P32442 (MEOX1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein MOX-1

Alternative name(s):
Mesenchyme homeobox 1

Gene names

Name:	Meox1
Synonyms:	Mox-1, Mox1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	253 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Role in mesoderm induction and its earliest regional specification, somitogenesis, and myogenic and sclerotomal differentiation.
Subcellular location	Nucleus Potential.
Tissue specificity	Heart, lateral plate derivatives, kidney, loose connective tissue at sites of bone formation and skeletal muscle-connective tissue apposition.
Developmental stage	After 7 dpc it is expressed in mesoderm lying posterior of the future primordial head and heart. Between 7.5 and 9.5 dpc it is expressed in presomitic mesoderm, epithelial and differentiating somites and in lateral plate mesoderm. In the body of mid-gestation embryos it is restricted to loose undifferentiated mesenchyme.
Sequence similarities	Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	positive regulation of transcription from RNA polymerase II promoter Inferred from direct assay. Source: MGI somite specification Inferred from genetic interaction. Source: MGI
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	HMG box domain binding Inferred from physical interaction. Source: UniProtKB chromatin binding Inferred from direct assay. Source: MGI sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from direct assay. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 253	253	Homeobox protein MOX-1		PRO_0000049196
Regions
	DNA binding	170 – 229	60	Homeobox

Sequences

	Sequence		Length	Mass (Da)
	P32442 [UniParc]. Last modified October 1, 1993. Version 1. Checksum: 5B8757EFE503EDDF	FASTA	253	27,980
	10 20 30 40 50 60 MDPVANSCVR NPQPPAPVWG CLRNPHSEDS SASGLSHYPP TPFSFHQKSD FPATAAYPDF 70 80 90 100 110 120 SASCLAATPH SLPRTERIFN EQHPAFPQTP DWHFPISEAG QRLNLGPAGS AREMGAGSPG 130 140 150 160 170 180 LVDGTAGLGE DCMVLGTIAN ETEKKSSRRK KERSDNQENG GGKPEGSSKA RKERTAFTKE 190 200 210 220 230 240 QLRELEAEFA HHNYLTRLRR YEIAVNLDLS ERQVKVWFQN RRMKWKRVKG GQPVSPQEQD 250 REDGDSAASP SSE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Mox-1 and Mox-2 define a novel homeobox gene subfamily and are differentially expressed during early mesodermal patterning in mouse embryos." Candia A.F., Hu J., Crosby J., Lalley P.A., Noden D., Nadeau J.H., Wright C.V.E. Development 116:1123-1136(1992) [PubMed: 1363541] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Mammary gland.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z15103 mRNA. Translation: CAA78812.1. BC011082 mRNA. Translation: AAH11082.1.
IPI	IPI00108443.
PIR	A49122.
RefSeq	NP_034921.1. NM_010791.3.
UniGene	Mm.3404.
3D structure databases
ProteinModelPortal	P32442.
SMR	P32442. Positions 174-227.
ModBase	Search...
Protein-protein interaction databases
STRING	P32442.
Proteomic databases
PRIDE	P32442.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000057054; ENSMUSP00000051158; ENSMUSG00000001493.
GeneID	17285.
KEGG	mmu:17285.
Organism-specific databases
CTD	4222.
MGI	MGI:103220. Meox1.
Phylogenomic databases
eggNOG	roNOG15965.
HOVERGEN	HBG052456.
OMA	ENRGKPE.
OrthoDB	EOG46DM3J.
PhylomeDB	P32442.
Gene expression databases
ArrayExpress	P32442.
Bgee	P32442.
CleanEx	MM_MEOX1.
Genevestigator	P32442.
GermOnline	ENSMUSG00000001493. Mus musculus.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017970. Homeobox_CS. IPR020479. Homeobox_eu. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
KO	K09322.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	291792.
SOURCE	Search...

Entry information

Entry name

MEOX1_MOUSE

Accession

Primary (citable) accession number: P32442

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
Last sequence update:	October 1, 1993
Last modified:	November 16, 2011
This is version 96 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program