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P32431 (PYRF_MUCCL) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Uridine 5'-monophosphate synthase
Short name=UMP synthase
Gene names
Name:pyrG
OrganismMucor circinelloides f. lusitanicus (Mucor racemosus var. lusitanicus)
Taxonomic identifier29924 [NCBI]
Taxonomic lineageEukaryotaFungiFungi incertae sedisEarly diverging fungal lineagesMucoromycotinaMucoralesMucorineaeMucoraceaeMucor

Protein attributes

Sequence length265 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Orotidine 5'-phosphate = UMP + CO2.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.

Sequence similarities

Belongs to the OMP decarboxylase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 265265Orotidine 5'-phosphate decarboxylase
PRO_0000134679

Regions

Region60 – 623Substrate binding By similarity
Region91 – 10010Substrate binding By similarity

Sites

Active site931Proton donor By similarity
Binding site381Substrate By similarity
Binding site2131Substrate By similarity
Binding site2321Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P32431 [UniParc].

Last modified October 1, 1993. Version 1.
Checksum: 10BF511627BCEA14

FASTA26529,514
        10         20         30         40         50         60 
MNTYKTYSER GQQHPNACAR SLFELMERNE SNLSVAVDVT TKKELLSIAD AVGPFVCVLK 

        70         80         90        100        110        120 
THIDIVEDFD HDLVAQLEQL AKKHDFLIFE DRKFADIGNT VKHQYANGIY KIASWSHITN 

       130        140        150        160        170        180 
AHTVPGEGII KGLGEVGLPL GRGLLLLAEM SSKGALTKGS YTSESVEMAR RNKDFVFGFI 

       190        200        210        220        230        240 
AQHKMNEHDD EDFVVMSPGV GLDVKGDGLG QQYRTPHEVI VESGGDIIIV GRGIYGNPDQ 

       250        260 
VEAQAKRYRQ AGWDAYLERV RLHKK 

« Hide

References

[1]"Cloning and sequence analysis of the Mucor circinelloides pyrG gene encoding orotidine-5'-monophosphate decarboxylase: use of pyrG for homologous transformation."
Benito E.P., Diaz-Minguez J.M., Iturriaga E.A., Campuzano V., Eslava A.P.
Gene 116:59-67(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 1216b / CBS 277.49 / NRRL 3631.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M69112 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortalP32431.
SMRP32431. Positions 6-260.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR01740. pyrF. 1 hit.
PROSITEPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRF_MUCCL
AccessionPrimary (citable) accession number: P32431
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: October 16, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways