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P32418 (NAC1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 142. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sodium/calcium exchanger 1
Alternative name(s):
Na(+)/Ca(2+)-exchange protein 1
Solute carrier family 8 member 1
Gene names
Name:SLC8A1
Synonyms:CNC, NCX1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length973 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Rapidly transports Ca2+ during excitation-contraction coupling. Ca2+ is extruded from the cell during relaxation so as to prevent overloading of intracellular stores. Ref.11

Enzyme regulation

By ATP.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in cardiac sarcolemma, brain, kidney, liver, pancreas, skeletal muscle, placenta and lung. Ref.11

Sequence similarities

Belongs to the sodium/potassium/calcium exchanger family. SLC8 subfamily.

Contains 2 Calx-beta domains.

Sequence caution

The sequence AAH98308.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Biological processAntiport
Calcium transport
Ion transport
Sodium transport
Transport
   Cellular componentCell membrane
Membrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
Signal
Transmembrane
Transmembrane helix
   LigandCalcium
Calmodulin-binding
Metal-binding
Sodium
   PTMGlycoprotein
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processblood coagulation

Traceable author statement. Source: Reactome

calcium ion export

Inferred from direct assay PubMed 19481548. Source: BHF-UCL

calcium ion homeostasis

Inferred from sequence or structural similarity. Source: BHF-UCL

calcium ion import

Inferred from direct assay Ref.1PubMed 19481548PubMed 19481548. Source: BHF-UCL

calcium ion transport into cytosol

Inferred from sequence or structural similarity. Source: BHF-UCL

cardiac muscle cell development

Inferred from sequence or structural similarity. Source: BHF-UCL

cardiac muscle contraction

Inferred from electronic annotation. Source: Ensembl

cell communication by electrical coupling involved in cardiac conduction

Inferred from sequence or structural similarity. Source: BHF-UCL

cellular response to caffeine

Inferred from sequence or structural similarity. Source: BHF-UCL

cellular response to reactive oxygen species

Inferred from direct assay PubMed 19481548PubMed 19481548. Source: BHF-UCL

cytosolic calcium ion transport

Traceable author statement PubMed 19095005. Source: BHF-UCL

embryonic heart tube development

Inferred from electronic annotation. Source: Ensembl

embryonic placenta development

Inferred from electronic annotation. Source: Ensembl

heart morphogenesis

Inferred from electronic annotation. Source: Ensembl

ion transport

Traceable author statement. Source: Reactome

muscle contraction

Traceable author statement Ref.1. Source: ProtInc

muscle fiber development

Inferred from electronic annotation. Source: Ensembl

negative regulation of cytosolic calcium ion concentration

Inferred from sequence or structural similarity. Source: BHF-UCL

post-embryonic development

Inferred from electronic annotation. Source: Ensembl

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

Inferred from sequence or structural similarity. Source: BHF-UCL

regulation of heart rate

Inferred from sequence or structural similarity. Source: BHF-UCL

regulation of the force of heart contraction

Inferred from sequence or structural similarity. Source: BHF-UCL

relaxation of cardiac muscle

Inferred by curator PubMed 19481548. Source: BHF-UCL

relaxation of smooth muscle

Inferred from sequence or structural similarity. Source: BHF-UCL

sodium ion export

Inferred from direct assay PubMed 19481548PubMed 19481548. Source: BHF-UCL

sodium ion import

Inferred from direct assay Ref.1. Source: BHF-UCL

transmembrane transport

Traceable author statement. Source: Reactome

vascular smooth muscle contraction

Inferred from sequence or structural similarity. Source: BHF-UCL

   Cellular_componentT-tubule

Inferred from sequence or structural similarity. Source: BHF-UCL

Z disc

Inferred from sequence or structural similarity. Source: BHF-UCL

basolateral plasma membrane

Inferred from electronic annotation. Source: Ensembl

integral component of plasma membrane

Inferred from direct assay Ref.1. Source: BHF-UCL

intercalated disc

Inferred from sequence or structural similarity. Source: BHF-UCL

plasma membrane

Traceable author statement PubMed 19095005. Source: BHF-UCL

sarcolemma

Inferred from sequence or structural similarity. Source: BHF-UCL

   Molecular_functionankyrin binding

Inferred from physical interaction PubMed 17178715. Source: BHF-UCL

calcium:sodium antiporter activity

Inferred from direct assay Ref.1PubMed 19481548PubMed 19481548. Source: BHF-UCL

cytoskeletal protein binding

Inferred from direct assay PubMed 16292983. Source: BHF-UCL

ion channel binding

Inferred from sequence or structural similarity. Source: BHF-UCL

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: P32418-1)

Also known as: NaCa1; NCX1.1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 3 (identifier: P32418-2)

Also known as: NaCa3; NCX1.3;

The sequence of this isoform differs from the canonical sequence as follows:
     605-613: TISVKVIDD → IITIRIFDR
     619-645: NKTFFLEIGEPRLVEMSEKKALLLNEL → ECSFSLVLEEPKWIRRGMK
     652-679: Missing.
Isoform 7 (identifier: P32418-3)

Also known as: NaCa7; NCX1.7;

The sequence of this isoform differs from the canonical sequence as follows:
     605-613: TISVKVIDD → IITIRIFDR
     619-645: NKTFFLEIGEPRLVEMSEKKALLLNEL → ECSFSLVLEEPKWIRRGMK
     652-656: Missing.
Isoform 10 (identifier: P32418-4)

Also known as: NaCa10; NCX1.10;

The sequence of this isoform differs from the canonical sequence as follows:
     605-613: TISVKVIDD → IITIRIFDR
     619-645: NKTFFLEIGEPRLVEMSEKKALLLNEL → ECSFSLVLEEPKWIRRGMK
Isoform 5 (identifier: P32418-5)

The sequence of this isoform differs from the canonical sequence as follows:
     652-656: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3535 Potential
Chain36 – 973938Sodium/calcium exchanger 1
PRO_0000019379

Regions

Topological domain36 – 7439Extracellular Potential
Transmembrane75 – 9521Helical; Potential
Topological domain96 – 13641Cytoplasmic Potential
Transmembrane137 – 15721Helical; Potential
Topological domain158 – 17013Extracellular Potential
Transmembrane171 – 19121Helical; Potential
Topological domain192 – 20413Cytoplasmic Potential
Transmembrane205 – 22521Helical; Potential
Topological domain226 – 2316Extracellular Potential
Transmembrane232 – 25221Helical; Potential
Topological domain253 – 800548Cytoplasmic Potential
Transmembrane801 – 82121Helical; Potential
Topological domain822 – 8243Extracellular Potential
Transmembrane825 – 84521Helical; Potential
Topological domain846 – 87429Cytoplasmic Potential
Transmembrane875 – 89521Helical; Potential
Topological domain896 – 90611Extracellular Potential
Transmembrane907 – 92721Helical; Potential
Topological domain928 – 94417Cytoplasmic Potential
Transmembrane945 – 96521Helical; Potential
Topological domain966 – 9738Extracellular Potential
Repeat141 – 18141Alpha-1
Domain396 – 496101Calx-beta 1
Domain527 – 627101Calx-beta 2
Repeat842 – 87837Alpha-2
Region254 – 27320Calmodulin-binding Potential
Compositional bias239 – 2424Poly-Phe
Compositional bias692 – 6954Poly-Glu
Compositional bias759 – 7635Poly-Asp

Sites

Metal binding4201Calcium 3 By similarity
Metal binding4561Calcium 1 By similarity
Metal binding4561Calcium 2 By similarity
Metal binding4811Calcium 4 By similarity
Metal binding4821Calcium 3 By similarity
Metal binding4821Calcium 4; via carbonyl oxygen By similarity
Metal binding4841Calcium 3; via carbonyl oxygen By similarity
Metal binding4861Calcium 1 By similarity
Metal binding4861Calcium 2 By similarity
Metal binding4861Calcium 3 By similarity
Metal binding4891Calcium 1 By similarity
Metal binding5331Calcium 3 By similarity
Metal binding5341Calcium 4 By similarity
Metal binding5351Calcium 3 By similarity
Metal binding5351Calcium 4 By similarity
Metal binding5511Calcium 6 By similarity
Metal binding5871Calcium 5 By similarity
Metal binding6131Calcium 5 By similarity
Metal binding6131Calcium 6 By similarity
Metal binding6151Calcium 6 By similarity
Metal binding6831Calcium 6 By similarity

Amino acid modifications

Modified residue3921Phosphoserine Potential
Glycosylation441N-linked (GlcNAc...) Potential
Glycosylation1601N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence605 – 6139TISVKVIDD → IITIRIFDR in isoform 3, isoform 7 and isoform 10.
VSP_003397
Alternative sequence619 – 64527NKTFF…LLNEL → ECSFSLVLEEPKWIRRGMK in isoform 3, isoform 7 and isoform 10.
VSP_003398
Alternative sequence652 – 67928Missing in isoform 3.
VSP_003400
Alternative sequence652 – 6565Missing in isoform 7 and isoform 5.
VSP_003399
Natural variant6921E → V.
Corresponds to variant rs5557 [ dbSNP | Ensembl ].
VAR_014847

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (NaCa1) (NCX1.1) [UniParc].

Last modified December 1, 2000. Version 3.
Checksum: 17DFC1B1F15921D8

FASTA973108,547
        10         20         30         40         50         60 
MYNMRRLSLS PTFSMGFHLL VTVSLLFSHV DHVIAETEME GEGNETGECT GSYYCKKGVI 

        70         80         90        100        110        120 
LPIWEPQDPS FGDKIARATV YFVAMVYMFL GVSIIADRFM SSIEVITSQE KEITIKKPNG 

       130        140        150        160        170        180 
ETTKTTVRIW NETVSNLTLM ALGSSAPEIL LSVIEVCGHN FTAGDLGPST IVGSAAFNMF 

       190        200        210        220        230        240 
IIIALCVYVV PDGETRKIKH LRVFFVTAAW SIFAYTWLYI ILSVISPGVV EVWEGLLTFF 

       250        260        270        280        290        300 
FFPICVVFAW VADRRLLFYK YVYKRYRAGK QRGMIIEHEG DRPSSKTEIE MDGKVVNSHV 

       310        320        330        340        350        360 
ENFLDGALVL EVDERDQDDE EARREMARIL KELKQKHPDK EIEQLIELAN YQVLSQQQKS 

       370        380        390        400        410        420 
RAFYRIQATR LMTGAGNILK RHAADQARKA VSMHEVNTEV TENDPVSKIF FEQGTYQCLE 

       430        440        450        460        470        480 
NCGTVALTII RRGGDLTNTV FVDFRTEDGT ANAGSDYEFT EGTVVFKPGD TQKEIRVGII 

       490        500        510        520        530        540 
DDDIFEEDEN FLVHLSNVKV SSEASEDGIL EANHVSTLAC LGSPSTATVT IFDDDHAGIF 

       550        560        570        580        590        600 
TFEEPVTHVS ESIGIMEVKV LRTSGARGNV IVPYKTIEGT ARGGGEDFED TCGELEFQND 

       610        620        630        640        650        660 
EIVKTISVKV IDDEEYEKNK TFFLEIGEPR LVEMSEKKAL LLNELGGFTI TGKYLFGQPV 

       670        680        690        700        710        720 
FRKVHAREHP ILSTVITIAD EYDDKQPLTS KEEEERRIAE MGRPILGEHT KLEVIIEESY 

       730        740        750        760        770        780 
EFKSTVDKLI KKTNLALVVG TNSWREQFIE AITVSAGEDD DDDECGEEKL PSCFDYVMHF 

       790        800        810        820        830        840 
LTVFWKVLFA FVPPTEYWNG WACFIVSILM IGLLTAFIGD LASHFGCTIG LKDSVTAVVF 

       850        860        870        880        890        900 
VALGTSVPDT FASKVAATQD QYADASIGNV TGSNAVNVFL GIGVAWSIAA IYHAANGEQF 

       910        920        930        940        950        960 
KVSPGTLAFS VTLFTIFAFI NVGVLLYRRR PEIGGELGGP RTAKLLTSCL FVLLWLLYIF 

       970 
FSSLEAYCHI KGF 

« Hide

Isoform 3 (NaCa3) (NCX1.3) [UniParc].

