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Protein

Putative prephenate dehydratase

Gene

PHA2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Present with 2020 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

Prephenate = phenylpyruvate + H2O + CO2.

Pathwayi: L-phenylalanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes phenylpyruvate from prephenate.
Proteins known to be involved in this subpathway in this organism are:
  1. Putative prephenate dehydratase (PHA2)
This subpathway is part of the pathway L-phenylalanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes phenylpyruvate from prephenate, the pathway L-phenylalanine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

  • chorismate mutase activity Source: InterPro
  • prephenate dehydratase activity Source: SGD

GO - Biological processi

  • L-phenylalanine biosynthetic process Source: SGD

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Phenylalanine biosynthesis

Enzyme and pathway databases

BioCyciYEAST:MONOMER3O-279
UniPathwayiUPA00121; UER00345

Names & Taxonomyi

Protein namesi
Recommended name:
Putative prephenate dehydratase (EC:4.2.1.51)
Short name:
PDT
Alternative name(s):
Phenylalanine-requiring protein 2
Gene namesi
Name:PHA2
Ordered Locus Names:YNL316C
ORF Names:N0351
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL316C
SGDiS000005260 PHA2

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001192061 – 334Putative prephenate dehydrataseAdd BLAST334

Proteomic databases

MaxQBiP32452
PaxDbiP32452
PRIDEiP32452

Interactioni

Protein-protein interaction databases

BioGridi35523, 59 interactors
DIPiDIP-4269N
IntActiP32452, 2 interactors
STRINGi4932.YNL316C

Structurei

3D structure databases

ProteinModelPortaliP32452
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 224Prephenate dehydratasePROSITE-ProRule annotationAdd BLAST218
Domaini244 – 322ACTPROSITE-ProRule annotationAdd BLAST79

Phylogenomic databases

HOGENOMiHOG000018970
InParanoidiP32452
KOiK04518
OMAiREVMSAC
OrthoDBiEOG092C3MV0

Family and domain databases

InterProiView protein in InterPro
IPR002912 ACT_dom
IPR008242 Chor_mutase/pphenate_deHydtase
IPR001086 Preph_deHydtase
PfamiView protein in Pfam
PF00800 PDT, 1 hit
PIRSFiPIRSF001500 Chor_mut_pdt_Ppr, 1 hit
PROSITEiView protein in PROSITE
PS51671 ACT, 1 hit
PS51171 PREPHENATE_DEHYDR_3, 1 hit

Sequencei

Sequence statusi: Complete.

P32452-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASKTLRVLF LGPKGTYSHQ AALQQFQSTS DVEYLPAASI PQCFNQLEND
60 70 80 90 100
TSIDYSVVPL ENSTNGQVVF SYDLLRDRMI KKALSLPAPA DTNRITPDIE
110 120 130 140 150
VIAEQYVPIT HCLISPIQLP NGIASLGNFE EVIIHSHPQV WGQVECYLRS
160 170 180 190 200
MAEKFPQVTF IRLDCSSTSE SVNQCIRSST ADCDNILHLA IASETAAQLH
210 220 230 240 250
KAYIIEHSIN DKLGNTTRFL VLKRRENAGD NEVEDTGLLR VNLLTFTTRQ
260 270 280 290 300
DDPGSLVDVL NILKIHSLNM CSINSRPFHL DEHDRNWRYL FFIEYYTEKN
310 320 330
TPKNKEKFYE DISDKSKQWC LWGTFPRNER YYHK
Length:334
Mass (Da):38,225
Last modified:October 17, 2006 - v3
Checksum:i1917F12AE5ECC249
GO

Sequence cautioni

The sequence AAA34448 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA86380 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA96246 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46259 Genomic DNA Translation: CAA86380.1 Different initiation.
Z71592 Genomic DNA Translation: CAA96246.1 Different initiation.
M87006 Genomic DNA Translation: AAA34448.1 Different initiation.
BK006947 Genomic DNA Translation: DAA10245.1
PIRiS59565
RefSeqiNP_014083.2, NM_001183154.1

Genome annotation databases

EnsemblFungiiYNL316C; YNL316C; YNL316C
GeneIDi855400
KEGGisce:YNL316C

Similar proteinsi

Entry informationi

Entry nameiPHA2_YEAST
AccessioniPrimary (citable) accession number: P32452
Secondary accession number(s): D6W0M9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 17, 2006
Last modified: May 23, 2018
This is version 138 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

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