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Protein

Sodium/calcium exchanger 1

Gene

SLC8A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Rapidly transports Ca2+ during excitation-contraction coupling. Ca2+ is extruded from the cell during relaxation so as to prevent overloading of intracellular stores.1 Publication

Enzyme regulationi

By ATP.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi420 – 4201Calcium 3By similarity
Metal bindingi456 – 4561Calcium 1By similarity
Metal bindingi456 – 4561Calcium 2By similarity
Metal bindingi481 – 4811Calcium 4By similarity
Metal bindingi482 – 4821Calcium 3By similarity
Metal bindingi482 – 4821Calcium 4; via carbonyl oxygenBy similarity
Metal bindingi484 – 4841Calcium 3; via carbonyl oxygenBy similarity
Metal bindingi486 – 4861Calcium 1By similarity
Metal bindingi486 – 4861Calcium 2By similarity
Metal bindingi486 – 4861Calcium 3By similarity
Metal bindingi489 – 4891Calcium 1By similarity
Metal bindingi533 – 5331Calcium 3By similarity
Metal bindingi534 – 5341Calcium 4By similarity
Metal bindingi535 – 5351Calcium 3By similarity
Metal bindingi535 – 5351Calcium 4By similarity
Metal bindingi551 – 5511Calcium 6By similarity
Metal bindingi587 – 5871Calcium 5By similarity
Metal bindingi613 – 6131Calcium 5By similarity
Metal bindingi613 – 6131Calcium 6By similarity
Metal bindingi615 – 6151Calcium 6By similarity
Metal bindingi683 – 6831Calcium 6By similarity

GO - Molecular functioni

  • ankyrin binding Source: BHF-UCL
  • calcium:sodium antiporter activity Source: BHF-UCL
  • cytoskeletal protein binding Source: BHF-UCL
  • ion channel binding Source: BHF-UCL
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • blood coagulation Source: Reactome
  • calcium ion export Source: BHF-UCL
  • calcium ion homeostasis Source: BHF-UCL
  • calcium ion import Source: BHF-UCL
  • calcium ion transmembrane transport Source: UniProtKB
  • calcium ion transport into cytosol Source: BHF-UCL
  • cardiac muscle cell development Source: BHF-UCL
  • cardiac muscle contraction Source: BHF-UCL
  • cell communication by electrical coupling involved in cardiac conduction Source: BHF-UCL
  • cellular response to caffeine Source: BHF-UCL
  • cellular response to cAMP Source: Ensembl
  • cellular response to hypoxia Source: Ensembl
  • cellular response to reactive oxygen species Source: BHF-UCL
  • cellular sodium ion homeostasis Source: BHF-UCL
  • cytosolic calcium ion transport Source: BHF-UCL
  • embryonic heart tube development Source: Ensembl
  • embryonic placenta development Source: Ensembl
  • heart morphogenesis Source: Ensembl
  • ion transport Source: Reactome
  • membrane depolarization during cardiac muscle cell action potential Source: BHF-UCL
  • muscle contraction Source: ProtInc
  • muscle fiber development Source: Ensembl
  • negative regulation of cytosolic calcium ion concentration Source: BHF-UCL
  • positive regulation of bone mineralization Source: UniProtKB
  • positive regulation of fibroblast migration Source: Ensembl
  • positive regulation of the force of heart contraction Source: BHF-UCL
  • post-embryonic development Source: Ensembl
  • regulation of cardiac muscle contraction by calcium ion signaling Source: BHF-UCL
  • regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion Source: BHF-UCL
  • regulation of cell communication by electrical coupling Source: BHF-UCL
  • regulation of heart rate Source: BHF-UCL
  • regulation of sodium ion transport Source: Ensembl
  • regulation of the force of heart contraction Source: BHF-UCL
  • relaxation of cardiac muscle Source: BHF-UCL
  • relaxation of smooth muscle Source: BHF-UCL
  • response to ATP Source: Ensembl
  • response to drug Source: Ensembl
  • response to glucose Source: Ensembl
  • response to hydrogen peroxide Source: Ensembl
  • response to immobilization stress Source: Ensembl
  • response to muscle stretch Source: BHF-UCL
  • response to nutrient Source: Ensembl
  • sodium ion export Source: BHF-UCL
  • sodium ion import Source: BHF-UCL
  • sodium ion transmembrane transport Source: UniProtKB
  • telencephalon development Source: Ensembl
  • transmembrane transport Source: Reactome
  • vascular smooth muscle contraction Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Antiport, Calcium transport, Ion transport, Sodium transport, Transport

Keywords - Ligandi

Calcium, Calmodulin-binding, Metal-binding, Sodium

Enzyme and pathway databases

ReactomeiREACT_19320. Sodium/Calcium exchangers.
REACT_23765. Reduction of cytosolic Ca++ levels.

