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UniProtKB - P32442 (MEOX1_MOUSE)

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Protein

Homeobox protein MOX-1

Gene

Meox1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints (PubMed:19520072). Binds specifically to the promoter of target genes and regulates their expression. Activates expression of NKX3-2 in the sclerotome (PubMed:15024065). Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner (PubMed:22206000). Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome (By similarity).By similarity7 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi170 – 229HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • chromatin binding Source: MGI
  • core promoter sequence-specific DNA binding Source: UniProtKB
  • HMG box domain binding Source: UniProtKB
  • RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
  • sequence-specific DNA binding Source: UniProtKB
  • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding Source: NTNU_SB
  • transcription factor activity, sequence-specific DNA binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  • hematopoietic stem cell differentiation Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  • sclerotome development Source: UniProtKB
  • somite development Source: UniProtKB
  • somite specification Source: MGI
Complete GO annotation...

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein MOX-1
Alternative name(s):
Mesenchyme homeobox 1
Gene namesi
Name:Meox1
Synonyms:Mox-1, Mox1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:103220. Meox1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice display mild defects in sclerotome derived vertebral and rib bones (PubMed:12925591). Abnormalities are restricted to the sclerotome and its derivatives and are characterized by a remodeling of the cranio-cervical joints, leading to the assimilation of the atlas into the basioccipital bone so that the skull rests on the axis (PubMed:19520072). Mice lacking Meox1 and Meox2 show extremely disrupted somite morphogenesis, patterning and differentiation. They lack an axial skeleton and skeletal muscles are severely deficient (PubMed:12925591).2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi219Q → E: Abolishes DNA-binding. Does not affect ability to activate expression of CDKN2A. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000491961 – 253Homeobox protein MOX-1Add BLAST253

Proteomic databases

PaxDbiP32442.
PRIDEiP32442.

PTM databases

PhosphoSitePlusiP32442.

Expressioni

Tissue specificityi

Heart, lateral plate derivatives, kidney, loose connective tissue at sites of bone formation and skeletal muscle-connective tissue apposition.1 Publication

Developmental stagei

After 7 dpc it is expressed in mesoderm lying posterior of the future primordial head and heart. Between 7.5 and 9.5 dpc it is expressed in presomitic mesoderm, epithelial and differentiating somites and in lateral plate mesoderm. In the body of mid-gestation embryos it is restricted to loose undifferentiated mesenchyme.1 Publication

Gene expression databases

BgeeiENSMUSG00000001493.
CleanExiMM_MEOX1.
GenevisibleiP32442. MM.

Interactioni

GO - Molecular functioni

  • HMG box domain binding Source: UniProtKB
Complete GO annotation...

Protein-protein interaction databases

BioGridi201394. 3 interactors.
STRINGi10090.ENSMUSP00000051158.

Structurei

3D structure databases

ProteinModelPortaliP32442.
SMRiP32442.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
GeneTreeiENSGT00760000118940.
HOGENOMiHOG000230987.
HOVERGENiHBG052456.
InParanoidiP32442.
KOiK09322.
OMAiWHFPVSE.
OrthoDBiEOG091G0PFO.
TreeFamiTF351603.

Family and domain databases

InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PRINTSiPR00024. HOMEOBOX.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P32442-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPVANSCVR NPQPPAPVWG CLRNPHSEDS SASGLSHYPP TPFSFHQKSD 
        60         70         80         90        100
FPATAAYPDF SASCLAATPH SLPRTERIFN EQHPAFPQTP DWHFPISEAG 
       110        120        130        140        150
QRLNLGPAGS AREMGAGSPG LVDGTAGLGE DCMVLGTIAN ETEKKSSRRK 
       160        170        180        190        200
KERSDNQENG GGKPEGSSKA RKERTAFTKE QLRELEAEFA HHNYLTRLRR 
       210        220        230        240        250
YEIAVNLDLS ERQVKVWFQN RRMKWKRVKG GQPVSPQEQD REDGDSAASP 

SSE
Length:253
Mass (Da):27,980
Last modified:October 1, 1993 - v1
Checksum:i5B8757EFE503EDDF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z15103 mRNA. Translation: CAA78812.1.
AK052370 mRNA. Translation: BAC34961.1.
CH466558 Genomic DNA. Translation: EDL34069.1.
BC011082 mRNA. Translation: AAH11082.1.
CCDSiCCDS25480.1.
PIRiA49122.
RefSeqiNP_034921.1. NM_010791.3.
UniGeneiMm.3404.

Genome annotation databases

EnsembliENSMUST00000057054; ENSMUSP00000051158; ENSMUSG00000001493.
GeneIDi17285.
KEGGimmu:17285.
UCSCiuc007lpx.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiMEOX1_MOUSE
AccessioniPrimary (citable) accession number: P32442
Secondary accession number(s): Q543E8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: June 7, 2017
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot