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P32418

- NAC1_HUMAN

UniProt

P32418 - NAC1_HUMAN

Protein

Sodium/calcium exchanger 1

Gene

SLC8A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 147 (01 Oct 2014)
      Sequence version 3 (01 Dec 2000)
      Previous versions | rss
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    Functioni

    Rapidly transports Ca2+ during excitation-contraction coupling. Ca2+ is extruded from the cell during relaxation so as to prevent overloading of intracellular stores.1 Publication

    Enzyme regulationi

    By ATP.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi420 – 4201Calcium 3By similarity
    Metal bindingi456 – 4561Calcium 1By similarity
    Metal bindingi456 – 4561Calcium 2By similarity
    Metal bindingi481 – 4811Calcium 4By similarity
    Metal bindingi482 – 4821Calcium 3By similarity
    Metal bindingi482 – 4821Calcium 4; via carbonyl oxygenBy similarity
    Metal bindingi484 – 4841Calcium 3; via carbonyl oxygenBy similarity
    Metal bindingi486 – 4861Calcium 1By similarity
    Metal bindingi486 – 4861Calcium 2By similarity
    Metal bindingi486 – 4861Calcium 3By similarity
    Metal bindingi489 – 4891Calcium 1By similarity
    Metal bindingi533 – 5331Calcium 3By similarity
    Metal bindingi534 – 5341Calcium 4By similarity
    Metal bindingi535 – 5351Calcium 3By similarity
    Metal bindingi535 – 5351Calcium 4By similarity
    Metal bindingi551 – 5511Calcium 6By similarity
    Metal bindingi587 – 5871Calcium 5By similarity
    Metal bindingi613 – 6131Calcium 5By similarity
    Metal bindingi613 – 6131Calcium 6By similarity
    Metal bindingi615 – 6151Calcium 6By similarity
    Metal bindingi683 – 6831Calcium 6By similarity

    GO - Molecular functioni

    1. ankyrin binding Source: BHF-UCL
    2. calcium:sodium antiporter activity Source: BHF-UCL
    3. cytoskeletal protein binding Source: BHF-UCL
    4. ion channel binding Source: BHF-UCL
    5. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. blood coagulation Source: Reactome
    2. calcium ion export Source: BHF-UCL
    3. calcium ion homeostasis Source: BHF-UCL
    4. calcium ion import Source: BHF-UCL
    5. calcium ion transport into cytosol Source: BHF-UCL
    6. cardiac muscle cell development Source: BHF-UCL
    7. cardiac muscle contraction Source: Ensembl
    8. cell communication by electrical coupling involved in cardiac conduction Source: BHF-UCL
    9. cellular response to caffeine Source: BHF-UCL
    10. cellular response to reactive oxygen species Source: BHF-UCL
    11. cytosolic calcium ion transport Source: BHF-UCL
    12. embryonic heart tube development Source: Ensembl
    13. embryonic placenta development Source: Ensembl
    14. heart morphogenesis Source: Ensembl
    15. ion transport Source: Reactome
    16. muscle contraction Source: ProtInc
    17. muscle fiber development Source: Ensembl
    18. negative regulation of cytosolic calcium ion concentration Source: BHF-UCL
    19. post-embryonic development Source: Ensembl
    20. regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion Source: BHF-UCL
    21. regulation of heart rate Source: BHF-UCL
    22. regulation of the force of heart contraction Source: BHF-UCL
    23. relaxation of cardiac muscle Source: BHF-UCL
    24. relaxation of smooth muscle Source: BHF-UCL
    25. sodium ion export Source: BHF-UCL
    26. sodium ion import Source: BHF-UCL
    27. transmembrane transport Source: Reactome
    28. vascular smooth muscle contraction Source: BHF-UCL

    Keywords - Biological processi

    Antiport, Calcium transport, Ion transport, Sodium transport, Transport

    Keywords - Ligandi

    Calcium, Calmodulin-binding, Metal-binding, Sodium

    Enzyme and pathway databases

    ReactomeiREACT_19320. Sodium/Calcium exchangers.
    REACT_23765. Reduction of cytosolic Ca++ levels.

    Protein family/group databases

    TCDBi2.A.19.3.4. the ca(2+):cation antiporter (caca) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium/calcium exchanger 1
    Alternative name(s):
    Na(+)/Ca(2+)-exchange protein 1
    Solute carrier family 8 member 1
    Gene namesi
    Name:SLC8A1
    Synonyms:CNC, NCX1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:11068. SLC8A1.

    Subcellular locationi

    GO - Cellular componenti

    1. basolateral plasma membrane Source: Ensembl
    2. integral component of plasma membrane Source: BHF-UCL
    3. intercalated disc Source: BHF-UCL
    4. plasma membrane Source: BHF-UCL
    5. sarcolemma Source: BHF-UCL
    6. T-tubule Source: BHF-UCL
    7. Z disc Source: BHF-UCL

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA314.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3535Sequence AnalysisAdd
    BLAST
    Chaini36 – 973938Sodium/calcium exchanger 1PRO_0000019379Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi44 – 441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi160 – 1601N-linked (GlcNAc...)Sequence Analysis
    Modified residuei392 – 3921PhosphoserineSequence Analysis

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiP32418.
    PRIDEiP32418.

    PTM databases

    PhosphoSiteiP32418.

    Expressioni

    Tissue specificityi

    Expressed in cardiac sarcolemma, brain, kidney, liver, pancreas, skeletal muscle, placenta and lung.1 Publication

    Gene expression databases

    ArrayExpressiP32418.
    BgeeiP32418.
    CleanExiHS_SLC8A1.
    GenevestigatoriP32418.

    Organism-specific databases

    HPAiCAB022694.

    Interactioni

    Protein-protein interaction databases

    BioGridi112436. 1 interaction.
    DIPiDIP-48356N.
    IntActiP32418. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP32418.
    SMRiP32418. Positions 406-727.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini36 – 7439ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini96 – 13641CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini158 – 17013ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini192 – 20413CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini226 – 2316ExtracellularSequence Analysis
    Topological domaini253 – 800548CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini822 – 8243ExtracellularSequence Analysis
    Topological domaini846 – 87429CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini896 – 90611ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini928 – 94417CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini966 – 9738ExtracellularSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei75 – 9521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei137 – 15721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei171 – 19121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei205 – 22521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei232 – 25221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei801 – 82121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei825 – 84521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei875 – 89521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei907 – 92721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei945 – 96521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati141 – 18141Alpha-1Add
    BLAST
    Domaini396 – 496101Calx-beta 1Add
    BLAST
    Domaini527 – 627101Calx-beta 2Add
    BLAST
    Repeati842 – 87837Alpha-2Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni254 – 27320Calmodulin-bindingSequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi239 – 2424Poly-Phe
    Compositional biasi692 – 6954Poly-Glu
    Compositional biasi759 – 7635Poly-Asp

    Sequence similaritiesi

    Contains 2 Calx-beta domains.Curated

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0530.
    HOGENOMiHOG000266971.
    HOVERGENiHBG006441.
    InParanoidiP32418.
    KOiK05849.
    OMAiDDEECGE.
    OrthoDBiEOG7S4X56.
    PhylomeDBiP32418.
    TreeFamiTF314308.

    Family and domain databases

    InterProiIPR003644. Calx_beta.
    IPR001623. DnaJ_domain.
    IPR004836. Na_Ca_Ex.
    IPR002987. NaCa_exhngr1.
    IPR004837. NaCa_Exmemb.
    [Graphical view]
    PfamiPF03160. Calx-beta. 2 hits.
    PF01699. Na_Ca_ex. 2 hits.
    [Graphical view]
    PRINTSiPR01259. NACAEXCHNGR.
    PR01260. NACAEXCHNGR1.
    SMARTiSM00237. Calx_beta. 2 hits.
    [Graphical view]
    TIGRFAMsiTIGR00845. caca. 1 hit.

    Sequences (5)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform 1 (identifier: P32418-1) [UniParc]FASTAAdd to Basket

    Also known as: NaCa1, NCX1.1

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MYNMRRLSLS PTFSMGFHLL VTVSLLFSHV DHVIAETEME GEGNETGECT    50
    GSYYCKKGVI LPIWEPQDPS FGDKIARATV YFVAMVYMFL GVSIIADRFM 100
    SSIEVITSQE KEITIKKPNG ETTKTTVRIW NETVSNLTLM ALGSSAPEIL 150
    LSVIEVCGHN FTAGDLGPST IVGSAAFNMF IIIALCVYVV PDGETRKIKH 200
    LRVFFVTAAW SIFAYTWLYI ILSVISPGVV EVWEGLLTFF FFPICVVFAW 250
    VADRRLLFYK YVYKRYRAGK QRGMIIEHEG DRPSSKTEIE MDGKVVNSHV 300
    ENFLDGALVL EVDERDQDDE EARREMARIL KELKQKHPDK EIEQLIELAN 350
    YQVLSQQQKS RAFYRIQATR LMTGAGNILK RHAADQARKA VSMHEVNTEV 400
    TENDPVSKIF FEQGTYQCLE NCGTVALTII RRGGDLTNTV FVDFRTEDGT 450
    ANAGSDYEFT EGTVVFKPGD TQKEIRVGII DDDIFEEDEN FLVHLSNVKV 500
    SSEASEDGIL EANHVSTLAC LGSPSTATVT IFDDDHAGIF TFEEPVTHVS 550
    ESIGIMEVKV LRTSGARGNV IVPYKTIEGT ARGGGEDFED TCGELEFQND 600
    EIVKTISVKV IDDEEYEKNK TFFLEIGEPR LVEMSEKKAL LLNELGGFTI 650
    TGKYLFGQPV FRKVHAREHP ILSTVITIAD EYDDKQPLTS KEEEERRIAE 700
    MGRPILGEHT KLEVIIEESY EFKSTVDKLI KKTNLALVVG TNSWREQFIE 750
    AITVSAGEDD DDDECGEEKL PSCFDYVMHF LTVFWKVLFA FVPPTEYWNG 800
    WACFIVSILM IGLLTAFIGD LASHFGCTIG LKDSVTAVVF VALGTSVPDT 850
    FASKVAATQD QYADASIGNV TGSNAVNVFL GIGVAWSIAA IYHAANGEQF 900
    KVSPGTLAFS VTLFTIFAFI NVGVLLYRRR PEIGGELGGP RTAKLLTSCL 950
    FVLLWLLYIF FSSLEAYCHI KGF 973
    Length:973
    Mass (Da):108,547
    Last modified:December 1, 2000 - v3
    Checksum:i17DFC1B1F15921D8
    GO
    Isoform 3 (identifier: P32418-2) [UniParc]FASTAAdd to Basket

    Also known as: NaCa3, NCX1.3

    The sequence of this isoform differs from the canonical sequence as follows:
         605-613: TISVKVIDD → IITIRIFDR
         619-645: NKTFFLEIGEPRLVEMSEKKALLLNEL → ECSFSLVLEEPKWIRRGMK
         652-679: Missing.

    Show »
    Length:937
    Mass (Da):104,689
    Checksum:i112BE915D7AE8723
    GO
    Isoform 7 (identifier: P32418-3) [UniParc]FASTAAdd to Basket

    Also known as: NaCa7, NCX1.7

    The sequence of this isoform differs from the canonical sequence as follows:
         605-613: TISVKVIDD → IITIRIFDR
         619-645: NKTFFLEIGEPRLVEMSEKKALLLNEL → ECSFSLVLEEPKWIRRGMK
         652-656: Missing.

    Show »
    Length:960
    Mass (Da):107,242
    Checksum:i85F0A9CD7BE0A806
    GO
    Isoform 10 (identifier: P32418-4) [UniParc]FASTAAdd to Basket

    Also known as: NaCa10, NCX1.10

    The sequence of this isoform differs from the canonical sequence as follows:
         605-613: TISVKVIDD → IITIRIFDR
         619-645: NKTFFLEIGEPRLVEMSEKKALLLNEL → ECSFSLVLEEPKWIRRGMK

    Show »
    Length:965
    Mass (Da):107,850
    Checksum:iFB6516EB3925B431
    GO
    Isoform 5 (identifier: P32418-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         652-656: Missing.