Protein family/group databases

TCDBi2.A.19.3.4. the ca(2+):cation antiporter (caca) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/calcium exchanger 1
Alternative name(s):
Na(+)/Ca(2+)-exchange protein 1
Solute carrier family 8 member 1
Gene namesi
Name:SLC8A1
Synonyms:CNC, NCX1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:11068. SLC8A1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini36 – 7439ExtracellularSequence AnalysisAdd
BLAST
Transmembranei75 – 9521HelicalSequence AnalysisAdd
BLAST
Topological domaini96 – 13641CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei137 – 15721HelicalSequence AnalysisAdd
BLAST
Topological domaini158 – 17013ExtracellularSequence AnalysisAdd
BLAST
Transmembranei171 – 19121HelicalSequence AnalysisAdd
BLAST
Topological domaini192 – 20413CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei205 – 22521HelicalSequence AnalysisAdd
BLAST
Topological domaini226 – 2316ExtracellularSequence Analysis
Transmembranei232 – 25221HelicalSequence AnalysisAdd
BLAST
Topological domaini253 – 800548CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei801 – 82121HelicalSequence AnalysisAdd
BLAST
Topological domaini822 – 8243ExtracellularSequence Analysis
Transmembranei825 – 84521HelicalSequence AnalysisAdd
BLAST
Topological domaini846 – 87429CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei875 – 89521HelicalSequence AnalysisAdd
BLAST
Topological domaini896 – 90611ExtracellularSequence AnalysisAdd
BLAST
Transmembranei907 – 92721HelicalSequence AnalysisAdd
BLAST
Topological domaini928 – 94417CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei945 – 96521HelicalSequence AnalysisAdd
BLAST
Topological domaini966 – 9738ExtracellularSequence Analysis

GO - Cellular componenti

  • basolateral plasma membrane Source: Ensembl
  • cytosol Source: GOC
  • dendritic shaft Source: Ensembl
  • dendritic spine Source: Ensembl
  • integral component of plasma membrane Source: BHF-UCL
  • intercalated disc Source: BHF-UCL
  • microtubule Source: Ensembl
  • mitochondrion Source: Ensembl
  • plasma membrane Source: BHF-UCL
  • sarcolemma Source: BHF-UCL
  • T-tubule Source: BHF-UCL
  • Z disc Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA314.

Chemistry

DrugBankiDB00132. Alpha-Linolenic Acid.
DB00159. Icosapent.

Polymorphism and mutation databases

BioMutaiSLC8A1.
DMDMi12644210.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3535Sequence AnalysisAdd
BLAST
Chaini36 – 973938Sodium/calcium exchanger 1PRO_0000019379Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi44 – 441N-linked (GlcNAc...)Sequence Analysis
Glycosylationi160 – 1601N-linked (GlcNAc...)Sequence Analysis
Modified residuei392 – 3921PhosphoserineSequence Analysis

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP32418.
PRIDEiP32418.

PTM databases

PhosphoSiteiP32418.

Expressioni

Tissue specificityi

Expressed in cardiac sarcolemma, brain, kidney, liver, pancreas, skeletal muscle, placenta and lung.1 Publication

Gene expression databases

BgeeiP32418.
CleanExiHS_SLC8A1.
ExpressionAtlasiP32418. baseline and differential.
GenevisibleiP32418. HS.

Organism-specific databases

HPAiCAB022694.

Interactioni

Protein-protein interaction databases

BioGridi112436. 1 interaction.
DIPiDIP-48356N.
IntActiP32418. 1 interaction.
STRINGi9606.ENSP00000332931.

