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Protein

2-deoxy-glucose resistant protein 2

Gene

DGR2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciYEAST:G3O-31904-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
2-deoxy-glucose resistant protein 2
Gene namesi
Name:DGR2
Ordered Locus Names:YKL121W
ORF Names:YKL525
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome XI

Organism-specific databases

CYGDiYKL121w.
EuPathDBiFungiDB:YKL121W.
SGDiS000001604. DGR2.

Pathology & Biotechi

Disruption phenotypei

Increases cellular tolerance to 2-deoxy-glucose.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8528522-deoxy-glucose resistant protein 2PRO_0000051479Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei716 – 7161Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP32330.
PaxDbiP32330.

Interactioni

Protein-protein interaction databases

BioGridi34014. 26 interactions.
IntActiP32330. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP32330.
SMRiP32330. Positions 171-391, 512-540.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati171 – 21040WD 1Add
BLAST
Repeati278 – 31639WD 2Add
BLAST
Repeati318 – 35841WD 3Add
BLAST
Repeati426 – 47146WD 4Add
BLAST
Repeati476 – 51540WD 5Add
BLAST
Repeati651 – 68939WD 6Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat DGR2 family.Curated
Contains 6 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiNOG270909.
GeneTreeiENSGT00530000063479.
InParanoidiP32330.
OMAiSASENHW.
OrthoDBiEOG7CRTZ9.

Family and domain databases

Gene3Di2.130.10.10. 4 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 4 hits.
[Graphical view]
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 3 hits.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32330-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKSKTSTLS YDETPNSNEG DRNATPVNPK EKSQTKHLNI PGDRSRHSSI
60 70 80 90 100
ADSKRSSSRY DGGYSADIIP AQLRFIDNID YGTRLRKTLH RNSVVSNGYN
110 120 130 140 150
KLSENDRWYF DLFDRKYFEN YLEEPTYIKI FKKKEGLEQF DRMFLAQELK
160 170 180 190 200
IPDVYKSTTY QGEPAVANSE LFKNSICCCT FSHDGKYMVI GCKDGSLHLW
210 220 230 240 250
KVINSPVKRS EMGRSEKSVS ASRANSLKIQ RHLASISSHN GSISSNDLKP
260 270 280 290 300
SDQFEGPSKQ LHLYAPVFYS DVFRVFMEHA LDILDANWSK NGFLITASMD
310 320 330 340 350
KTAKLWHPER KYSLKTFVHP DFVTSAIFFP NDDRFIITGC LDHRCRLWSI
360 370 380 390 400
LDNEVSYAFD CKDLITSLTL SPPGGEYTII GTFNGYIYVL LTHGLKFVSS
410 420 430 440 450
FHVSDKSTQG TTKNSFHPSS EYGKVQHGPR ITGLQCFFSK VDKNLRLIVT
460 470 480 490 500
TNDSKIQIFD LNEKKPLELF KGFQSGSSRH RGQFLMMKNE PVVFTGSDDH
510 520 530 540 550
WFYTWKMQSF NLSAEMNCTA PHRKKRLSGS MSLKGLLRIV SNKSTNDECL
560 570 580 590 600
TETSNQSSSH TFTNSSKNVL QTQTVGSQAI KNNHYISFHA HNSPVTCASI
610 620 630 640 650
APDVAIKNLS LSNDLIFELT SQYFKEMGQN YSESKETCDN KPNHPVTETG
660 670 680 690 700
GFSSNLSNVV NNVGTILITT DSQGLIRVFR TDILPEIRKK IIEKFHEYNL
710 720 730 740 750
FHLEAAGKIN NHNNDSILEN RMDERSSTED NEFSTTPPSN THNSRPSHDF
760 770 780 790 800
CELHPNNSPV ISGMPSRASA IFKNSIFNKS NGSFISLKSR SESTSSTVFG
810 820 830 840 850
PHDIPRVSTT YPKLKCDVCN GSNFECASKN PIAGGDSGFT CADCGTILNN

FR
Length:852
Mass (Da):96,022
Last modified:October 1, 1993 - v1
Checksum:iA673BAF9AF22B608
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S44213 Genomic DNA. Translation: AAB23072.2.
Z28121 Genomic DNA. Translation: CAA81962.1.
BK006944 Genomic DNA. Translation: DAA09039.1.
PIRiS25359.
RefSeqiNP_012801.1. NM_001179687.1.

Genome annotation databases

EnsemblFungiiYKL121W; YKL121W; YKL121W.
GeneIDi853738.
KEGGisce:YKL121W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S44213 Genomic DNA. Translation: AAB23072.2.
Z28121 Genomic DNA. Translation: CAA81962.1.
BK006944 Genomic DNA. Translation: DAA09039.1.
PIRiS25359.
RefSeqiNP_012801.1. NM_001179687.1.

3D structure databases

ProteinModelPortaliP32330.
SMRiP32330. Positions 171-391, 512-540.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34014. 26 interactions.
IntActiP32330. 1 interaction.

Proteomic databases

MaxQBiP32330.
PaxDbiP32330.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYKL121W; YKL121W; YKL121W.
GeneIDi853738.
KEGGisce:YKL121W.

Organism-specific databases

CYGDiYKL121w.
EuPathDBiFungiDB:YKL121W.
SGDiS000001604. DGR2.

Phylogenomic databases

eggNOGiNOG270909.
GeneTreeiENSGT00530000063479.
InParanoidiP32330.
OMAiSASENHW.
OrthoDBiEOG7CRTZ9.

Enzyme and pathway databases

BioCyciYEAST:G3O-31904-MONOMER.

Miscellaneous databases

NextBioi974787.
PROiP32330.

Family and domain databases

Gene3Di2.130.10.10. 4 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 4 hits.
[Graphical view]
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 3 hits.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of a segment of yeast chromosome XI identifies a new mitochondrial carrier, a new member of the G protein family, and a protein with the PAAKK motif of the H1 histones."
    Colleaux L., Richard G.-F., Thierry A., Dujon B.
    Yeast 8:325-336(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete DNA sequence of yeast chromosome XI."
    Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
    , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
    Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "A catabolic block does not sufficiently explain how 2-deoxy-D-glucose inhibits cell growth."
    Ralser M., Wamelink M.M., Struys E.A., Joppich C., Krobitsch S., Jakobs C., Lehrach H.
    Proc. Natl. Acad. Sci. U.S.A. 105:17807-17811(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
  7. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-716, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiDGR2_YEAST
AccessioniPrimary (citable) accession number: P32330
Secondary accession number(s): D6VXG9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: July 22, 2015
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 504 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.