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Protein

Kinesin-related protein SMY1

Gene

SMY1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Possible microtubule-based motor that can interact or substitute with myosin 2 (MYO2).

Miscellaneous

Present with 1920 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi114 – 121ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATPase activity Source: GO_Central
  • ATP binding Source: UniProtKB-KW
  • microtubule binding Source: InterPro
  • microtubule motor activity Source: GO_Central
  • motor activity Source: SGD

GO - Biological processi

  • microtubule-based movement Source: GO_Central
  • vesicle docking involved in exocytosis Source: SGD

Keywordsi

Molecular functionMotor protein
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-31874-MONOMER
ReactomeiR-SCE-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-SCE-983189 Kinesins

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-related protein SMY1
Alternative name(s):
Suppressor protein SMY1
Gene namesi
Name:SMY1
Ordered Locus Names:YKL079W
ORF Names:YKL409
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKL079W
SGDiS000001562 SMY1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001254541 – 656Kinesin-related protein SMY1Add BLAST656

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei583PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP32364
PaxDbiP32364
PRIDEiP32364

PTM databases

iPTMnetiP32364

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi34053, 210 interactors
DIPiDIP-4476N
IntActiP32364, 3 interactors
MINTiP32364
STRINGi4932.YKL079W

Structurei

3D structure databases

ProteinModelPortaliP32364
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 364Kinesin motorPROSITE-ProRule annotationAdd BLAST338

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00650000093360
InParanoidiP32364
KOiK10396
OMAiVKYDADT
OrthoDBiEOG092C2D4G

Family and domain databases

Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
PANTHERiPTHR24115 PTHR24115, 1 hit
PfamiView protein in Pfam
PF00225 Kinesin, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit

Sequencei

Sequence statusi: Complete.

P32364-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHWNIISKEQ SSSSVSLPTL DSSEPCHIEV ILRAIPEKGL QNNESTFKID
60 70 80 90 100
PYENTVLFRT NNPLHETTKE THSTFQFDKV FDANATQEDV QKFLVHPIIN
110 120 130 140 150
DVLNGYNGTV ITYGPSFSGK SYSLIGSKES EGILPNICKT LFDTLEKNEE
160 170 180 190 200
TKGDSFSVSV LAFEIYMEKT YDLLVPLPER KPLKLHRSSS KMDLEIKDIC
210 220 230 240 250
PAHVGSYEDL RSYIQAVQNV GNRMACGDKT ERSRSHLVFQ LHVEQRNRKD
260 270 280 290 300
DILKNSSLYL VDLHGAEKFD KRTESTLSQD ALKKLNQSIE ALKNTVRSLS
310 320 330 340 350
MKERDSAYSA KGSHSSAYRE SQLTEVLKDS LGGNRKTKVI LTCFLSNVPT
360 370 380 390 400
TLSTLEFGDS IRQINNKVTD NTTGLNLKKK MDLFIQDMKI KDDNYVAQIN
410 420 430 440 450
ILKAEIDSLK SLHNKSLPED DEKKMLENTK KENIKLKLQL DSITQLLSSS
460 470 480 490 500
TNEDPNNRID EEVSEILTKR CEQIAQLELS FDRQMNSNSK LQQELEYKKS
510 520 530 540 550
KEEALESMNV RLLEQIQLQE REIQELLTTN AILKGELETH TKLTETRSER
560 570 580 590 600
IKSLESSVKE LSLNKSAIPS PRRGSMSSSS GNTMLHIEEG SEISNSPWSA
610 620 630 640 650
NTSSKPLVWG ARKVSSSSIA TTGSQESFVA RPFKKGLNLH SIKVTSSTPK

SPSSGS
Length:656
Mass (Da):73,799
Last modified:October 1, 1993 - v1
Checksum:iEC070EADE9EC88BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77143 Genomic DNA Translation: AAA34441.1
M69021 Genomic DNA Translation: AAA35056.1
X75560 Genomic DNA Translation: CAA53238.1
Z28079 Genomic DNA Translation: CAA81916.1
BK006944 Genomic DNA Translation: DAA09078.1
PIRiS25732
RefSeqiNP_012844.1, NM_001179645.1

Genome annotation databases

EnsemblFungiiYKL079W; YKL079W; YKL079W
GeneIDi853783
KEGGisce:YKL079W

Similar proteinsi

Entry informationi

Entry nameiSMY1_YEAST
AccessioniPrimary (citable) accession number: P32364
Secondary accession number(s): D6VXK8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: May 23, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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