ID PSA5_YEAST Reviewed; 260 AA. AC P32379; D6VV33; DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1996, sequence version 2. DT 27-MAR-2024, entry version 232. DE RecName: Full=Proteasome subunit alpha type-5; DE AltName: Full=Macropain subunit PUP2; DE AltName: Full=Multicatalytic endopeptidase complex subunit PUP2; DE AltName: Full=Proteasome component PUP2; DE AltName: Full=Proteinase YSCE subunit PUP2; GN Name=PUP2; Synonyms=DOA5; OrderedLocusNames=YGR253C; ORFNames=G9155; OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; OC Saccharomycetales; Saccharomycetaceae; Saccharomyces. OX NCBI_TaxID=559292; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=1544471; DOI=10.1016/0014-5793(92)80095-x; RA Georgatsou E., Georgakopoulos T., Thireos G.; RT "Molecular cloning of an essential yeast gene encoding a proteasomal RT subunit."; RL FEBS Lett. 299:39-43(1992). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND MUTAGENESIS OF GLY-49. RX PubMed=7781614; DOI=10.1002/j.1460-2075.1995.tb07260.x; RA Chen P., Hochstrasser M.; RT "Biogenesis, structure and function of the yeast 20S proteasome."; RL EMBO J. 14:2620-2630(1995). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=ATCC 204508 / S288c; RX PubMed=9133741; RX DOI=10.1002/(sici)1097-0061(19970330)13:4<369::aid-yea81>3.0.co;2-v; RA Mazzoni C., Ruzzi M., Rinaldi T., Solinas F., Montebove F., Frontali L.; RT "Sequence analysis of a 10.5 kb DNA fragment from the yeast chromosome VII RT reveals the presence of three new open reading frames and of a tRNAThr RT gene."; RL Yeast 13:369-372(1997). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 204508 / S288c; RX PubMed=9169869; RA Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., RA Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., RA Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., RA Coblenz A., Coglievina M., Coissac E., Defoor E., Del Bino S., Delius H., RA Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., RA Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., RA Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., RA Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., RA Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., RA Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., RA Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., RA Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., RA Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., RA Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., RA Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., RA Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., RA Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., RA Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., RA Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., RA Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., RA Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., RA Zaccaria P., Zimmermann M., Zollner A., Kleine K.; RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."; RL Nature 387:81-84(1997). RN [5] RP GENOME REANNOTATION. RC STRAIN=ATCC 204508 / S288c; RX PubMed=24374639; DOI=10.1534/g3.113.008995; RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.; RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now."; RL G3 (Bethesda) 4:389-398(2014). RN [6] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=ATCC 204508 / S288c; RX PubMed=17322287; DOI=10.1101/gr.6037607; RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J., RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., RA LaBaer J.; RT "Approaching a complete repository of sequence-verified protein-encoding RT clones for Saccharomyces cerevisiae."; RL Genome Res. 17:536-543(2007). RN [7] RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS]. RX PubMed=14562106; DOI=10.1038/nature02046; RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., RA O'Shea E.K., Weissman J.S.; RT "Global analysis of protein expression in yeast."; RL Nature 425:737-741(2003). RN [8] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-55; SER-56 AND SER-251, AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC STRAIN=ADR376; RX PubMed=17330950; DOI=10.1021/pr060559j; RA Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., RA Elias J.E., Gygi S.P.; RT "Large-scale phosphorylation analysis of alpha-factor-arrested RT Saccharomyces cerevisiae."; RL J. Proteome Res. 6:1190-1197(2007). RN [9] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-251, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=18407956; DOI=10.1074/mcp.m700468-mcp200; RA Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; RT "A multidimensional chromatography technology for in-depth phosphoproteome RT analysis."; RL Mol. Cell. Proteomics 7:1389-1396(2008). RN [10] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-251, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19779198; DOI=10.1126/science.1172867; RA Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.; RT "Global analysis of Cdk1 substrate phosphorylation sites provides insights RT into evolution."; RL Science 325:1682-1686(2009). RN [11] RP X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 9-250 OF COMPLEX WITH THE 20S RP PROTEASOME. RX PubMed=9087403; DOI=10.1038/386463a0; RA Groll M., Ditzel L., Loewe J., Stock D., Bochtler M., Bartunik H.D., RA Huber R.; RT "Structure of 20S proteasome from yeast at 2.4-A resolution."; RL Nature 386:463-471(1997). RN [12] RP X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS). RX PubMed=11081519; DOI=10.1038/35040607; RA Whitby F.G., Masters E.I., Kramer L., Knowlton J.R., Yao Y., Wang C.C., RA Hill C.P.; RT "Structural basis for the activation of 20S proteasomes by 11S RT regulators."; RL Nature 408:115-120(2000). RN [13] RP X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 1-250 OF COMPLEX WITH THE 20S RP PROTEASOME. RX PubMed=11062564; DOI=10.1038/80992; RA Groll M., Bajorek M., Koehler A., Moroder L., Rubin D.M., Huber R., RA Glickman M.H., Finley D.; RT "A gated channel into the proteasome core particle."; RL Nat. Struct. Biol. 7:1062-1067(2000). RN [14] RP X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 9-250 OF COMPLEX WITH THE 20S RP PROTEASOME. RX PubMed=11493007; DOI=10.1006/jmbi.2001.4869; RA Groll M., Koguchi Y., Huber R., Kohno J.; RT "Crystal structure of the 20 S proteasome:TMC-95A complex: a non-covalent RT proteasome inhibitor."; RL J. Mol. Biol. 311:543-548(2001). RN [15] RP X-RAY CRYSTALLOGRAPHY (2.81 ANGSTROMS) OF 9-250 OF COMPLEX WITH THE 20S RP PROTEASOME. RX PubMed=16793518; DOI=10.1016/j.chembiol.2006.04.005; RA Groll M., Goetz M., Kaiser M., Weyher E., Moroder L.; RT "TMC-95-based inhibitor design provides evidence for the catalytic RT versatility of the proteasome."; RL Chem. Biol. 13:607-614(2006). RN [16] RP X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 9-250 OF COMPLEX WITH THE 20S RP PROTEASOME. RX PubMed=16608349; DOI=10.1021/ja058320b; RA Groll M., Huber R., Potts B.C.M.; RT "Crystal structures of salinosporamide A (NPI-0052) and B (NPI-0047) in RT complex with the 20S proteasome reveal important consequences of beta- RT lactone ring opening and a mechanism for irreversible binding."; RL J. Am. Chem. Soc. 128:5136-5141(2006). RN [17] RP X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 9-250 OF COMPLEX WITH THE 20S RP PROTEASOME. RX PubMed=16531229; DOI=10.1016/j.str.2005.11.019; RA Groll M., Berkers C.R., Ploegh H.L., Ovaa H.; RT "Crystal structure of the boronic acid-based proteasome inhibitor RT bortezomib in complex with the yeast 20S proteasome."; RL Structure 14:451-456(2006). RN [18] RP X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 1-250 IN COMPLEX WITH THE RP PROTEASOME. RX PubMed=20227375; DOI=10.1016/j.molcel.2010.02.002; RA Sadre-Bazzaz K., Whitby F.G., Robinson H., Formosa T., Hill C.P.; RT "Structure of a Blm10 complex reveals common mechanisms for proteasome RT binding and gate opening."; RL Mol. Cell 37:728-735(2010). RN [19] RP STRUCTURE BY ELECTRON MICROSCOPY (7.4 ANGSTROMS) OF THE 26S PROTEASOME. RX PubMed=22927375; DOI=10.1073/pnas.1213333109; RA Beck F., Unverdorben P., Bohn S., Schweitzer A., Pfeifer G., Sakata E., RA Nickell S., Plitzko J.M., Villa E., Baumeister W., Forster F.; RT "Near-atomic resolution structural model of the yeast 26S proteasome."; RL Proc. Natl. Acad. Sci. U.S.A. 109:14870-14875(2012). CC -!- FUNCTION: The proteasome degrades poly-ubiquitinated proteins in the CC cytoplasm and in the nucleus. It is essential for the regulated CC turnover of proteins and for the removal of misfolded proteins. The CC proteasome is a multicatalytic proteinase complex that is characterized CC by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu CC adjacent to the leaving group at neutral or slightly basic pH. It has CC an ATP-dependent proteolytic activity. CC -!- SUBUNIT: The 26S proteasome consists of a 20S proteasome core and two CC 19S regulatory subunits. The 20S proteasome core is composed of 28 CC subunits that are arranged in four stacked rings, resulting in a CC barrel-shaped structure. The two end rings are each formed by seven CC alpha subunits, and the two central rings are each formed by seven beta CC subunits. The catalytic chamber with the active sites is on the inside CC of the barrel. {ECO:0000269|PubMed:20227375}. CC -!- INTERACTION: CC P32379; Q12245: POC4; NbExp=2; IntAct=EBI-13971, EBI-2343020; CC -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus. CC -!- MISCELLANEOUS: Present with 17100 molecules/cell in log phase SD CC medium. {ECO:0000269|PubMed:14562106}. CC -!- SIMILARITY: Belongs to the peptidase T1A family. {ECO:0000255|PROSITE- CC ProRule:PRU00808}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X64918; CAA46111.1; -; Genomic_DNA. DR EMBL; X99228; CAA67615.1; -; Genomic_DNA. DR EMBL; Z73038; CAA97282.1; -; Genomic_DNA. DR EMBL; AY558511; AAS56837.1; -; Genomic_DNA. DR EMBL; BK006941; DAA08344.1; -; Genomic_DNA. DR PIR; S64585; S64585. DR RefSeq; NP_011769.1; NM_001181382.1. DR PDB; 1FNT; X-ray; 3.20 A; E/S=1-260. DR PDB; 1G0U; X-ray; 2.40 A; D/R=1-250. DR PDB; 1G65; X-ray; 2.25 A; D/R=9-250. DR PDB; 1JD2; X-ray; 3.00 A; D/Y=9-120, D/Y=131-250. DR PDB; 1RYP; X-ray; 1.90 A; E/S=9-250. DR PDB; 1Z7Q; X-ray; 3.22 A; E/S=1-260. DR PDB; 2F16; X-ray; 2.80 A; D/R=9-250. DR PDB; 2FAK; X-ray; 2.80 A; D/R=9-250. DR PDB; 2GPL; X-ray; 2.81 A; D/R=9-250. DR PDB; 2Z5C; X-ray; 2.90 A; C/F=1-260. DR PDB; 2ZCY; X-ray; 2.90 A; D/R=1-260. DR PDB; 3BDM; X-ray; 2.70 A; D/R=1-260. DR PDB; 3D29; X-ray; 2.60 A; D/R=9-250. DR PDB; 3DY3; X-ray; 2.81 A; D/R=9-250. DR PDB; 3DY4; X-ray; 2.80 A; D/R=9-250. DR PDB; 3E47; X-ray; 3.00 A; D/R=9-250. DR PDB; 3GPJ; X-ray; 2.70 A; D/R=9-250. DR PDB; 3GPT; X-ray; 2.41 A; D/R=9-250. DR PDB; 3GPW; X-ray; 2.50 A; D/R=9-250. DR PDB; 3HYE; X-ray; 2.50 A; D/R=9-250. DR PDB; 3JCO; EM; 4.80 A; E/e=1-260. DR PDB; 3JCP; EM; 4.60 A; E/e=1-260. DR PDB; 3MG0; X-ray; 2.68 A; D/R=9-250. DR PDB; 3MG4; X-ray; 3.11 A; D/R=9-250. DR PDB; 3MG6; X-ray; 2.60 A; D/R=1-250. DR PDB; 3MG7; X-ray; 2.78 A; D/R=1-250. DR PDB; 3MG8; X-ray; 2.59 A; D/R=1-250. DR PDB; 3NZJ; X-ray; 2.40 A; D/R=1-260. DR PDB; 3NZW; X-ray; 2.50 A; D/R=1-260. DR PDB; 3NZX; X-ray; 2.70 A; D/R=1-260. DR PDB; 3OEU; X-ray; 2.60 A; D/R=1-260. DR PDB; 3OEV; X-ray; 2.85 A; D/R=1-260. DR PDB; 3OKJ; X-ray; 2.70 A; D/R=9-250. DR PDB; 3SDI; X-ray; 2.65 A; D/R=1-260. DR PDB; 3SDK; X-ray; 2.70 A; D/R=1-260. DR PDB; 3SHJ; X-ray; 2.80 A; D/R=9-250. DR PDB; 3TDD; X-ray; 2.70 A; D/R=9-250. DR PDB; 3UN4; X-ray; 3.40 A; D/R=1-260. DR PDB; 3UN8; X-ray; 2.70 A; D/R=1-260. DR PDB; 3WXR; X-ray; 3.15 A; E/S=1-260. DR PDB; 4CR2; EM; 7.70 A; E=1-260. DR PDB; 4CR3; EM; 9.30 A; E=1-260. DR PDB; 4CR4; EM; 8.80 A; E=1-260. DR PDB; 4EU2; X-ray; 2.51 A; E/S=9-250. DR PDB; 4FZC; X-ray; 2.80 A; D/R=9-250. DR PDB; 4FZG; X-ray; 3.00 A; D/R=9-250. DR PDB; 4G4S; X-ray; 2.49 A; E=1-260. DR PDB; 4GK7; X-ray; 2.80 A; D/R=9-250. DR PDB; 4HNP; X-ray; 2.80 A; D/R=9-250. DR PDB; 4HRC; X-ray; 2.80 A; D/R=9-250. DR PDB; 4HRD; X-ray; 2.80 A; D/R=9-250. DR PDB; 4INR; X-ray; 2.70 A; D/R=1-260. DR PDB; 4INT; X-ray; 2.90 A; D/R=1-260. DR PDB; 4INU; X-ray; 3.10 A; D/R=1-260. DR PDB; 4J70; X-ray; 2.80 A; D/R=1-260. DR PDB; 4JSQ; X-ray; 2.80 A; D/R=1-260. DR PDB; 4JSU; X-ray; 2.90 A; D/R=1-260. DR PDB; 4JT0; X-ray; 3.10 A; D/R=1-260. DR PDB; 4LQI; X-ray; 2.70 A; D/R=9-250. DR PDB; 4LTC; X-ray; 2.50 A; D/R=1-260. DR PDB; 4NNN; X-ray; 2.50 A; D/R=1-260. DR PDB; 4NNW; X-ray; 2.60 A; D/R=1-260. DR PDB; 4NO1; X-ray; 2.50 A; D/R=1-260. DR PDB; 4NO6; X-ray; 3.00 A; D/R=1-260. DR PDB; 4NO8; X-ray; 2.70 A; D/R=1-260. DR PDB; 4NO9; X-ray; 2.90 A; D/R=1-260. DR PDB; 4Q1S; X-ray; 2.60 A; D/R=1-260. DR PDB; 4QBY; X-ray; 3.00 A; D/R=1-260. DR PDB; 4QLQ; X-ray; 2.40 A; D/R=1-260. DR PDB; 4QLS; X-ray; 2.80 A; D/R=1-260. DR PDB; 4QLT; X-ray; 2.80 A; D/R=1-260. DR PDB; 4QLU; X-ray; 2.80 A; D/R=1-260. DR PDB; 4QLV; X-ray; 2.90 A; D/R=1-260. DR PDB; 4QUX; X-ray; 3.00 A; D/R=1-260. DR PDB; 4QUY; X-ray; 2.80 A; D/R=1-260. DR PDB; 4QV0; X-ray; 3.10 A; D/R=1-260. DR PDB; 4QV1; X-ray; 2.50 