Reviewed, UniProtKB/Swiss-Prot P32443 (MEOX2_MOUSE)

Names and origin

Protein names

Recommended name:
    Homeobox protein MOX-2
Alternative name(s):
    Mesenchyme homeobox 2

Gene names

Name:	Meox2
Synonyms:	Gax, Mox-2, Mox2

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	303 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Role in mesoderm induction and its earliest regional specification, somitogenesis, and myogenic and sclerotomal differentiation. May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle.
Subunit structure	Interacts with RNF10 By similarity.
Subcellular location	Nucleus Potential.
Developmental stage	It is not expressed before 8-8.5 dpc. At 8-8.5 dpc it is found on the entire epithelium of the somite. At 9.5 dpc its expression is restricted to the sclerotome. At 10.5 dpc it is found in sclerotomally derived cells including the vertebral and costal precursors.
Sequence similarities	Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Gene Ontology (GO)
Biological process	angiogenesis Inferred from mutant phenotype. Source: MGI limb development Inferred from mutant phenotype. Source: MGI palate development Inferred from mutant phenotype. Source: MGI regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro skeletal muscle tissue development Inferred from mutant phenotype. Source: MGI somite specification Inferred from genetic interaction. Source: MGI
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 303	303	Homeobox protein MOX-2		PRO_0000049198
Regions
	DNA binding	186 – 245	60	Homeobox
	Compositional bias	42 – 47	6	Poly-Ser
	Compositional bias	63 – 85	23	Gln/His-rich (OPA repeat)
	Compositional bias	68 – 79	12	Poly-His
	Compositional bias	80 – 85	6	Poly-Gln

Sequences

	Sequence		Length	Mass (Da)
	P32443-1 [UniParc]. Last modified October 1, 1993. Version 1. Checksum: 41BD05FC39AA4427	FASTA	303	33,506
	10 20 30 40 50 60 MEHPLFGCLR SPHATAQGLH PFSQSSLALH GRSDHMSYPE LSTSSSSCII AGYPNEEGMF 70 80 90 100 110 120 ASQHHRGHHH HHHHHHHHHQ QQQHQALQSN WHLPQMSSPP SAARHSLCLQ PDSGGPPELG 130 140 150 160 170 180 SSPPVLCSNS SSLGSSTPTG AACAPGDYGR QALSPADVEK RSGSKRKSDS SDSQEGNYKS 190 200 210 220 230 240 EVNSKPRKER TAFTKEQIRE LEAEFAHHNY LTRLRRYEIA VNLDLTERQV KVWFQNRRMK 250 260 270 280 290 300 WKRVKGGQQG AAAREKELVN VKKGTLLPSE LSGIGAATLQ QTGDSLANED SRDSDHSSEH AHL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Mox-1 and Mox-2 define a novel homeobox gene subfamily and are differentially expressed during early mesodermal patterning in mouse embryos." Candia A.F., Hu J., Crosby J., Lalley P.A., Noden D., Nadeau J.H., Wright C.V.E. Development 116:1123-1136(1992) [PubMed: 1363541] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Amino acid sequence of Mox-2 and comparison to its Xenopus and rat homologs." Candia A.F., Kovalik J.-P., Wright C.V.E. Nucleic Acids Res. 21:4982-4982(1993) [PubMed: 7909944] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Forelimb, Heart and Placenta.
[4]	"Regulation of Gax homeobox gene transcription by a combination of positive factors including myocyte-specific enhancer factor 2." Andres V., Fisher S., Wearsch P., Walsh K. Mol. Cell. Biol. 15:4272-4281(1995) [PubMed: 7623821] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-11.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z16406 mRNA. Translation: CAA78899.1. AK028352 mRNA. Translation: BAC25898.1. AK031152 mRNA. Translation: BAC27282.1. AK142690 mRNA. Translation: BAE25163.1. S79168 Genomic DNA. No translation available.
IPI	IPI00108444.
PIR	B49122.
RefSeq	NP_032610.1.
UniGene	Mm.341398
3D structure databases
HSSP	HSSP built from PDB template 9ANT based on UniProtKB P02833.
ModBase	Search...
PTM databases
PhosphoSite	P32443.
Proteomic databases
PRIDE	P32443.
Genome annotation databases
Ensembl	ENSMUSG00000036144. Mus musculus. [Contig view]
GeneID	17286.
KEGG	mmu:17286.
Organism-specific databases
MGI	MGI:103219. Meox2.
Phylogenomic databases
HOGENOM	P32443.
HOVERGEN	P32443.
OMA	P32443. NDDSHDS.
Gene expression databases
ArrayExpress	P32443.
Bgee	P32443.
CleanEx	MM_MEOX2.
GermOnline	ENSMUSG00000036144. Mus musculus.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017970. Homeobox_CS. IPR012287. Homeodomain-rel. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
ProDom	PD000010. Homeobox. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00389. HOX. 1 hit. [Graphical view]
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	291796.
SOURCE	Search...

Entry information

Entry name

MEOX2_MOUSE

Accession

Primary (citable) accession number: P32443
Secondary accession number(s): Q544T6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
Last sequence update:	October 1, 1993
Last modified:	June 16, 2009
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)