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Protein

Mitochondrial oxaloacetate transport protein

Gene

OAC1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transports oxaloacetate and sulfate.

GO - Molecular functioni

  • isopropylmalate transmembrane transporter activity Source: SGD
  • malonate(1-) transmembrane transporter activity Source: SGD
  • oxaloacetate transmembrane transporter activity Source: SGD
  • sulfate transmembrane transporter activity Source: SGD

GO - Biological processi

  • isopropylmalate transport Source: SGD
  • oxaloacetate transport Source: SGD
  • sulfate transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31903-MONOMER.

Protein family/group databases

TCDBi2.A.29.15.1. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial oxaloacetate transport protein
Alternative name(s):
Mitochondrial carrier protein PMT
Gene namesi
Name:OAC1
Synonyms:PMT, PMT1
Ordered Locus Names:YKL120W
ORF Names:YKL522
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKL120W.
SGDiS000001603. OAC1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei79 – 99Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei132 – 152Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei193 – 213Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei233 – 253Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei284 – 305Helical; Name=6Sequence analysisAdd BLAST22

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000906891 – 324Mitochondrial oxaloacetate transport proteinAdd BLAST324

Proteomic databases

MaxQBiP32332.
PRIDEiP32332.

Interactioni

Protein-protein interaction databases

BioGridi34015. 41 interactors.
DIPiDIP-5417N.
IntActiP32332. 4 interactors.
MINTiMINT-559146.

Structurei

3D structure databases

ProteinModelPortaliP32332.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati20 – 111Solcar 1Add BLAST92
Repeati126 – 218Solcar 2Add BLAST93
Repeati227 – 312Solcar 3Add BLAST86

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00550000074760.
HOGENOMiHOG000165141.
InParanoidiP32332.
KOiK15117.
OMAiQQTYYKG.
OrthoDBiEOG092C3R1T.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32332-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSDNSKQDK QIEKTAAQKI SKFGSFVAGG LAACIAVTVT NPIELIKIRM
60 70 80 90 100
QLQGEMSASA AKVYKNPIQG MAVIFKNEGI KGLQKGLNAA YIYQIGLNGS
110 120 130 140 150
RLGFYEPIRS SLNQLFFPDQ EPHKVQSVGV NVFSGAASGI IGAVIGSPLF
160 170 180 190 200
LVKTRLQSYS EFIKIGEQTH YTGVWNGLVT IFKTEGVKGL FRGIDAAILR
210 220 230 240 250
TGAGSSVQLP IYNTAKNILV KNDLMKDGPA LHLTASTISG LGVAVVMNPW
260 270 280 290 300
DVILTRIYNQ KGDLYKGPID CLVKTVRIEG VTALYKGFAA QVFRIAPHTI
310 320
MCLTFMEQTM KLVYSIESRV LGHN
Length:324
Mass (Da):35,153
Last modified:October 1, 1993 - v1
Checksum:i696193F8979266AE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04948 Genomic DNA. Translation: AAA34886.1.
AJ238698 Genomic DNA. Translation: CAB52216.1.
S44213 Genomic DNA. Translation: AAB23071.2.
Z28120 Genomic DNA. Translation: CAA81961.1.
BK006944 Genomic DNA. Translation: DAA09040.1.
PIRiS25357.
RefSeqiNP_012802.1. NM_001179686.1.

Genome annotation databases

EnsemblFungiiYKL120W; YKL120W; YKL120W.
GeneIDi853739.
KEGGisce:YKL120W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04948 Genomic DNA. Translation: AAA34886.1.
AJ238698 Genomic DNA. Translation: CAB52216.1.
S44213 Genomic DNA. Translation: AAB23071.2.
Z28120 Genomic DNA. Translation: CAA81961.1.
BK006944 Genomic DNA. Translation: DAA09040.1.
PIRiS25357.
RefSeqiNP_012802.1. NM_001179686.1.

3D structure databases

ProteinModelPortaliP32332.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34015. 41 interactors.
DIPiDIP-5417N.
IntActiP32332. 4 interactors.
MINTiMINT-559146.

Protein family/group databases

TCDBi2.A.29.15.1. the mitochondrial carrier (mc) family.

Proteomic databases

MaxQBiP32332.
PRIDEiP32332.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYKL120W; YKL120W; YKL120W.
GeneIDi853739.
KEGGisce:YKL120W.

Organism-specific databases

EuPathDBiFungiDB:YKL120W.
SGDiS000001603. OAC1.

Phylogenomic databases

GeneTreeiENSGT00550000074760.
HOGENOMiHOG000165141.
InParanoidiP32332.
KOiK15117.
OMAiQQTYYKG.
OrthoDBiEOG092C3R1T.

Enzyme and pathway databases

BioCyciYEAST:G3O-31903-MONOMER.

Miscellaneous databases

PROiP32332.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOAC1_YEAST
AccessioniPrimary (citable) accession number: P32332
Secondary accession number(s): D6VXH0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: November 30, 2016
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 5350 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.