A; D/R=1-260. DR PDB; 4QV3; X-ray; 3.00 A; D/R=1-260. DR PDB; 4QV4; X-ray; 2.70 A; D/R=1-260. DR PDB; 4QV5; X-ray; 2.70 A; D/R=1-260. DR PDB; 4QV6; X-ray; 2.80 A; D/R=1-260. DR PDB; 4QV7; X-ray; 2.60 A; D/R=1-260. DR PDB; 4QV8; X-ray; 2.90 A; D/R=1-260. DR PDB; 4QV9; X-ray; 2.60 A; D/R=1-260. DR PDB; 4QVL; X-ray; 2.80 A; D/R=1-260. DR PDB; 4QVM; X-ray; 2.80 A; D/R=1-260. DR PDB; 4QVN; X-ray; 2.90 A; D/R=1-260. DR PDB; 4QVP; X-ray; 2.30 A; D/R=1-260. DR PDB; 4QVQ; X-ray; 2.60 A; D/R=1-260. DR PDB; 4QVV; X-ray; 2.80 A; D/R=1-260. DR PDB; 4QVW; X-ray; 3.00 A; D/R=1-260. DR PDB; 4QVY; X-ray; 2.51 A; D/R=1-260. DR PDB; 4QW0; X-ray; 2.90 A; D/R=1-260. DR PDB; 4QW1; X-ray; 2.90 A; D/R=1-260. DR PDB; 4QW3; X-ray; 2.90 A; D/R=1-260. DR PDB; 4QW4; X-ray; 2.80 A; D/R=1-260. DR PDB; 4QW5; X-ray; 3.00 A; D/R=1-260. DR PDB; 4QW6; X-ray; 2.90 A; D/R=1-260. DR PDB; 4QW7; X-ray; 2.70 A; D/R=1-260. DR PDB; 4QWF; X-ray; 3.00 A; D/R=1-260. DR PDB; 4QWG; X-ray; 2.60 A; D/R=1-260. DR PDB; 4QWI; X-ray; 2.60 A; D/R=1-260. DR PDB; 4QWJ; X-ray; 2.90 A; D/R=1-260. DR PDB; 4QWK; X-ray; 2.80 A; D/R=1-260. DR PDB; 4QWL; X-ray; 2.60 A; D/R=1-260. DR PDB; 4QWR; X-ray; 2.90 A; D/R=1-260. DR PDB; 4QWS; X-ray; 3.00 A; D/R=1-260. DR PDB; 4QWU; X-ray; 3.00 A; D/R=1-260. DR PDB; 4QWX; X-ray; 2.90 A; D/R=1-260. DR PDB; 4QXJ; X-ray; 2.80 A; D/R=1-260. DR PDB; 4QZ0; X-ray; 3.00 A; D/R=1-260. DR PDB; 4QZ1; X-ray; 3.00 A; D/R=1-260. DR PDB; 4QZ2; X-ray; 2.70 A; D/R=1-260. DR PDB; 4QZ3; X-ray; 2.80 A; D/R=1-260. DR PDB; 4QZ4; X-ray; 3.00 A; D/R=1-260. DR PDB; 4QZ5; X-ray; 2.80 A; D/R=1-260. DR PDB; 4QZ6; X-ray; 2.90 A; D/R=1-260. DR PDB; 4QZ7; X-ray; 2.80 A; D/R=1-260. DR PDB; 4QZW; X-ray; 3.00 A; D/R=1-260. DR PDB; 4QZX; X-ray; 2.60 A; D/R=1-260. DR PDB; 4QZZ; X-ray; 2.90 A; D/R=1-260. DR PDB; 4R00; X-ray; 2.80 A; D/R=1-260. DR PDB; 4R02; X-ray; 2.50 A; D/R=1-260. DR PDB; 4R17; X-ray; 2.10 A; D/R=1-260. DR PDB; 4R18; X-ray; 2.40 A; D/R=1-260. DR PDB; 4RUR; X-ray; 2.50 A; D/R=1-260. DR PDB; 4V7O; X-ray; 3.00 A; AJ/AV/BE/BS=1-250. DR PDB; 4X6Z; X-ray; 2.70 A; E/S=1-260. DR PDB; 4Y69; X-ray; 2.90 A; D/R=1-260. DR PDB; 4Y6A; X-ray; 2.60 A; D/R=1-260. DR PDB; 4Y6V; X-ray; 2.80 A; D/R=1-260. DR PDB; 4Y6Z; X-ray; 2.70 A; D/R=1-260. DR PDB; 4Y70; X-ray; 2.40 A; D/R=1-260. DR PDB; 4Y74; X-ray; 2.70 A; D/R=1-260. DR PDB; 4Y75; X-ray; 2.80 A; D/R=1-260. DR PDB; 4Y77; X-ray; 2.50 A; D/R=1-260. DR PDB; 4Y78; X-ray; 2.80 A; D/R=1-260. DR PDB; 4Y7W; X-ray; 2.50 A; D/R=1-260. DR PDB; 4Y7X; X-ray; 2.60 A; D/R=1-260. DR PDB; 4Y7Y; X-ray; 2.40 A; D/R=1-260. DR PDB; 4Y80; X-ray; 2.50 A; D/R=1-260. DR PDB; 4Y81; X-ray; 2.80 A; D/R=1-260. DR PDB; 4Y82; X-ray; 2.80 A; D/R=1-260. DR PDB; 4Y84; X-ray; 2.70 A; D/R=1-260. DR PDB; 4Y8G; X-ray; 2.60 A; D/R=1-260. DR PDB; 4Y8H; X-ray; 2.50 A; D/R=1-260. DR PDB; 4Y8I; X-ray; 2.60 A; D/R=1-260. DR PDB; 4Y8J; X-ray; 2.70 A; D/R=1-260. DR PDB; 4Y8K; X-ray; 2.60 A; D/R=1-260. DR PDB; 4Y8L; X-ray; 2.40 A; D/R=1-260. DR PDB; 4Y8M; X-ray; 2.80 A; D/R=1-260. DR PDB; 4Y8N; X-ray; 2.60 A; D/R=1-260. DR PDB; 4Y8O; X-ray; 2.70 A; D/R=1-260. DR PDB; 4Y8P; X-ray; 2.80 A; D/R=1-260. DR PDB; 4Y8Q; X-ray; 2.60 A; D/R=1-260. DR PDB; 4Y8R; X-ray; 2.70 A; D/R=1-260. DR PDB; 4Y8S; X-ray; 2.70 A; D/R=1-260. DR PDB; 4Y8T; X-ray; 2.70 A; D/R=1-260. DR PDB; 4Y8U; X-ray; 2.90 A; D/R=1-260. DR PDB; 4Y9Y; X-ray; 2.80 A; D/R=1-260. DR PDB; 4Y9Z; X-ray; 2.80 A; D/R=1-260. DR PDB; 4YA0; X-ray; 2.80 A; D/R=1-260. DR PDB; 4YA1; X-ray; 2.90 A; D/R=1-260. DR PDB; 4YA2; X-ray; 2.70 A; D/R=1-260. DR PDB; 4YA3; X-ray; 2.70 A; D/R=1-260. DR PDB; 4YA4; X-ray; 2.90 A; D/R=1-260. DR PDB; 4YA5; X-ray; 2.50 A; D/R=1-260. DR PDB; 4YA7; X-ray; 2.70 A; D/R=1-260. DR PDB; 4YA9; X-ray; 2.70 A; D/R=1-260. DR PDB; 4Z1L; X-ray; 3.00 A; D/R=1-260. DR PDB; 5A5B; EM; 9.50 A; E=1-260. DR PDB; 5AHJ; X-ray; 2.80 A; D/R=1-260. DR PDB; 5BOU; X-ray; 2.60 A; D/R=1-260. DR PDB; 5BXL; X-ray; 2.80 A; D/R=1-260. DR PDB; 5BXN; X-ray; 2.80 A; D/R=1-260. DR PDB; 5CGF; X-ray; 2.80 A; D/R=1-260. DR PDB; 5CGG; X-ray; 2.90 A; D/R=1-260. DR PDB; 5CGH; X-ray; 2.50 A; D/R=1-260. DR PDB; 5CGI; X-ray; 2.80 A; D/R=1-260. DR PDB; 5CZ4; X-ray; 2.30 A; D/R=1-260. DR PDB; 5CZ5; X-ray; 2.80 A; D/R=1-260. DR PDB; 5CZ6; X-ray; 2.70 A; D/R=1-260. DR PDB; 5CZ7; X-ray; 2.50 A; D/R=1-260. DR PDB; 5CZ8; X-ray; 2.80 A; D/R=1-260. DR PDB; 5CZ9; X-ray; 2.90 A; D/R=1-260. DR PDB; 5CZA; X-ray; 2.50 A; D/R=1-260. DR PDB; 5D0S; X-ray; 2.50 A; D/R=1-260. DR PDB; 5D0T; X-ray; 2.60 A; D/R=1-260. DR PDB; 5D0V; X-ray; 2.90 A; D/R=1-260. DR PDB; 5D0W; X-ray; 2.80 A; D/R=1-260. DR PDB; 5D0X; X-ray; 2.60 A; D/R=1-260. DR PDB; 5D0Z; X-ray; 2.90 A; D/R=1-260. DR PDB; 5DKI; X-ray; 2.80 A; D/R=1-260. DR PDB; 5DKJ; X-ray; 2.80 A; D/R=1-260. DR PDB; 5FG7; X-ray; 2.70 A; D/R=1-260. DR PDB; 5FG9; X-ray; 2.60 A; D/R=1-260. DR PDB; 5FGA; X-ray; 2.70 A; D/R=1-260. DR PDB; 5FGD; X-ray; 2.80 A; D/R=1-260. DR PDB; 5FGE; X-ray; 2.60 A; D/R=1-260. DR PDB; 5FGF; X-ray; 2.60 A; D/R=1-260. DR PDB; 5FGG; X-ray; 2.70 A; D/R=1-260. DR PDB; 5FGH; X-ray; 2.80 A; D/R=1-260. DR PDB; 5FGI; X-ray; 2.90 A; D/R=1-260. DR PDB; 5FHS; X-ray; 2.70 A; D/R=1-260. DR PDB; 5JHR; X-ray; 2.90 A; D/R=1-260. DR PDB; 5JHS; X-ray; 3.00 A; D/R=1-260. DR PDB; 5L52; X-ray; 2.70 A; D/R=1-260. DR PDB; 5L54; X-ray; 2.80 A; D/R=1-260. DR PDB; 5L55; X-ray; 2.90 A; D/R=1-260. DR PDB; 5L5A; X-ray; 2.40 A; D/R=1-260. DR PDB; 5L5B; X-ray; 2.80 A; D/R=1-260. DR PDB; 5L5D; X-ray; 2.80 A; D/R=1-260. DR PDB; 5L5E; X-ray; 2.90 A; D/R=1-260. DR PDB; 5L5F; X-ray; 2.50 A; D/R=1-260. DR PDB; 5L5H; X-ray; 2.60 A; D/R=1-260. DR PDB; 5L5I; X-ray; 2.90 A; D/R=1-260. DR PDB; 5L5J; X-ray; 2.90 A; D/R=1-260. DR PDB; 5L5O; X-ray; 2.60 A; D/R=1-260. DR PDB; 5L5P; X-ray; 2.80 A; D/R=1-260. DR PDB; 5L5Q; X-ray; 2.80 A; D/R=1-260. DR PDB; 5L5R; X-ray; 2.90 A; D/R=1-260. DR PDB; 5L5S; X-ray; 2.60 A; D/R=1-260. DR PDB; 5L5T; X-ray; 2.90 A; D/R=1-260. DR PDB; 5L5U; X-ray; 2.60 A; D/R=1-260. DR PDB; 5L5V; X-ray; 2.70 A; D/R=1-260. DR PDB; 5L5W; X-ray; 2.80 A; D/R=1-260. DR PDB; 5L5X; X-ray; 2.90 A; D/R=1-260. DR PDB; 5L5Y; X-ray; 2.70 A; D/R=1-260. DR PDB; 5L5Z; X-ray; 2.70 A; D/R=1-260. DR PDB; 5L60; X-ray; 2.70 A; D/R=1-260. DR PDB; 5L61; X-ray; 2.80 A; D/R=1-260. DR PDB; 5L62; X-ray; 2.80 A; D/R=1-260. DR PDB; 5L63; X-ray; 2.70 A; D/R=1-260. DR PDB; 5L64; X-ray; 2.70 A; D/R=1-260. DR PDB; 5L65; X-ray; 2.90 A; D/R=1-260. DR PDB; 5L66; X-ray; 2.80 A; D/R=1-260. DR PDB; 5L67; X-ray; 2.60 A; D/R=1-260. DR PDB; 5L68; X-ray; 2.80 A; D/R=1-260. DR PDB; 5L69; X-ray; 2.70 A; D/R=1-260. DR PDB; 5L6A; X-ray; 2.80 A; D/R=1-260. DR PDB; 5L6B; X-ray; 2.60 A; D/R=1-260. DR PDB; 5L6C; X-ray; 2.60 A; D/R=1-260. DR PDB; 5LAI; X-ray; 2.50 A; D/R=1-260. DR PDB; 5LAJ; X-ray; 2.90 A; D/R=1-260. DR PDB; 5LTT; X-ray; 2.70 A; D/R=1-260. DR PDB; 5M2B; X-ray; 2.70 A; D/R=1-260. DR PDB; 5MP9; EM; 4.10 A; E/e=1-260. DR PDB; 5MPA; EM; 4.50 A; E/e=1-260. DR PDB; 5MPB; EM; 7.80 A; E/e=1-260. DR PDB; 5MPC; EM; 7.70 A; E/e=1-260. DR PDB; 5NIF; X-ray; 3.00 A; E/S=1-260. DR PDB; 5WVI; EM; 6.30 A; E/m=1-260. DR PDB; 5WVK; EM; 4.20 A; E/m=1-260. DR PDB; 6EF0; EM; 4.43 A; E=1-249. DR PDB; 6EF1; EM; 4.73 A; E=9-250. DR PDB; 6EF2; EM; 4.27 A; E=2-248. DR PDB; 6EF3; EM; 4.17 A; E=1-260. DR PDB; 6FVT; EM; 4.10 A; E/e=7-250. DR PDB; 6FVU; EM; 4.50 A; E/e=2-250. DR PDB; 6FVV; EM; 5.40 A; E/e=7-250. DR PDB; 6FVW; EM; 4.50 A; E/e=6-250. DR PDB; 6FVX; EM; 4.90 A; E/e=7-250. DR PDB; 6FVY; EM; 6.10 A; E/e=6-250. DR PDB; 6G7F; X-ray; 2.70 A; D/R=1-260. DR PDB; 6G8M; X-ray; 2.70 A; D/R=1-260. DR PDB; 6G8N; X-ray; 3.00 A; D/R=1-260. DR PDB; 6GOP; X-ray; 2.90 A; D/R=1-260. DR PDB; 6H39; X-ray; 2.50 A; D/R=1-260. DR PDB; 6HTB; X-ray; 2.70 A; D/R=1-260. DR PDB; 6HTC; X-ray; 2.80 A; D/R=1-260. DR PDB; 6HTD; X-ray; 3.00 A; D/R=1-260. DR PDB; 6HTP; X-ray; 3.00 A; D/R=1-260. DR PDB; 6HTR; X-ray; 2.60 A; D/R=1-260. DR PDB; 6HUB; X-ray; 2.90 A; D/R=1-260. DR PDB; 6HUC; X-ray; 3.00 A; D/R=1-260. DR PDB; 6HUQ; X-ray; 3.00 A; D/R=1-260. DR PDB; 6HUU; X-ray; 2.80 A; D/R=1-260. DR PDB; 6HUV; X-ray; 3.10 A; D/R=1-260. DR PDB; 6HV3; X-ray; 2.70 A; D/R=1-260. DR PDB; 6HV4; X-ray; 3.00 A; D/R=1-260. DR PDB; 6HV5; X-ray; 3.00 A; D/R=1-260. DR PDB; 6HV7; X-ray; 3.40 A; D/R=1-260. DR PDB; 6HVA; X-ray; 2.90 A; D/R=1-260. DR PDB; 6HVR; X-ray; 2.70 A; D/R=1-260. DR PDB; 6HVS; X-ray; 3.10 A; D/R=1-260. DR PDB; 6HVT; X-ray; 2.90 A; D/R=1-260. DR PDB; 6HVU; X-ray; 2.90 A; D/R=1-260. DR PDB; 6HVV; X-ray; 2.70 A; D/R=1-260. DR PDB; 6HVW; X-ray; 3.00 A; D/R=1-260. DR PDB; 6HVX; X-ray; 2.80 A; D/R=1-260. DR PDB; 6HVY; X-ray; 2.70 A; D/R=1-260. DR PDB; 6HW0; X-ray; 2.80 A; D/R=1-260. DR PDB; 6HW3; X-ray; 2.60 A; D/R=1-260. DR PDB; 6HW4; X-ray; 2.90 A; D/R=1-260. DR PDB; 6HW5; X-ray; 2.90 A; D/R=1-260. DR PDB; 6HW6; X-ray; 2.70 A; D/R=1-260. DR PDB; 