Checksum: 112BE915D7AE8723
Show »

FASTA937104,689
Isoform 7 (NaCa7) (NCX1.7) [UniParc].

Checksum: 85F0A9CD7BE0A806
Show »

FASTA960107,242
Isoform 10 (NaCa10) (NCX1.10) [UniParc].

Checksum: FB6516EB3925B431
Show »

FASTA965107,850
Isoform 5 [UniParc].

Checksum: D965406E3FF9EC08
Show »

FASTA968107,938

References

« Hide 'large scale' references
[1]"Molecular cloning and characterization of the human cardiac Na+/Ca2+ exchanger cDNA."
Komuro I., Wenninger K.E., Philipson K.D., Izumo S.
Proc. Natl. Acad. Sci. U.S.A. 89:4769-4773(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Heart.
[2]"NCX1 Na/Ca exchanger splice variants in pancreatic islet cells."
Van Eylen F., Bollen A., Herchuelz A.
J. Endocrinol. 168:517-526(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 7).
[3]"Na+/Ca2+ exchanger isoforms in cultured human retinal pigment epithelium."
Mangini N.J., Chen W., Wang Q., Kennedy B.G.
Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 7).
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Placenta.
[5]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"Na+/Ca2+ exchanger isoforms of rat odontoblasts and osteoblasts."
Lundquist P., Lundgren T., Gritli-Linde A., Linde A.
Calcif. Tissue Int. 67:60-67(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 459-681 (ISOFORM 10).
[8]"Homo sapiens protein coding cDNA."
Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 558-973 (ISOFORM 5).
Tissue: Brain.
[9]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 594-973 (ISOFORM 5).
[10]"Functional expression of human renal Na+/Ca2+ exchanger in insect cells."
Loo T.W., Clarke D.M.
Am. J. Physiol. 267:F70-F74(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 600-684 (ISOFORM 3).
Tissue: Embryonic kidney.
[11]"Expression of the Na-Ca exchanger in diverse tissues: a study using the cloned human cardiac Na-Ca exchanger."
Kofuji P., Hadley R.W., Kieval R.S., Lederer W.J., Schulze D.H.
Am. J. Physiol. 263:C1241-C1249(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY.
[12]"The topology of the cardiac Na(+)/Ca(2)(+) exchanger, NCX1."
Ren X., Philipson K.D.
J. Mol. Cell. Cardiol. 57:68-71(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M91368 mRNA. Translation: AAA35702.1.
AF108388 mRNA. Translation: AAF08987.1.
AF108389 mRNA. Translation: AAF08988.1.
AF128524 mRNA. Translation: AAD26362.1.
AK291696 mRNA. Translation: BAF84385.1.
AC007254 Genomic DNA. Translation: AAF19235.1.
AC007281 Genomic DNA. Translation: AAF19237.1.
AC007377 Genomic DNA. Translation: AAX81985.1.
CH471053 Genomic DNA. Translation: EAX00331.1.
CH471053 Genomic DNA. Translation: EAX00332.1.
CH471053 Genomic DNA. Translation: EAX00333.1.
CH471053 Genomic DNA. Translation: EAX00334.1.
CH471053 Genomic DNA. Translation: EAX00335.1.
CH471053 Genomic DNA. Translation: EAX00336.1.
AF115505 mRNA. Translation: AAD17213.1.
AB209075 mRNA. Translation: BAD92312.1.
BC098308 mRNA. Translation: AAH98308.1. Different initiation.
PIRS32815.
RefSeqNP_001106271.1. NM_001112800.1.
NP_001106272.1. NM_001112801.1.
NP_001106273.1. NM_001112802.1.
NP_001239553.1. NM_001252624.1.
NP_066920.1. NM_021097.2.
XP_005264571.1. XM_005264514.1.
UniGeneHs.31961.
Hs.468274.
Hs.744988.

