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Protein

Kinesin-related protein SMY1

Gene

SMY1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Possible microtubule-based motor that can interact or substitute with myosin 2 (MYO2).

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi114 – 1218ATPPROSITE-ProRule annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • microtubule motor activity Source: InterPro
  • motor activity Source: SGD

GO - Biological processi

  • exocytosis Source: SGD
  • microtubule-based movement Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-31874-MONOMER.
ReactomeiR-SCE-6811434. COPI-dependent Golgi-to-ER retrograde traffic.
R-SCE-983189. Kinesins.

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-related protein SMY1
Alternative name(s):
Suppressor protein SMY1
Gene namesi
Name:SMY1
Ordered Locus Names:YKL079W
ORF Names:YKL409
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKL079W.
SGDiS000001562. SMY1.

Subcellular locationi

GO - Cellular componenti

  • cellular bud neck Source: SGD
  • cellular bud tip Source: SGD
  • cytoplasm Source: UniProtKB-KW
  • incipient cellular bud site Source: SGD
  • mating projection tip Source: SGD
  • microtubule Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 656656Kinesin-related protein SMY1PRO_0000125454Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei583 – 5831PhosphothreonineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP32364.

PTM databases

iPTMnetiP32364.

Interactioni

Protein-protein interaction databases

BioGridi34053. 156 interactions.
DIPiDIP-4476N.
IntActiP32364. 3 interactions.
MINTiMINT-473438.

Structurei

3D structure databases

ProteinModelPortaliP32364.
SMRiP32364. Positions 28-371.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 364338Kinesin motorPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation
Contains 1 kinesin motor domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00830000128292.
InParanoidiP32364.
KOiK10396.
OMAiNTNENEM.
OrthoDBiEOG092C2D4G.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 2 hits.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32364-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHWNIISKEQ SSSSVSLPTL DSSEPCHIEV ILRAIPEKGL QNNESTFKID
60 70 80 90 100
PYENTVLFRT NNPLHETTKE THSTFQFDKV FDANATQEDV QKFLVHPIIN
110 120 130 140 150
DVLNGYNGTV ITYGPSFSGK SYSLIGSKES EGILPNICKT LFDTLEKNEE
160 170 180 190 200
TKGDSFSVSV LAFEIYMEKT YDLLVPLPER KPLKLHRSSS KMDLEIKDIC
210 220 230 240 250
PAHVGSYEDL RSYIQAVQNV GNRMACGDKT ERSRSHLVFQ LHVEQRNRKD
260 270 280 290 300
DILKNSSLYL VDLHGAEKFD KRTESTLSQD ALKKLNQSIE ALKNTVRSLS
310 320 330 340 350
MKERDSAYSA KGSHSSAYRE SQLTEVLKDS LGGNRKTKVI LTCFLSNVPT
360 370 380 390 400
TLSTLEFGDS IRQINNKVTD NTTGLNLKKK MDLFIQDMKI KDDNYVAQIN
410 420 430 440 450
ILKAEIDSLK SLHNKSLPED DEKKMLENTK KENIKLKLQL DSITQLLSSS
460 470 480 490 500
TNEDPNNRID EEVSEILTKR CEQIAQLELS FDRQMNSNSK LQQELEYKKS
510 520 530 540 550
KEEALESMNV RLLEQIQLQE REIQELLTTN AILKGELETH TKLTETRSER
560 570 580 590 600
IKSLESSVKE LSLNKSAIPS PRRGSMSSSS GNTMLHIEEG SEISNSPWSA
610 620 630 640 650
NTSSKPLVWG ARKVSSSSIA TTGSQESFVA RPFKKGLNLH SIKVTSSTPK

SPSSGS
Length:656
Mass (Da):73,799
Last modified:October 1, 1993 - v1
Checksum:iEC070EADE9EC88BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77143 Genomic DNA. Translation: AAA34441.1.
M69021 Genomic DNA. Translation: AAA35056.1.
X75560 Genomic DNA. Translation: CAA53238.1.
Z28079 Genomic DNA. Translation: CAA81916.1.
BK006944 Genomic DNA. Translation: DAA09078.1.
PIRiS25732.
RefSeqiNP_012844.1. NM_001179645.1.

Genome annotation databases

EnsemblFungiiYKL079W; YKL079W; YKL079W.
GeneIDi853783.
KEGGisce:YKL079W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77143 Genomic DNA. Translation: AAA34441.1.
M69021 Genomic DNA. Translation: AAA35056.1.
X75560 Genomic DNA. Translation: CAA53238.1.
Z28079 Genomic DNA. Translation: CAA81916.1.
BK006944 Genomic DNA. Translation: DAA09078.1.
PIRiS25732.
RefSeqiNP_012844.1. NM_001179645.1.

3D structure databases

ProteinModelPortaliP32364.
SMRiP32364. Positions 28-371.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34053. 156 interactions.
DIPiDIP-4476N.
IntActiP32364. 3 interactions.
MINTiMINT-473438.

PTM databases

iPTMnetiP32364.

Proteomic databases

MaxQBiP32364.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYKL079W; YKL079W; YKL079W.
GeneIDi853783.
KEGGisce:YKL079W.

Organism-specific databases

EuPathDBiFungiDB:YKL079W.
SGDiS000001562. SMY1.

Phylogenomic databases

GeneTreeiENSGT00830000128292.
InParanoidiP32364.
KOiK10396.
OMAiNTNENEM.
OrthoDBiEOG092C2D4G.

Enzyme and pathway databases

BioCyciYEAST:G3O-31874-MONOMER.
ReactomeiR-SCE-6811434. COPI-dependent Golgi-to-ER retrograde traffic.
R-SCE-983189. Kinesins.

Miscellaneous databases

PROiP32364.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 2 hits.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSMY1_YEAST
AccessioniPrimary (citable) accession number: P32364
Secondary accession number(s): D6VXK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: September 7, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1920 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.