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Protein

Vacuolar ATPase assembly integral membrane protein VPH2

Gene

VPH2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for vacuolar ATPase assembly.

GO - Biological processi

  • vacuolar acidification Source: SGD
  • vacuolar proton-transporting V-type ATPase complex assembly Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-31902-MONOMER.

Protein family/group databases

TCDBi9.B.206.2.1. the tmem199 (tmem199) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar ATPase assembly integral membrane protein VPH2
Alternative name(s):
Protein VMA12
Gene namesi
Name:VPH2
Synonyms:CLS10, VMA12
Ordered Locus Names:YKL119C
ORF Names:YKL520
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKL119C.
SGDiS000001602. VPH2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 134CytoplasmicSequence analysisAdd BLAST134
Transmembranei135 – 155HelicalSequence analysisAdd BLAST21
Topological domaini156 – 167LumenalSequence analysisAdd BLAST12
Transmembranei168 – 186HelicalSequence analysisAdd BLAST19
Topological domaini187 – 215CytoplasmicSequence analysisAdd BLAST29

GO - Cellular componenti

  • endoplasmic reticulum membrane Source: SGD
  • integral component of membrane Source: UniProtKB-KW
  • Vma12-Vma22 assembly complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000658741 – 215Vacuolar ATPase assembly integral membrane protein VPH2Add BLAST215

Proteomic databases

MaxQBiP32341.
PRIDEiP32341.

Interactioni

Protein-protein interaction databases

BioGridi34016. 223 interactors.
DIPiDIP-5907N.
IntActiP32341. 2 interactors.
MINTiMINT-687909.

Structurei

3D structure databases

ProteinModelPortaliP32341.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000246816.
InParanoidiP32341.
OMAiVTTVFNI.
OrthoDBiEOG092C4SIM.

Family and domain databases

InterProiIPR021013. ATPase_Vma12.
[Graphical view]
PfamiPF11712. Vma12. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32341-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFEIKLNDRI TEFLRKFKNS AKSNEGIDED IDLFLKRHAI PMQSLLFYVK
60 70 80 90 100
EYRKDSDLQC SIKELLKPLE FEFKPKAVRG LHYSEDFKKK LEFLKYQEQE
110 120 130 140 150
LEYQSMVKRS KSVFSLQEDD ELTPSQINKQ IKEQVTTVFN VLVSVISVVV
160 170 180 190 200
AIWYWTGSST NFPVHVRLLL CLFFGILVLV ADVVVYNSYL KKLEEAKVKE
210
KTKVEKKKVL SKITL
Length:215
Mass (Da):25,287
Last modified:October 1, 1993 - v1
Checksum:i96498A7AC1197C08
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D11472 Genomic DNA. Translation: BAA02029.1.
M93350 Genomic DNA. Translation: AAA35212.1.
Z28118 Genomic DNA. Translation: CAA81960.1.
S93804 Genomic DNA. Translation: AAB22004.1.
S44213 Genomic DNA. Translation: AAB23070.2.
BK006944 Genomic DNA. Translation: DAA09041.1.
PIRiS25358.
RefSeqiNP_012803.1. NM_001179685.1.

Genome annotation databases

EnsemblFungiiYKL119C; YKL119C; YKL119C.
GeneIDi853741.
KEGGisce:YKL119C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D11472 Genomic DNA. Translation: BAA02029.1.
M93350 Genomic DNA. Translation: AAA35212.1.
Z28118 Genomic DNA. Translation: CAA81960.1.
S93804 Genomic DNA. Translation: AAB22004.1.
S44213 Genomic DNA. Translation: AAB23070.2.
BK006944 Genomic DNA. Translation: DAA09041.1.
PIRiS25358.
RefSeqiNP_012803.1. NM_001179685.1.

3D structure databases

ProteinModelPortaliP32341.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34016. 223 interactors.
DIPiDIP-5907N.
IntActiP32341. 2 interactors.
MINTiMINT-687909.

Protein family/group databases

TCDBi9.B.206.2.1. the tmem199 (tmem199) family.

Proteomic databases

MaxQBiP32341.
PRIDEiP32341.

Protocols and materials databases

DNASUi853741.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYKL119C; YKL119C; YKL119C.
GeneIDi853741.
KEGGisce:YKL119C.

Organism-specific databases

EuPathDBiFungiDB:YKL119C.
SGDiS000001602. VPH2.

Phylogenomic databases

HOGENOMiHOG000246816.
InParanoidiP32341.
OMAiVTTVFNI.
OrthoDBiEOG092C4SIM.

Enzyme and pathway databases

BioCyciYEAST:G3O-31902-MONOMER.

Miscellaneous databases

PROiP32341.

Family and domain databases

InterProiIPR021013. ATPase_Vma12.
[Graphical view]
PfamiPF11712. Vma12. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVPH2_YEAST
AccessioniPrimary (citable) accession number: P32341
Secondary accession number(s): D6VXH1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: November 2, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2030 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.