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P32375

- ALN_YEAST

UniProt

P32375 - ALN_YEAST

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Protein

Allantoinase

Gene
DAL1, YIR027C
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Utilization of purines as secondary nitrogen sources, when primary sources are limiting.

Catalytic activityi

(S)-allantoin + H2O = allantoate.

Cofactori

Binds 2 zinc ions per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi70 – 701Zinc 1 By similarity
Metal bindingi72 – 721Zinc 1 By similarity
Metal bindingi157 – 1571Zinc 1; via carbamate group By similarity
Metal bindingi157 – 1571Zinc 2; via carbamate group By similarity
Metal bindingi193 – 1931Zinc 2 By similarity
Metal bindingi250 – 2501Zinc 2 By similarity
Metal bindingi323 – 3231Zinc 1 By similarity

GO - Molecular functioni

  1. allantoinase activity Source: SGD
  2. cobalt ion binding Source: InterPro
  3. endodeoxyribonuclease activity, producing 5'-phosphomonoesters Source: InterPro
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. allantoin assimilation pathway Source: SGD
  2. purine nucleobase metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Purine metabolism

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciMetaCyc:YIR027C-MONOMER.
YEAST:YIR027C-MONOMER.
UniPathwayiUPA00395; UER00653.

Names & Taxonomyi

Protein namesi
Recommended name:
Allantoinase (EC:3.5.2.5)
Gene namesi
Name:DAL1
Ordered Locus Names:YIR027C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome IX

Organism-specific databases

CYGDiYIR027c.
SGDiS000001466. DAL1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 460460AllantoinasePRO_0000165939Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei157 – 1571N6-carboxylysine By similarity

Post-translational modificationi

Carbamylation allows a single lysine to coordinate two zinc ions By similarity.

Proteomic databases

PaxDbiP32375.

Expressioni

Gene expression databases

GenevestigatoriP32375.

Interactioni

Subunit structurei

Homotetramer By similarity.

Protein-protein interaction databases

BioGridi35018. 23 interactions.
DIPiDIP-4280N.
MINTiMINT-509404.
STRINGi4932.YIR027C.

Structurei

3D structure databases

ProteinModelPortaliP32375.
SMRiP32375. Positions 11-455.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0044.
GeneTreeiENSGT00740000115468.
HOGENOMiHOG000219146.
KOiK01466.
OMAiSTHIKEG.
OrthoDBiEOG7K9KC6.

Family and domain databases

Gene3Di2.30.40.10. 2 hits.
InterProiIPR017593. Allantoinase.
IPR006680. Amidohydro_1.
IPR002195. Dihydroorotase_CS.
IPR018228. DNase_TatD-rel_CS.
IPR011059. Metal-dep_hydrolase_composite.
[Graphical view]
PfamiPF01979. Amidohydro_1. 1 hit.
[Graphical view]
SUPFAMiSSF51338. SSF51338. 1 hit.
TIGRFAMsiTIGR03178. allantoinase. 1 hit.
PROSITEiPS00482. DIHYDROOROTASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32375-1 [UniParc]FASTAAdd to Basket

« Hide

MPINAITSDH VIINGANKPA TIVYSTESGT ILDVLEGSVV MEKTEITKYE    50
IHTLENVSPC TILPGLVDSH VHLNEPGRTS WEGFETGTQA AISGGVTTVV 100
DMPLNAIPPT TNVENFRIKL EAAEGQMWCD VGFWGGLVPH NLPDLIPLVK 150
AGVRGFKGFL LDSGVEEFPP IGKEYIEEAL KVLAEEDTMM MFHAELPKAH 200
EDQQQPEQSH REYSSFLSSR PDSFEIDAIN LILECLRARN GPVPPVHIVH 250
LASMKAIPLI RKARASGLPV TTETCFHYLC IAAEQIPDGA TYFKCCPPIR 300
SESNRQGLWD ALREGVIGSV VSDHSPCTPE LKNLQKGDFF DSWGGIASVG 350
LGLPLMFTQG CSLVDIVTWC CKNTSHQVGL SHQKGTIAPG YDADLVVFDT 400
ASKHKISNSS VYFKNKLTAY NGMTVKGTVL KTILRGQVVY TNANGVSKTP 450
LGQTLLDSRR 460
Length:460
Mass (Da):50,126
Last modified:February 1, 1995 - v2
Checksum:i887480809B6A8F42
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti438 – 46023VVYTN…LDSRR → WYIRMPTESRKHHWVKLCLI LDVKLKLQIFIKEIL in AAA34553. 1 PublicationAdd
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M69294 Genomic DNA. Translation: AAA34553.1.
Z38061 Genomic DNA. Translation: CAA86187.1.
BK006942 Genomic DNA. Translation: DAA08574.1.
PIRiS48489.
RefSeqiNP_012293.3. NM_001179549.3.

Genome annotation databases

EnsemblFungiiYIR027C; YIR027C; YIR027C.
GeneIDi854845.
KEGGisce:YIR027C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M69294 Genomic DNA. Translation: AAA34553.1 .
Z38061 Genomic DNA. Translation: CAA86187.1 .
BK006942 Genomic DNA. Translation: DAA08574.1 .
PIRi S48489.
RefSeqi NP_012293.3. NM_001179549.3.

3D structure databases

ProteinModelPortali P32375.
SMRi P32375. Positions 11-455.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35018. 23 interactions.
DIPi DIP-4280N.
MINTi MINT-509404.
STRINGi 4932.YIR027C.

Proteomic databases

PaxDbi P32375.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YIR027C ; YIR027C ; YIR027C .
GeneIDi 854845.
KEGGi sce:YIR027C.

Organism-specific databases

CYGDi YIR027c.
SGDi S000001466. DAL1.

Phylogenomic databases

eggNOGi COG0044.
GeneTreei ENSGT00740000115468.
HOGENOMi HOG000219146.
KOi K01466.
OMAi STHIKEG.
OrthoDBi EOG7K9KC6.

Enzyme and pathway databases

UniPathwayi UPA00395 ; UER00653 .
BioCyci MetaCyc:YIR027C-MONOMER.
YEAST:YIR027C-MONOMER.

Miscellaneous databases

NextBioi 977734.
PROi P32375.

Gene expression databases

Genevestigatori P32375.

Family and domain databases

Gene3Di 2.30.40.10. 2 hits.
InterProi IPR017593. Allantoinase.
IPR006680. Amidohydro_1.
IPR002195. Dihydroorotase_CS.
IPR018228. DNase_TatD-rel_CS.
IPR011059. Metal-dep_hydrolase_composite.
[Graphical view ]
Pfami PF01979. Amidohydro_1. 1 hit.
[Graphical view ]
SUPFAMi SSF51338. SSF51338. 1 hit.
TIGRFAMsi TIGR03178. allantoinase. 1 hit.
PROSITEi PS00482. DIHYDROOROTASE_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The allantoinase (DAL1) gene of Saccharomyces cerevisiae."
    Buckholz R.G., Cooper T.G.
    Yeast 7:913-923(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Erratum
    Buckholz R.G., Cooper T.G.
    Yeast 8:239-239(1992)
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.

Entry informationi

Entry nameiALN_YEAST
AccessioniPrimary (citable) accession number: P32375
Secondary accession number(s): D6VVV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: February 1, 1995
Last modified: June 11, 2014
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

External Data

Dasty 3

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