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P32410

- RL37_HALMA

UniProt

P32410 - RL37_HALMA

Protein

50S ribosomal protein L37e

Gene

rpl37e

Organism
Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Binds to the 23S rRNA.

    Cofactori

    Binds 1 zinc ion per subunit.Curated

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi20 – 201ZincCurated
    Metal bindingi23 – 231ZincCurated
    Metal bindingi35 – 351ZincCurated
    Metal bindingi38 – 381ZincCurated

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri20 – 3819C4-typeCuratedAdd
    BLAST

    GO - Molecular functioni

    1. rRNA binding Source: UniProtKB-KW
    2. structural constituent of ribosome Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. translation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Keywords - Ligandi

    Metal-binding, RNA-binding, rRNA-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    50S ribosomal protein L37e
    Alternative name(s):
    L35e
    Gene namesi
    Name:rpl37e
    Ordered Locus Names:rrnAC0797.1
    OrganismiHaloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
    Taxonomic identifieri272569 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloarcula
    ProteomesiUP000001169: Chromosome I

    Subcellular locationi

    GO - Cellular componenti

    1. ribosome Source: UniProtKB-KW

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 575650S ribosomal protein L37ePRO_0000139726Add
    BLAST

    Interactioni

    Subunit structurei

    Part of the 50S ribosomal subunit. Interacts weakly with protein L4.2 Publications

    Structurei

    Secondary structure

    1
    57
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi6 – 94
    Beta strandi17 – 193
    Turni21 – 233
    Beta strandi25 – 295
    Turni30 – 334
    Turni36 – 383
    Turni40 – 423
    Helixi50 – 523

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1FFKX-ray2.40X2-57[»]
    1JJ2X-ray2.40Z2-57[»]
    1K73X-ray3.0122-57[»]
    1K8AX-ray3.0022-57[»]
    1K9MX-ray3.0022-57[»]
    1KC8X-ray3.0122-57[»]
    1KD1X-ray3.0022-57[»]
    1KQSX-ray3.10Z2-57[»]
    1M1KX-ray3.2022-57[»]
    1M90X-ray2.8022-57[»]
    1N8RX-ray3.0022-57[»]
    1NJIX-ray3.0022-57[»]
    1Q7YX-ray3.2022-57[»]
    1Q81X-ray2.9522-57[»]
    1Q82X-ray2.9822-57[»]
    1Q86X-ray3.0022-57[»]
    1QVFX-ray3.10Z2-57[»]
    1QVGX-ray2.90Z2-57[»]
    1S72X-ray2.4011-57[»]
    1VQ4X-ray2.7011-57[»]
    1VQ5X-ray2.6011-57[»]
    1VQ6X-ray2.7011-57[»]
    1VQ7X-ray2.5011-57[»]
    1VQ8X-ray2.2011-57[»]
    1VQ9X-ray2.4011-57[»]
    1VQKX-ray2.3011-57[»]
    1VQLX-ray2.3011-57[»]
    1VQMX-ray2.3011-57[»]
    1VQNX-ray2.4011-57[»]
    1VQOX-ray2.2011-57[»]
    1VQPX-ray2.2511-57[»]
    1W2BX-ray3.50Z2-57[»]
    1YHQX-ray2.4011-57[»]
    1YI2X-ray2.6511-57[»]
    1YIJX-ray2.6011-57[»]
    1YITX-ray2.8011-57[»]
    1YJ9X-ray2.9011-57[»]
    1YJNX-ray3.0011-57[»]
    1YJWX-ray2.9011-57[»]
    2OTJX-ray2.9011-57[»]
    2OTLX-ray2.7011-57[»]
    2QA4X-ray3.0011-57[»]
    2QEXX-ray2.9011-57[»]
    3CC2X-ray2.4011-57[»]
    3CC4X-ray2.7011-57[»]
    3CC7X-ray2.7011-57[»]
    3CCEX-ray2.7511-57[»]
    3CCJX-ray2.7011-57[»]
    3CCLX-ray2.9011-57[»]
    3CCMX-ray2.5511-57[»]
    3CCQX-ray2.9011-57[»]
    3CCRX-ray3.0011-57[»]
    3CCSX-ray2.9511-57[»]
    3CCUX-ray2.8011-57[»]
    3CCVX-ray2.9011-57[»]
    3CD6X-ray2.7511-57[»]
    3CMAX-ray2.8011-57[»]
    3CMEX-ray2.9511-57[»]
    3CPWX-ray2.70Z1-57[»]
    3CXCX-ray3.00Z2-57[»]
    3G4SX-ray3.2012-57[»]
    3G6EX-ray2.7012-57[»]
    3G71X-ray2.8512-57[»]
    3I55X-ray3.1111-57[»]
    3I56X-ray2.9011-57[»]
    3OW2X-ray2.70Z2-57[»]
    4ADXelectron microscopy6.6011-57[»]
    4HUBX-ray2.4011-57[»]
    ProteinModelPortaliP32410.
    SMRiP32410. Positions 2-57.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP32410.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L37e family.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri20 – 3819C4-typeCuratedAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Family and domain databases

    Gene3Di2.20.25.30. 1 hit.
    HAMAPiMF_00547. Ribosomal_L37e.
    InterProiIPR011331. Ribosomal_L37ae/L37e.
    IPR001569. Ribosomal_L37e.
    IPR018267. Ribosomal_L37e_CS.
    IPR011332. Ribosomal_zn-bd.
    [Graphical view]
    PANTHERiPTHR10768. PTHR10768. 1 hit.
    PfamiPF01907. Ribosomal_L37e. 1 hit.
    [Graphical view]
    ProDomiPD005132. Ribosomal_L37e. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF57829. SSF57829. 1 hit.
    PROSITEiPS01077. RIBOSOMAL_L37E. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P32410-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTGAGTPSQG KKNTTTHTKC RRCGEKSYHT KKKVCSSCGF GKSAKRRDYE   50
    WQSKAGE 57
    Length:57
    Mass (Da):6,314
    Last modified:January 23, 2007 - v2
    Checksum:iA21A05AACA3112EC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY596297 Genomic DNA. No translation available.
    PIRiS33789.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY596297 Genomic DNA. No translation available.
    PIRi S33789.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1FFK X-ray 2.40 X 2-57 [» ]
    1JJ2 X-ray 2.40 Z 2-57 [» ]
    1K73 X-ray 3.01 2 2-57 [» ]
    1K8A X-ray 3.00 2 2-57 [» ]
    1K9M X-ray 3.00 2 2-57 [» ]
    1KC8 X-ray 3.01 2 2-57 [» ]
    1KD1 X-ray 3.00 2 2-57 [» ]
    1KQS X-ray 3.10 Z 2-57 [» ]
    1M1K X-ray 3.20 2 2-57 [» ]
    1M90 X-ray 2.80 2 2-57 [» ]
    1N8R X-ray 3.00 2 2-57 [» ]
    1NJI X-ray 3.00 2 2-57 [» ]
    1Q7Y X-ray 3.20 2 2-57 [» ]
    1Q81 X-ray 2.95 2 2-57 [» ]
    1Q82 X-ray 2.98 2 2-57 [» ]
    1Q86 X-ray 3.00 2 2-57 [» ]
    1QVF X-ray 3.10 Z 2-57 [» ]
    1QVG X-ray 2.90 Z 2-57 [» ]
    1S72 X-ray 2.40 1 1-57 [» ]
    1VQ4 X-ray 2.70 1 1-57 [» ]
    1VQ5 X-ray 2.60 1 1-57 [» ]
    1VQ6 X-ray 2.70 1 1-57 [» ]
    1VQ7 X-ray 2.50 1 1-57 [» ]
    1VQ8 X-ray 2.20 1 1-57 [» ]
    1VQ9 X-ray 2.40 1 1-57 [» ]
    1VQK X-ray 2.30 1 1-57 [» ]
    1VQL X-ray 2.30 1 1-57 [» ]
    1VQM X-ray 2.30 1 1-57 [» ]
    1VQN X-ray 2.40 1 1-57 [» ]
    1VQO X-ray 2.20 1 1-57 [» ]
    1VQP X-ray 2.25 1 1-57 [» ]
    1W2B X-ray 3.50 Z 2-57 [» ]
    1YHQ X-ray 2.40 1 1-57 [» ]
    1YI2 X-ray 2.65 1 1-57 [» ]
    1YIJ X-ray 2.60 1 1-57 [» ]
    1YIT X-ray 2.80 1 1-57 [» ]
    1YJ9 X-ray 2.90 1 1-57 [» ]
    1YJN X-ray 3.00 1 1-57 [» ]
    1YJW X-ray 2.90 1 1-57 [» ]
    2OTJ X-ray 2.90 1 1-57 [» ]
    2OTL X-ray 2.70 1 1-57 [» ]
    2QA4 X-ray 3.00 1 1-57 [» ]
    2QEX X-ray 2.90 1 1-57 [» ]
    3CC2 X-ray 2.40 1 1-57 [» ]
    3CC4 X-ray 2.70 1 1-57 [» ]
    3CC7 X-ray 2.70 1 1-57 [» ]
    3CCE X-ray 2.75 1 1-57 [» ]
    3CCJ X-ray 2.70 1 1-57 [» ]
    3CCL X-ray 2.90 1 1-57 [» ]
    3CCM X-ray 2.55 1 1-57 [» ]
    3CCQ X-ray 2.90 1 1-57 [» ]
    3CCR X-ray 3.00 1 1-57 [» ]
    3CCS X-ray 2.95 1 1-57 [» ]
    3CCU X-ray 2.80 1 1-57 [» ]
    3CCV X-ray 2.90 1 1-57 [» ]
    3CD6 X-ray 2.75 1 1-57 [» ]
    3CMA X-ray 2.80 1 1-57 [» ]
    3CME X-ray 2.95 1 1-57 [» ]
    3CPW X-ray 2.70 Z 1-57 [» ]
    3CXC X-ray 3.00 Z 2-57 [» ]
    3G4S X-ray 3.20 1 2-57 [» ]
    3G6E X-ray 2.70 1 2-57 [» ]
    3G71 X-ray 2.85 1 2-57 [» ]
    3I55 X-ray 3.11 1 1-57 [» ]
    3I56 X-ray 2.90 1 1-57 [» ]
    3OW2 X-ray 2.70 Z 2-57 [» ]
    4ADX electron microscopy 6.60 1 1-57 [» ]
    4HUB X-ray 2.40 1 1-57 [» ]
    ProteinModelPortali P32410.
    SMRi P32410. Positions 2-57.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei P32410.

    Family and domain databases

    Gene3Di 2.20.25.30. 1 hit.
    HAMAPi MF_00547. Ribosomal_L37e.
    InterProi IPR011331. Ribosomal_L37ae/L37e.
    IPR001569. Ribosomal_L37e.
    IPR018267. Ribosomal_L37e_CS.
    IPR011332. Ribosomal_zn-bd.
    [Graphical view ]
    PANTHERi PTHR10768. PTHR10768. 1 hit.
    Pfami PF01907. Ribosomal_L37e. 1 hit.
    [Graphical view ]
    ProDomi PD005132. Ribosomal_L37e. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF57829. SSF57829. 1 hit.
    PROSITEi PS01077. RIBOSOMAL_L37E. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    2. "HL35e and HLA: primary structure of two very basic and cysteine-rich ribosomal proteins from Haloarcula marismortui."
      Bergmann U., Wittmann-Liebold B.
      Biochim. Biophys. Acta 1173:195-200(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-57.
    3. "The complete atomic structure of the large ribosomal subunit at 2.4 A resolution."
      Ban N., Nissen P., Hansen J., Moore P.B., Steitz T.A.
      Science 289:905-920(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    4. "The structural basis of ribosome activity in peptide bond synthesis."
      Nissen P., Hansen J., Ban N., Moore P.B., Steitz T.A.
      Science 289:920-930(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    5. "A pre-translocational intermediate in protein synthesis observed in crystals of enzymatically active 50S subunits."
      Schmeing T.M., Seila A.C., Hansen J.L., Freeborn B., Soukup J.K., Scaringe S.A., Strobel S.A., Moore P.B., Steitz T.A.
      Nat. Struct. Biol. 9:225-230(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF THE 50S SUBUNIT.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    6. "The kink-turn: a new RNA secondary structure motif."
      Klein D.J., Schmeing T.M., Moore P.B., Steitz T.A.
      EMBO J. 20:4214-4221(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    7. "The structures of four macrolide antibiotics bound to the large ribosomal subunit."
      Hansen J.L., Ippolito J.A., Ban N., Nissen P., Moore P.B., Steitz T.A.
      Mol. Cell 10:117-128(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FOUR MACROLIDE ANTIBIOTICS.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    8. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF THE 50S SUBUNIT.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    9. "Structures of five antibiotics bound at the peptidyl transferase center of the large ribosomal subunit."
      Hansen J.L., Moore P.B., Steitz T.A.
      J. Mol. Biol. 330:1061-1075(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FIVE ANTIBIOTICS AT THE PEPTIDYL TRANSFERASE CENTER.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    10. "Structures of deacylated tRNA mimics bound to the E site of the large ribosomal subunit."
      Schmeing T.M., Moore P.B., Steitz T.A.
      RNA 9:1345-1352(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF THE 50S SUBUNIT WITH TWO DIFFERENT E SITE SUBSTRATES.
    11. "Revisiting the Haloarcula marismortui 50S ribosomal subunit model."
      Gabdulkhakov A., Nikonov S., Garber M.
      Acta Crystallogr. D 69:997-1004(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.

    Entry informationi

    Entry nameiRL37_HALMA
    AccessioniPrimary (citable) accession number: P32410
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 93 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Ribosomal proteins
      Ribosomal proteins families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3