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P32443 (MEOX2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein MOX-2
Alternative name(s):
Mesenchyme homeobox 2
Gene names
Name:Meox2
Synonyms:Gax, Mox-2, Mox2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length303 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Role in mesoderm induction and its earliest regional specification, somitogenesis, and myogenic and sclerotomal differentiation. May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle.

Subunit structure

Interacts with RNF10 By similarity.

Subcellular location

Nucleus By similarity. Nucleus speckle By similarity.

Developmental stage

It is not expressed before 8-8.5 dpc. At 8-8.5 dpc it is found on the entire epithelium of the somite. At 9.5 dpc its expression is restricted to the sclerotome. At 10.5 dpc it is found in sclerotomally derived cells including the vertebral and costal precursors.

Domain

The polyhistidine repeat may act as a targeting signal to nuclear speckles By similarity.

Sequence similarities

Contains 1 homeobox DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 303303Homeobox protein MOX-2
PRO_0000049198

Regions

DNA binding186 – 24560Homeobox
Compositional bias42 – 476Poly-Ser
Compositional bias63 – 8523Gln/His-rich (OPA repeat)
Compositional bias68 – 7912Poly-His
Compositional bias80 – 856Poly-Gln

Sequences

Sequence LengthMass (Da)Tools
P32443 [UniParc].

Last modified October 1, 1993. Version 1.
Checksum: 41BD05FC39AA4427

FASTA30333,506
        10         20         30         40         50         60 
MEHPLFGCLR SPHATAQGLH PFSQSSLALH GRSDHMSYPE LSTSSSSCII AGYPNEEGMF 

        70         80         90        100        110        120 
ASQHHRGHHH HHHHHHHHHQ QQQHQALQSN WHLPQMSSPP SAARHSLCLQ PDSGGPPELG 

       130        140        150        160        170        180 
SSPPVLCSNS SSLGSSTPTG AACAPGDYGR QALSPADVEK RSGSKRKSDS SDSQEGNYKS 

       190        200        210        220        230        240 
EVNSKPRKER TAFTKEQIRE LEAEFAHHNY LTRLRRYEIA VNLDLTERQV KVWFQNRRMK 

       250        260        270        280        290        300 
WKRVKGGQQG AAAREKELVN VKKGTLLPSE LSGIGAATLQ QTGDSLANED SRDSDHSSEH 


AHL 

« Hide

References

« Hide 'large scale' references
[1]"Mox-1 and Mox-2 define a novel homeobox gene subfamily and are differentially expressed during early mesodermal patterning in mouse embryos."
Candia A.F., Hu J., Crosby J., Lalley P.A., Noden D., Nadeau J.H., Wright C.V.E.
Development 116:1123-1136(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Amino acid sequence of Mox-2 and comparison to its Xenopus and rat homologs."
Candia A.F., Kovalik J.-P., Wright C.V.E.
Nucleic Acids Res. 21:4982-4982(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Forelimb, Heart and Placenta.
[4]"Regulation of Gax homeobox gene transcription by a combination of positive factors including myocyte-specific enhancer factor 2."
Andres V., Fisher S., Wearsch P., Walsh K.
Mol. Cell. Biol. 15:4272-4281(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-11.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z16406 mRNA. Translation: CAA78899.1.
AK028352 mRNA. Translation: BAC25898.1.
AK031152 mRNA. Translation: BAC27282.1.
AK142690 mRNA. Translation: BAE25163.1.
S79168 Genomic DNA. No translation available.
CCDSCCDS25888.1.
PIRB49122.
RefSeqNP_032610.1. NM_008584.3.
UniGeneMm.341398.

3D structure databases

ProteinModelPortalP32443.
SMRP32443. Positions 193-243.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid201395. 4 interactions.

PTM databases

PhosphoSiteP32443.

Proteomic databases

PRIDEP32443.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000041183; ENSMUSP00000043587; ENSMUSG00000036144.
GeneID17286.
KEGGmmu:17286.
UCSCuc007nkf.1. mouse.

Organism-specific databases

CTD4223.
MGIMGI:103219. Meox2.

Phylogenomic databases

eggNOGNOG250192.
GeneTreeENSGT00750000117293.
HOGENOMHOG000230987.
HOVERGENHBG052456.
InParanoidP32443.
KOK09322.
OMAPADFGRQ.
OrthoDBEOG7JDQZZ.
PhylomeDBP32443.
TreeFamTF351603.

Gene expression databases

BgeeP32443.
CleanExMM_MEOX2.
GenevestigatorP32443.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio291796.
PROP32443.
SOURCESearch...

Entry information

Entry nameMEOX2_MOUSE
AccessionPrimary (citable) accession number: P32443
Secondary accession number(s): Q544T6
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: July 9, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot