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P32459

- ALLA_YEAST

UniProt

P32459 - ALLA_YEAST

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Protein

Ureidoglycolate lyase

Gene

DAL3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as secondary nitrogen source when primary sources are limiting.1 Publication

Catalytic activityi

(S)-ureidoglycolate = glyoxylate + urea.1 Publication

pH dependencei

Optimum pH is 7.3.1 Publication

Pathwayi

GO - Molecular functioni

  1. ureidoglycolate hydrolase activity Source: InterPro
  2. ureidoglycolate lyase activity Source: SGD

GO - Biological processi

  1. allantoin catabolic process Source: SGD
  2. purine nucleobase metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Purine metabolism

Enzyme and pathway databases

BioCyciMetaCyc:YIR032C-MONOMER.
YEAST:YIR032C-MONOMER.
UniPathwayiUPA00395.

Names & Taxonomyi

Protein namesi
Recommended name:
Ureidoglycolate lyase (EC:4.3.2.3)
Alternative name(s):
Degradation of allantoin protein 3
Ureidoglycolatase
Ureidoglycolate hydrolase
Gene namesi
Name:DAL3
Ordered Locus Names:YIR032C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome IX

Organism-specific databases

CYGDiYIR032c.
SGDiS000001471. DAL3.

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 195195Ureidoglycolate lyasePRO_0000120562Add
BLAST

Proteomic databases

MaxQBiP32459.
PaxDbiP32459.

Expressioni

Inductioni

Subject to nitrogen catabolite repression.1 Publication

Gene expression databases

GenevestigatoriP32459.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi35023. 17 interactions.
DIPiDIP-1284N.
IntActiP32459. 2 interactions.
MINTiMINT-393452.
STRINGi4932.YIR032C.

Structurei

3D structure databases

ProteinModelPortaliP32459.
SMRiP32459. Positions 1-194.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ureidoglycolate lyase family.Curated

Phylogenomic databases

eggNOGiCOG3194.
HOGENOMiHOG000256169.
InParanoidiP32459.
KOiK01483.
OMAiNWNIFRC.
OrthoDBiEOG7CG79G.

Family and domain databases

Gene3Di2.60.120.480. 1 hit.
InterProiIPR011051. RmlC_Cupin.
IPR007247. Ureidogly_hydro.
IPR024060. Ureidoglycolate_hydrolase_dom.
[Graphical view]
PANTHERiPTHR21221. PTHR21221. 1 hit.
PfamiPF04115. Ureidogly_hydro. 1 hit.
[Graphical view]
PIRSFiPIRSF017306. Ureidogly_hydro. 1 hit.
SUPFAMiSSF51182. SSF51182. 1 hit.

Sequencei

Sequence statusi: Complete.

P32459-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVTVVAETLT KESFEEYGTI ISPDEEISRM QNLEKGANQG TAIKLLQVSQ
60 70 80 90 100
VENKSTSKVP NWNLFRCFPQ PHLNRVFTQG SNQAISHSIK VLEKHPCSTQ
110 120 130 140 150
TFVPMGRTSA EVAYLVVVAK EIGNKPDLST LRAFTCLGNQ AVTYGLGTWH
160 170 180 190
APMIVLGKEE HLDFSVLIYE SLDPDRPEKD CVEEHYSDGD VCIII
Length:195
Mass (Da):21,727
Last modified:October 1, 1993 - v1
Checksum:i6230AEE69585206B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64778 Genomic DNA. Translation: AAA73025.1.
Z38061 Genomic DNA. Translation: CAA86192.1.
BK006942 Genomic DNA. Translation: DAA08579.1.
PIRiS42022.
RefSeqiNP_012298.1. NM_001179554.1.

Genome annotation databases

EnsemblFungiiYIR032C; YIR032C; YIR032C.
GeneIDi854850.
KEGGisce:YIR032C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64778 Genomic DNA. Translation: AAA73025.1 .
Z38061 Genomic DNA. Translation: CAA86192.1 .
BK006942 Genomic DNA. Translation: DAA08579.1 .
PIRi S42022.
RefSeqi NP_012298.1. NM_001179554.1.

3D structure databases

ProteinModelPortali P32459.
SMRi P32459. Positions 1-194.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35023. 17 interactions.
DIPi DIP-1284N.
IntActi P32459. 2 interactions.
MINTi MINT-393452.
STRINGi 4932.YIR032C.

Proteomic databases

MaxQBi P32459.
PaxDbi P32459.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YIR032C ; YIR032C ; YIR032C .
GeneIDi 854850.
KEGGi sce:YIR032C.

Organism-specific databases

CYGDi YIR032c.
SGDi S000001471. DAL3.

Phylogenomic databases

eggNOGi COG3194.
HOGENOMi HOG000256169.
InParanoidi P32459.
KOi K01483.
OMAi NWNIFRC.
OrthoDBi EOG7CG79G.

Enzyme and pathway databases

UniPathwayi UPA00395 .
BioCyci MetaCyc:YIR032C-MONOMER.
YEAST:YIR032C-MONOMER.

Miscellaneous databases

NextBioi 977749.

Gene expression databases

Genevestigatori P32459.

Family and domain databases

Gene3Di 2.60.120.480. 1 hit.
InterProi IPR011051. RmlC_Cupin.
IPR007247. Ureidogly_hydro.
IPR024060. Ureidoglycolate_hydrolase_dom.
[Graphical view ]
PANTHERi PTHR21221. PTHR21221. 1 hit.
Pfami PF04115. Ureidogly_hydro. 1 hit.
[Graphical view ]
PIRSFi PIRSF017306. Ureidogly_hydro. 1 hit.
SUPFAMi SSF51182. SSF51182. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The ureidoglycollate hydrolase (DAL3) gene in Saccharomyces cerevisiae."
    Yoo H.S., Cooper T.G.
    Yeast 7:693-698(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: BIOPHYSICOCHEMICAL PROPERTIES.
  5. "Identification of the ureidoglycolate hydrolase gene in the DAL gene cluster of Saccharomyces cerevisiae."
    Yoo H.S., Genbauffe F.S., Cooper T.G.
    Mol. Cell. Biol. 5:2279-2288(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY, INDUCTION.

Entry informationi

Entry nameiALLA_YEAST
AccessioniPrimary (citable) accession number: P32459
Secondary accession number(s): D6VVW3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: October 29, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Caution

This enzyme was also named ureidoglycolate hydrolase in the literature. However, this is the recommended name of another enzyme (EC 3.5.3.19) acting on ureidoglycolate. To make the distinction between ammonia- or urea-releasing activities from ureidoglycolate, the use of this ambiguous name is deprecated.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

External Data

Dasty 3