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P32330

- DGR2_YEAST

UniProt

P32330 - DGR2_YEAST

Protein

2-deoxy-glucose resistant protein 2

Gene

DGR2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Oct 1993)
      Previous versions | rss
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    Functioni

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31904-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2-deoxy-glucose resistant protein 2
    Gene namesi
    Name:DGR2
    Ordered Locus Names:YKL121W
    ORF Names:YKL525
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XI

    Organism-specific databases

    CYGDiYKL121w.
    SGDiS000001604. DGR2.

    Pathology & Biotechi

    Disruption phenotypei

    Increases cellular tolerance to 2-deoxy-glucose.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 8528522-deoxy-glucose resistant protein 2PRO_0000051479Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei716 – 7161Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP32330.
    PaxDbiP32330.

    Expressioni

    Gene expression databases

    GenevestigatoriP32330.

    Interactioni

    Protein-protein interaction databases

    BioGridi34014. 26 interactions.
    IntActiP32330. 1 interaction.
    STRINGi4932.YKL121W.

    Structurei

    3D structure databases

    ProteinModelPortaliP32330.
    SMRiP32330. Positions 171-509.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati171 – 21040WD 1Add
    BLAST
    Repeati278 – 31639WD 2Add
    BLAST
    Repeati318 – 35841WD 3Add
    BLAST
    Repeati426 – 47146WD 4Add
    BLAST
    Repeati476 – 51540WD 5Add
    BLAST
    Repeati651 – 68939WD 6Add
    BLAST

    Sequence similaritiesi

    Belongs to the WD repeat DGR2 family.Curated
    Contains 6 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiNOG270909.
    GeneTreeiENSGT00530000063479.
    OMAiKTFVHPD.
    OrthoDBiEOG7CRTZ9.

    Family and domain databases

    Gene3Di2.130.10.10. 4 hits.
    InterProiIPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF00400. WD40. 4 hits.
    [Graphical view]
    SMARTiSM00320. WD40. 4 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 3 hits.
    PROSITEiPS50082. WD_REPEATS_2. 1 hit.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P32330-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFKSKTSTLS YDETPNSNEG DRNATPVNPK EKSQTKHLNI PGDRSRHSSI    50
    ADSKRSSSRY DGGYSADIIP AQLRFIDNID YGTRLRKTLH RNSVVSNGYN 100
    KLSENDRWYF DLFDRKYFEN YLEEPTYIKI FKKKEGLEQF DRMFLAQELK 150
    IPDVYKSTTY QGEPAVANSE LFKNSICCCT FSHDGKYMVI GCKDGSLHLW 200
    KVINSPVKRS EMGRSEKSVS ASRANSLKIQ RHLASISSHN GSISSNDLKP 250
    SDQFEGPSKQ LHLYAPVFYS DVFRVFMEHA LDILDANWSK NGFLITASMD 300
    KTAKLWHPER KYSLKTFVHP DFVTSAIFFP NDDRFIITGC LDHRCRLWSI 350
    LDNEVSYAFD CKDLITSLTL SPPGGEYTII GTFNGYIYVL LTHGLKFVSS 400
    FHVSDKSTQG TTKNSFHPSS EYGKVQHGPR ITGLQCFFSK VDKNLRLIVT 450
    TNDSKIQIFD LNEKKPLELF KGFQSGSSRH RGQFLMMKNE PVVFTGSDDH 500
    WFYTWKMQSF NLSAEMNCTA PHRKKRLSGS MSLKGLLRIV SNKSTNDECL 550
    TETSNQSSSH TFTNSSKNVL QTQTVGSQAI KNNHYISFHA HNSPVTCASI 600
    APDVAIKNLS LSNDLIFELT SQYFKEMGQN YSESKETCDN KPNHPVTETG 650
    GFSSNLSNVV NNVGTILITT DSQGLIRVFR TDILPEIRKK IIEKFHEYNL 700
    FHLEAAGKIN NHNNDSILEN RMDERSSTED NEFSTTPPSN THNSRPSHDF 750
    CELHPNNSPV ISGMPSRASA IFKNSIFNKS NGSFISLKSR SESTSSTVFG 800
    PHDIPRVSTT YPKLKCDVCN GSNFECASKN PIAGGDSGFT CADCGTILNN 850
    FR 852
    Length:852
    Mass (Da):96,022
    Last modified:October 1, 1993 - v1
    Checksum:iA673BAF9AF22B608
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S44213 Genomic DNA. Translation: AAB23072.2.
    Z28121 Genomic DNA. Translation: CAA81962.1.
    BK006944 Genomic DNA. Translation: DAA09039.1.
    PIRiS25359.
    RefSeqiNP_012801.1. NM_001179687.1.

    Genome annotation databases

    EnsemblFungiiYKL121W; YKL121W; YKL121W.
    GeneIDi853738.
    KEGGisce:YKL121W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S44213 Genomic DNA. Translation: AAB23072.2 .
    Z28121 Genomic DNA. Translation: CAA81962.1 .
    BK006944 Genomic DNA. Translation: DAA09039.1 .
    PIRi S25359.
    RefSeqi NP_012801.1. NM_001179687.1.

    3D structure databases

    ProteinModelPortali P32330.
    SMRi P32330. Positions 171-509.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 34014. 26 interactions.
    IntActi P32330. 1 interaction.
    STRINGi 4932.YKL121W.

    Proteomic databases

    MaxQBi P32330.
    PaxDbi P32330.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YKL121W ; YKL121W ; YKL121W .
    GeneIDi 853738.
    KEGGi sce:YKL121W.

    Organism-specific databases

    CYGDi YKL121w.
    SGDi S000001604. DGR2.

    Phylogenomic databases

    eggNOGi NOG270909.
    GeneTreei ENSGT00530000063479.
    OMAi KTFVHPD.
    OrthoDBi EOG7CRTZ9.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31904-MONOMER.

    Miscellaneous databases

    NextBioi 974787.

    Gene expression databases

    Genevestigatori P32330.

    Family and domain databases

    Gene3Di 2.130.10.10. 4 hits.
    InterProi IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF00400. WD40. 4 hits.
    [Graphical view ]
    SMARTi SM00320. WD40. 4 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 3 hits.
    PROSITEi PS50082. WD_REPEATS_2. 1 hit.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence of a segment of yeast chromosome XI identifies a new mitochondrial carrier, a new member of the G protein family, and a protein with the PAAKK motif of the H1 histones."
      Colleaux L., Richard G.-F., Thierry A., Dujon B.
      Yeast 8:325-336(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Complete DNA sequence of yeast chromosome XI."
      Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
      , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
      Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    5. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. "A catabolic block does not sufficiently explain how 2-deoxy-D-glucose inhibits cell growth."
      Ralser M., Wamelink M.M., Struys E.A., Joppich C., Krobitsch S., Jakobs C., Lehrach H.
      Proc. Natl. Acad. Sci. U.S.A. 105:17807-17811(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE.
    7. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-716, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiDGR2_YEAST
    AccessioniPrimary (citable) accession number: P32330
    Secondary accession number(s): D6VXG9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: October 1, 1993
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 504 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XI
      Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

    External Data

    Dasty 3