    Show »
    Length:968
    Mass (Da):107,938
    Checksum:iD965406E3FF9EC08
    GO

    Sequence cautioni

    The sequence AAH98308.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti692 – 6921E → V.
    Corresponds to variant rs5557 [ dbSNP | Ensembl ].
    VAR_014847

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei605 – 6139TISVKVIDD → IITIRIFDR in isoform 3, isoform 7 and isoform 10. 5 PublicationsVSP_003397
    Alternative sequencei619 – 64527NKTFF…LLNEL → ECSFSLVLEEPKWIRRGMK in isoform 3, isoform 7 and isoform 10. 5 PublicationsVSP_003398Add
    BLAST
    Alternative sequencei652 – 67928Missing in isoform 3. 3 PublicationsVSP_003400Add
    BLAST
    Alternative sequencei652 – 6565Missing in isoform 7 and isoform 5. 4 PublicationsVSP_003399

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M91368 mRNA. Translation: AAA35702.1.
    AF108388 mRNA. Translation: AAF08987.1.
    AF108389 mRNA. Translation: AAF08988.1.
    AF128524 mRNA. Translation: AAD26362.1.
    AK291696 mRNA. Translation: BAF84385.1.
    AC007254 Genomic DNA. Translation: AAF19235.1.
    AC007281 Genomic DNA. Translation: AAF19237.1.
    AC007377 Genomic DNA. Translation: AAX81985.1.
    CH471053 Genomic DNA. Translation: EAX00331.1.
    CH471053 Genomic DNA. Translation: EAX00332.1.
    CH471053 Genomic DNA. Translation: EAX00333.1.
    CH471053 Genomic DNA. Translation: EAX00334.1.
    CH471053 Genomic DNA. Translation: EAX00335.1.
    CH471053 Genomic DNA. Translation: EAX00336.1.
    AF115505 mRNA. Translation: AAD17213.1.
    AB209075 mRNA. Translation: BAD92312.1.
    BC098308 mRNA. Translation: AAH98308.1. Different initiation.
    CCDSiCCDS1806.1. [P32418-1]
    CCDS46264.1. [P32418-2]
    CCDS46265.1. [P32418-5]
    CCDS59430.1. [P32418-4]
    PIRiS32815.
    RefSeqiNP_001106271.1. NM_001112800.1. [P32418-5]
    NP_001106272.1. NM_001112801.1. [P32418-3]
    NP_001106273.1. NM_001112802.1. [P32418-2]
    NP_001239553.1. NM_001252624.1. [P32418-4]
    NP_066920.1. NM_021097.2. [P32418-1]
    XP_005264571.1. XM_005264514.1. [P32418-2]
    XP_006712144.1. XM_006712081.1. [P32418-1]
    XP_006712145.1. XM_006712082.1. [P32418-1]
    XP_006712146.1. XM_006712083.1. [P32418-1]
    XP_006712147.1. XM_006712084.1. [P32418-1]
    XP_006712148.1. XM_006712085.1. [P32418-1]
    UniGeneiHs.31961.
    Hs.468274.
    Hs.744988.

    Genome annotation databases

    EnsembliENST00000332839; ENSP00000332931; ENSG00000183023. [P32418-1]
    ENST00000402441; ENSP00000385188; ENSG00000183023. [P32418-2]
    ENST00000403092; ENSP00000384763; ENSG00000183023. [P32418-1]
    ENST00000405269; ENSP00000385535; ENSG00000183023. [P32418-2]
    ENST00000405901; ENSP00000385678; ENSG00000183023. [P32418-5]
    ENST00000406391; ENSP00000385811; ENSG00000183023. [P32418-2]
    ENST00000406785; ENSP00000383886; ENSG00000183023. [P32418-2]
    ENST00000408028; ENSP00000384908; ENSG00000183023. [P32418-4]
    GeneIDi6546.
    KEGGihsa:6546.
    UCSCiuc002rrx.3. human. [P32418-1]
    uc002rrz.3. human. [P32418-3]
    uc002rsa.3. human. [P32418-2]
    uc002rsb.2. human. [P32418-4]

