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Protein

Kinesin-related protein SMY1

Gene

SMY1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Possible microtubule-based motor that can interact or substitute with myosin 2 (MYO2).

Miscellaneous

Present with 1920 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi114 – 121ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATPase activity Source: GO_Central
  • ATP binding Source: UniProtKB-KW
  • microtubule binding Source: InterPro
  • microtubule motor activity Source: GO_Central
  • motor activity Source: SGD

GO - Biological processi

  • microtubule-based movement Source: GO_Central
  • vesicle docking involved in exocytosis Source: SGD

Keywordsi

Molecular functionMotor protein
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-31874-MONOMER.
ReactomeiR-SCE-6811434. COPI-dependent Golgi-to-ER retrograde traffic.
R-SCE-983189. Kinesins.

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-related protein SMY1
Alternative name(s):
Suppressor protein SMY1
Gene namesi
Name:SMY1
Ordered Locus Names:YKL079W
ORF Names:YKL409
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKL079W.
SGDiS000001562. SMY1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001254541 – 656Kinesin-related protein SMY1Add BLAST656

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei583PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP32364.
PRIDEiP32364.

PTM databases

iPTMnetiP32364.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi34053. 207 interactors.
DIPiDIP-4476N.
IntActiP32364. 3 interactors.
MINTiMINT-473438.
STRINGi4932.YKL079W.

Structurei

3D structure databases

ProteinModelPortaliP32364.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 364Kinesin motorPROSITE-ProRule annotationAdd BLAST338

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00650000093360.
InParanoidiP32364.
KOiK10396.
OMAiQIVITSW.
OrthoDBiEOG092C2D4G.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiView protein in InterPro
IPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR036961. Kinesin_motor_dom_sf.
IPR027417. P-loop_NTPase.
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiView protein in Pfam
PF00225. Kinesin. 1 hit.
PRINTSiPR00380. KINESINHEAVY.
SMARTiView protein in SMART
SM00129. KISc. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P32364-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHWNIISKEQ SSSSVSLPTL DSSEPCHIEV ILRAIPEKGL QNNESTFKID
60 70 80 90 100
PYENTVLFRT NNPLHETTKE THSTFQFDKV FDANATQEDV QKFLVHPIIN
110 120 130 140 150
DVLNGYNGTV ITYGPSFSGK SYSLIGSKES EGILPNICKT LFDTLEKNEE
160 170 180 190 200
TKGDSFSVSV LAFEIYMEKT YDLLVPLPER KPLKLHRSSS KMDLEIKDIC
210 220 230 240 250
PAHVGSYEDL RSYIQAVQNV GNRMACGDKT ERSRSHLVFQ LHVEQRNRKD
260 270 280 290 300
DILKNSSLYL VDLHGAEKFD KRTESTLSQD ALKKLNQSIE ALKNTVRSLS
310 320 330 340 350
MKERDSAYSA KGSHSSAYRE SQLTEVLKDS LGGNRKTKVI LTCFLSNVPT
360 370 380 390 400
TLSTLEFGDS IRQINNKVTD NTTGLNLKKK MDLFIQDMKI KDDNYVAQIN
410 420 430 440 450
ILKAEIDSLK SLHNKSLPED DEKKMLENTK KENIKLKLQL DSITQLLSSS
460 470 480 490 500
TNEDPNNRID EEVSEILTKR CEQIAQLELS FDRQMNSNSK LQQELEYKKS
510 520 530 540 550
KEEALESMNV RLLEQIQLQE REIQELLTTN AILKGELETH TKLTETRSER
560 570 580 590 600
IKSLESSVKE LSLNKSAIPS PRRGSMSSSS GNTMLHIEEG SEISNSPWSA
610 620 630 640 650
NTSSKPLVWG ARKVSSSSIA TTGSQESFVA RPFKKGLNLH SIKVTSSTPK

SPSSGS
Length:656
Mass (Da):73,799
Last modified:October 1, 1993 - v1
Checksum:iEC070EADE9EC88BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77143 Genomic DNA. Translation: AAA34441.1.
M69021 Genomic DNA. Translation: AAA35056.1.
X75560 Genomic DNA. Translation: CAA53238.1.
Z28079 Genomic DNA. Translation: CAA81916.1.
BK006944 Genomic DNA. Translation: DAA09078.1.
PIRiS25732.
RefSeqiNP_012844.1. NM_001179645.1.

Genome annotation databases

EnsemblFungiiYKL079W; YKL079W; YKL079W.
GeneIDi853783.
KEGGisce:YKL079W.

Similar proteinsi

Entry informationi

Entry nameiSMY1_YEAST
AccessioniPrimary (citable) accession number: P32364
Secondary accession number(s): D6VXK8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: November 22, 2017
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names