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P32443

- MEOX2_MOUSE

UniProt

P32443 - MEOX2_MOUSE

Protein

Homeobox protein MOX-2

Gene

Meox2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 1 (01 Oct 1993)
      Previous versions | rss
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    Functioni

    Role in mesoderm induction and its earliest regional specification, somitogenesis, and myogenic and sclerotomal differentiation. May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi186 – 24560HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: Ensembl
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. angiogenesis Source: MGI
    2. limb development Source: MGI
    3. palate development Source: MGI
    4. skeletal muscle tissue development Source: MGI
    5. somite specification Source: MGI

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein MOX-2
    Alternative name(s):
    Mesenchyme homeobox 2
    Gene namesi
    Name:Meox2
    Synonyms:Gax, Mox-2, Mox2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:103219. Meox2.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation. Nucleus speckle PROSITE-ProRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. nuclear speck Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 303303Homeobox protein MOX-2PRO_0000049198Add
    BLAST

    Proteomic databases

    PRIDEiP32443.

    PTM databases

    PhosphoSiteiP32443.

    Expressioni

    Developmental stagei

    It is not expressed before 8-8.5 dpc. At 8-8.5 dpc it is found on the entire epithelium of the somite. At 9.5 dpc its expression is restricted to the sclerotome. At 10.5 dpc it is found in sclerotomally derived cells including the vertebral and costal precursors.

    Gene expression databases

    BgeeiP32443.
    CleanExiMM_MEOX2.
    GenevestigatoriP32443.

    Interactioni

    Subunit structurei

    Interacts with RNF10.By similarity

    Protein-protein interaction databases

    BioGridi201395. 4 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP32443.
    SMRiP32443. Positions 193-243.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi42 – 476Poly-Ser
    Compositional biasi63 – 8523Gln/His-rich (OPA repeat)Add
    BLAST
    Compositional biasi68 – 7912Poly-HisAdd
    BLAST
    Compositional biasi80 – 856Poly-Gln

    Domaini

    The polyhistidine repeat may act as a targeting signal to nuclear speckles.By similarity

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG250192.
    GeneTreeiENSGT00750000117293.
    HOGENOMiHOG000230987.
    HOVERGENiHBG052456.
    InParanoidiP32443.
    KOiK09322.
    OMAiPADFGRQ.
    OrthoDBiEOG7JDQZZ.
    PhylomeDBiP32443.
    TreeFamiTF351603.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P32443-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEHPLFGCLR SPHATAQGLH PFSQSSLALH GRSDHMSYPE LSTSSSSCII    50
    AGYPNEEGMF ASQHHRGHHH HHHHHHHHHQ QQQHQALQSN WHLPQMSSPP 100
    SAARHSLCLQ PDSGGPPELG SSPPVLCSNS SSLGSSTPTG AACAPGDYGR 150
    QALSPADVEK RSGSKRKSDS SDSQEGNYKS EVNSKPRKER TAFTKEQIRE 200
    LEAEFAHHNY LTRLRRYEIA VNLDLTERQV KVWFQNRRMK WKRVKGGQQG 250
    AAAREKELVN VKKGTLLPSE LSGIGAATLQ QTGDSLANED SRDSDHSSEH 300
    AHL 303
    Length:303
    Mass (Da):33,506
    Last modified:October 1, 1993 - v1
    Checksum:i41BD05FC39AA4427
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z16406 mRNA. Translation: CAA78899.1.
    AK028352 mRNA. Translation: BAC25898.1.
    AK031152 mRNA. Translation: BAC27282.1.
    AK142690 mRNA. Translation: BAE25163.1.
    S79168 Genomic DNA. No translation available.
    CCDSiCCDS25888.1.
    PIRiB49122.
    RefSeqiNP_032610.1. NM_008584.3.
    UniGeneiMm.341398.

    Genome annotation databases

    EnsembliENSMUST00000041183; ENSMUSP00000043587; ENSMUSG00000036144.
    GeneIDi17286.
    KEGGimmu:17286.
    UCSCiuc007nkf.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z16406 mRNA. Translation: CAA78899.1 .
    AK028352 mRNA. Translation: BAC25898.1 .
    AK031152 mRNA. Translation: BAC27282.1 .
    AK142690 mRNA. Translation: BAE25163.1 .
    S79168 Genomic DNA. No translation available.
    CCDSi CCDS25888.1.
    PIRi B49122.
    RefSeqi NP_032610.1. NM_008584.3.
    UniGenei Mm.341398.

    3D structure databases

    ProteinModelPortali P32443.
    SMRi P32443. Positions 193-243.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 201395. 4 interactions.

    PTM databases

    PhosphoSitei P32443.

    Proteomic databases

    PRIDEi P32443.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000041183 ; ENSMUSP00000043587 ; ENSMUSG00000036144 .
    GeneIDi 17286.
    KEGGi mmu:17286.
    UCSCi uc007nkf.1. mouse.

    Organism-specific databases

    CTDi 4223.
    MGIi MGI:103219. Meox2.

    Phylogenomic databases

    eggNOGi NOG250192.
    GeneTreei ENSGT00750000117293.
    HOGENOMi HOG000230987.
    HOVERGENi HBG052456.
    InParanoidi P32443.
    KOi K09322.
    OMAi PADFGRQ.
    OrthoDBi EOG7JDQZZ.
    PhylomeDBi P32443.
    TreeFami TF351603.

    Miscellaneous databases

    NextBioi 291796.
    PROi P32443.
    SOURCEi Search...

    Gene expression databases

    Bgeei P32443.
    CleanExi MM_MEOX2.
    Genevestigatori P32443.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mox-1 and Mox-2 define a novel homeobox gene subfamily and are differentially expressed during early mesodermal patterning in mouse embryos."
      Candia A.F., Hu J., Crosby J., Lalley P.A., Noden D., Nadeau J.H., Wright C.V.E.
      Development 116:1123-1136(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Amino acid sequence of Mox-2 and comparison to its Xenopus and rat homologs."
      Candia A.F., Kovalik J.-P., Wright C.V.E.
      Nucleic Acids Res. 21:4982-4982(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Forelimb, Heart and Placenta.
    4. "Regulation of Gax homeobox gene transcription by a combination of positive factors including myocyte-specific enhancer factor 2."
      Andres V., Fisher S., Wearsch P., Walsh K.
      Mol. Cell. Biol. 15:4272-4281(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-11.

    Entry informationi

    Entry nameiMEOX2_MOUSE
    AccessioniPrimary (citable) accession number: P32443
    Secondary accession number(s): Q544T6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: October 1, 1993
    Last modified: October 1, 2014
    This is version 120 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3