6HW7; X-ray; 2.70 A; D/R=1-260. DR PDB; 6HW8; X-ray; 2.80 A; D/R=1-260. DR PDB; 6HW9; X-ray; 2.80 A; D/R=1-260. DR PDB; 6HWA; X-ray; 2.80 A; D/R=1-260. DR PDB; 6HWB; X-ray; 2.60 A; D/R=1-260. DR PDB; 6HWC; X-ray; 2.80 A; D/R=1-260. DR PDB; 6HWD; X-ray; 2.80 A; D/R=1-260. DR PDB; 6HWE; X-ray; 2.30 A; D/R=1-260. DR PDB; 6HWF; X-ray; 2.50 A; D/R=1-260. DR PDB; 6J2C; EM; 7.00 A; E/m=1-260. DR PDB; 6J2N; EM; 7.50 A; E/m=1-260. DR PDB; 6J2Q; EM; 3.80 A; E/m=1-260. DR PDB; 6J2X; EM; 3.80 A; E/m=1-260. DR PDB; 6J30; EM; 4.50 A; E/m=1-260. DR PDB; 6ZOU; X-ray; 2.90 A; D/R=1-260. DR PDB; 6ZP6; X-ray; 2.80 A; D/R=1-260. DR PDB; 6ZP8; X-ray; 3.00 A; D/R=1-260. DR PDB; 7LS5; EM; 2.74 A; E/S=1-260. DR PDB; 7LS6; EM; 3.17 A; E=1-260. DR PDB; 7LSX; EM; 3.61 A; E=1-260. DR PDB; 7O2L; X-ray; 3.00 A; D/R=1-260. DR PDB; 7QO3; EM; 6.10 A; E/e=1-260. DR PDB; 7QO5; EM; 6.00 A; E/e=1-260. DR PDB; 7TEJ; EM; 2.74 A; E/S=1-260. DR PDB; 7TEO; EM; 2.97 A; E/S=1-260. DR PDB; 8OLR; X-ray; 2.80 A; D/R=1-260. DR PDB; 8T08; EM; 3.00 A; E/V=1-260. DR PDB; 8T0M; EM; 2.40 A; E/S=1-260. DR PDBsum; 1FNT; -. DR PDBsum; 1G0U; -. DR PDBsum; 1G65; -. DR PDBsum; 1JD2; -. DR PDBsum; 1RYP; -. DR PDBsum; 1Z7Q; -. DR PDBsum; 2F16; -. DR PDBsum; 2FAK; -. DR PDBsum; 2GPL; -. DR PDBsum; 2Z5C; -. DR PDBsum; 2ZCY; -. DR PDBsum; 3BDM; -. DR PDBsum; 3D29; -. DR PDBsum; 3DY3; -. DR PDBsum; 3DY4; -. DR PDBsum; 3E47; -. DR PDBsum; 3GPJ; -. DR PDBsum; 3GPT; -. DR PDBsum; 3GPW; -. DR PDBsum; 3HYE; -. DR PDBsum; 3JCO; -. DR PDBsum; 3JCP; -. DR PDBsum; 3MG0; -. DR PDBsum; 3MG4; -. DR PDBsum; 3MG6; -. DR PDBsum; 3MG7; -. DR PDBsum; 3MG8; -. DR PDBsum; 3NZJ; -. DR PDBsum; 3NZW; -. DR PDBsum; 3NZX; -. DR PDBsum; 3OEU; -. DR PDBsum; 3OEV; -. DR PDBsum; 3OKJ; -. DR PDBsum; 3SDI; -. DR PDBsum; 3SDK; -. DR PDBsum; 3SHJ; -. DR PDBsum; 3TDD; -. DR PDBsum; 3UN4; -. DR PDBsum; 3UN8; -. DR PDBsum; 3WXR; -. DR PDBsum; 4CR2; -. DR PDBsum; 4CR3; -. DR PDBsum; 4CR4; -. DR PDBsum; 4EU2; -. DR PDBsum; 4FZC; -. DR PDBsum; 4FZG; -. DR PDBsum; 4G4S; -. DR PDBsum; 4GK7; -. DR PDBsum; 4HNP; -. DR PDBsum; 4HRC; -. DR PDBsum; 4HRD; -. DR PDBsum; 4INR; -. DR PDBsum; 4INT; -. DR PDBsum; 4INU; -. DR PDBsum; 4J70; -. DR PDBsum; 4JSQ; -. DR PDBsum; 4JSU; -. DR PDBsum; 4JT0; -. DR PDBsum; 4LQI; -. DR PDBsum; 4LTC; -. DR PDBsum; 4NNN; -. DR PDBsum; 4NNW; -. DR PDBsum; 4NO1; -. DR PDBsum; 4NO6; -. DR PDBsum; 4NO8; -. DR PDBsum; 4NO9; -. DR PDBsum; 4Q1S; -. DR PDBsum; 4QBY; -. DR PDBsum; 4QLQ; -. DR PDBsum; 4QLS; -. DR PDBsum; 4QLT; -. DR PDBsum; 4QLU; -. DR PDBsum; 4QLV; -. DR PDBsum; 4QUX; -. DR PDBsum; 4QUY; -. DR PDBsum; 4QV0; -. DR PDBsum; 4QV1; -. DR PDBsum; 4QV3; -. DR PDBsum; 4QV4; -. DR PDBsum; 4QV5; -. DR PDBsum; 4QV6; -. DR PDBsum; 4QV7; -. DR PDBsum; 4QV8; -. DR PDBsum; 4QV9; -. DR PDBsum; 4QVL; -. DR PDBsum; 4QVM; -. DR PDBsum; 4QVN; -. DR PDBsum; 4QVP; -. DR PDBsum; 4QVQ; -. DR PDBsum; 4QVV; -. DR PDBsum; 4QVW; -. DR PDBsum; 4QVY; -. DR PDBsum; 4QW0; -. DR PDBsum; 4QW1; -. DR PDBsum; 4QW3; -. DR PDBsum; 4QW4; -. DR PDBsum; 4QW5; -. DR PDBsum; 4QW6; -. DR PDBsum; 4QW7; -. DR PDBsum; 4QWF; -. DR PDBsum; 4QWG; -. DR PDBsum; 4QWI; -. DR PDBsum; 4QWJ; -. DR PDBsum; 4QWK; -. DR PDBsum; 4QWL; -. DR PDBsum; 4QWR; -. DR PDBsum; 4QWS; -. DR PDBsum; 4QWU; -. DR PDBsum; 4QWX; -. DR PDBsum; 4QXJ; -. DR PDBsum; 4QZ0; -. DR PDBsum; 4QZ1; -. DR PDBsum; 4QZ2; -. DR PDBsum; 4QZ3; -. DR PDBsum; 4QZ4; -. DR PDBsum; 4QZ5; -. DR PDBsum; 4QZ6; -. DR PDBsum; 4QZ7; -. DR PDBsum; 4QZW; -. DR PDBsum; 4QZX; -. DR PDBsum; 4QZZ; -. DR PDBsum; 4R00; -. DR PDBsum; 4R02; -. DR PDBsum; 4R17; -. DR PDBsum; 4R18; -. DR PDBsum; 4RUR; -. DR PDBsum; 4V7O; -. DR PDBsum; 4X6Z; -. DR PDBsum; 4Y69; -. DR PDBsum; 4Y6A; -. DR PDBsum; 4Y6V; -. DR PDBsum; 4Y6Z; -. DR PDBsum; 4Y70; -. DR PDBsum; 4Y74; -. DR PDBsum; 4Y75; -. DR PDBsum; 4Y77; -. DR PDBsum; 4Y78; -. DR PDBsum; 4Y7W; -. DR PDBsum; 4Y7X; -. DR PDBsum; 4Y7Y; -. DR PDBsum; 4Y80; -. DR PDBsum; 4Y81; -. DR PDBsum; 4Y82; -. DR PDBsum; 4Y84; -. DR PDBsum; 4Y8G; -. DR PDBsum; 4Y8H; -. DR PDBsum; 4Y8I; -. DR PDBsum; 4Y8J; -. DR PDBsum; 4Y8K; -. DR PDBsum; 4Y8L; -. DR PDBsum; 4Y8M; -. DR PDBsum; 4Y8N; -. DR PDBsum; 4Y8O; -. DR PDBsum; 4Y8P; -. DR PDBsum; 4Y8Q; -. DR PDBsum; 4Y8R; -. DR PDBsum; 4Y8S; -. DR PDBsum; 4Y8T; -. DR PDBsum; 4Y8U; -. DR PDBsum; 4Y9Y; -. DR PDBsum; 4Y9Z; -. DR PDBsum; 4YA0; -. DR PDBsum; 4YA1; -. DR PDBsum; 4YA2; -. DR PDBsum; 4YA3; -. DR