    Polymorphism databases

    DMDMi12644210.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M91368 mRNA. Translation: AAA35702.1 .
    AF108388 mRNA. Translation: AAF08987.1 .
    AF108389 mRNA. Translation: AAF08988.1 .
    AF128524 mRNA. Translation: AAD26362.1 .
    AK291696 mRNA. Translation: BAF84385.1 .
    AC007254 Genomic DNA. Translation: AAF19235.1 .
    AC007281 Genomic DNA. Translation: AAF19237.1 .
    AC007377 Genomic DNA. Translation: AAX81985.1 .
    CH471053 Genomic DNA. Translation: EAX00331.1 .
    CH471053 Genomic DNA. Translation: EAX00332.1 .
    CH471053 Genomic DNA. Translation: EAX00333.1 .
    CH471053 Genomic DNA. Translation: EAX00334.1 .
    CH471053 Genomic DNA. Translation: EAX00335.1 .
    CH471053 Genomic DNA. Translation: EAX00336.1 .
    AF115505 mRNA. Translation: AAD17213.1 .
    AB209075 mRNA. Translation: BAD92312.1 .
    BC098308 mRNA. Translation: AAH98308.1 . Different initiation.
    CCDSi CCDS1806.1. [P32418-1 ]
    CCDS46264.1. [P32418-2 ]
    CCDS46265.1. [P32418-5 ]
    CCDS59430.1. [P32418-4 ]
    PIRi S32815.
    RefSeqi NP_001106271.1. NM_001112800.1. [P32418-5 ]
    NP_001106272.1. NM_001112801.1. [P32418-3 ]
    NP_001106273.1. NM_001112802.1. [P32418-2 ]
    NP_001239553.1. NM_001252624.1. [P32418-4 ]
    NP_066920.1. NM_021097.2. [P32418-1 ]
    XP_005264571.1. XM_005264514.1. [P32418-2 ]
    XP_006712144.1. XM_006712081.1. [P32418-1 ]
    XP_006712145.1. XM_006712082.1. [P32418-1 ]
    XP_006712146.1. XM_006712083.1. [P32418-1 ]
    XP_006712147.1. XM_006712084.1. [P32418-1 ]
    XP_006712148.1. XM_006712085.1. [P32418-1 ]
    UniGenei Hs.31961.
    Hs.468274.
    Hs.744988.

    3D structure databases

    ProteinModelPortali P32418.
    SMRi P32418. Positions 406-727.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112436. 1 interaction.
    DIPi DIP-48356N.
    IntActi P32418. 1 interaction.

    Chemistry

    ChEMBLi CHEMBL4076.
    DrugBanki DB00132. Alpha-Linolenic Acid.
    DB00159. Icosapent.

    Protein family/group databases

    TCDBi 2.A.19.3.4. the ca(2+):cation antiporter (caca) family.

    PTM databases

    PhosphoSitei P32418.

    Polymorphism databases

    DMDMi 12644210.

    Proteomic databases

    PaxDbi P32418.
    PRIDEi P32418.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000332839 ; ENSP00000332931 ; ENSG00000183023 . [P32418-1 ]
    ENST00000402441 ; ENSP00000385188 ; ENSG00000183023 . [P32418-2 ]
    ENST00000403092 ; ENSP00000384763 ; ENSG00000183023 . [P32418-1 ]
    ENST00000405269 ; ENSP00000385535 ; ENSG00000183023 . [P32418-2 ]
    ENST00000405901 ; ENSP00000385678 ; ENSG00000183023 . [P32418-5 ]
    ENST00000406391 ; ENSP00000385811 ; ENSG00000183023 . [P32418-2 ]
    ENST00000406785 ; ENSP00000383886 ; ENSG00000183023 . [P32418-2 ]
    ENST00000408028 ; ENSP00000384908 ; ENSG00000183023 . [P32418-4 ]
    GeneIDi 6546.
    KEGGi hsa:6546.
    UCSCi uc002rrx.3. human. [P32418-1 ]
    uc002rrz.3. human. [P32418-3 ]
    uc002rsa.3. human. [P32418-2 ]
    uc002rsb.2. human. [P32418-4 ]

    Organism-specific databases

    CTDi 6546.
    GeneCardsi GC02M040339.
    HGNCi HGNC:11068. SLC8A1.
    HPAi CAB022694.
    MIMi 182305. gene.
    neXtProti NX_P32418.
    PharmGKBi PA314.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0530.
    HOGENOMi HOG000266971.
    HOVERGENi HBG006441.
    InParanoidi P32418.
    KOi K05849.
    OMAi DDEECGE.
    OrthoDBi EOG7S4X56.
    PhylomeDBi P32418.
    TreeFami TF314308.

    Enzyme and pathway databases

    Reactomei REACT_19320. Sodium/Calcium exchangers.
    REACT_23765. Reduction of cytosolic Ca++ levels.

    Miscellaneous databases

    ChiTaRSi SLC8A1. human.
    GenomeRNAii 6546.
    NextBioi 25469.
    PROi P32418.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P32418.
    Bgeei P32418.
    CleanExi HS_SLC8A1.
    Genevestigatori P32418.

    Family and domain databases

    InterProi IPR003644. Calx_beta.
    IPR001623. DnaJ_domain.
    IPR004836. Na_Ca_Ex.
    IPR002987. NaCa_exhngr1.
    IPR004837. NaCa_Exmemb.
    [Graphical view ]
    Pfami PF03160. Calx-beta. 2 hits.
    PF01699. Na_Ca_ex. 2 hits.
    [Graphical view ]
    PRINTSi PR01259. NACAEXCHNGR.
    PR01260. NACAEXCHNGR1.
    SMARTi SM00237. Calx_beta. 2 hits.
    [Graphical view ]
    TIGRFAMsi TIGR00845. caca. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of the human cardiac Na+/Ca2+ exchanger cDNA."
      Komuro I., Wenninger K.E., Philipson K.D., Izumo S.
      Proc. Natl. Acad. Sci. U.S.A. 89:4769-4773(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Heart.
    2. "NCX1 Na/Ca exchanger splice variants in pancreatic islet cells."
      Van Eylen F., Bollen A., Herchuelz A.
      J. Endocrinol. 168:517-526(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 7).
    3. "Na+/Ca2+ exchanger isoforms in cultured human retinal pigment epithelium."
      Mangini N.J., Chen W., Wang Q., Kennedy B.G.
      Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 7).
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Placenta.
    5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "Na+/Ca2+ exchanger isoforms of rat odontoblasts and osteoblasts."
      Lundquist P., Lundgren T., Gritli-Linde A., Linde A.
      Calcif. Tissue Int. 67:60-67(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 459-681 (ISOFORM 10).
    8. "Homo sapiens protein coding cDNA."
      Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 558-973 (ISOFORM 5).
      Tissue: Brain.
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 594-973 (ISOFORM 5).
    10. "Functional expression of human renal Na+/Ca2+ exchanger in insect cells."
      Loo T.W., Clarke D.M.
      Am. J. Physiol. 267:F70-F74(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 600-684 (ISOFORM 3).
      Tissue: Embryonic kidney.
    11. "Expression of the Na-Ca exchanger in diverse tissues: a study using the cloned human cardiac Na-Ca exchanger."
      Kofuji P., Hadley R.W., Kieval R.S., Lederer W.J., Schulze D.H.
      Am. J. Physiol. 263:C1241-C1249(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.
    12. "The topology of the cardiac Na(+)/Ca(2)(+) exchanger, NCX1."
      Ren X., Philipson K.D.
      J. Mol. Cell. Cardiol. 57:68-71(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY.

    Entry informationi

    Entry nameiNAC1_HUMAN
    AccessioniPrimary (citable) accession number: P32418
    Secondary accession number(s): A8K6N1
    , D6W595, O95849, Q4QQG6, Q587I6, Q59GN4, Q9UBL8, Q9UD55, Q9UDN1, Q9UDN2, Q9UKX6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: December 1, 2000
    Last modified: October 1, 2014
    This is version 147 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3