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P32410

- RL37_HALMA

UniProt

P32410 - RL37_HALMA

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Protein
50S ribosomal protein L37e
Gene
rpl37e, rrnAC0797.1
Organism
Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Binds to the 23S rRNA.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit Inferred.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi20 – 201Zinc Inferred
Metal bindingi23 – 231Zinc Inferred
Metal bindingi35 – 351Zinc Inferred
Metal bindingi38 – 381Zinc Inferred

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri20 – 3819C4-type Inferred
Add
BLAST

GO - Molecular functioni

  1. rRNA binding Source: UniProtKB-KW
  2. structural constituent of ribosome Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

Metal-binding, RNA-binding, rRNA-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
50S ribosomal protein L37e
Alternative name(s):
L35e
Gene namesi
Name:rpl37e
Ordered Locus Names:rrnAC0797.1
OrganismiHaloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Taxonomic identifieri272569 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloarcula
ProteomesiUP000001169: Chromosome I

Subcellular locationi

GO - Cellular componenti

  1. ribosome Source: UniProtKB-KW
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 575650S ribosomal protein L37eUniRule annotation
PRO_0000139726Add
BLAST

Interactioni

Subunit structurei

Part of the 50S ribosomal subunit. Interacts weakly with protein L4.9 Publications

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi6 – 94
Beta strandi17 – 193
Turni21 – 233
Beta strandi25 – 295
Turni30 – 334
Turni36 – 383
Turni40 – 423
Helixi50 – 523

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1FFKX-ray2.40X2-57[»]
1JJ2X-ray2.40Z2-57[»]
1K73X-ray3.0122-57[»]
1K8AX-ray3.0022-57[»]
1K9MX-ray3.0022-57[»]
1KC8X-ray3.0122-57[»]
1KD1X-ray3.0022-57[»]
1KQSX-ray3.10Z2-57[»]
1M1KX-ray3.2022-57[»]
1M90X-ray2.8022-57[»]
1N8RX-ray3.0022-57[»]
1NJIX-ray3.0022-57[»]
1Q7YX-ray3.2022-57[»]
1Q81X-ray2.9522-57[»]
1Q82X-ray2.9822-57[»]
1Q86X-ray3.0022-57[»]
1QVFX-ray3.10Z2-57[»]
1QVGX-ray2.90Z2-57[»]
1S72X-ray2.4011-57[»]
1VQ4X-ray2.7011-57[»]
1VQ5X-ray2.6011-57[»]
1VQ6X-ray2.7011-57[»]
1VQ7X-ray2.5011-57[»]
1VQ8X-ray2.2011-57[»]
1VQ9X-ray2.4011-57[»]
1VQKX-ray2.3011-57[»]
1VQLX-ray2.3011-57[»]
1VQMX-ray2.3011-57[»]
1VQNX-ray2.4011-57[»]
1VQOX-ray2.2011-57[»]
1VQPX-ray2.2511-57[»]
1W2BX-ray3.50Z2-57[»]
1YHQX-ray2.4011-57[»]
1YI2X-ray2.6511-57[»]
1YIJX-ray2.6011-57[»]
1YITX-ray2.8011-57[»]
1YJ9X-ray2.9011-57[»]
1YJNX-ray3.0011-57[»]
1YJWX-ray2.9011-57[»]
2OTJX-ray2.9011-57[»]
2OTLX-ray2.7011-57[»]
2QA4X-ray3.0011-57[»]
2QEXX-ray2.9011-57[»]
3CC2X-ray2.4011-57[»]
3CC4X-ray2.7011-57[»]
3CC7X-ray2.7011-57[»]
3CCEX-ray2.7511-57[»]
3CCJX-ray2.7011-57[»]
3CCLX-ray2.9011-57[»]
3CCMX-ray2.5511-57[»]
3CCQX-ray2.9011-57[»]
3CCRX-ray3.0011-57[»]
3CCSX-ray2.9511-57[»]
3CCUX-ray2.8011-57[»]
3CCVX-ray2.9011-57[»]
3CD6X-ray2.7511-57[»]
3CMAX-ray2.8011-57[»]
3CMEX-ray2.9511-57[»]
3CPWX-ray2.70Z1-57[»]
3CXCX-ray3.00Z2-57[»]
3G4SX-ray3.2012-57[»]
3G6EX-ray2.7012-57[»]
3G71X-ray2.8512-57[»]
3I55X-ray3.1111-57[»]
3I56X-ray2.9011-57[»]
3OW2X-ray2.70Z2-57[»]
4ADXelectron microscopy6.6011-57[»]
4HUBX-ray2.4011-57[»]
ProteinModelPortaliP32410.
SMRiP32410. Positions 2-57.

Miscellaneous databases

EvolutionaryTraceiP32410.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Zinc-finger

Family and domain databases

Gene3Di2.20.25.30. 1 hit.
HAMAPiMF_00547. Ribosomal_L37e.
InterProiIPR011331. Ribosomal_L37ae/L37e.
IPR001569. Ribosomal_L37e.
IPR018267. Ribosomal_L37e_CS.
IPR011332. Ribosomal_zn-bd.
[Graphical view]
PANTHERiPTHR10768. PTHR10768. 1 hit.
PfamiPF01907. Ribosomal_L37e. 1 hit.
[Graphical view]
ProDomiPD005132. Ribosomal_L37e. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF57829. SSF57829. 1 hit.
PROSITEiPS01077. RIBOSOMAL_L37E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P32410-1 [UniParc]FASTAAdd to Basket

« Hide

MTGAGTPSQG KKNTTTHTKC RRCGEKSYHT KKKVCSSCGF GKSAKRRDYE   50
WQSKAGE 57
Length:57
Mass (Da):6,314
Last modified:January 23, 2007 - v2
Checksum:iA21A05AACA3112EC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY596297 Genomic DNA. No translation available.
PIRiS33789.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY596297 Genomic DNA. No translation available.
PIRi S33789.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1FFK X-ray 2.40 X 2-57 [» ]
1JJ2 X-ray 2.40 Z 2-57 [» ]
1K73 X-ray 3.01 2 2-57 [» ]
1K8A X-ray 3.00 2 2-57 [» ]
1K9M X-ray 3.00 2 2-57 [» ]
1KC8 X-ray 3.01 2 2-57 [» ]
1KD1 X-ray 3.00 2 2-57 [» ]
1KQS X-ray 3.10 Z 2-57 [» ]
1M1K X-ray 3.20 2 2-57 [» ]
1M90 X-ray 2.80 2 2-57 [» ]
1N8R X-ray 3.00 2 2-57 [» ]
1NJI X-ray 3.00 2 2-57 [» ]
1Q7Y X-ray 3.20 2 2-57 [» ]
1Q81 X-ray 2.95 2 2-57 [» ]
1Q82 X-ray 2.98 2 2-57 [» ]
1Q86 X-ray 3.00 2 2-57 [» ]
1QVF X-ray 3.10 Z 2-57 [» ]
1QVG X-ray 2.90 Z 2-57 [» ]
1S72 X-ray 2.40 1 1-57 [» ]
1VQ4 X-ray 2.70 1 1-57 [» ]
1VQ5 X-ray 2.60 1 1-57 [» ]
1VQ6 X-ray 2.70 1 1-57 [» ]
1VQ7 X-ray 2.50 1 1-57 [» ]
1VQ8 X-ray 2.20 1 1-57 [» ]
1VQ9 X-ray 2.40 1 1-57 [» ]
1VQK X-ray 2.30 1 1-57 [» ]
1VQL X-ray 2.30 1 1-57 [» ]
1VQM X-ray 2.30 1 1-57 [» ]
1VQN X-ray 2.40 1 1-57 [» ]
1VQO X-ray 2.20 1 1-57 [» ]
1VQP X-ray 2.25 1 1-57 [» ]
1W2B X-ray 3.50 Z 2-57 [» ]
1YHQ X-ray 2.40 1 1-57 [» ]
1YI2 X-ray 2.65 1 1-57 [» ]
1YIJ X-ray 2.60 1 1-57 [» ]
1YIT X-ray 2.80 1 1-57 [» ]
1YJ9 X-ray 2.90 1 1-57 [» ]
1YJN X-ray 3.00 1 1-57 [» ]
1YJW X-ray 2.90 1 1-57 [» ]
2OTJ X-ray 2.90 1 1-57 [» ]
2OTL X-ray 2.70 1 1-57 [» ]
2QA4 X-ray 3.00 1 1-57 [» ]
2QEX X-ray 2.90 1 1-57 [» ]
3CC2 X-ray 2.40 1 1-57 [» ]
3CC4 X-ray 2.70 1 1-57 [» ]
3CC7 X-ray 2.70 1 1-57 [» ]
3CCE X-ray 2.75 1 1-57 [» ]
3CCJ X-ray 2.70 1 1-57 [» ]
3CCL X-ray 2.90 1 1-57 [» ]
3CCM X-ray 2.55 1 1-57 [» ]
3CCQ X-ray 2.90 1 1-57 [» ]
3CCR X-ray 3.00 1 1-57 [» ]
3CCS X-ray 2.95 1 1-57 [» ]
3CCU X-ray 2.80 1 1-57 [» ]
3CCV X-ray 2.90 1 1-57 [» ]
3CD6 X-ray 2.75 1 1-57 [» ]
3CMA X-ray 2.80 1 1-57 [» ]
3CME X-ray 2.95 1 1-57 [» ]
3CPW X-ray 2.70 Z 1-57 [» ]
3CXC X-ray 3.00 Z 2-57 [» ]
3G4S X-ray 3.20 1 2-57 [» ]
3G6E X-ray 2.70 1 2-57 [» ]
3G71 X-ray 2.85 1 2-57 [» ]
3I55 X-ray 3.11 1 1-57 [» ]
3I56 X-ray 2.90 1 1-57 [» ]
3OW2 X-ray 2.70 Z 2-57 [» ]
4ADX electron microscopy 6.60 1 1-57 [» ]
4HUB X-ray 2.40 1 1-57 [» ]
ProteinModelPortali P32410.
SMRi P32410. Positions 2-57.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P32410.