3D structure databases

ProteinModelPortalP32418.
SMRP32418. Positions 406-727, 801-893.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112436. 1 interaction.
DIPDIP-48356N.
IntActP32418. 1 interaction.

Chemistry

ChEMBLCHEMBL4076.
DrugBankDB00132. Alpha-Linolenic Acid.
DB00159. Icosapent.

Protein family/group databases

TCDB2.A.19.3.4. the ca(2+):cation antiporter (caca) family.

PTM databases

PhosphoSiteP32418.

Polymorphism databases

DMDM12644210.

Proteomic databases

PaxDbP32418.
PRIDEP32418.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000332839; ENSP00000332931; ENSG00000183023. [P32418-1]
ENST00000402441; ENSP00000385188; ENSG00000183023. [P32418-2]
ENST00000403092; ENSP00000384763; ENSG00000183023. [P32418-1]
ENST00000405269; ENSP00000385535; ENSG00000183023. [P32418-2]
ENST00000405901; ENSP00000385678; ENSG00000183023. [P32418-5]
ENST00000406391; ENSP00000385811; ENSG00000183023. [P32418-2]
ENST00000406785; ENSP00000383886; ENSG00000183023. [P32418-2]
ENST00000408028; ENSP00000384908; ENSG00000183023. [P32418-4]
ENST00000542756; ENSP00000440727; ENSG00000183023. [P32418-5]
GeneID6546.
KEGGhsa:6546.
UCSCuc002rrx.3. human. [P32418-1]
uc002rrz.3. human. [P32418-3]
uc002rsa.3. human. [P32418-2]
uc002rsb.2. human. [P32418-4]

Organism-specific databases

CTD6546.
GeneCardsGC02M040339.
HGNCHGNC:11068. SLC8A1.
HPACAB022694.
MIM182305. gene.
neXtProtNX_P32418.
PharmGKBPA314.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0530.
HOGENOMHOG000266971.
HOVERGENHBG006441.
InParanoidP32418.
KOK05849.
OMADDEECGE.
OrthoDBEOG7S4X56.
PhylomeDBP32418.
TreeFamTF314308.

Enzyme and pathway databases

ReactomeREACT_15518. Transmembrane transport of small molecules.
REACT_604. Hemostasis.

Gene expression databases

ArrayExpressP32418.
BgeeP32418.
CleanExHS_SLC8A1.
GenevestigatorP32418.

Family and domain databases

InterProIPR003644. Calx_beta.
IPR001623. DnaJ_domain.
IPR004836. Na_Ca_Ex.
IPR002987. NaCa_exhngr1.
IPR004837. NaCa_Exmemb.
[Graphical view]
PfamPF03160. Calx-beta. 2 hits.
PF01699. Na_Ca_ex. 2 hits.
[Graphical view]
PRINTSPR01259. NACAEXCHNGR.
PR01260. NACAEXCHNGR1.
SMARTSM00237. Calx_beta. 2 hits.
[Graphical view]
TIGRFAMsTIGR00845. caca. 1 hit.
ProtoNetSearch...

Other

ChiTaRSSLC8A1. human.
GenomeRNAi6546.
NextBio25469.
PROP32418.
SOURCESearch...

Entry information

Entry nameNAC1_HUMAN
AccessionPrimary (citable) accession number: P32418
Secondary accession number(s): A8K6N1 expand/collapse secondary AC list , D6W595, O95849, Q4QQG6, Q587I6, Q59GN4, Q9UBL8, Q9UD55, Q9UDN1, Q9UDN2, Q9UKX6
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: December 1, 2000
Last modified: April 16, 2014
This is version 142 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM