P32459 (ALLA_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ureidoglycolate hydrolase
EC=3.5.3.19

Gene names

Name:	DAL3
Ordered Locus Names:	YIR032C

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	195 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Utilization of purines as secondary nitrogen sources, when primary sources are limiting.
Catalytic activity	(S)-ureidoglycolate + H2O = glyoxylate + 2 NH3 + CO2.
Pathway	Nitrogen metabolism; (S)-allantoin degradation; glyoxylate from (S)-ureidoglycolate: step 1/1.
Subcellular location	Cell membrane; Lipid-anchor; Cytoplasmic side Potential.
Sequence similarities	Belongs to the ureidoglycolate hydrolase family.

Ontologies

Keywords
Biological process	Purine metabolism
Cellular component	Cell membrane Membrane
Molecular function	Hydrolase
PTM	Lipoprotein Methylation Prenylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	allantoin catabolic process Inferred by curator. Source: SGD purine base metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ureidoglycolate hydrolase activity Inferred from mutant phenotype. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 192	192	Ureidoglycolate hydrolase		PRO_0000120562
	Propeptide	193 – 195	3	Removed in mature form Potential		PRO_0000366195
Amino acid modifications
	Modified residue	192	1	Cysteine methyl ester Potential
	Lipidation	192	1	S-farnesyl cysteine Potential

Sequences

	Sequence		Length	Mass (Da)
	P32459 [UniParc]. Last modified October 1, 1993. Version 1. Checksum: 6230AEE69585206B	FASTA	195	21,727
	10 20 30 40 50 60 MVTVVAETLT KESFEEYGTI ISPDEEISRM QNLEKGANQG TAIKLLQVSQ VENKSTSKVP 70 80 90 100 110 120 NWNLFRCFPQ PHLNRVFTQG SNQAISHSIK VLEKHPCSTQ TFVPMGRTSA EVAYLVVVAK 130 140 150 160 170 180 EIGNKPDLST LRAFTCLGNQ AVTYGLGTWH APMIVLGKEE HLDFSVLIYE SLDPDRPEKD 190 CVEEHYSDGD VCIII

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The ureidoglycollate hydrolase (DAL3) gene in Saccharomyces cerevisiae." Yoo H.S., Cooper T.G. Yeast 7:693-698(1991) [PubMed: 1776360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome IX." Churcher C.M., Bowman S., Badcock K., Bankier A.T., Brown D., Chillingworth T., Connor R., Devlin K., Gentles S., Hamlin N., Harris D.E., Horsnell T., Hunt S., Jagels K., Jones M., Lye G., Moule S., Odell C. , Pearson D., Rajandream M.A., Rice P., Rowley N., Skelton J., Smith V., Walsh S.V., Whitehead S., Barrell B.G. Nature 387:84-87(1997) [PubMed: 9169870] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M64778 Genomic DNA. Translation: AAA73025.1. Z38061 Genomic DNA. Translation: CAA86192.1. BK006942 Genomic DNA. Translation: DAA08579.1.
PIR	S42022.
RefSeq	NP_012298.1. NM_001179554.1.
3D structure databases
ProteinModelPortal	P32459.
SMR	P32459. Positions 1-194.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-1284N.
IntAct	P32459. 4 interactions.
MINT	MINT-393452.
STRING	P32459.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YIR032C; YIR032C; YIR032C.
GeneID	854850.
KEGG	sce:YIR032C.
NMPDR	fig|4932.3.peg.1842.
Organism-specific databases
CYGD	YIR032c.
SGD	S000001471. DAL3.
Phylogenomic databases
eggNOG	fuNOG10612.
GeneTree	EFGT00050000006324.
HOGENOM	HBG289179.
OMA	HPFSTQT.
OrthoDB	EOG4RJKB5.
Enzyme and pathway databases
BioCyc	MetaCyc:YIR032C-MONOMER.
Gene expression databases
ArrayExpress	P32459.
Genevestigator	P32459.
GermOnline	YIR032C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR011051. Cupin_RmlC_type. IPR007247. Ureidogly_hydro. IPR024060. Ureidoglycolate_hydrolase_dom. [Graphical view]
Gene3D	G3DSA:2.60.120.480. G3DSA:2.60.120.480. 1 hit.
KO	K01483.
PANTHER	PTHR21221. Ureidogly_hydro. 1 hit.
Pfam	PF04115. Ureidogly_hydro. 1 hit. [Graphical view]
PIRSF	PIRSF017306. Ureidogly_hydro. 1 hit.
SUPFAM	SSF51182. RmlC_like_cupin. 1 hit.
ProtoNet	Search...
Other
NextBio	977749.

Entry information

Entry name

ALLA_YEAST

Accession

Primary (citable) accession number: P32459
Secondary accession number(s): D6VVW3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
Last sequence update:	October 1, 1993
Last modified:	December 14, 2011
This is version 99 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program