Reviewed,
UniProtKB/Swiss-Prot P32392 (ARP3_DROME)
Last modified
June 16, 2009.
Version 74.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Actin-related protein 3 Alternative name(s): Actin-like protein 3 Actin-like protein 66B Actin-2 | ||||||
| Gene names |
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| Organism | Drosophila melanogaster (Fruit fly) [Complete proteome] | ||||||
| Taxonomic identifier | 7227 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora |
Protein attributes
| Sequence length | 418 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament By similarity. |
| Subunit structure | Component of the Arp2/3 complex By similarity. |
| Subcellular location | Cytoplasm › cytoskeleton By similarity. |
| Sequence similarities | Belongs to the actin family. ARP3 subfamily. |
Ontologies
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| Cog3 | Q961G1 | 1 | EBI-176768,EBI-119125 | |
| woc | Q9VB55 | 1 | EBI-176768,EBI-184355 |
Sequence annotation (Features)
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| X71789 Genomic DNA. Translation: CAA50674.1. AE014296 Genomic DNA. Translation: AAF50488.1. AY051859 mRNA. Translation: AAK93283.1. | |
| RefSeq | NP_523968.1. |
| UniGene | Dm.881 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1K8K based on UniProtKB P32391. |
| SMR | P32392. Positions 3-417. |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP:20563N. |
| IntAct | P32392. 7 interactions. |
Genome annotation databases | |
| Ensembl | FBgn0011744. Drosophila melanogaster. [Contig view] |
| GeneID | 38898. |
| KEGG | dme:Dmel_CG7558. |
| NMPDR | fig|7227.3.peg.8786. |
Organism-specific databases | |
| FlyBase | FBgn0011744. Arp66B. |
Phylogenomic databases | |
| HOGENOM | P32392. |
| OMA | P32392. TEDLDFF. |
Enzyme and pathway databases | |
| BioCyc | DMEL-XXX-02:DMEL-XXX-02-015686-MON. |
Gene expression databases | |
| ArrayExpress | P32392. |
| GermOnline | CG7558. Drosophila melanogaster. |
Family and domain databases | |
| InterPro | IPR004000. Actin-like. IPR015623. Arp3. [Graphical view] |
| PANTHER | PTHR11937. Actin_like. 1 hit. PTHR11937:SF31. Arp3. 1 hit. |
| Pfam | PF00022. Actin. 1 hit. [Graphical view] |
| SMART | SM00268. ACTIN. 1 hit. [Graphical view] |
| PROSITE | PS01132. ACTINS_ACT_LIKE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 810922. |
Entry information
| Entry name | ARP3_DROME | ||||||||
| Accession | Primary (citable) accession number: P32392 Secondary accession number(s): Q9VSD5 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Drosophila annotation project | ||||||||
Relevant documents
| Drosophila Drosophila: entries, gene names and cross-references to FlyBase |
| SIMILARITY comments Index of protein domains and families |

Clusters with


