P32351 (IMPX_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sugar utilization regulatory protein IMP2

Gene names

Name:	IMP2'
Synonyms:	IMP2
Ordered Locus Names:	YIL154C

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	346 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Controls the nucleo-mitochondrial dependence of galactose, maltose and raffinose utilization. Becomes essential in the absence of functioning mitochondria.
Miscellaneous	Present with 5110 molecules/cell in log phase SD medium.

Ontologies

Keywords
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA repair Inferred from mutant phenotype PubMed 8628275. Source: SGD cellular carbohydrate metabolic process Inferred from mutant phenotype Ref.1. Source: SGD
Cellular_component	cytoplasm Inferred from direct assay PubMed 14562095. Source: SGD
Molecular_function	transcription coactivator activity Inferred from direct assay PubMed 8628275. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 346	346	Sugar utilization regulatory protein IMP2		PRO_0000084187
Amino acid modifications
	Modified residue	24	1	Phosphothreonine Ref.5
Experimental info
	Sequence conflict	181	1	D → G in CAA43930. Ref.1
	Sequence conflict	279	1	D → H in CAA43930. Ref.1
	Sequence conflict	282	1	D → H in CAA43930. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P32351 [UniParc]. Last modified February 1, 1995. Version 2. Checksum: 5350D3B7E8DAE7D4	FASTA	346	39,071
	10 20 30 40 50 60 MQKSILLTKP DGTQSNLHSI KTETPTTVEF DSEQMERGHR ERGRSKKKRG ERDSNVSSLS 70 80 90 100 110 120 RSRSRASSRS RVREEEFLKW TVLRQDPSMR LRVVDVDSEE EGEGNDEDDD DGDGDDMDEE 130 140 150 160 170 180 ESDEEQVSDI ENDLEIDEEF HYDLGMKVLP NFCTSINEVL DSSKPWIAKY EISIRGHENE 190 200 210 220 230 240 DVSLEQLDGG YVRAMQLLTK GAGAEAGNQR SFILYTDLSS ESTYALTYLM GAAVNQGDTV 250 260 270 280 290 300 YIVHWEPSKP TDDSQMFANV ARIRKHVMHL FDCVAGVLDD LDVVVLSLTH PYPKHLLNEM 310 320 330 340 IHGLKPVALC CSLSVILSTL QNFVCSVPIL AVRKKLKRAK RKGISE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"IMP2, a nuclear gene controlling the mitochondrial dependence of galactose, maltose and raffinose utilization in Saccharomyces cerevisiae." Donnini C., Lodi T., Ferrero I., Puglisi P.P. Yeast 8:83-93(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-346.
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome IX." Churcher C.M., Bowman S., Badcock K., Bankier A.T., Brown D., Chillingworth T., Connor R., Devlin K., Gentles S., Hamlin N., Harris D.E., Horsnell T., Hunt S., Jagels K., Jones M., Lye G., Moule S., Odell C. , Pearson D., Rajandream M.A., Rice P., Rowley N., Skelton J., Smith V., Walsh S.V., Whitehead S., Barrell B.G. Nature 387:84-87(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]	"Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae." Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P. J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-24, MASS SPECTROMETRY. Strain: ADR376.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z38059 Genomic DNA. Translation: CAA86124.1. X61928 Genomic DNA. Translation: CAA43930.1. BK006942 Genomic DNA. Translation: DAA08399.1.
PIR	S48380.
RefSeq	NP_012112.3. NM_001179502.3.
3D structure databases
ProteinModelPortal	P32351.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-5664N.
IntAct	P32351. 5 interactions.
MINT	MINT-543256.
STRING	4932.YIL154C.
Proteomic databases
PaxDb	P32351.
PeptideAtlas	P32351.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YIL154C; YIL154C; YIL154C.
GeneID	854652.
KEGG	sce:YIL149C. sce:YIL154C.
Organism-specific databases
CYGD	YIL154c.
SGD	S000001416. IMP2'.
Phylogenomic databases
eggNOG	NOG46919.
HOGENOM	HOG000113065.
KO	K09291.
OMA	HLLNEMI.
OrthoDB	EOG44J5SG.
Gene expression databases
Genevestigator	P32351.
GermOnline	YIL154C. Saccharomyces cerevisiae.
Family and domain databases
ProtoNet	Search...
Other
NextBio	977205.

Entry information

Entry name

IMPX_YEAST

Accession

Primary (citable) accession number: P32351
Secondary accession number(s): D6VVD3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
Last sequence update:	February 1, 1995
Last modified:	April 3, 2013
This is version 93 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program