SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P32443

- MEOX2_MOUSE

UniProt

P32443 - MEOX2_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Homeobox protein MOX-2
Gene
Meox2, Gax, Mox-2, Mox2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Role in mesoderm induction and its earliest regional specification, somitogenesis, and myogenic and sclerotomal differentiation. May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi186 – 24560Homeobox
Add
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: Ensembl
  2. sequence-specific DNA binding transcription factor activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. angiogenesis Source: MGI
  2. limb development Source: MGI
  3. palate development Source: MGI
  4. skeletal muscle tissue development Source: MGI
  5. somite specification Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein MOX-2
Alternative name(s):
Mesenchyme homeobox 2
Gene namesi
Name:Meox2
Synonyms:Gax, Mox-2, Mox2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:103219. Meox2.

Subcellular locationi

Nucleus By similarity. Nucleus speckle By similarity

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nuclear speck Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 303303Homeobox protein MOX-2
PRO_0000049198Add
BLAST

Proteomic databases

PRIDEiP32443.

PTM databases

PhosphoSiteiP32443.

Expressioni

Developmental stagei

It is not expressed before 8-8.5 dpc. At 8-8.5 dpc it is found on the entire epithelium of the somite. At 9.5 dpc its expression is restricted to the sclerotome. At 10.5 dpc it is found in sclerotomally derived cells including the vertebral and costal precursors.

Gene expression databases

BgeeiP32443.
CleanExiMM_MEOX2.
GenevestigatoriP32443.

Interactioni

Subunit structurei

Interacts with RNF10 By similarity.

Protein-protein interaction databases

BioGridi201395. 4 interactions.

Structurei

3D structure databases

ProteinModelPortaliP32443.
SMRiP32443. Positions 193-243.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi42 – 476Poly-Ser
Compositional biasi63 – 8523Gln/His-rich (OPA repeat)
Add
BLAST
Compositional biasi68 – 7912Poly-His
Add
BLAST
Compositional biasi80 – 856Poly-Gln

Domaini

The polyhistidine repeat may act as a targeting signal to nuclear speckles By similarity.

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG250192.
GeneTreeiENSGT00750000117293.
HOGENOMiHOG000230987.
HOVERGENiHBG052456.
InParanoidiP32443.
KOiK09322.
OMAiPADFGRQ.
OrthoDBiEOG7JDQZZ.
PhylomeDBiP32443.
TreeFamiTF351603.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32443-1 [UniParc]FASTAAdd to Basket

« Hide

MEHPLFGCLR SPHATAQGLH PFSQSSLALH GRSDHMSYPE LSTSSSSCII    50
AGYPNEEGMF ASQHHRGHHH HHHHHHHHHQ QQQHQALQSN WHLPQMSSPP 100
SAARHSLCLQ PDSGGPPELG SSPPVLCSNS SSLGSSTPTG AACAPGDYGR 150
QALSPADVEK RSGSKRKSDS SDSQEGNYKS EVNSKPRKER TAFTKEQIRE 200
LEAEFAHHNY LTRLRRYEIA VNLDLTERQV KVWFQNRRMK WKRVKGGQQG 250
AAAREKELVN VKKGTLLPSE LSGIGAATLQ QTGDSLANED SRDSDHSSEH 300
AHL 303
Length:303
Mass (Da):33,506
Last modified:October 1, 1993 - v1
Checksum:i41BD05FC39AA4427
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z16406 mRNA. Translation: CAA78899.1.
AK028352 mRNA. Translation: BAC25898.1.
AK031152 mRNA. Translation: BAC27282.1.
AK142690 mRNA. Translation: BAE25163.1.
S79168 Genomic DNA. No translation available.
CCDSiCCDS25888.1.
PIRiB49122.
RefSeqiNP_032610.1. NM_008584.3.
UniGeneiMm.341398.

Genome annotation databases

EnsembliENSMUST00000041183; ENSMUSP00000043587; ENSMUSG00000036144.
GeneIDi17286.
KEGGimmu:17286.
UCSCiuc007nkf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z16406 mRNA. Translation: CAA78899.1 .
AK028352 mRNA. Translation: BAC25898.1 .
AK031152 mRNA. Translation: BAC27282.1 .
AK142690 mRNA. Translation: BAE25163.1 .
S79168 Genomic DNA. No translation available.
CCDSi CCDS25888.1.
PIRi B49122.
RefSeqi NP_032610.1. NM_008584.3.
UniGenei Mm.341398.

3D structure databases

ProteinModelPortali P32443.
SMRi P32443. Positions 193-243.
ModBasei Search...

Protein-protein interaction databases

BioGridi 201395. 4 interactions.

PTM databases

PhosphoSitei P32443.

Proteomic databases

PRIDEi P32443.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000041183 ; ENSMUSP00000043587 ; ENSMUSG00000036144 .
GeneIDi 17286.
KEGGi mmu:17286.
UCSCi uc007nkf.1. mouse.

Organism-specific databases

CTDi 4223.
MGIi MGI:103219. Meox2.

Phylogenomic databases

eggNOGi NOG250192.
GeneTreei ENSGT00750000117293.
HOGENOMi HOG000230987.
HOVERGENi HBG052456.
InParanoidi P32443.
KOi K09322.
OMAi PADFGRQ.
OrthoDBi EOG7JDQZZ.
PhylomeDBi P32443.
TreeFami TF351603.

Miscellaneous databases

NextBioi 291796.
PROi P32443.
SOURCEi Search...

Gene expression databases

Bgeei P32443.
CleanExi MM_MEOX2.
Genevestigatori P32443.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mox-1 and Mox-2 define a novel homeobox gene subfamily and are differentially expressed during early mesodermal patterning in mouse embryos."
    Candia A.F., Hu J., Crosby J., Lalley P.A., Noden D., Nadeau J.H., Wright C.V.E.
    Development 116:1123-1136(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Amino acid sequence of Mox-2 and comparison to its Xenopus and rat homologs."
    Candia A.F., Kovalik J.-P., Wright C.V.E.
    Nucleic Acids Res. 21:4982-4982(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Forelimb, Heart and Placenta.
  4. "Regulation of Gax homeobox gene transcription by a combination of positive factors including myocyte-specific enhancer factor 2."
    Andres V., Fisher S., Wearsch P., Walsh K.
    Mol. Cell. Biol. 15:4272-4281(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-11.

Entry informationi

Entry nameiMEOX2_MOUSE
AccessioniPrimary (citable) accession number: P32443
Secondary accession number(s): Q544T6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: July 9, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi