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P32418

- NAC1_HUMAN

UniProt

P32418 - NAC1_HUMAN

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Protein
Sodium/calcium exchanger 1
Gene
SLC8A1, CNC, NCX1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Rapidly transports Ca2+ during excitation-contraction coupling. Ca2+ is extruded from the cell during relaxation so as to prevent overloading of intracellular stores.1 Publication

Enzyme regulationi

By ATP.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi420 – 4201Calcium 3 By similarity
Metal bindingi456 – 4561Calcium 1 By similarity
Metal bindingi456 – 4561Calcium 2 By similarity
Metal bindingi481 – 4811Calcium 4 By similarity
Metal bindingi482 – 4821Calcium 3 By similarity
Metal bindingi482 – 4821Calcium 4; via carbonyl oxygen By similarity
Metal bindingi484 – 4841Calcium 3; via carbonyl oxygen By similarity
Metal bindingi486 – 4861Calcium 1 By similarity
Metal bindingi486 – 4861Calcium 2 By similarity
Metal bindingi486 – 4861Calcium 3 By similarity
Metal bindingi489 – 4891Calcium 1 By similarity
Metal bindingi533 – 5331Calcium 3 By similarity
Metal bindingi534 – 5341Calcium 4 By similarity
Metal bindingi535 – 5351Calcium 3 By similarity
Metal bindingi535 – 5351Calcium 4 By similarity
Metal bindingi551 – 5511Calcium 6 By similarity
Metal bindingi587 – 5871Calcium 5 By similarity
Metal bindingi613 – 6131Calcium 5 By similarity
Metal bindingi613 – 6131Calcium 6 By similarity
Metal bindingi615 – 6151Calcium 6 By similarity
Metal bindingi683 – 6831Calcium 6 By similarity

GO - Molecular functioni

  1. ankyrin binding Source: BHF-UCL
  2. calcium:sodium antiporter activity Source: BHF-UCL
  3. cytoskeletal protein binding Source: BHF-UCL
  4. ion channel binding Source: BHF-UCL
  5. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. blood coagulation Source: Reactome
  2. calcium ion export Source: BHF-UCL
  3. calcium ion homeostasis Source: BHF-UCL
  4. calcium ion import Source: BHF-UCL
  5. calcium ion transport into cytosol Source: BHF-UCL
  6. cardiac muscle cell development Source: BHF-UCL
  7. cardiac muscle contraction Source: Ensembl
  8. cell communication by electrical coupling involved in cardiac conduction Source: BHF-UCL
  9. cellular response to caffeine Source: BHF-UCL
  10. cellular response to reactive oxygen species Source: BHF-UCL
  11. cytosolic calcium ion transport Source: BHF-UCL
  12. embryonic heart tube development Source: Ensembl
  13. embryonic placenta development Source: Ensembl
  14. heart morphogenesis Source: Ensembl
  15. ion transport Source: Reactome
  16. muscle contraction Source: ProtInc
  17. muscle fiber development Source: Ensembl
  18. negative regulation of cytosolic calcium ion concentration Source: BHF-UCL
  19. post-embryonic development Source: Ensembl
  20. regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion Source: BHF-UCL
  21. regulation of heart rate Source: BHF-UCL
  22. regulation of the force of heart contraction Source: BHF-UCL
  23. relaxation of cardiac muscle Source: BHF-UCL
  24. relaxation of smooth muscle Source: BHF-UCL
  25. sodium ion export Source: BHF-UCL
  26. sodium ion import Source: BHF-UCL
  27. transmembrane transport Source: Reactome
  28. vascular smooth muscle contraction Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Antiport, Calcium transport, Ion transport, Sodium transport, Transport

Keywords - Ligandi

Calcium, Calmodulin-binding, Metal-binding, Sodium

Enzyme and pathway databases

ReactomeiREACT_19320. Sodium/Calcium exchangers.
REACT_23765. Reduction of cytosolic Ca++ levels.

Protein family/group databases

TCDBi2.A.19.3.4. the ca(2+):cation antiporter (caca) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/calcium exchanger 1
Alternative name(s):
Na(+)/Ca(2+)-exchange protein 1
Solute carrier family 8 member 1
Gene namesi
Name:SLC8A1
Synonyms:CNC, NCX1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:11068. SLC8A1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini36 – 7439Extracellular Reviewed prediction
Add
BLAST
Transmembranei75 – 9521Helical; Reviewed prediction
Add
BLAST
Topological domaini96 – 13641Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei137 – 15721Helical; Reviewed prediction
Add
BLAST
Topological domaini158 – 17013Extracellular Reviewed prediction
Add
BLAST
Transmembranei171 – 19121Helical; Reviewed prediction
Add
BLAST
Topological domaini192 – 20413Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei205 – 22521Helical; Reviewed prediction
Add
BLAST
Topological domaini226 – 2316Extracellular Reviewed prediction
Transmembranei232 – 25221Helical; Reviewed prediction
Add
BLAST
Topological domaini253 – 800548Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei801 – 82121Helical; Reviewed prediction
Add
BLAST
Topological domaini822 – 8243Extracellular Reviewed prediction
Transmembranei825 – 84521Helical; Reviewed prediction
Add
BLAST
Topological domaini846 – 87429Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei875 – 89521Helical; Reviewed prediction
Add
BLAST
Topological domaini896 – 90611Extracellular Reviewed prediction
Add
BLAST
Transmembranei907 – 92721Helical; Reviewed prediction
Add
BLAST
Topological domaini928 – 94417Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei945 – 96521Helical; Reviewed prediction
Add
BLAST
Topological domaini966 – 9738Extracellular Reviewed prediction

GO - Cellular componenti

  1. T-tubule Source: BHF-UCL
  2. Z disc Source: BHF-UCL
  3. basolateral plasma membrane Source: Ensembl
  4. integral component of plasma membrane Source: BHF-UCL
  5. intercalated disc Source: BHF-UCL
  6. plasma membrane Source: BHF-UCL
  7. sarcolemma Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA314.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3535 Reviewed prediction
Add
BLAST
Chaini36 – 973938Sodium/calcium exchanger 1
PRO_0000019379Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi44 – 441N-linked (GlcNAc...) Reviewed prediction
Glycosylationi160 – 1601N-linked (GlcNAc...) Reviewed prediction
Modified residuei392 – 3921Phosphoserine Reviewed prediction

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP32418.
PRIDEiP32418.

PTM databases

PhosphoSiteiP32418.

Expressioni

Tissue specificityi

Expressed in cardiac sarcolemma, brain, kidney, liver, pancreas, skeletal muscle, placenta and lung.1 Publication

Gene expression databases

ArrayExpressiP32418.
BgeeiP32418.
CleanExiHS_SLC8A1.
GenevestigatoriP32418.

Organism-specific databases

HPAiCAB022694.

Interactioni

Protein-protein interaction databases

BioGridi112436. 1 interaction.
DIPiDIP-48356N.
IntActiP32418. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP32418.
SMRiP32418. Positions 406-727.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati141 – 18141Alpha-1
Add
BLAST
Domaini396 – 496101Calx-beta 1
Add
BLAST
Domaini527 – 627101Calx-beta 2
Add
BLAST
Repeati842 – 87837Alpha-2
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni254 – 27320Calmodulin-binding Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi239 – 2424Poly-Phe
Compositional biasi692 – 6954Poly-Glu
Compositional biasi759 – 7635Poly-Asp

Sequence similaritiesi

Contains 2 Calx-beta domains.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0530.
HOGENOMiHOG000266971.
HOVERGENiHBG006441.
InParanoidiP32418.
KOiK05849.
OMAiDDEECGE.
OrthoDBiEOG7S4X56.
PhylomeDBiP32418.
TreeFamiTF314308.

Family and domain databases

InterProiIPR003644. Calx_beta.
IPR001623. DnaJ_domain.
IPR004836. Na_Ca_Ex.
IPR002987. NaCa_exhngr1.
IPR004837. NaCa_Exmemb.
[Graphical view]
PfamiPF03160. Calx-beta. 2 hits.
PF01699. Na_Ca_ex. 2 hits.
[Graphical view]
PRINTSiPR01259. NACAEXCHNGR.
PR01260. NACAEXCHNGR1.
SMARTiSM00237. Calx_beta. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00845. caca. 1 hit.

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: P32418-1) [UniParc]FASTAAdd to Basket

Also known as: NaCa1, NCX1.1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MYNMRRLSLS PTFSMGFHLL VTVSLLFSHV DHVIAETEME GEGNETGECT    50
GSYYCKKGVI LPIWEPQDPS FGDKIARATV YFVAMVYMFL GVSIIADRFM 100
SSIEVITSQE KEITIKKPNG ETTKTTVRIW NETVSNLTLM ALGSSAPEIL 150
LSVIEVCGHN FTAGDLGPST IVGSAAFNMF IIIALCVYVV PDGETRKIKH 200
LRVFFVTAAW SIFAYTWLYI ILSVISPGVV EVWEGLLTFF FFPICVVFAW 250
VADRRLLFYK YVYKRYRAGK QRGMIIEHEG DRPSSKTEIE MDGKVVNSHV 300
ENFLDGALVL EVDERDQDDE EARREMARIL KELKQKHPDK EIEQLIELAN 350
YQVLSQQQKS RAFYRIQATR LMTGAGNILK RHAADQARKA VSMHEVNTEV 400
TENDPVSKIF FEQGTYQCLE NCGTVALTII RRGGDLTNTV FVDFRTEDGT 450
ANAGSDYEFT EGTVVFKPGD TQKEIRVGII DDDIFEEDEN FLVHLSNVKV 500
SSEASEDGIL EANHVSTLAC LGSPSTATVT IFDDDHAGIF TFEEPVTHVS 550
ESIGIMEVKV LRTSGARGNV IVPYKTIEGT ARGGGEDFED TCGELEFQND 600
EIVKTISVKV IDDEEYEKNK TFFLEIGEPR LVEMSEKKAL LLNELGGFTI 650
TGKYLFGQPV FRKVHAREHP ILSTVITIAD EYDDKQPLTS KEEEERRIAE 700
MGRPILGEHT KLEVIIEESY EFKSTVDKLI KKTNLALVVG TNSWREQFIE 750
AITVSAGEDD DDDECGEEKL PSCFDYVMHF LTVFWKVLFA FVPPTEYWNG 800
WACFIVSILM IGLLTAFIGD LASHFGCTIG LKDSVTAVVF VALGTSVPDT 850
FASKVAATQD QYADASIGNV TGSNAVNVFL GIGVAWSIAA IYHAANGEQF 900
KVSPGTLAFS VTLFTIFAFI NVGVLLYRRR PEIGGELGGP RTAKLLTSCL 950
FVLLWLLYIF FSSLEAYCHI KGF 973
Length:973
Mass (Da):108,547
Last modified:December 1, 2000 - v3
Checksum:i17DFC1B1F15921D8
GO
Isoform 3 (identifier: P32418-2) [UniParc]FASTAAdd to Basket

Also known as: NaCa3, NCX1.3

The sequence of this isoform differs from the canonical sequence as follows:
     605-613: TISVKVIDD → IITIRIFDR
     619-645: NKTFFLEIGEPRLVEMSEKKALLLNEL → ECSFSLVLEEPKWIRRGMK
     652-679: Missing.

Show »
Length:937
Mass (Da):104,689
Checksum:i112BE915D7AE8723
GO
Isoform 7 (identifier: P32418-3) [UniParc]FASTAAdd to Basket

Also known as: NaCa7, NCX1.7

The sequence of this isoform differs from the canonical sequence as follows:
     605-613: TISVKVIDD → IITIRIFDR
     619-645: NKTFFLEIGEPRLVEMSEKKALLLNEL → ECSFSLVLEEPKWIRRGMK
     652-656: Missing.

