P32424 (BR2_RANBP) Reviewed, UniProtKB/Swiss-Prot
Last modified
April 5, 2011.
Version 48.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Brevinin-2 |
| Organism | Rana brevipoda porsa (Japanese frog) |
| Taxonomic identifier | 88447 [NCBI] |
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Neobatrachia › Ranoidea › Ranidae › Raninae › Rana › Pelophylax |
Protein attributes
| Sequence length | 33 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species, and a very high hemolytic activity. |
| Subcellular location | |
| Tissue specificity | Expressed by the skin glands. |
| Sequence similarities | Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Cytolysis Hemolysis |
| Cellular component | Secreted |
| Molecular function | Amphibian defense peptide Antibiotic Antimicrobial |
| PTM | Disulfide bond |
| Technical term | Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | cytolysis Inferred from electronic annotation. Source: UniProtKB-KW defense response to bacteriumInferred from electronic annotation. Source: UniProtKB-KW hemolysis in other organismInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
References
| [1] | "Brevinin-1 and -2, unique antimicrobial peptides from the skin of the frog, Rana brevipoda porsa." Morikawa N., Hagiwara K., Nakajima T. Biochem. Biophys. Res. Commun. 189:184-190(1992) [PubMed: 1449472] [Abstract] Cited for: PROTEIN SEQUENCE, DISULFIDE BOND. Tissue: Skin secretion. |
Cross-references
Sequence databases | |
|---|---|
| PIR | JC1356. |
3D structure databases | |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Family and domain databases | |
| InterPro | IPR012521. Antimicrobial_frog_2. [Graphical view] |
| Pfam | PF08023. Antimicrobial_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | BR2_RANBP | ||||||||
| Accession | Primary (citable) accession number: P32424 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

Clusters with