the use of this ambiguous name is deprecated.Curated

Catalytic activityi

(S)-ureidoglycolate = glyoxylate + urea.1 Publication

pH dependencei

Optimum pH is 7.3.1 Publication

Pathwayi: (S)-allantoin degradation

This protein is involved in the pathway (S)-allantoin degradation, which is part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the pathway (S)-allantoin degradation and in Nitrogen metabolism.

GO - Molecular functioni

  • ureidoglycolate hydrolase activity Source: InterPro
  • ureidoglycolate lyase activity Source: SGD

GO - Biological processi

  • allantoin catabolic process Source: SGD
  • purine nucleobase metabolic process Source: UniProtKB-KW

Keywordsi

Molecular functionLyase
Biological processPurine metabolism

Enzyme and pathway databases

BioCyciMetaCyc:YIR032C-MONOMER
YEAST:YIR032C-MONOMER
UniPathwayiUPA00395

Names & Taxonomyi

Protein namesi
Recommended name:
Ureidoglycolate lyase (EC:4.3.2.3)
Alternative name(s):
Degradation of allantoin protein 3
Ureidoglycolatase
Ureidoglycolate hydrolase
Gene namesi
Name:DAL3
Ordered Locus Names:YIR032C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IX

Organism-specific databases

EuPathDBiFungiDB:YIR032C
SGDiS000001471 DAL3

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001205621 – 195Ureidoglycolate lyaseAdd BLAST195

Proteomic databases

MaxQBiP32459
PaxDbiP32459
PRIDEiP32459

Expressioni

Inductioni

Subject to nitrogen catabolite repression.1 Publication

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi35023, 120 interactors
DIPiDIP-1284N
IntActiP32459, 2 interactors
MINTiP32459
STRINGi4932.YIR032C

Structurei

3D structure databases

ProteinModelPortaliP32459
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ureidoglycolate lyase family.Curated

Phylogenomic databases

HOGENOMiHOG000256169
InParanoidiP32459
KOiK01483
OMAiNWNIFRC
OrthoDBiEOG092C41PE

Family and domain databases

Gene3Di2.60.120.480, 1 hit
InterProiView protein in InterPro
IPR011051 RmlC_Cupin_sf
IPR007247 Ureidogly_lyase
IPR024060 Ureidoglycolate_lyase_dom_sf
PANTHERiPTHR21221 PTHR21221, 1 hit
PfamiView protein in Pfam
PF04115 Ureidogly_lyase, 1 hit
SUPFAMiSSF51182 SSF51182, 1 hit

Sequencei

Sequence statusi: Complete.

P32459-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTVVAETLT KESFEEYGTI ISPDEEISRM QNLEKGANQG TAIKLLQVSQ
60 70 80 90 100
VENKSTSKVP NWNLFRCFPQ PHLNRVFTQG SNQAISHSIK VLEKHPCSTQ
110 120 130 140 150
TFVPMGRTSA EVAYLVVVAK EIGNKPDLST LRAFTCLGNQ AVTYGLGTWH
160 170 180 190
APMIVLGKEE HLDFSVLIYE SLDPDRPEKD CVEEHYSDGD VCIII
Length:195
Mass (Da):21,727
Last modified:October 1, 1993 - v1
Checksum:i6230AEE69585206B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64778 Genomic DNA Translation: AAA73025.1
Z38061 Genomic DNA Translation: CAA86192.1
BK006942 Genomic DNA Translation: DAA08579.1
PIRiS42022
RefSeqiNP_012298.1, NM_001179554.1

Genome annotation databases

EnsemblFungiiYIR032C; YIR032C; YIR032C
GeneIDi854850
KEGGisce:YIR032C

Similar proteinsi

Entry informationi

Entry nameiALLA_YEAST
AccessioniPrimary (citable) accession number: P32459
Secondary accession number(s): D6VVW3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: May 23, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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