Show »
Length:960
Mass (Da):107,242
Checksum:i85F0A9CD7BE0A806
GO
Isoform 10 (identifier: P32418-4) [UniParc]FASTAAdd to Basket

Also known as: NaCa10, NCX1.10

The sequence of this isoform differs from the canonical sequence as follows:
     605-613: TISVKVIDD → IITIRIFDR
     619-645: NKTFFLEIGEPRLVEMSEKKALLLNEL → ECSFSLVLEEPKWIRRGMK

Show »
Length:965
Mass (Da):107,850
Checksum:iFB6516EB3925B431
GO
Isoform 5 (identifier: P32418-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     652-656: Missing.

Show »
Length:968
Mass (Da):107,938
Checksum:iD965406E3FF9EC08
GO

Sequence cautioni

The sequence AAH98308.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti692 – 6921E → V.
Corresponds to variant rs5557 [ dbSNP | Ensembl ].
VAR_014847

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei605 – 6139TISVKVIDD → IITIRIFDR in isoform 3, isoform 7 and isoform 10.
VSP_003397
Alternative sequencei619 – 64527NKTFF…LLNEL → ECSFSLVLEEPKWIRRGMK in isoform 3, isoform 7 and isoform 10.
VSP_003398Add
BLAST
Alternative sequencei652 – 67928Missing in isoform 3.
VSP_003400Add
BLAST
Alternative sequencei652 – 6565Missing in isoform 7 and isoform 5.
VSP_003399

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M91368 mRNA. Translation: AAA35702.1.
AF108388 mRNA. Translation: AAF08987.1.
AF108389 mRNA. Translation: AAF08988.1.
AF128524 mRNA. Translation: AAD26362.1.
AK291696 mRNA. Translation: BAF84385.1.
AC007254 Genomic DNA. Translation: AAF19235.1.
AC007281 Genomic DNA. Translation: AAF19237.1.
AC007377 Genomic DNA. Translation: AAX81985.1.
CH471053 Genomic DNA. Translation: EAX00331.1.
CH471053 Genomic DNA. Translation: EAX00332.1.
CH471053 Genomic DNA. Translation: EAX00333.1.
CH471053 Genomic DNA. Translation: EAX00334.1.
CH471053 Genomic DNA. Translation: EAX00335.1.
CH471053 Genomic DNA. Translation: EAX00336.1.
AF115505 mRNA. Translation: AAD17213.1.
AB209075 mRNA. Translation: BAD92312.1.
BC098308 mRNA. Translation: AAH98308.1. Different initiation.
CCDSiCCDS1806.1. [P32418-1]
CCDS46264.1. [P32418-2]
CCDS46265.1. [P32418-5]
CCDS59430.1. [P32418-4]
PIRiS32815.
RefSeqiNP_001106271.1. NM_001112800.1. [P32418-5]
NP_001106272.1. NM_001112801.1. [P32418-3]
NP_001106273.1. NM_001112802.1. [P32418-2]
NP_001239553.1. NM_001252624.1. [P32418-4]
NP_066920.1. NM_021097.2. [P32418-1]
XP_005264571.1. XM_005264514.1. [P32418-2]
XP_006712144.1. XM_006712081.1. [P32418-1]
XP_006712145.1. XM_006712082.1. [P32418-1]
XP_006712146.1. XM_006712083.1. [P32418-1]
XP_006712147.1. XM_006712084.1. [P32418-1]
XP_006712148.1. XM_006712085.1. [P32418-1]
UniGeneiHs.31961.
Hs.468274.
Hs.744988.

Genome annotation databases

EnsembliENST00000332839; ENSP00000332931; ENSG00000183023. [P32418-1]
ENST00000402441; ENSP00000385188; ENSG00000183023. [P32418-2]
ENST00000403092; ENSP00000384763; ENSG00000183023. [P32418-1]
ENST00000405269; ENSP00000385535; ENSG00000183023. [P32418-2]
ENST00000405901; ENSP00000385678; ENSG00000183023. [P32418-5]
ENST00000406391; ENSP00000385811; ENSG00000183023. [P32418-2]
ENST00000406785; ENSP00000383886; ENSG00000183023. [P32418-2]
ENST00000408028; ENSP00000384908; ENSG00000183023. [P32418-4]
ENST00000542756; ENSP00000440727; ENSG00000183023. [P32418-5]
GeneIDi6546.
KEGGihsa:6546.
UCSCiuc002rrx.3. human. [P32418-1]
uc002rrz.3. human. [P32418-3]
uc002rsa.3. human. [P32418-2]
uc002rsb.2. human. [P32418-4]

Polymorphism databases

DMDMi12644210.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M91368 mRNA. Translation: AAA35702.1 .
AF108388 mRNA. Translation: AAF08987.1 .
AF108389 mRNA. Translation: AAF08988.1 .
AF128524 mRNA. Translation: AAD26362.1 .
AK291696 mRNA. Translation: BAF84385.1 .
AC007254 Genomic DNA. Translation: AAF19235.1 .
AC007281 Genomic DNA. Translation: AAF19237.1 .
AC007377 Genomic DNA. Translation: AAX81985.1 .
CH471053 Genomic DNA. Translation: EAX00331.1 .
CH471053 Genomic DNA. Translation: EAX00332.1 .
CH471053 Genomic DNA. Translation: EAX00333.1 .
CH471053 Genomic DNA. Translation: EAX00334.1 .
CH471053 Genomic DNA. Translation: EAX00335.1 .
CH471053 Genomic DNA. Translation: EAX00336.1 .
AF115505 mRNA. Translation: AAD17213.1 .
AB209075 mRNA. Translation: BAD92312.1 .
BC098308 mRNA. Translation: AAH98308.1 . Different initiation.
CCDSi CCDS1806.1. [P32418-1 ]
CCDS46264.1. [P32418-2 ]
CCDS46265.1. [P32418-5 ]
CCDS59430.1. [P32418-4 ]
PIRi S32815.
RefSeqi NP_001106271.1. NM_001112800.1. [P32418-5 ]
NP_001106272.1. NM_001112801.1. [P32418-3 ]
NP_001106273.1. NM_001112802.1. [P32418-2 ]
NP_001239553.1. NM_001252624.1. [P32418-4 ]
NP_066920.1. NM_021097.2. [P32418-1 ]
XP_005264571.1. XM_005264514.1. [P32418-2 ]
XP_006712144.1. XM_006712081.1. [P32418-1 ]
XP_006712145.1. XM_006712082.1. [P32418-1 ]
XP_006712146.1. XM_006712083.1. [P32418-1 ]
XP_006712147.1. XM_006712084.1. [P32418-1 ]
XP_006712148.1. XM_006712085.1. [P32418-1 ]
UniGenei Hs.31961.
Hs.468274.
Hs.744988.

3D structure databases

ProteinModelPortali P32418.
SMRi P32418. Positions 406-727.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112436. 1 interaction.
DIPi DIP-48356N.
IntActi P32418. 1 interaction.

Chemistry

ChEMBLi CHEMBL4076.
DrugBanki DB00132. Alpha-Linolenic Acid.
DB00159. Icosapent.

Protein family/group databases

TCDBi 2.A.19.3.4. the ca(2+):cation antiporter (caca) family.

PTM databases

PhosphoSitei P32418.

Polymorphism databases

DMDMi 12644210.

Proteomic databases

PaxDbi P32418.
PRIDEi P32418.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000332839 ; ENSP00000332931 ; ENSG00000183023 . [P32418-1 ]
ENST00000402441 ; ENSP00000385188 ; ENSG00000183023 . [P32418-2 ]
ENST00000403092 ; ENSP00000384763 ; ENSG00000183023 . [P32418-1 ]
ENST00000405269 ; ENSP00000385535 ; ENSG00000183023 . [P32418-2 ]
ENST00000405901 ; ENSP00000385678 ; ENSG00000183023 . [P32418-5 ]
ENST00000406391 ; ENSP00000385811 ; ENSG00000183023 . [P32418-2 ]
ENST00000406785 ; ENSP00000383886 ; ENSG00000183023 . [P32418-2 ]
ENST00000408028 ; ENSP00000384908 ; ENSG00000183023 . [P32418-4 ]
ENST00000542756 ; ENSP00000440727 ; ENSG00000183023 . [P32418-5 ]
GeneIDi 6546.
KEGGi hsa:6546.
UCSCi uc002rrx.3. human. [P32418-1 ]
uc002rrz.3. human. [P32418-3 ]
uc002rsa.3. human. [P32418-2 ]
uc002rsb.2. human. [P32418-4 ]

Organism-specific databases

CTDi 6546.
GeneCardsi GC02M040339.
HGNCi HGNC:11068. SLC8A1.
HPAi CAB022694.
MIMi 182305. gene.
neXtProti NX_P32418.
PharmGKBi PA314.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0530.
HOGENOMi HOG000266971.
HOVERGENi HBG006441.
InParanoidi P32418.
KOi K05849.
OMAi DDEECGE.
OrthoDBi EOG7S4X56.
PhylomeDBi P32418.
TreeFami TF314308.

Enzyme and pathway databases

Reactomei REACT_19320. Sodium/Calcium exchangers.
REACT_23765. Reduction of cytosolic Ca++ levels.

Miscellaneous databases

ChiTaRSi SLC8A1. human.
GenomeRNAii 6546.
NextBioi 25469.
PROi P32418.
SOURCEi Search...

Gene expression databases

ArrayExpressi P32418.
Bgeei P32418.
CleanExi HS_SLC8A1.
Genevestigatori P32418.

Family and domain databases

InterProi IPR003644. Calx_beta.
IPR001623. DnaJ_domain.
IPR004836. Na_Ca_Ex.
IPR002987. NaCa_exhngr1.
IPR004837. NaCa_Exmemb.
[Graphical view ]
Pfami PF03160. Calx-beta. 2 hits.
PF01699. Na_Ca_ex. 2 hits.
[Graphical view ]
PRINTSi PR01259. NACAEXCHNGR.
PR01260. NACAEXCHNGR1.
SMARTi SM00237. Calx_beta. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR00845. caca. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of the human cardiac Na+/Ca2+ exchanger cDNA."
    Komuro I., Wenninger K.E., Philipson K.D., Izumo S.
    Proc. Natl. Acad. Sci. U.S.A. 89:4769-4773(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Heart.
  2. "NCX1 Na/Ca exchanger splice variants in pancreatic islet cells."
    Van Eylen F., Bollen A., Herchuelz A.
    J. Endocrinol. 168:517-526(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 7).
  3. "Na+/Ca2+ exchanger isoforms in cultured human retinal pigment epithelium."
    Mangini N.J., Chen W., Wang Q., Kennedy B.G.
    Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 7).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Placenta.
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "Na+/Ca2+ exchanger isoforms of rat odontoblasts and osteoblasts."
    Lundquist P., Lundgren T., Gritli-Linde A., Linde A.
    Calcif. Tissue Int. 67:60-67(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 459-681 (ISOFORM 10).
  8. "Homo sapiens protein coding cDNA."
    Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 558-973 (ISOFORM 5).
    Tissue: Brain.
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 594-973 (ISOFORM 5).
  10. "Functional expression of human renal Na+/Ca2+ exchanger in insect cells."
    Loo T.W., Clarke D.M.
    Am. J. Physiol. 267:F70-F74(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 600-684 (ISOFORM 3).
    Tissue: Embryonic kidney.
  11. "Expression of the Na-Ca exchanger in diverse tissues: a study using the cloned human cardiac Na-Ca exchanger."
    Kofuji P., Hadley R.W., Kieval R.S., Lederer W.J., Schulze D.H.
    Am. J. Physiol. 263:C1241-C1249(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  12. "The topology of the cardiac Na(+)/Ca(2)(+) exchanger, NCX1."
    Ren X., Philipson K.D.
    J. Mol. Cell. Cardiol. 57:68-71(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY.

Entry informationi

Entry nameiNAC1_HUMAN
AccessioniPrimary (citable) accession number: P32418
Secondary accession number(s): A8K6N1
, D6W595, O95849, Q4QQG6, Q587I6, Q59GN4, Q9UBL8, Q9UD55, Q9UDN1, Q9UDN2, Q9UKX6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: December 1, 2000
Last modified: September 3, 2014
This is version 146 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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