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Protein

54S ribosomal protein L41, mitochondrial

Gene

MRP20

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.2 Publications

Miscellaneous

Present with 2200 molecules/cell in log phase SD medium.1 Publication

Caution

It is uncertain whether Met-1 or Met-11 is the initiator.Curated

GO - Molecular functioni

  • RNA binding Source: GO_Central
  • structural constituent of ribosome Source: SGD

GO - Biological processi

  • mitochondrial translation Source: SGD

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-29949-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
54S ribosomal protein L41, mitochondrial
Alternative name(s):
Mitochondrial large ribosomal subunit protein uL23m1 Publication
YmL41
Gene namesi
Name:MRP20
Synonyms:MRPL41
Ordered Locus Names:YDR405W
ORF Names:D9509.23
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR405W
SGDiS000002813 MRP20

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 45Mitochondrion1 PublicationAdd BLAST45
ChainiPRO_000003048846 – 26354S ribosomal protein L41, mitochondrialAdd BLAST218

Proteomic databases

MaxQBiP32387
PaxDbiP32387
PRIDEiP32387

PTM databases

iPTMnetiP32387

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins. uL23m forms the wall of the exit tunnel (PubMed:2060626, PubMed:9151978, PubMed:24675956). Interacts with the C-terminus of OXA1 (PubMed:14657017).4 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi32465, 150 interactors
DIPiDIP-6703N
IntActiP32387, 17 interactors
MINTiP32387
STRINGi4932.YDR405W

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J6Belectron microscopy3.20P1-263[»]
5MRCelectron microscopy3.25P55-261[»]
5MREelectron microscopy3.75P55-261[»]
5MRFelectron microscopy4.97P55-261[»]
ProteinModelPortaliP32387
SMRiP32387
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000246534
InParanoidiP32387
KOiK02892
OMAiLYFPKAR
OrthoDBiEOG092C4LSY

Family and domain databases

Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR012678 Ribosomal_L23/L15e_core_dom_sf
IPR013025 Ribosomal_L25/23
PfamiView protein in Pfam
PF00276 Ribosomal_L23, 1 hit
SUPFAMiSSF54189 SSF54189, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P32387-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRLTVGTKN MLYPLQKTLA VGSCKPEQVP IRSLASVVES SSKILDKSGS
60 70 80 90 100
DREVDINVSE KIYKWTKAGI EQGKEHFKVG GNKVYFPKAR IILLRPNAKH
110 120 130 140 150
TPYQAKFIVP KSFNKLDLRD YLYHIYGLRA MNITTQLLHG KFNRMNLQTT
160 170 180 190 200
RFREPQIKKM TIEMEEPFIW PEEPRPDENS FWDSTTPDNM EKYREERLNC
210 220 230 240 250
LGSDANKPGT AFDGVVGPYE RVAQPFIPRF LKREIDNKRE RHAAELQRAD
260
KLIALNRYIE DLH
Length:263
Mass (Da):30,566
Last modified:October 1, 1993 - v1
Checksum:iB8B1E51BAC60C673
GO

Sequence cautioni

The sequence AAA34790 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti52R → Q AA sequence (PubMed:2060626).Curated1
Sequence conflicti155P → Y AA sequence (PubMed:9151978).Curated1
Sequence conflicti253I → K AA sequence (PubMed:9151978).Curated1
Sequence conflicti259I → K AA sequence (PubMed:9151978).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81696 Genomic DNA Translation: AAA34789.1
M81696 Genomic DNA Translation: AAA34790.1 Different initiation.
U32274 Genomic DNA Translation: AAB64845.1
BK006938 Genomic DNA Translation: DAA12247.1
PIRiB42105
RefSeqiNP_010693.3, NM_001180713.3

Genome annotation databases

EnsemblFungiiYDR405W; YDR405W; YDR405W
GeneIDi852014
KEGGisce:YDR405W

Similar proteinsi

Entry informationi

Entry nameiRM41_YEAST
AccessioniPrimary (citable) accession number: P32387
Secondary accession number(s): D6VT37
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: March 28, 2018
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health