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P32459

- ALLA_YEAST

UniProt

P32459 - ALLA_YEAST

Protein

Ureidoglycolate lyase

Gene

DAL3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 1 (01 Oct 1993)
      Previous versions | rss
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    Functioni

    Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as secondary nitrogen source when primary sources are limiting.1 Publication

    Catalytic activityi

    (S)-ureidoglycolate = glyoxylate + urea.1 Publication

    pH dependencei

    Optimum pH is 7.3.1 Publication

    Pathwayi

    GO - Molecular functioni

    1. ureidoglycolate hydrolase activity Source: InterPro
    2. ureidoglycolate lyase activity Source: SGD

    GO - Biological processi

    1. allantoin catabolic process Source: SGD
    2. purine nucleobase metabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Purine metabolism

    Enzyme and pathway databases

    BioCyciMetaCyc:YIR032C-MONOMER.
    YEAST:YIR032C-MONOMER.
    UniPathwayiUPA00395.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ureidoglycolate lyase (EC:4.3.2.3)
    Alternative name(s):
    Degradation of allantoin protein 3
    Ureidoglycolatase
    Ureidoglycolate hydrolase
    Gene namesi
    Name:DAL3
    Ordered Locus Names:YIR032C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome IX

    Organism-specific databases

    CYGDiYIR032c.
    SGDiS000001471. DAL3.

    Subcellular locationi

    GO - Cellular componenti

    1. membrane Source: SGD

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 195195Ureidoglycolate lyasePRO_0000120562Add
    BLAST

    Proteomic databases

    MaxQBiP32459.
    PaxDbiP32459.

    Expressioni

    Inductioni

    Subject to nitrogen catabolite repression.1 Publication

    Gene expression databases

    GenevestigatoriP32459.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    BioGridi35023. 17 interactions.
    DIPiDIP-1284N.
    IntActiP32459. 2 interactions.
    MINTiMINT-393452.
    STRINGi4932.YIR032C.

    Structurei

    3D structure databases

    ProteinModelPortaliP32459.
    SMRiP32459. Positions 1-194.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ureidoglycolate lyase family.Curated

    Phylogenomic databases

    eggNOGiCOG3194.
    HOGENOMiHOG000256169.
    KOiK01483.
    OMAiNWNIFRC.
    OrthoDBiEOG7CG79G.

    Family and domain databases

    Gene3Di2.60.120.480. 1 hit.
    InterProiIPR011051. RmlC_Cupin.
    IPR007247. Ureidogly_hydro.
    IPR024060. Ureidoglycolate_hydrolase_dom.
    [Graphical view]
    PANTHERiPTHR21221. PTHR21221. 1 hit.
    PfamiPF04115. Ureidogly_hydro. 1 hit.
    [Graphical view]
    PIRSFiPIRSF017306. Ureidogly_hydro. 1 hit.
    SUPFAMiSSF51182. SSF51182. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P32459-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVTVVAETLT KESFEEYGTI ISPDEEISRM QNLEKGANQG TAIKLLQVSQ    50
    VENKSTSKVP NWNLFRCFPQ PHLNRVFTQG SNQAISHSIK VLEKHPCSTQ 100
    TFVPMGRTSA EVAYLVVVAK EIGNKPDLST LRAFTCLGNQ AVTYGLGTWH 150
    APMIVLGKEE HLDFSVLIYE SLDPDRPEKD CVEEHYSDGD VCIII 195
    Length:195
    Mass (Da):21,727
    Last modified:October 1, 1993 - v1
    Checksum:i6230AEE69585206B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M64778 Genomic DNA. Translation: AAA73025.1.
    Z38061 Genomic DNA. Translation: CAA86192.1.
    BK006942 Genomic DNA. Translation: DAA08579.1.
    PIRiS42022.
    RefSeqiNP_012298.1. NM_001179554.1.

    Genome annotation databases

    EnsemblFungiiYIR032C; YIR032C; YIR032C.
    GeneIDi854850.
    KEGGisce:YIR032C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M64778 Genomic DNA. Translation: AAA73025.1 .
    Z38061 Genomic DNA. Translation: CAA86192.1 .
    BK006942 Genomic DNA. Translation: DAA08579.1 .
    PIRi S42022.
    RefSeqi NP_012298.1. NM_001179554.1.

    3D structure databases

    ProteinModelPortali P32459.
    SMRi P32459. Positions 1-194.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35023. 17 interactions.
    DIPi DIP-1284N.
    IntActi P32459. 2 interactions.
    MINTi MINT-393452.
    STRINGi 4932.YIR032C.

    Proteomic databases

    MaxQBi P32459.
    PaxDbi P32459.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YIR032C ; YIR032C ; YIR032C .
    GeneIDi 854850.
    KEGGi sce:YIR032C.

    Organism-specific databases

    CYGDi YIR032c.
    SGDi S000001471. DAL3.

    Phylogenomic databases

    eggNOGi COG3194.
    HOGENOMi HOG000256169.
    KOi K01483.
    OMAi NWNIFRC.
    OrthoDBi EOG7CG79G.

    Enzyme and pathway databases

    UniPathwayi UPA00395 .
    BioCyci MetaCyc:YIR032C-MONOMER.
    YEAST:YIR032C-MONOMER.

    Miscellaneous databases

    NextBioi 977749.

    Gene expression databases

    Genevestigatori P32459.

    Family and domain databases

    Gene3Di 2.60.120.480. 1 hit.
    InterProi IPR011051. RmlC_Cupin.
    IPR007247. Ureidogly_hydro.
    IPR024060. Ureidoglycolate_hydrolase_dom.
    [Graphical view ]
    PANTHERi PTHR21221. PTHR21221. 1 hit.
    Pfami PF04115. Ureidogly_hydro. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF017306. Ureidogly_hydro. 1 hit.
    SUPFAMi SSF51182. SSF51182. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The ureidoglycollate hydrolase (DAL3) gene in Saccharomyces cerevisiae."
      Yoo H.S., Cooper T.G.
      Yeast 7:693-698(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: BIOPHYSICOCHEMICAL PROPERTIES.
    5. "Identification of the ureidoglycolate hydrolase gene in the DAL gene cluster of Saccharomyces cerevisiae."
      Yoo H.S., Genbauffe F.S., Cooper T.G.
      Mol. Cell. Biol. 5:2279-2288(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, CATALYTIC ACTIVITY, INDUCTION.

    Entry informationi

    Entry nameiALLA_YEAST
    AccessioniPrimary (citable) accession number: P32459
    Secondary accession number(s): D6VVW3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: October 1, 1993
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Caution

    This enzyme was also named ureidoglycolate hydrolase in the literature. However, this is the recommended name of another enzyme (EC 3.5.3.19) acting on ureidoglycolate. To make the distinction between ammonia- or urea-releasing activities from ureidoglycolate, the use of this ambiguous name is deprecated.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    4. Yeast chromosome IX
      Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

    External Data

    Dasty 3