Structurei

3D structure databases

ProteinModelPortaliP32418.
SMRiP32418. Positions 406-727.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati141 – 18141Alpha-1Add
BLAST
Domaini396 – 496101Calx-beta 1Add
BLAST
Domaini527 – 627101Calx-beta 2Add
BLAST
Repeati842 – 87837Alpha-2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni254 – 27320Calmodulin-bindingSequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi239 – 2424Poly-Phe
Compositional biasi692 – 6954Poly-Glu
Compositional biasi759 – 7635Poly-Asp

Sequence similaritiesi

Contains 2 Calx-beta domains.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0530.
GeneTreeiENSGT00730000110414.
HOGENOMiHOG000266971.
HOVERGENiHBG006441.
InParanoidiP32418.
KOiK05849.
OMAiDDEECGE.
OrthoDBiEOG7S4X56.
PhylomeDBiP32418.
TreeFamiTF314308.

Family and domain databases

InterProiIPR003644. Calx_beta.
IPR001623. DnaJ_domain.
IPR004836. Na_Ca_Ex.
IPR002987. NaCa_exhngr1.
IPR004837. NaCa_Exmemb.
[Graphical view]
PfamiPF03160. Calx-beta. 2 hits.
PF01699. Na_Ca_ex. 2 hits.
[Graphical view]
PRINTSiPR01259. NACAEXCHNGR.
PR01260. NACAEXCHNGR1.
SMARTiSM00237. Calx_beta. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00845. caca. 1 hit.

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: P32418-1) [UniParc]FASTAAdd to basket

Also known as: NaCa1, NCX1.1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYNMRRLSLS PTFSMGFHLL VTVSLLFSHV DHVIAETEME GEGNETGECT
60 70 80 90 100
GSYYCKKGVI LPIWEPQDPS FGDKIARATV YFVAMVYMFL GVSIIADRFM
110 120 130 140 150
SSIEVITSQE KEITIKKPNG ETTKTTVRIW NETVSNLTLM ALGSSAPEIL
160 170 180 190 200
LSVIEVCGHN FTAGDLGPST IVGSAAFNMF IIIALCVYVV PDGETRKIKH
210 220 230 240 250
LRVFFVTAAW SIFAYTWLYI ILSVISPGVV EVWEGLLTFF FFPICVVFAW
260 270 280 290 300
VADRRLLFYK YVYKRYRAGK QRGMIIEHEG DRPSSKTEIE MDGKVVNSHV
310 320 330 340 350
ENFLDGALVL EVDERDQDDE EARREMARIL KELKQKHPDK EIEQLIELAN
360 370 380 390 400
YQVLSQQQKS RAFYRIQATR LMTGAGNILK RHAADQARKA VSMHEVNTEV
410 420 430 440 450
TENDPVSKIF FEQGTYQCLE NCGTVALTII RRGGDLTNTV FVDFRTEDGT
460 470 480 490 500
ANAGSDYEFT EGTVVFKPGD TQKEIRVGII DDDIFEEDEN FLVHLSNVKV
510 520 530 540 550
SSEASEDGIL EANHVSTLAC LGSPSTATVT IFDDDHAGIF TFEEPVTHVS
560 570 580 590 600
ESIGIMEVKV LRTSGARGNV IVPYKTIEGT ARGGGEDFED TCGELEFQND
610 620 630 640 650
EIVKTISVKV IDDEEYEKNK TFFLEIGEPR LVEMSEKKAL LLNELGGFTI
660 670 680 690 700
TGKYLFGQPV FRKVHAREHP ILSTVITIAD EYDDKQPLTS KEEEERRIAE
710 720 730 740 750
MGRPILGEHT KLEVIIEESY EFKSTVDKLI KKTNLALVVG TNSWREQFIE
760 770 780 790 800
AITVSAGEDD DDDECGEEKL PSCFDYVMHF LTVFWKVLFA FVPPTEYWNG
810 820 830 840 850
WACFIVSILM IGLLTAFIGD LASHFGCTIG LKDSVTAVVF VALGTSVPDT
860 870 880 890 900
FASKVAATQD QYADASIGNV TGSNAVNVFL GIGVAWSIAA IYHAANGEQF
910 920 930 940 950
KVSPGTLAFS VTLFTIFAFI NVGVLLYRRR PEIGGELGGP RTAKLLTSCL
960 970
FVLLWLLYIF FSSLEAYCHI KGF
Length:973
Mass (Da):108,547
Last modified:December 1, 2000 - v3
Checksum:i17DFC1B1F15921D8
GO
Isoform 3 (identifier: P32418-2) [UniParc]FASTAAdd to basket

Also known as: NaCa3, NCX1.3

The sequence of this isoform differs from the canonical sequence as follows:
     605-613: TISVKVIDD → IITIRIFDR
     619-645: NKTFFLEIGEPRLVEMSEKKALLLNEL → ECSFSLVLEEPKWIRRGMK
     652-679: Missing.

Show »
Length:937
Mass (Da):104,689
Checksum:i112BE915D7AE8723
GO
Isoform 7 (identifier: P32418-3) [UniParc]FASTAAdd to basket

Also known as: NaCa7, NCX1.7

The sequence of this isoform differs from the canonical sequence as follows:
     605-613: TISVKVIDD → IITIRIFDR
     619-645: NKTFFLEIGEPRLVEMSEKKALLLNEL → ECSFSLVLEEPKWIRRGMK
     652-656: Missing.

Show »
Length:960
Mass (Da):107,242
Checksum:i85F0A9CD7BE0A806
GO
Isoform 10 (identifier: P32418-4) [UniParc]FASTAAdd to basket

Also known as: NaCa10, NCX1.10

The sequence of this isoform differs from the canonical sequence as follows:
     605-613: TISVKVIDD → IITIRIFDR
     619-645: NKTFFLEIGEPRLVEMSEKKALLLNEL → ECSFSLVLEEPKWIRRGMK

Show »
Length:965
Mass (Da):107,850
Checksum:iFB6516EB3925B431
GO
Isoform 5 (identifier: P32418-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     652-656: Missing.

Show »
Length:968
Mass (Da):107,938
Checksum:iD965406E3FF9EC08
GO

Sequence cautioni

The sequence AAH98308.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti692 – 6921E → V.
Corresponds to variant rs5557 [ dbSNP | Ensembl ].
VAR_014847

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei605 – 6139TISVKVIDD → IITIRIFDR in isoform 3, isoform 7 and isoform 10. 5 PublicationsVSP_003397
Alternative sequencei619 – 64527NKTFF…LLNEL → ECSFSLVLEEPKWIRRGMK in isoform 3, isoform 7 and isoform 10. 5 PublicationsVSP_003398Add
BLAST
Alternative sequencei652 – 67928Missing in isoform 3. 3 PublicationsVSP_003400Add
BLAST
Alternative sequencei652 – 6565Missing in isoform 7 and isoform 5. 4 PublicationsVSP_003399

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91368 mRNA. Translation: AAA35702.1.
AF108388 mRNA. Translation: AAF08987.1.
AF108389 mRNA. Translation: AAF08988.1.
AF128524 mRNA. Translation: AAD26362.1.
AK291696 mRNA. Translation: BAF84385.1.
AC007254 Genomic DNA. Translation: AAF19235.1.
AC007281 Genomic DNA. Translation: AAF19237.1.
AC007377 Genomic DNA. Translation: AAX81985.1.
CH471053 Genomic DNA. Translation: EAX00331.1.
CH471053 Genomic DNA. Translation: EAX00332.1.
CH471053 Genomic DNA. Translation: EAX00333.1.
CH471053 Genomic DNA. Translation: EAX00334.1.
CH471053 Genomic DNA. Translation: EAX00335.1.
CH471053 Genomic DNA. Translation: EAX00336.1.
AF115505 mRNA. Translation: AAD17213.1.
AB209075 mRNA. Translation: BAD92312.1.
BC098308 mRNA. Translation: AAH98308.1. Different initiation.
CCDSiCCDS1806.1. [P32418-1]
CCDS46264.1. [P32418-2]
CCDS46265.1. [P32418-5]
CCDS59430.1. [P32418-4]
PIRiS32815.
RefSeqiNP_001106271.1. NM_001112800.1. [P32418-5]
NP_001106272.1. NM_001112801.1. [P32418-3]
NP_001106273.1. NM_001112802.1. [P32418-2]
NP_001239553.1. NM_001252624.1. [P32418-4]
NP_066920.1. NM_021097.2. [P32418-1]
XP_005264571.1. XM_005264514.2. [P32418-2]
XP_006712144.1. XM_006712081.1. [P32418-1]
XP_006712145.1. XM_006712082.2. [P32418-1]
XP_006712146.1. XM_006712083.2. [P32418-1]
XP_006712147.1. XM_006712084.2. [P32418-1]
XP_006712148.1. XM_006712085.2. [P32418-1]
XP_011531356.1. XM_011533054.1. [P32418-1]
XP_011531357.1. XM_011533055.1. [P32418-1]
XP_011531358.1. XM_011533056.1. [P32418-1]
UniGeneiHs.31961.
Hs.468274.
Hs.744988.

Genome annotation databases

EnsembliENST00000332839; ENSP00000332931; ENSG00000183023.
ENST00000402441; ENSP00000385188; ENSG00000183023. [P32418-2]
ENST00000403092; ENSP00000384763; ENSG00000183023.
ENST00000405269; ENSP00000385535; ENSG00000183023. [P32418-2]
ENST00000405901; ENSP00000385678; ENSG00000183023. [P32418-5]
ENST00000406391; ENSP00000385811; ENSG00000183023. [P32418-2]
ENST00000406785; ENSP00000383886; ENSG00000183023. [P32418-2]
ENST00000408028; ENSP00000384908; ENSG00000183023. [P32418-4]
GeneIDi6546.
KEGGihsa:6546.
UCSCiuc002rrx.3. human. [P32418-1]
uc002rrz.3. human. [P32418-3]
uc002rsa.3. human. [P32418-2]
uc002rsb.2. human. [P32418-4]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91368 mRNA. Translation: AAA35702.1.
AF108388 mRNA. Translation: AAF08987.1.
AF108389 mRNA. Translation: AAF08988.1.
AF128524 mRNA. Translation: AAD26362.1.
AK291696 mRNA. Translation: BAF84385.1.
AC007254 Genomic DNA. Translation: AAF19235.1.
AC007281 Genomic DNA. Translation: AAF19237.1.
AC007377 Genomic DNA. Translation: AAX81985.1.
CH471053 Genomic DNA. Translation: EAX00331.1.
CH471053 Genomic DNA. Translation: EAX00332.1.
CH471053 Genomic DNA. Translation: EAX00333.1.
CH471053 Genomic DNA. Translation: EAX00334.1.
CH471053 Genomic DNA. Translation: EAX00335.1.
CH471053 Genomic DNA. Translation: EAX00336.1.
AF115505 mRNA. Translation: AAD17213.1.
AB209075 mRNA. Translation: BAD92312.1.
BC098308 mRNA. Translation: AAH98308.1. Different initiation.
CCDSiCCDS1806.1. [P32418-1]
CCDS46264.1. [P32418-2]
CCDS46265.1. [P32418-5]
CCDS59430.1. [P32418-4]
PIRiS32815.
RefSeqiNP_001106271.1. NM_001112800.1. [P32418-5]
NP_001106272.1. NM_001112801.1. [P32418-3]
NP_001106273.1. NM_001112802.1. [P32418-2]
NP_001239553.1. NM_001252624.1. [P32418-4]
NP_066920.1. NM_021097.2. [P32418-1]
XP_005264571.1. XM_005264514.2. [P32418-2]
XP_006712144.1. XM_006712081.1. [P32418-1]
XP_006712145.1. XM_006712082.2. [P32418-1]
XP_006712146.1. XM_006712083.2. [P32418-1]
XP_006712147.1. XM_006712084.2. [P32418-1]
XP_006712148.1. XM_006712085.2. [P32418-1]
XP_011531356.1. XM_011533054.1. [P32418-1]
XP_011531357.1. XM_011533055.1. [P32418-1]
XP_011531358.1. XM_011533056.1. [P32418-1]
UniGeneiHs.31961.
Hs.468274.
Hs.744988.

3D structure databases

ProteinModelPortaliP32418.
SMRiP32418. Positions 406-727.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112436. 1 interaction.
DIPiDIP-48356N.
IntActiP32418. 1 interaction.
STRINGi9606.ENSP00000332931.

Chemistry

ChEMBLiCHEMBL4076.
DrugBankiDB00132. Alpha-Linolenic Acid.
DB00159. Icosapent.

Protein family/group databases

TCDBi2.A.19.3.4. the ca(2+):cation antiporter (caca) family.

PTM databases

PhosphoSiteiP32418.

Polymorphism and mutation databases

BioMutaiSLC8A1.
DMDMi12644210.

Proteomic databases

PaxDbiP32418.
PRIDEiP32418.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332839; ENSP00000332931; ENSG00000183023.
ENST00000402441; ENSP00000385188; ENSG00000183023. [P32418-2]
ENST00000403092; ENSP00000384763; ENSG00000183023.
ENST00000405269; ENSP00000385535; ENSG00000183023. [P32418-2]
ENST00000405901; ENSP00000385678; ENSG00000183023. [P32418-5]
ENST00000406391; ENSP00000385811; ENSG00000183023. [P32418-2]
ENST00000406785; ENSP00000383886; ENSG00000183023. [P32418-2]
ENST00000408028; ENSP00000384908; ENSG00000183023. [P32418-4]
GeneIDi6546.
KEGGihsa:6546.
UCSCiuc002rrx.3. human. [P32418-1]
uc002rrz.3. human. [P32418-3]
uc002rsa.3. human. [P32418-2]
uc002rsb.2. human. [P32418-4]

Organism-specific databases

CTDi6546.
GeneCardsiGC02M040339.
HGNCiHGNC:11068. SLC8A1.
HPAiCAB022694.
MIMi182305. gene.
neXtProtiNX_P32418.
PharmGKBiPA314.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0530.
GeneTreeiENSGT00730000110414.
HOGENOMiHOG000266971.
HOVERGENiHBG006441.
InParanoidiP32418.
KOiK05849.
OMAiDDEECGE.
OrthoDBiEOG7S4X56.
PhylomeDBiP32418.
TreeFamiTF314308.

Enzyme and pathway databases

ReactomeiREACT_19320. Sodium/Calcium exchangers.
REACT_23765. Reduction of cytosolic Ca++ levels.

Miscellaneous databases

ChiTaRSiSLC8A1. human.
GenomeRNAii6546.
NextBioi25469.
PROiP32418.
SOURCEiSearch...

Gene expression databases

BgeeiP32418.
CleanExiHS_SLC8A1.
ExpressionAtlasiP32418. baseline and differential.
GenevisibleiP32418. HS.

Family and domain databases

InterProiIPR003644. Calx_beta.
IPR001623. DnaJ_domain.
IPR004836. Na_Ca_Ex.
IPR002987. NaCa_exhngr1.
IPR004837. NaCa_Exmemb.
[Graphical view]
PfamiPF03160. Calx-beta. 2 hits.
PF01699. Na_Ca_ex. 2 hits.
[Graphical view]
PRINTSiPR01259. NACAEXCHNGR.
PR01260. NACAEXCHNGR1.
SMARTiSM00237. Calx_beta. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00845. caca. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of the human cardiac Na+/Ca2+ exchanger cDNA."
    Komuro I., Wenninger K.E., Philipson K.D., Izumo S.
    Proc. Natl. Acad. Sci. U.S.A. 89:4769-4773(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Heart.
  2. "NCX1 Na/Ca exchanger splice variants in pancreatic islet cells."
    Van Eylen F., Bollen A., Herchuelz A.
    J. Endocrinol. 168:517-526(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 7).
  3. "Na+/Ca2+ exchanger isoforms in cultured human retinal pigment epithelium."
    Mangini N.J., Chen W., Wang Q., Kennedy B.G.
    Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 7).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Placenta.
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "Na+/Ca2+ exchanger isoforms of rat odontoblasts and osteoblasts."
    Lundquist P., Lundgren T., Gritli-Linde A., Linde A.
    Calcif. Tissue Int. 67:60-67(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 459-681 (ISOFORM 10).
  8. "Homo sapiens protein coding cDNA."
    Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 558-973 (ISOFORM 5).
    Tissue: Brain.
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 594-973 (ISOFORM 5).
  10. "Functional expression of human renal Na+/Ca2+ exchanger in insect cells."
    Loo T.W., Clarke D.M.
    Am. J. Physiol. 267:F70-F74(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 600-684 (ISOFORM 3).
    Tissue: Embryonic kidney.
  11. "Expression of the Na-Ca exchanger in diverse tissues: a study using the cloned human cardiac Na-Ca exchanger."
    Kofuji P., Hadley R.W., Kieval R.S., Lederer W.J., Schulze D.H.
    Am. J. Physiol. 263:C1241-C1249(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  12. "The topology of the cardiac Na(+)/Ca(2)(+) exchanger, NCX1."
    Ren X., Philipson K.D.
    J. Mol. Cell. Cardiol. 57:68-71(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY.

Entry informationi

Entry nameiNAC1_HUMAN
AccessioniPrimary (citable) accession number: P32418
Secondary accession number(s): A8K6N1
, D6W595, O95849, Q4QQG6, Q587I6, Q59GN4, Q9UBL8, Q9UD55, Q9UDN1, Q9UDN2, Q9UKX6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: December 1, 2000
Last modified: July 22, 2015
This is version 153 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.