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P32431

- PYRF_MUCCL

UniProt

P32431 - PYRF_MUCCL

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Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrG

Organism
Mucor circinelloides f. lusitanicus (Mucor racemosus var. lusitanicus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei38 – 381SubstrateBy similarity
Active sitei93 – 931Proton donorPROSITE-ProRule annotation
Binding sitei213 – 2131SubstrateBy similarity
Binding sitei232 – 2321SubstrateBy similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-EC

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Uridine 5'-monophosphate synthase
Short name:
UMP synthase
Gene namesi
Name:pyrG
OrganismiMucor circinelloides f. lusitanicus (Mucor racemosus var. lusitanicus)
Taxonomic identifieri29924 [NCBI]
Taxonomic lineageiEukaryotaFungiFungi incertae sedisEarly diverging fungal lineagesMucoromycotinaMucoralesMucorineaeMucoraceaeMucor

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 265265Orotidine 5'-phosphate decarboxylasePRO_0000134679Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP32431.
SMRiP32431. Positions 6-260.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni60 – 623Substrate bindingBy similarity
Regioni91 – 10010Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the OMP decarboxylase family.Curated

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32431-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNTYKTYSER GQQHPNACAR SLFELMERNE SNLSVAVDVT TKKELLSIAD
60 70 80 90 100
AVGPFVCVLK THIDIVEDFD HDLVAQLEQL AKKHDFLIFE DRKFADIGNT
110 120 130 140 150
VKHQYANGIY KIASWSHITN AHTVPGEGII KGLGEVGLPL GRGLLLLAEM
160 170 180 190 200
SSKGALTKGS YTSESVEMAR RNKDFVFGFI AQHKMNEHDD EDFVVMSPGV
210 220 230 240 250
GLDVKGDGLG QQYRTPHEVI VESGGDIIIV GRGIYGNPDQ VEAQAKRYRQ
260
AGWDAYLERV RLHKK
Length:265
Mass (Da):29,514
Last modified:October 1, 1993 - v1
Checksum:i10BF511627BCEA14
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M69112 Genomic DNA. No translation available.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M69112 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali P32431.
SMRi P32431. Positions 6-260.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR01740. pyrF. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and sequence analysis of the Mucor circinelloides pyrG gene encoding orotidine-5'-monophosphate decarboxylase: use of pyrG for homologous transformation."
    Benito E.P., Diaz-Minguez J.M., Iturriaga E.A., Campuzano V., Eslava A.P.
    Gene 116:59-67(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 1216b / CBS 277.49 / NRRL 3631.

Entry informationi

Entry nameiPYRF_MUCCL
AccessioniPrimary (citable) accession number: P32431
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: October 1, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3