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P32330

- DGR2_YEAST

UniProt

P32330 - DGR2_YEAST

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Protein
2-deoxy-glucose resistant protein 2
Gene
DGR2, YKL121W, YKL525
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciYEAST:G3O-31904-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
2-deoxy-glucose resistant protein 2
Gene namesi
Name:DGR2
Ordered Locus Names:YKL121W
ORF Names:YKL525
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XI

Organism-specific databases

CYGDiYKL121w.
SGDiS000001604. DGR2.

Pathology & Biotechi

Disruption phenotypei

Increases cellular tolerance to 2-deoxy-glucose.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8528522-deoxy-glucose resistant protein 2
PRO_0000051479Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei716 – 7161Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP32330.
PaxDbiP32330.

Expressioni

Gene expression databases

GenevestigatoriP32330.

Interactioni

Protein-protein interaction databases

BioGridi34014. 26 interactions.
IntActiP32330. 1 interaction.
STRINGi4932.YKL121W.

Structurei

3D structure databases

ProteinModelPortaliP32330.
SMRiP32330. Positions 171-509.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati171 – 21040WD 1
Add
BLAST
Repeati278 – 31639WD 2
Add
BLAST
Repeati318 – 35841WD 3
Add
BLAST
Repeati426 – 47146WD 4
Add
BLAST
Repeati476 – 51540WD 5
Add
BLAST
Repeati651 – 68939WD 6
Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat DGR2 family.
Contains 6 WD repeats.

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiNOG270909.
GeneTreeiENSGT00530000063479.
OMAiKTFVHPD.
OrthoDBiEOG7CRTZ9.

Family and domain databases

Gene3Di2.130.10.10. 4 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 4 hits.
[Graphical view]
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 3 hits.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32330-1 [UniParc]FASTAAdd to Basket

« Hide

MFKSKTSTLS YDETPNSNEG DRNATPVNPK EKSQTKHLNI PGDRSRHSSI    50
ADSKRSSSRY DGGYSADIIP AQLRFIDNID YGTRLRKTLH RNSVVSNGYN 100
KLSENDRWYF DLFDRKYFEN YLEEPTYIKI FKKKEGLEQF DRMFLAQELK 150
IPDVYKSTTY QGEPAVANSE LFKNSICCCT FSHDGKYMVI GCKDGSLHLW 200
KVINSPVKRS EMGRSEKSVS ASRANSLKIQ RHLASISSHN GSISSNDLKP 250
SDQFEGPSKQ LHLYAPVFYS DVFRVFMEHA LDILDANWSK NGFLITASMD 300
KTAKLWHPER KYSLKTFVHP DFVTSAIFFP NDDRFIITGC LDHRCRLWSI 350
LDNEVSYAFD CKDLITSLTL SPPGGEYTII GTFNGYIYVL LTHGLKFVSS 400
FHVSDKSTQG TTKNSFHPSS EYGKVQHGPR ITGLQCFFSK VDKNLRLIVT 450
TNDSKIQIFD LNEKKPLELF KGFQSGSSRH RGQFLMMKNE PVVFTGSDDH 500
WFYTWKMQSF NLSAEMNCTA PHRKKRLSGS MSLKGLLRIV SNKSTNDECL 550
TETSNQSSSH TFTNSSKNVL QTQTVGSQAI KNNHYISFHA HNSPVTCASI 600
APDVAIKNLS LSNDLIFELT SQYFKEMGQN YSESKETCDN KPNHPVTETG 650
GFSSNLSNVV NNVGTILITT DSQGLIRVFR TDILPEIRKK IIEKFHEYNL 700
FHLEAAGKIN NHNNDSILEN RMDERSSTED NEFSTTPPSN THNSRPSHDF 750
CELHPNNSPV ISGMPSRASA IFKNSIFNKS NGSFISLKSR SESTSSTVFG 800
PHDIPRVSTT YPKLKCDVCN GSNFECASKN PIAGGDSGFT CADCGTILNN 850
FR 852
Length:852
Mass (Da):96,022
Last modified:October 1, 1993 - v1
Checksum:iA673BAF9AF22B608
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S44213 Genomic DNA. Translation: AAB23072.2.
Z28121 Genomic DNA. Translation: CAA81962.1.
BK006944 Genomic DNA. Translation: DAA09039.1.
PIRiS25359.
RefSeqiNP_012801.1. NM_001179687.1.

Genome annotation databases

EnsemblFungiiYKL121W; YKL121W; YKL121W.
GeneIDi853738.
KEGGisce:YKL121W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S44213 Genomic DNA. Translation: AAB23072.2 .
Z28121 Genomic DNA. Translation: CAA81962.1 .
BK006944 Genomic DNA. Translation: DAA09039.1 .
PIRi S25359.
RefSeqi NP_012801.1. NM_001179687.1.

3D structure databases

ProteinModelPortali P32330.
SMRi P32330. Positions 171-509.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 34014. 26 interactions.
IntActi P32330. 1 interaction.
STRINGi 4932.YKL121W.

Proteomic databases

MaxQBi P32330.
PaxDbi P32330.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YKL121W ; YKL121W ; YKL121W .
GeneIDi 853738.
KEGGi sce:YKL121W.

Organism-specific databases

CYGDi YKL121w.
SGDi S000001604. DGR2.

Phylogenomic databases

eggNOGi NOG270909.
GeneTreei ENSGT00530000063479.
OMAi KTFVHPD.
OrthoDBi EOG7CRTZ9.

Enzyme and pathway databases

BioCyci YEAST:G3O-31904-MONOMER.

Miscellaneous databases

NextBioi 974787.

Gene expression databases

Genevestigatori P32330.

Family and domain databases

Gene3Di 2.130.10.10. 4 hits.
InterProi IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF00400. WD40. 4 hits.
[Graphical view ]
SMARTi SM00320. WD40. 4 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 3 hits.
PROSITEi PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of a segment of yeast chromosome XI identifies a new mitochondrial carrier, a new member of the G protein family, and a protein with the PAAKK motif of the H1 histones."
    Colleaux L., Richard G.-F., Thierry A., Dujon B.
    Yeast 8:325-336(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete DNA sequence of yeast chromosome XI."
    Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
    , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
    Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "A catabolic block does not sufficiently explain how 2-deoxy-D-glucose inhibits cell growth."
    Ralser M., Wamelink M.M., Struys E.A., Joppich C., Krobitsch S., Jakobs C., Lehrach H.
    Proc. Natl. Acad. Sci. U.S.A. 105:17807-17811(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
  7. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-716, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiDGR2_YEAST
AccessioniPrimary (citable) accession number: P32330
Secondary accession number(s): D6VXG9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: May 14, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 504 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

External Data

Dasty 3

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