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Protein

Spindle pole body component 110

Gene

SPC110

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the spindle pole body (SPB) required for the proper execution of spindle pole body (SPB) duplication. Potential role in cross-linking filaments or anchoring other molecules. It is essential for growth.6 Publications

Miscellaneous

Present with 279 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • structural constituent of cytoskeleton Source: SGD

GO - Biological processi

  • gamma-tubulin complex assembly Source: SGD
  • karyogamy involved in conjugation with cellular fusion Source: SGD
  • microtubule nucleation Source: SGD
  • mitotic spindle elongation Source: SGD
  • protein complex oligomerization Source: SGD

Enzyme and pathway databases

BioCyciYEAST:G3O-29907-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Spindle pole body component 110
Alternative name(s):
Extragenic suppressor of CMD1-1 mutant protein 1
Nuclear filament-related protein 1
Spindle pole body spacer protein SPC110
Gene namesi
Name:SPC110
Synonyms:NUF1, XCM1
Ordered Locus Names:YDR356W
ORF Names:D9476.3
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR356W
SGDiS000002764 SPC110

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi91S → A: Leads to a mild increase in the proportion of preanaphase spindles at the expense of elongated spindles. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000579931 – 944Spindle pole body component 110Add BLAST944

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18PhosphothreonineCombined sources1
Modified residuei60Phosphoserine; by MPS1Combined sources1 Publication1
Modified residuei64Phosphothreonine; by MPS11 Publication1
Modified residuei68Phosphothreonine; by MPS11 Publication1
Modified residuei80PhosphoserineCombined sources1
Modified residuei529PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP32380
PaxDbiP32380
PRIDEiP32380

PTM databases

iPTMnetiP32380

Interactioni

Subunit structurei

Homodimer. Component of the SPC110 complex containing at least CMD1, SPC29 and SCP110. Interacts with SPC97 and SPC98.4 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi32412, 298 interactors
DIPiDIP-702N
IntActiP32380, 31 interactors
MINTiP32380
STRINGi4932.YDR356W

Structurei

Secondary structure

1944
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi901 – 933Combined sources33

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4DS7X-ray2.15E/F/G/H891-944[»]
ProteinModelPortaliP32380
SMRiP32380
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni900 – 927Calmodulin-bindingAdd BLAST28

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili164 – 791Add BLAST628

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi54 – 59Nuclear localization signalSequence analysis6
Motifi726 – 731Nuclear localization signalSequence analysis6
Motifi742 – 747Nuclear localization signalSequence analysis6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi731 – 944Arg/Tyr-richAdd BLAST214

Sequence similaritiesi

Belongs to the SPC110 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

InParanoidiP32380
OMAiSYIMADY
OrthoDBiEOG092C0GBL

Sequencei

Sequence statusi: Complete.

P32380-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEASHLPNG SLKNMEFTPV GFIKSKRNTT QTQVVSPTKV PNANNGDENE
60 70 80 90 100
GPVKKRQRRS IDDTIDSTRL FSEASQFDDS FPEIKANIPP SPRSGNVDKS
110 120 130 140 150
RKRNLIDDLK KDVPMSQPLK EQEVREHQMK KERFDRALES KLLGKRHITY
160 170 180 190 200
ANSDISNKEL YINEIKSLKH EIKELRKEKN DTLNNYDTLE EETDDLKNRL
210 220 230 240 250
QALEKELDAK NKIVNSRKVD DHSGCIEERE QMERKLAELE RKLKTVKDQV
260 270 280 290 300
LELENNSDVQ SLKLRSKEDE LKNLMNELNE LKSNAEEKDT QLEFKKNELR
310 320 330 340 350
KRTNELNELK IKSDEMDLQL KQKQNESKRL KDELNELETK FSENGSQSSA
360 370 380 390 400
KENELKMLKN KIAELEEEIS TKNSQLIAKE GKLASLMAQL TQLESKLNQR
410 420 430 440 450
DSQLGSREEE LKKTNDKLQK DIRIAREETV SKDERIIDLQ KKVKQLENDL
460 470 480 490 500
FVIKKTHSES KTITDNELES KDKLIKILEN DLKVAQEKYS KMEKELKERE
510 520 530 540 550
FNYKISESKL EDEKTTLNEK ISNLAAENSQ LKNKIEDNST ATHHMKENYE
560 570 580 590 600
KQLESLRKDI EEYKESAKDS EDKIEELKIR IAENSAKVSE KRSKDIKQKD
610 620 630 640 650
EQISDLTQNL KLQEDEISSL KSIIDRYKKD FNQLKSEQSN IQHDLNLQIL
660 670 680 690 700
NLENKLIESE DELKSLRDSQ KIEIENWKRK YNNLSLENDR LLTEKESASD
710 720 730 740 750
KEREISILNR KLDEMDKEKW NLQESKEKYK RELQKVITAN DRLRREKEEL
760 770 780 790 800
NENSNNIRIM EDKMTRIKKN YLSEITSLQE ENRRLEERLI LNERRKDNDS
810 820 830 840 850
TMQLNDIISY YKLKYHSEVR HNNDLKVIND YLNKVLALGT RRLRLDTRKG
860 870 880 890 900
EHSLNISLPD DDELDRDYYN SHVYTRYHDY EYPLRFNLNR RGPYFERRLS
910 920 930 940
FKTVALLVLA CVRMKRIAFY RRSDDNRLRI LRDRIESSSG RISW
Length:944
Mass (Da):111,782
Last modified:October 1, 1993 - v1
Checksum:i04FAA074BB8A0BC8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11582 Genomic DNA Translation: CAA77668.1
X73297 Genomic DNA Translation: CAA51733.1
U28372 Genomic DNA Translation: AAB64791.1
BK006938 Genomic DNA Translation: DAA12195.1
PIRiS26710
RefSeqiNP_010643.3, NM_001180664.3

Genome annotation databases

EnsemblFungiiYDR356W; YDR356W; YDR356W
GeneIDi851957
KEGGisce:YDR356W

Similar proteinsi

Entry informationi

Entry nameiSP110_YEAST
AccessioniPrimary (citable) accession number: P32380
Secondary accession number(s): D6VSY5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: May 23, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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