Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P32430 (PYRF_CANMA) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Uridine 5'-monophosphate synthase
Short name=UMP synthase
Gene names
Name:URA3
Synonyms:PYRG
OrganismCandida maltosa (Yeast)
Taxonomic identifier5479 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length266 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Orotidine 5'-phosphate = UMP + CO2.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.

Sequence similarities

Belongs to the OMP decarboxylase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 266266Orotidine 5'-phosphate decarboxylase
PRO_0000134651

Regions

Region60 – 623Substrate binding By similarity
Region92 – 10110Substrate binding By similarity

Sites

Active site941Proton donor By similarity
Binding site381Substrate By similarity
Binding site2181Substrate By similarity
Binding site2361Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P32430 [UniParc].

Last modified October 1, 1993. Version 1.
Checksum: 060E7A163BA9978C

FASTA26629,306
        10         20         30         40         50         60 
MVSTKTYTTR ASTHPSPVAQ RLFHLMDTKK ANLCASVDVQ TTSEFLSLID KLGPYICLVK 

        70         80         90        100        110        120 
THIDIIDDFS YEGTIVPLLE LARKHNFMIF EDRKFADIGN TVKHQYTSGV YKISSWSDIT 

       130        140        150        160        170        180 
NAHGVTGAGV VDGLKQGALE TTKEPRGLLM LAELSSKGSL AYGEYTEKTV EIAKLDKEFV 

       190        200        210        220        230        240 
IGFIAQRDMG GHDEGFDWIV MTPGVGLDDK GDGLGQQYRT VDEVVSTGTD VIIVGRGLFG 

       250        260 
KGRDPEVEGK RYRDAGWNAY LKRTGQ 

« Hide

References

[1]"Cloning of the C-URA3 gene and construction of a triple auxotroph (his5, ade1, ura3) as a useful host for the genetic engineering of Candida maltosa."
Ohkuma M., Muraoka S., Hwang C.W., Ohta A., Takagi M.
Curr. Genet. 23:205-210(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 28140 / CBS 5611 / IAM 12247 / JCM 1504 / NBRC 1977.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D12720 Genomic DNA. Translation: BAA02215.1.
PIRJS0721. S29791.

3D structure databases

ProteinModelPortalP32430.
SMRP32430. Positions 6-266.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR01740. pyrF. 1 hit.
PROSITEPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRF_CANMA
AccessionPrimary (citable) accession number: P32430
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: October 16, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways