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Protein

Spindle pole body component 110

Gene

SPC110

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the spindle pole body (SPB) required for the proper execution of spindle pole body (SPB) duplication. Potential role in cross-linking filaments or anchoring other molecules. It is essential for growth.6 Publications

GO - Molecular functioni

  • structural constituent of cytoskeleton Source: SGD

GO - Biological processi

  • karyogamy involved in conjugation with cellular fusion Source: SGD
  • microtubule nucleation Source: SGD
  • mitotic spindle elongation Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-29907-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Spindle pole body component 110
Alternative name(s):
Extragenic suppressor of CMD1-1 mutant protein 1
Nuclear filament-related protein 1
Spindle pole body spacer protein SPC110
Gene namesi
Name:SPC110
Synonyms:NUF1, XCM1
Ordered Locus Names:YDR356W
ORF Names:D9476.3
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR356W.
SGDiS000002764. SPC110.

Subcellular locationi

GO - Cellular componenti

  • central plaque of spindle pole body Source: SGD
  • inner plaque of spindle pole body Source: SGD
  • nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi91 – 911S → A: Leads to a mild increase in the proportion of preanaphase spindles at the expense of elongated spindles. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 944944Spindle pole body component 110PRO_0000057993Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei18 – 181PhosphothreonineCombined sources
Modified residuei60 – 601Phosphoserine; by MPS1Combined sources1 Publication
Modified residuei64 – 641Phosphothreonine; by MPS11 Publication
Modified residuei68 – 681Phosphothreonine; by MPS11 Publication
Modified residuei80 – 801PhosphoserineCombined sources
Modified residuei529 – 5291PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP32380.

PTM databases

iPTMnetiP32380.

Interactioni

Subunit structurei

Homodimer. Component of the SPC110 complex containing at least CMD1, SPC29 and SCP110. Interacts with SPC97 and SPC98.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CMD1P067872EBI-12369,EBI-3976
MLP2P404573EBI-12369,EBI-25261

Protein-protein interaction databases

BioGridi32412. 174 interactions.
DIPiDIP-702N.
IntActiP32380. 27 interactions.
MINTiMINT-644728.

Structurei

Secondary structure

1
944
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi901 – 93333Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4DS7X-ray2.15E/F/G/H891-944[»]
ProteinModelPortaliP32380.
SMRiP32380. Positions 898-936.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni900 – 92728Calmodulin-bindingAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili164 – 791628Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi54 – 596Nuclear localization signalSequence analysis
Motifi726 – 7316Nuclear localization signalSequence analysis
Motifi742 – 7476Nuclear localization signalSequence analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi731 – 944214Arg/Tyr-richAdd
BLAST

Sequence similaritiesi

Belongs to the SPC110 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

InParanoidiP32380.
OMAiNENISCA.
OrthoDBiEOG092C0GBL.

Sequencei

Sequence statusi: Complete.

P32380-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEASHLPNG SLKNMEFTPV GFIKSKRNTT QTQVVSPTKV PNANNGDENE
60 70 80 90 100
GPVKKRQRRS IDDTIDSTRL FSEASQFDDS FPEIKANIPP SPRSGNVDKS
110 120 130 140 150
RKRNLIDDLK KDVPMSQPLK EQEVREHQMK KERFDRALES KLLGKRHITY
160 170 180 190 200
ANSDISNKEL YINEIKSLKH EIKELRKEKN DTLNNYDTLE EETDDLKNRL
210 220 230 240 250
QALEKELDAK NKIVNSRKVD DHSGCIEERE QMERKLAELE RKLKTVKDQV
260 270 280 290 300
LELENNSDVQ SLKLRSKEDE LKNLMNELNE LKSNAEEKDT QLEFKKNELR
310 320 330 340 350
KRTNELNELK IKSDEMDLQL KQKQNESKRL KDELNELETK FSENGSQSSA
360 370 380 390 400
KENELKMLKN KIAELEEEIS TKNSQLIAKE GKLASLMAQL TQLESKLNQR
410 420 430 440 450
DSQLGSREEE LKKTNDKLQK DIRIAREETV SKDERIIDLQ KKVKQLENDL
460 470 480 490 500
FVIKKTHSES KTITDNELES KDKLIKILEN DLKVAQEKYS KMEKELKERE
510 520 530 540 550
FNYKISESKL EDEKTTLNEK ISNLAAENSQ LKNKIEDNST ATHHMKENYE
560 570 580 590 600
KQLESLRKDI EEYKESAKDS EDKIEELKIR IAENSAKVSE KRSKDIKQKD
610 620 630 640 650
EQISDLTQNL KLQEDEISSL KSIIDRYKKD FNQLKSEQSN IQHDLNLQIL
660 670 680 690 700
NLENKLIESE DELKSLRDSQ KIEIENWKRK YNNLSLENDR LLTEKESASD
710 720 730 740 750
KEREISILNR KLDEMDKEKW NLQESKEKYK RELQKVITAN DRLRREKEEL
760 770 780 790 800
NENSNNIRIM EDKMTRIKKN YLSEITSLQE ENRRLEERLI LNERRKDNDS
810 820 830 840 850
TMQLNDIISY YKLKYHSEVR HNNDLKVIND YLNKVLALGT RRLRLDTRKG
860 870 880 890 900
EHSLNISLPD DDELDRDYYN SHVYTRYHDY EYPLRFNLNR RGPYFERRLS
910 920 930 940
FKTVALLVLA CVRMKRIAFY RRSDDNRLRI LRDRIESSSG RISW
Length:944
Mass (Da):111,782
Last modified:October 1, 1993 - v1
Checksum:i04FAA074BB8A0BC8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11582 Genomic DNA. Translation: CAA77668.1.
X73297 Genomic DNA. Translation: CAA51733.1.
U28372 Genomic DNA. Translation: AAB64791.1.
BK006938 Genomic DNA. Translation: DAA12195.1.
PIRiS26710.
RefSeqiNP_010643.3. NM_001180664.3.

Genome annotation databases

EnsemblFungiiYDR356W; YDR356W; YDR356W.
GeneIDi851957.
KEGGisce:YDR356W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11582 Genomic DNA. Translation: CAA77668.1.
X73297 Genomic DNA. Translation: CAA51733.1.
U28372 Genomic DNA. Translation: AAB64791.1.
BK006938 Genomic DNA. Translation: DAA12195.1.
PIRiS26710.
RefSeqiNP_010643.3. NM_001180664.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4DS7X-ray2.15E/F/G/H891-944[»]
ProteinModelPortaliP32380.
SMRiP32380. Positions 898-936.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32412. 174 interactions.
DIPiDIP-702N.
IntActiP32380. 27 interactions.
MINTiMINT-644728.

PTM databases

iPTMnetiP32380.

Proteomic databases

MaxQBiP32380.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR356W; YDR356W; YDR356W.
GeneIDi851957.
KEGGisce:YDR356W.

Organism-specific databases

EuPathDBiFungiDB:YDR356W.
SGDiS000002764. SPC110.

Phylogenomic databases

InParanoidiP32380.
OMAiNENISCA.
OrthoDBiEOG092C0GBL.

Enzyme and pathway databases

BioCyciYEAST:G3O-29907-MONOMER.

Miscellaneous databases

PROiP32380.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiSP110_YEAST
AccessioniPrimary (citable) accession number: P32380
Secondary accession number(s): D6VSY5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: September 7, 2016
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 279 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.