PDBsum; 4YA4; -. DR PDBsum; 4YA5; -. DR PDBsum; 4YA7; -. DR PDBsum; 4YA9; -. DR PDBsum; 4Z1L; -. DR PDBsum; 5A5B; -. DR PDBsum; 5AHJ; -. DR PDBsum; 5BOU; -. DR PDBsum; 5BXL; -. DR PDBsum; 5BXN; -. DR PDBsum; 5CGF; -. DR PDBsum; 5CGG; -. DR PDBsum; 5CGH; -. DR PDBsum; 5CGI; -. DR PDBsum; 5CZ4; -. DR PDBsum; 5CZ5; -. DR PDBsum; 5CZ6; -. DR PDBsum; 5CZ7; -. DR PDBsum; 5CZ8; -. DR PDBsum; 5CZ9; -. DR PDBsum; 5CZA; -. DR PDBsum; 5D0S; -. DR PDBsum; 5D0T; -. DR PDBsum; 5D0V; -. DR PDBsum; 5D0W; -. DR PDBsum; 5D0X; -. DR PDBsum; 5D0Z; -. DR PDBsum; 5DKI; -. DR PDBsum; 5DKJ; -. DR PDBsum; 5FG7; -. DR PDBsum; 5FG9; -. DR PDBsum; 5FGA; -. DR PDBsum; 5FGD; -. DR PDBsum; 5FGE; -. DR PDBsum; 5FGF; -. DR PDBsum; 5FGG; -. DR PDBsum; 5FGH; -. DR PDBsum; 5FGI; -. DR PDBsum; 5FHS; -. DR PDBsum; 5JHR; -. DR PDBsum; 5JHS; -. DR PDBsum; 5L52; -. DR PDBsum; 5L54; -. DR PDBsum; 5L55; -. DR PDBsum; 5L5A; -. DR PDBsum; 5L5B; -. DR PDBsum; 5L5D; -. DR PDBsum; 5L5E; -. DR PDBsum; 5L5F; -. DR PDBsum; 5L5H; -. DR PDBsum; 5L5I; -. DR PDBsum; 5L5J; -. DR PDBsum; 5L5O; -. DR PDBsum; 5L5P; -. DR PDBsum; 5L5Q; -. DR PDBsum; 5L5R; -. DR PDBsum; 5L5S; -. DR PDBsum; 5L5T; -. DR PDBsum; 5L5U; -. DR PDBsum; 5L5V; -. DR PDBsum; 5L5W; -. DR PDBsum; 5L5X; -. DR PDBsum; 5L5Y; -. DR PDBsum; 5L5Z; -. DR PDBsum; 5L60; -. DR PDBsum; 5L61; -. DR PDBsum; 5L62; -. DR PDBsum; 5L63; -. DR PDBsum; 5L64; -. DR PDBsum; 5L65; -. DR PDBsum; 5L66; -. DR PDBsum; 5L67; -. DR PDBsum; 5L68; -. DR PDBsum; 5L69; -. DR PDBsum; 5L6A; -. DR PDBsum; 5L6B; -. DR PDBsum; 5L6C; -. DR PDBsum; 5LAI; -. DR PDBsum; 5LAJ; -. DR PDBsum; 5LTT; -. DR PDBsum; 5M2B; -. DR PDBsum; 5MP9; -. DR PDBsum; 5MPA; -. DR PDBsum; 5MPB; -. DR PDBsum; 5MPC; -. DR PDBsum; 5NIF; -. DR PDBsum; 5WVI; -. DR PDBsum; 5WVK; -. DR PDBsum; 6EF0; -. DR PDBsum; 6EF1; -. DR PDBsum; 6EF2; -. DR PDBsum; 6EF3; -. DR PDBsum; 6FVT; -. DR PDBsum; 6FVU; -. DR PDBsum; 6FVV; -. DR PDBsum; 6FVW; -. DR PDBsum; 6FVX; -. DR PDBsum; 6FVY; -. DR PDBsum; 6G7F; -. DR PDBsum; 6G8M; -. DR PDBsum; 6G8N; -. DR PDBsum; 6GOP; -. DR PDBsum; 6H39; -. DR PDBsum; 6HTB; -. DR PDBsum; 6HTC; -. DR PDBsum; 6HTD; -. DR PDBsum; 6HTP; -. DR PDBsum; 6HTR; -. DR PDBsum; 6HUB; -. DR PDBsum; 6HUC; -. DR PDBsum; 6HUQ; -. DR PDBsum; 6HUU; -. DR PDBsum; 6HUV; -. DR PDBsum; 6HV3; -. DR PDBsum; 6HV4; -. DR PDBsum; 6HV5; -. DR PDBsum; 6HV7; -. DR PDBsum; 6HVA; -. DR PDBsum; 6HVR; -. DR PDBsum; 6HVS; -. DR PDBsum; 6HVT; -. DR PDBsum; 6HVU; -. DR PDBsum; 6HVV; -. DR PDBsum; 6HVW; -. DR PDBsum; 6HVX; -. DR PDBsum; 6HVY; -. DR PDBsum; 6HW0; -. DR PDBsum; 6HW3; -. DR PDBsum; 6HW4; -. DR PDBsum; 6HW5; -. DR PDBsum; 6HW6; -. DR PDBsum; 6HW7; -. DR PDBsum; 6HW8; -. DR PDBsum; 6HW9; -. DR PDBsum; 6HWA; -. DR PDBsum; 6HWB; -. DR PDBsum; 6HWC; -. DR PDBsum; 6HWD; -. DR PDBsum; 6HWE; -. DR PDBsum; 6HWF; -. DR PDBsum; 6J2C; -. DR PDBsum; 6J2N; -. DR PDBsum; 6J2Q; -. DR PDBsum; 6J2X; -. DR PDBsum; 6J30; -. DR PDBsum; 6ZOU; -. DR PDBsum; 6ZP6; -. DR PDBsum; 6ZP8; -. DR PDBsum; 7LS5; -. DR PDBsum; 7LS6; -. DR PDBsum; 7LSX; -. DR PDBsum; 7O2L; -. DR PDBsum; 7QO3; -. DR PDBsum; 7QO5; -. DR PDBsum; 7TEJ; -. DR PDBsum; 7TEO; -. DR PDBsum; 8OLR; -. DR PDBsum; 8T08; -. DR PDBsum; 8T0M; -. DR AlphaFoldDB; P32379; -. DR EMDB; EMD-14082; -. DR EMDB; EMD-14084; -. DR EMDB; EMD-23502; -. DR EMDB; EMD-23503; -. DR EMDB; EMD-23508; -. DR EMDB; EMD-25847; -. DR EMDB; EMD-25848; -. DR EMDB; EMD-3534; -. DR EMDB; EMD-3535; -. DR EMDB; EMD-3536; -. DR EMDB; EMD-3537; -. DR EMDB; EMD-40938; -. DR EMDB; EMD-40944; -. DR EMDB; EMD-4321; -. DR EMDB; EMD-4322; -. DR EMDB; EMD-4323; -. DR EMDB; EMD-4324; -. DR EMDB; EMD-6693; -. DR EMDB; EMD-6694; -. DR EMDB; EMD-9042; -. DR EMDB; EMD-9043; -. DR EMDB; EMD-9044; -. DR EMDB; EMD-9045; -. DR EMDB; EMD-9769; -. DR EMDB; EMD-9770; -. DR EMDB; EMD-9771; -. DR EMDB; EMD-9772; -. DR EMDB; EMD-9773; -. DR SMR; P32379; -. DR BioGRID; 33504; 203. DR ComplexPortal; CPX-2262; 26S Proteasome complex. DR DIP; DIP-1193N; -. DR IntAct; P32379; 13. DR MINT; P32379; -. DR STRING; 4932.YGR253C; -. DR iPTMnet; P32379; -. DR MaxQB; P32379; -. DR PaxDb; 4932-YGR253C; -. DR PeptideAtlas; P32379; -. DR EnsemblFungi; YGR253C_mRNA; YGR253C; YGR253C. DR GeneID; 853168; -. DR KEGG; sce:YGR253C; -. DR AGR; SGD:S000003485; -. DR SGD; S000003485; PUP2. DR VEuPathDB; FungiDB:YGR253C; -. DR eggNOG; KOG0176; Eukaryota. DR GeneTree; ENSGT00550000074958; -. DR HOGENOM; CLU_035750_4_2_1; -. DR InParanoid; P32379; -. DR OMA; FWFTYNR; -. DR OrthoDB; 166567at2759; -. DR BioCyc; YEAST:G3O-30926-MONOMER; -. DR Reactome; R-SCE-1236978; Cross-presentation of soluble exogenous antigens (endosomes). DR Reactome; R-SCE-5668541; TNFR2 non-canonical NF-kB pathway. DR Reactome; R-SCE-5689880; Ub-specific processing proteases. DR Reactome; R-SCE-6798695; Neutrophil degranulation. DR BioGRID-ORCS; 853168; 9 hits in 10 CRISPR screens. DR EvolutionaryTrace; P32379; -. DR PRO; PR:P32379; -. DR Proteomes; UP000002311; Chromosome VII. DR RNAct; P32379; Protein. DR GO; GO:0005634; C:nucleus; IBA:GO_Central. DR GO; GO:0000502; C:proteasome complex; IPI:ComplexPortal. DR GO; GO:0019773; C:proteasome core complex, alpha-subunit complex; IDA:SGD. DR GO; GO:0034515; C:proteasome storage granule; IDA:SGD. DR GO; GO:0010498; P:proteasomal protein catabolic process; IBA:GO_Central. DR GO; GO:0010499; P:proteasomal ubiquitin-independent protein catabolic process; IDA:SGD. DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IDA:SGD. DR CDD; cd03753; proteasome_alpha_type_5; 1. DR Gene3D; 3.60.20.10; Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1; 1. DR InterPro; IPR029055; Ntn_hydrolases_N. DR InterPro; IPR023332; Proteasome_alpha-type. DR InterPro; IPR033812; Proteasome_alpha_type_5. DR InterPro; IPR000426; Proteasome_asu_N. DR InterPro; IPR001353; Proteasome_sua/b. DR PANTHER; PTHR11599:SF14; PROTEASOME SUBUNIT ALPHA TYPE-5; 1. DR PANTHER; PTHR11599; PROTEASOME SUBUNIT ALPHA/BETA; 1. DR Pfam; PF00227; Proteasome; 1. DR Pfam; PF10584; Proteasome_A_N; 1. DR SMART; SM00948; Proteasome_A_N; 1. DR SUPFAM; SSF56235; N-terminal nucleophile aminohydrolases (Ntn hydrolases); 1. DR PROSITE; PS00388; PROTEASOME_ALPHA_1; 1. DR PROSITE; PS51475; PROTEASOME_ALPHA_2; 1. PE 1: Evidence at protein level; KW 3D-structure; Cytoplasm; Nucleus; Phosphoprotein; Proteasome; KW Reference proteome. FT CHAIN 1..260 FT /note="Proteasome subunit alpha type-5" FT /id="PRO_0000124129" FT MOD_RES 55 FT /note="Phosphothreonine" FT /evidence="ECO:0007744|PubMed:17330950" FT MOD_RES 56 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:17330950" FT MOD_RES 251 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:17330950, FT ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198" FT MUTAGEN 49 FT /note="G->D: In DOA5-1; slight decrease in activity." FT /evidence="ECO:0000269|PubMed:7781614" FT CONFLICT 192 FT /note="T -> S (in Ref. 1; CAA46111)" FT /evidence="ECO:0000305" FT TURN 8..10 FT /evidence="ECO:0007829|PDB:8T08" FT STRAND 19..21 FT /evidence="ECO:0007829|PDB:7TEJ" FT HELIX 22..31 FT /evidence="ECO:0007829|PDB:1RYP" FT STRAND 37..41 FT /evidence="ECO:0007829|PDB:1RYP" FT STRAND 46..51 FT /evidence="ECO:0007829|PDB:1RYP" FT STRAND 55..59 FT /evidence="ECO:0007829|PDB:1G65" FT HELIX 61..63 FT /evidence="ECO:0007829|PDB:1RYP" FT STRAND 67..71 FT /evidence="ECO:0007829|PDB:1RYP" FT STRAND 74..81 FT /evidence="ECO:0007829|PDB:1RYP" FT HELIX 82..84 FT /evidence="ECO:0007829|PDB:1RYP" FT HELIX 85..103 FT /evidence="ECO:0007829|PDB:1RYP" FT HELIX 109..117 FT /evidence="ECO:0007829|PDB:1RYP" FT TURN 118..121 FT /evidence="ECO:0007829|PDB:1RYP" FT STRAND 124..126 FT /evidence="ECO:0007829|PDB:1RYP" FT STRAND 128..130 FT /evidence="ECO:0007829|PDB:4LTC" FT STRAND 134..136 FT /evidence="ECO:0007829|PDB:1RYP" FT STRAND 139..148 FT /evidence="ECO:0007829|PDB:1RYP" FT TURN 149..151 FT /evidence="ECO:0007829|PDB:1RYP" FT STRAND 152..158 FT /evidence="ECO:0007829|PDB:1RYP" FT TURN 160..162 FT /evidence="ECO:0007829|PDB:4G4S" FT STRAND 164..173 FT /evidence="ECO:0007829|PDB:1RYP" FT HELIX 176..186 FT /evidence="ECO:0007829|PDB:1RYP" FT HELIX 193..207 FT /evidence="ECO:0007829|PDB:1RYP" FT STRAND 208..210 FT /evidence="ECO:0007829|PDB:1FNT" FT STRAND 216..223 FT /evidence="ECO:0007829|PDB:1RYP" FT TURN 224..226 FT /evidence="ECO:0007829|PDB:1RYP" FT STRAND 227..230 FT /evidence="ECO:0007829|PDB:1RYP" FT HELIX 233..247 FT /evidence="ECO:0007829|PDB:1RYP" SQ SEQUENCE 260 AA; 28617 MW; E8EDEB212BF4EC6E CRC64; MFLTRSEYDR GVSTFSPEGR LFQVEYSLEA IKLGSTAIGI ATKEGVVLGV EKRATSPLLE SDSIEKIVEI DRHIGCAMSG LTADARSMIE HARTAAVTHN LYYDEDINVE SLTQSVCDLA LRFGEGASGE ERLMSRPFGV ALLIAGHDAD DGYQLFHAEP SGTFYRYNAK AIGSGSEGAQ AELLNEWHSS LTLKEAELLV LKILKQVMEE KLDENNAQLS CITKQDGFKI YDNEKTAELI KELKEKEAAE SPEEADVEMS //