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Protein

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

Gene

SDH2

Organism
Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).By similarity

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.

Cofactori

Protein has several cofactor binding sites:

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (eukaryal route).
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (UMAG_01172), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (SDH2)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (eukaryal route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi106Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi111Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi114Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi126Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi195Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi198Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi201Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi205Iron-sulfur 3 (3Fe-4S)By similarity1
Binding sitei210Ubiquinone; shared with DHSDBy similarity1
Metal bindingi252Iron-sulfur 3 (3Fe-4S)By similarity1
Metal bindingi258Iron-sulfur 3 (3Fe-4S)By similarity1
Metal bindingi262Iron-sulfur 2 (4Fe-4S)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Transport, Tricarboxylic acid cycle
Ligand2Fe-2S, 3Fe-4S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (EC:1.3.5.1)
Alternative name(s):
Iron-sulfur subunit of complex II
Short name:
Ip
Gene namesi
Name:SDH2
Synonyms:CBXR
ORF Names:UMAG_00844
OrganismiUstilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)
Taxonomic identifieri237631 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaUstilaginomycotinaUstilaginomycetesUstilaginalesUstilaginaceaeUstilago
Proteomesi
  • UP000000561 Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:UMAG_00844

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000010352? – 295Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

PRIDEiP32420

Interactioni

Subunit structurei

Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.By similarity

Protein-protein interaction databases

STRINGi5270.UM00844P0

Structurei

3D structure databases

ProteinModelPortaliP32420
SMRiP32420
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini67 – 1442Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd BLAST78
Domaini185 – 2154Fe-4S ferredoxin-typePROSITE-ProRule annotationAdd BLAST31

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000160590
InParanoidiP32420
KOiK00235
OMAiDGQYFGP
OrthoDBiEOG092C401C

Family and domain databases

CDDicd00207 fer2, 1 hit
Gene3Di1.10.1060.10, 1 hit
3.10.20.30, 1 hit
InterProiView protein in InterPro
IPR036010 2Fe-2S_ferredoxin-like_sf
IPR001041 2Fe-2S_ferredoxin-type
IPR006058 2Fe2S_fd_BS
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR012675 Beta-grasp_dom_sf
IPR009051 Helical_ferredxn
IPR004489 Succ_DH/fum_Rdtase_Fe-S
IPR025192 Succ_DH/fum_Rdtase_N
PfamiView protein in Pfam
PF13085 Fer2_3, 1 hit
SUPFAMiSSF46548 SSF46548, 1 hit
SSF54292 SSF54292, 1 hit
TIGRFAMsiTIGR00384 dhsB, 1 hit
PROSITEiView protein in PROSITE
PS00197 2FE2S_FER_1, 1 hit
PS51085 2FE2S_FER_2, 1 hit
PS00198 4FE4S_FER_1, 1 hit
PS51379 4FE4S_FER_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P32420-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLFNVSNGL RTALRPSVAS SSRVAAFSTT AAARLATPTS DNVGSSGKPQ
60 70 80 90 100
HLKQFKIYRW NPDKPSEKPR LQSYTLDLNQ TGPMVLDALI KIKNEIDPTL
110 120 130 140 150
TFRRSCREGI CGSCAMNIDG VNTLACLCRI DKQNDTKIYP LPHMYIVKDL
160 170 180 190 200
VPDLTQFYKQ YRSIEPFLKS NNTPSEGEHL QSPEERRRLD GLYECILCAC
210 220 230 240 250
CSTSCPSYWW NQDEYLGPAV LMQAYRWMAD SRDDFGEERR QKLENTFSLY
260 270 280 290
RCHTIMNCSR TCPKNLNPGK AIAQIKKDMA VGAPKASERP IMASS
Length:295
Mass (Da):33,282
Last modified:October 1, 1993 - v1
Checksum:iF374A20BA8F8E7E5
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti253H → L in carboxin-resistant mutant. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62762 Genomic DNA Translation: CAA44612.1
Z11738 Genomic DNA Translation: CAA77798.1
CM003141 Genomic DNA Translation: KIS70918.1
PIRiS26978
RefSeqiXP_011386878.1, XM_011388576.1

Genome annotation databases

EnsemblFungiiKIS70918; KIS70918; UMAG_00844
GeneIDi23562034
KEGGiuma:UMAG_00844

Entry informationi

Entry nameiSDHB_USTMA
AccessioniPrimary (citable) accession number: P32420
Secondary accession number(s): A0A0D1CWY8, Q12722, Q4PGB9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: May 23, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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