Family and domain databases

Gene3Di 2.20.25.30. 1 hit.
HAMAPi MF_00547. Ribosomal_L37e.
InterProi IPR011331. Ribosomal_L37ae/L37e.
IPR001569. Ribosomal_L37e.
IPR018267. Ribosomal_L37e_CS.
IPR011332. Ribosomal_zn-bd.
[Graphical view ]
PANTHERi PTHR10768. PTHR10768. 1 hit.
Pfami PF01907. Ribosomal_L37e. 1 hit.
[Graphical view ]
ProDomi PD005132. Ribosomal_L37e. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF57829. SSF57829. 1 hit.
PROSITEi PS01077. RIBOSOMAL_L37E. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  2. "HL35e and HLA: primary structure of two very basic and cysteine-rich ribosomal proteins from Haloarcula marismortui."
    Bergmann U., Wittmann-Liebold B.
    Biochim. Biophys. Acta 1173:195-200(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-57.
  3. "The complete atomic structure of the large ribosomal subunit at 2.4 A resolution."
    Ban N., Nissen P., Hansen J., Moore P.B., Steitz T.A.
    Science 289:905-920(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  4. "The structural basis of ribosome activity in peptide bond synthesis."
    Nissen P., Hansen J., Ban N., Moore P.B., Steitz T.A.
    Science 289:920-930(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  5. "A pre-translocational intermediate in protein synthesis observed in crystals of enzymatically active 50S subunits."
    Schmeing T.M., Seila A.C., Hansen J.L., Freeborn B., Soukup J.K., Scaringe S.A., Strobel S.A., Moore P.B., Steitz T.A.
    Nat. Struct. Biol. 9:225-230(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF THE 50S SUBUNIT.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  6. "The kink-turn: a new RNA secondary structure motif."
    Klein D.J., Schmeing T.M., Moore P.B., Steitz T.A.
    EMBO J. 20:4214-4221(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  7. "The structures of four macrolide antibiotics bound to the large ribosomal subunit."
    Hansen J.L., Ippolito J.A., Ban N., Nissen P., Moore P.B., Steitz T.A.
    Mol. Cell 10:117-128(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FOUR MACROLIDE ANTIBIOTICS.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  8. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF THE 50S SUBUNIT.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  9. "Structures of five antibiotics bound at the peptidyl transferase center of the large ribosomal subunit."
    Hansen J.L., Moore P.B., Steitz T.A.
    J. Mol. Biol. 330:1061-1075(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FIVE ANTIBIOTICS AT THE PEPTIDYL TRANSFERASE CENTER.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  10. "Structures of deacylated tRNA mimics bound to the E site of the large ribosomal subunit."
    Schmeing T.M., Moore P.B., Steitz T.A.
    RNA 9:1345-1352(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF THE 50S SUBUNIT WITH TWO DIFFERENT E SITE SUBSTRATES.
  11. "Revisiting the Haloarcula marismortui 50S ribosomal subunit model."
    Gabdulkhakov A., Nikonov S., Garber M.
    Acta Crystallogr. D 69:997-1004(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.

Entry informationi

Entry nameiRL37_HALMA
AccessioniPrimary (citable) accession number: P32410
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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