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P32330 (DGR2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
2-deoxy-glucose resistant protein 2
Gene names
Name:DGR2
Ordered Locus Names:YKL121W
ORF Names:YKL525
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length852 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Disruption phenotype

Increases cellular tolerance to 2-deoxy-glucose. Ref.6

Miscellaneous

Present with 504 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the WD repeat DGR2 family.

Contains 6 WD repeats.

Ontologies

Keywords
   DomainRepeat
WD repeat
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 8528522-deoxy-glucose resistant protein 2
PRO_0000051479

Regions

Repeat171 – 21040WD 1
Repeat278 – 31639WD 2
Repeat318 – 35841WD 3
Repeat426 – 47146WD 4
Repeat476 – 51540WD 5
Repeat651 – 68939WD 6

Amino acid modifications

Modified residue7161Phosphoserine Ref.7

Sequences

Sequence LengthMass (Da)Tools
P32330 [UniParc].

Last modified October 1, 1993. Version 1.
Checksum: A673BAF9AF22B608

FASTA85296,022
        10         20         30         40         50         60 
MFKSKTSTLS YDETPNSNEG DRNATPVNPK EKSQTKHLNI PGDRSRHSSI ADSKRSSSRY 

        70         80         90        100        110        120 
DGGYSADIIP AQLRFIDNID YGTRLRKTLH RNSVVSNGYN KLSENDRWYF DLFDRKYFEN 

       130        140        150        160        170        180 
YLEEPTYIKI FKKKEGLEQF DRMFLAQELK IPDVYKSTTY QGEPAVANSE LFKNSICCCT 

       190        200        210        220        230        240 
FSHDGKYMVI GCKDGSLHLW KVINSPVKRS EMGRSEKSVS ASRANSLKIQ RHLASISSHN 

       250        260        270        280        290        300 
GSISSNDLKP SDQFEGPSKQ LHLYAPVFYS DVFRVFMEHA LDILDANWSK NGFLITASMD 

       310        320        330        340        350        360 
KTAKLWHPER KYSLKTFVHP DFVTSAIFFP NDDRFIITGC LDHRCRLWSI LDNEVSYAFD 

       370        380        390        400        410        420 
CKDLITSLTL SPPGGEYTII GTFNGYIYVL LTHGLKFVSS FHVSDKSTQG TTKNSFHPSS 

       430        440        450        460        470        480 
EYGKVQHGPR ITGLQCFFSK VDKNLRLIVT TNDSKIQIFD LNEKKPLELF KGFQSGSSRH 

       490        500        510        520        530        540 
RGQFLMMKNE PVVFTGSDDH WFYTWKMQSF NLSAEMNCTA PHRKKRLSGS MSLKGLLRIV 

       550        560        570        580        590        600 
SNKSTNDECL TETSNQSSSH TFTNSSKNVL QTQTVGSQAI KNNHYISFHA HNSPVTCASI 

       610        620        630        640        650        660 
APDVAIKNLS LSNDLIFELT SQYFKEMGQN YSESKETCDN KPNHPVTETG GFSSNLSNVV 

       670        680        690        700        710        720 
NNVGTILITT DSQGLIRVFR TDILPEIRKK IIEKFHEYNL FHLEAAGKIN NHNNDSILEN 

       730        740        750        760        770        780 
RMDERSSTED NEFSTTPPSN THNSRPSHDF CELHPNNSPV ISGMPSRASA IFKNSIFNKS 

       790        800        810        820        830        840 
NGSFISLKSR SESTSSTVFG PHDIPRVSTT YPKLKCDVCN GSNFECASKN PIAGGDSGFT 

       850 
CADCGTILNN FR 

« Hide

References

« Hide 'large scale' references
[1]"Sequence of a segment of yeast chromosome XI identifies a new mitochondrial carrier, a new member of the G protein family, and a protein with the PAAKK motif of the H1 histones."
Colleaux L., Richard G.-F., Thierry A., Dujon B.
Yeast 8:325-336(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Complete DNA sequence of yeast chromosome XI."
Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C. expand/collapse author list , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[6]"A catabolic block does not sufficiently explain how 2-deoxy-D-glucose inhibits cell growth."
Ralser M., Wamelink M.M., Struys E.A., Joppich C., Krobitsch S., Jakobs C., Lehrach H.
Proc. Natl. Acad. Sci. U.S.A. 105:17807-17811(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: DISRUPTION PHENOTYPE.
[7]"Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-716, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S44213 Genomic DNA. Translation: AAB23072.2.
Z28121 Genomic DNA. Translation: CAA81962.1.
BK006944 Genomic DNA. Translation: DAA09039.1.
PIRS25359.
RefSeqNP_012801.1. NM_001179687.1.

3D structure databases

ProteinModelPortalP32330.
SMRP32330. Positions 171-509.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid34014. 26 interactions.
IntActP32330. 1 interaction.
STRING4932.YKL121W.

Proteomic databases

MaxQBP32330.
PaxDbP32330.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYKL121W; YKL121W; YKL121W.
GeneID853738.
KEGGsce:YKL121W.

Organism-specific databases

CYGDYKL121w.
SGDS000001604. DGR2.

Phylogenomic databases

eggNOGNOG270909.
GeneTreeENSGT00530000063479.
OMAKTFVHPD.
OrthoDBEOG7CRTZ9.

Enzyme and pathway databases

BioCycYEAST:G3O-31904-MONOMER.

Gene expression databases

GenevestigatorP32330.

Family and domain databases

Gene3D2.130.10.10. 4 hits.
InterProIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamPF00400. WD40. 4 hits.
[Graphical view]
SMARTSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMSSF50978. SSF50978. 3 hits.
PROSITEPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio974787.

Entry information

Entry nameDGR2_YEAST
AccessionPrimary (citable) accession number: P32330
Secondary accession number(s): D6VXG9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: May 14, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XI

Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families