P32410 (RL37_HALMA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
50S ribosomal protein L37e

Alternative name(s):
L35e

Gene names

Name:	rpl37e
Ordered Locus Names:	rrnAC0797.1

Organism

Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui) [Complete proteome] [HAMAP]

Taxonomic identifier

272569 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Haloarcula › Haloarcula marismortui

Protein attributes

Sequence length	57 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds to the 23S rRNA. HAMAP-Rule MF_00547
Cofactor	Binds 1 zinc ion per subunit Probable.
Subunit structure	Part of the 50S ribosomal subunit. Interacts weakly with protein L4. Ref.3 Ref.4 Ref.5 Ref.6 Ref.7 Ref.8 Ref.9 Ref.10
Sequence similarities	Belongs to the ribosomal protein L37e family.

Ontologies

Keywords
Domain	Zinc-finger
Ligand	Metal-binding RNA-binding Zinc rRNA-binding
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	3D-structure Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological_process	translation Inferred from electronic annotation. Source: HAMAP
Cellular_component	ribosome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	rRNA binding Inferred from electronic annotation. Source: UniProtKB-KW structural constituent of ribosome Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

1

1

Removed Ref.2

Chain

2 – 57

56

50S ribosomal protein L37e HAMAP-Rule MF_00547

PRO_0000139726

Regions

Zinc finger

20 – 38

19

C4-type Probable

Sites

Metal binding

20

1

Zinc Probable

Metal binding

23

1

Zinc Probable

Metal binding

35

1

Zinc Probable

Metal binding

38

1

Zinc Probable

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

57

Helix Strand Turn

Details...

Helix

6 – 9

4

Beta strand

17 – 19

3

Turn

21 – 23

3

Beta strand

25 – 29

5

Turn

30 – 33

4

Turn

36 – 38

3

Turn

40 – 42

3

Helix

50 – 52

3

Sequences

	Sequence		Length	Mass (Da)
	P32410 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: A21A05AACA3112EC	FASTA	57	6,314
	10 20 30 40 50 MTGAGTPSQG KKNTTTHTKC RRCGEKSYHT KKKVCSSCGF GKSAKRRDYE WQSKAGE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequence of Haloarcula marismortui: a halophilic archaeon from the Dead Sea." Baliga N.S., Bonneau R., Facciotti M.T., Pan M., Glusman G., Deutsch E.W., Shannon P., Chiu Y., Weng R.S., Gan R.R., Hung P., Date S.V., Marcotte E., Hood L., Ng W.V. Genome Res. 14:2221-2234(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
[2]	"HL35e and HLA: primary structure of two very basic and cysteine-rich ribosomal proteins from Haloarcula marismortui." Bergmann U., Wittmann-Liebold B. Biochim. Biophys. Acta 1173:195-200(1993) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-57.
[3]	"The complete atomic structure of the large ribosomal subunit at 2.4 A resolution." Ban N., Nissen P., Hansen J., Moore P.B., Steitz T.A. Science 289:905-920(2000) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT. Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
[4]	"The structural basis of ribosome activity in peptide bond synthesis." Nissen P., Hansen J., Ban N., Moore P.B., Steitz T.A. Science 289:920-930(2000) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT. Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
[5]	"A pre-translocational intermediate in protein synthesis observed in crystals of enzymatically active 50S subunits." Schmeing T.M., Seila A.C., Hansen J.L., Freeborn B., Soukup J.K., Scaringe S.A., Strobel S.A., Moore P.B., Steitz T.A. Nat. Struct. Biol. 9:225-230(2002) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF THE 50S SUBUNIT. Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
[6]	"The kink-turn: a new RNA secondary structure motif." Klein D.J., Schmeing T.M., Moore P.B., Steitz T.A. EMBO J. 20:4214-4221(2001) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT. Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
[7]	"The structures of four macrolide antibiotics bound to the large ribosomal subunit." Hansen J.L., Ippolito J.A., Ban N., Nissen P., Moore P.B., Steitz T.A. Mol. Cell 10:117-128(2002) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FOUR MACROLIDE ANTIBIOTICS. Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
[8]	"Structural insights into peptide bond formation." Hansen J.L., Schmeing T.M., Moore P.B., Steitz T.A. Proc. Natl. Acad. Sci. U.S.A. 99:11670-11675(2002) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF THE 50S SUBUNIT. Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
[9]	"Structures of five antibiotics bound at the peptidyl transferase center of the large ribosomal subunit." Hansen J.L., Moore P.B., Steitz T.A. J. Mol. Biol. 330:1061-1075(2003) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FIVE ANTIBIOTICS AT THE PEPTIDYL TRANSFERASE CENTER. Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
[10]	"Structures of deacylated tRNA mimics bound to the E site of the large ribosomal subunit." Schmeing T.M., Moore P.B., Steitz T.A. RNA 9:1345-1352(2003) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF THE 50S SUBUNIT WITH TWO DIFFERENT E SITE SUBSTRATES.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AY596297 Genomic DNA. No translation available.

PIR

S33789.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1FFK	X-ray	2.40	X	2-57	[»]
1JJ2	X-ray	2.40	Z	2-57	[»]
1K73	X-ray	3.01	2	2-57	[»]
1K8A	X-ray	3.00	2	2-57	[»]
1K9M	X-ray	3.00	2	2-57	[»]
1KC8	X-ray	3.01	2	2-57	[»]
1KD1	X-ray	3.00	2	2-57	[»]
1KQS	X-ray	3.10	Z	2-57	[»]
1M1K	X-ray	3.20	2	2-57	[»]
1M90	X-ray	2.80	2	2-57	[»]
1N8R	X-ray	3.00	2	2-57	[»]
1NJI	X-ray	3.00	2	2-57	[»]
1Q7Y	X-ray	3.20	2	2-57	[»]
1Q81	X-ray	2.95	2	2-57	[»]
1Q82	X-ray	2.98	2	2-57	[»]
1Q86	X-ray	3.00	2	2-57	[»]
1QVF	X-ray	3.10	Z	2-57	[»]
1QVG	X-ray	2.90	Z	2-57	[»]
1S72	X-ray	2.40	1	1-57	[»]
1VQ4	X-ray	2.70	1	1-57	[»]
1VQ5	X-ray	2.60	1	1-57	[»]
1VQ6	X-ray	2.70	1	1-57	[»]
1VQ7	X-ray	2.50	1	1-57	[»]
1VQ8	X-ray	2.20	1	1-57	[»]
1VQ9	X-ray	2.40	1	1-57	[»]
1VQK	X-ray	2.30	1	1-57	[»]
1VQL	X-ray	2.30	1	1-57	[»]
1VQM	X-ray	2.30	1	1-57	[»]
1VQN	X-ray	2.40	1	1-57	[»]
1VQO	X-ray	2.20	1	1-57	[»]
1VQP	X-ray	2.25	1	1-57	[»]
1W2B	X-ray	3.50	Z	2-56	[»]
1YHQ	X-ray	2.40	1	1-57	[»]
1YI2	X-ray	2.65	1	1-57	[»]
1YIJ	X-ray	2.60	1	1-57	[»]
1YIT	X-ray	2.80	1	1-57	[»]
1YJ9	X-ray	2.90	1	1-57	[»]
1YJN	X-ray	3.00	1	1-57	[»]
1YJW	X-ray	2.90	1	1-57	[»]
2OTJ	X-ray	2.90	1	1-57	[»]
2OTL	X-ray	2.70	1	1-57	[»]
2QA4	X-ray	3.00	1	1-57	[»]
2QEX	X-ray	2.90	1	1-57	[»]
3CC2	X-ray	2.40	1	1-57	[»]
3CC4	X-ray	2.70	1	1-57	[»]
3CC7	X-ray	2.70	1	1-57	[»]
3CCE	X-ray	2.75	1	1-57	[»]
3CCJ	X-ray	2.70	1	1-57	[»]
3CCL	X-ray	2.90	1	1-57	[»]
3CCM	X-ray	2.55	1	1-57	[»]
3CCQ	X-ray	2.90	1	1-57	[»]
3CCR	X-ray	3.00	1	1-57	[»]
3CCS	X-ray	2.95	1	1-57	[»]
3CCU	X-ray	2.80	1	1-57	[»]
3CCV	X-ray	2.90	1	1-57	[»]
3CD6	X-ray	2.75	1	1-57	[»]
3CMA	X-ray	2.80	1	1-57	[»]
3CME	X-ray	2.95	1	1-57	[»]
3CPW	X-ray	2.70	Z	1-57	[»]
3CXC	X-ray	3.00	Z	2-56	[»]
3G4S	X-ray	3.20	1	2-57	[»]
3G6E	X-ray	2.70	1	2-57	[»]
3G71	X-ray	2.85	1	2-57	[»]
3I55	X-ray	3.11	1	1-57	[»]
3I56	X-ray	2.90	1	1-57	[»]
3OW2	X-ray	2.70	Z	2-57	[»]

ProteinModelPortal

P32410.

SMR

P32410. Positions 2-57.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Organism-specific databases

CMR

Search...

Family and domain databases

Gene3D

2.20.25.30. 1 hit.

HAMAP

MF_00547. Ribosomal_L37e.

InterPro

IPR011331. Ribosomal_L37ae/L37e.
IPR001569. Ribosomal_L37e.
IPR018267. Ribosomal_L37e_CS.
IPR011332. Ribosomal_zn-bd_dom.
[Graphical view]

PANTHER

PTHR10768. PTHR10768. 1 hit.

Pfam

PF01907. Ribosomal_L37e. 1 hit.
[Graphical view]

ProDom

PD005132. Ribosomal_L37e. 1 hit.
[Graphical view] [Entries sharing at least one domain]

SUPFAM

SSF57829. Ribosomal_zn-bd. 1 hit.

PROSITE

PS01077. RIBOSOMAL_L37E. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P32410.

Entry information

Entry name

RL37_HALMA

Accession

Primary (citable) accession number: P32410

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 87 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program