UniProtKB - P32442 (MEOX1_MOUSE)
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Protein
Homeobox protein MOX-1
Gene
Meox1
Organism
Mus musculus (Mouse)
Status
Functioni
Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints (PubMed:19520072). Binds specifically to the promoter of target genes and regulates their expression. Activates expression of NKX3-2 in the sclerotome (PubMed:15024065). Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner (PubMed:22206000). Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome (By similarity).By similarity7 Publications
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 170 – 229 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- chromatin binding Source: MGI
- core promoter sequence-specific DNA binding Source: UniProtKB
- DNA binding transcription factor activity Source: UniProtKB
- HMG box domain binding Source: UniProtKB
- RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB
- sequence-specific DNA binding Source: UniProtKB
- transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB
GO - Biological processi
- hematopoietic stem cell differentiation Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: NTNU_SB
- sclerotome development Source: UniProtKB
- somite development Source: UniProtKB
- somite specification Source: MGI
Keywordsi
Molecular function | Activator, Developmental protein, DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Homeobox protein MOX-1Alternative name(s): Mesenchyme homeobox 1 |
Gene namesi | Name:Meox1 Synonyms:Mox-1, Mox1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:103220. Meox1. |
Pathology & Biotechi
Disruption phenotypei
Mice display mild defects in sclerotome derived vertebral and rib bones (PubMed:12925591). Abnormalities are restricted to the sclerotome and its derivatives and are characterized by a remodeling of the cranio-cervical joints, leading to the assimilation of the atlas into the basioccipital bone so that the skull rests on the axis (PubMed:19520072). Mice lacking Meox1 and Meox2 show extremely disrupted somite morphogenesis, patterning and differentiation. They lack an axial skeleton and skeletal muscles are severely deficient (PubMed:12925591).2 Publications
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 219 | Q → E: Abolishes DNA-binding. Does not affect ability to activate expression of CDKN2A. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000049196 | 1 – 253 | Homeobox protein MOX-1Add BLAST | 253 |
Proteomic databases
PaxDbi | P32442. |
PRIDEi | P32442. |
PTM databases
PhosphoSitePlusi | P32442. |
Expressioni
Tissue specificityi
Heart, lateral plate derivatives, kidney, loose connective tissue at sites of bone formation and skeletal muscle-connective tissue apposition.1 Publication
Developmental stagei
After 7 dpc it is expressed in mesoderm lying posterior of the future primordial head and heart. Between 7.5 and 9.5 dpc it is expressed in presomitic mesoderm, epithelial and differentiating somites and in lateral plate mesoderm. In the body of mid-gestation embryos it is restricted to loose undifferentiated mesenchyme.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000001493. |
CleanExi | MM_MEOX1. |
Genevisiblei | P32442. MM. |
Interactioni
GO - Molecular functioni
- HMG box domain binding Source: UniProtKB
Protein-protein interaction databases
BioGridi | 201394. 3 interactors. |
STRINGi | 10090.ENSMUSP00000051158. |
Structurei
3D structure databases
ProteinModelPortali | P32442. |
SMRi | P32442. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Keywords - Domaini
HomeoboxPhylogenomic databases
eggNOGi | KOG0489. Eukaryota. ENOG410ZTBY. LUCA. |
GeneTreei | ENSGT00910000144024. |
HOGENOMi | HOG000230987. |
HOVERGENi | HBG052456. |
InParanoidi | P32442. |
KOi | K09322. |
OMAi | WHFPVSE. |
OrthoDBi | EOG091G0PFO. |
TreeFami | TF351603. |
Family and domain databases
CDDi | cd00086. homeodomain. 1 hit. |
InterProi | View protein in InterPro IPR009057. Homeobox-like_sf. IPR017970. Homeobox_CS. IPR001356. Homeobox_dom. IPR020479. Homeobox_metazoa. |
Pfami | View protein in Pfam PF00046. Homeobox. 1 hit. |
PRINTSi | PR00024. HOMEOBOX. |
SMARTi | View protein in SMART SM00389. HOX. 1 hit. |
SUPFAMi | SSF46689. SSF46689. 1 hit. |
PROSITEi | View protein in PROSITE PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. |
i Sequence
Sequence statusi: Complete.
P32442-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDPVANSCVR NPQPPAPVWG CLRNPHSEDS SASGLSHYPP TPFSFHQKSD
60 70 80 90 100
FPATAAYPDF SASCLAATPH SLPRTERIFN EQHPAFPQTP DWHFPISEAG
110 120 130 140 150
QRLNLGPAGS AREMGAGSPG LVDGTAGLGE DCMVLGTIAN ETEKKSSRRK
160 170 180 190 200
KERSDNQENG GGKPEGSSKA RKERTAFTKE QLRELEAEFA HHNYLTRLRR
210 220 230 240 250
YEIAVNLDLS ERQVKVWFQN RRMKWKRVKG GQPVSPQEQD REDGDSAASP
SSE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z15103 mRNA. Translation: CAA78812.1. AK052370 mRNA. Translation: BAC34961.1. CH466558 Genomic DNA. Translation: EDL34069.1. BC011082 mRNA. Translation: AAH11082.1. |
CCDSi | CCDS25480.1. |
PIRi | A49122. |
RefSeqi | NP_034921.1. NM_010791.3. |
UniGenei | Mm.3404. |
Genome annotation databases
Ensembli | ENSMUST00000057054; ENSMUSP00000051158; ENSMUSG00000001493. |
GeneIDi | 17285. |
KEGGi | mmu:17285. |
UCSCi | uc007lpx.1. mouse. |
Similar proteinsi
Entry informationi
Entry namei | MEOX1_MOUSE | |
Accessioni | P32442Primary (citable) accession number: P32442 Secondary accession number(s): Q543E8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1993 |
Last sequence update: | October 1, 1993 | |
Last modified: | March 28, 2018 | |
This is version 137 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |