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Protein

Deoxycytidylate deaminase

Gene

DCTD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Supplies the nucleotide substrate for thymidylate synthetase.

Catalytic activityi

dCMP + H2O = dUMP + NH3.

Cofactori

Enzyme regulationi

Allosteric enzyme whose activity is greatly influenced by the end products of its metabolic pathway, dCTP and dTTP.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi84Zinc; catalytic1 Publication1
Active sitei86Proton donorBy similarity1
Metal bindingi110Zinc; catalytic1 Publication1
Metal bindingi113Zinc; catalytic1 Publication1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide biosynthesis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciMetaCyc:HS05252-MONOMER.
ZFISH:HS05252-MONOMER.
ReactomeiR-HSA-500753. Pyrimidine biosynthesis.
SABIO-RKP32321.

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxycytidylate deaminase (EC:3.5.4.12)
Alternative name(s):
dCMP deaminase
Gene namesi
Name:DCTD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:2710. DCTD.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi1635.
OpenTargetsiENSG00000129187.
PharmGKBiPA138.

Chemistry databases

ChEMBLiCHEMBL5675.
DrugBankiDB00987. Cytarabine.

Polymorphism and mutation databases

BioMutaiDCTD.
DMDMi23503055.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001716911 – 178Deoxycytidylate deaminaseAdd BLAST178

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei174PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP32321.
MaxQBiP32321.
PaxDbiP32321.
PeptideAtlasiP32321.
PRIDEiP32321.

PTM databases

iPTMnetiP32321.
PhosphoSitePlusiP32321.

Expressioni

Gene expression databases

BgeeiENSG00000129187.
CleanExiHS_DCTD.
ExpressionAtlasiP32321. baseline and differential.
GenevisibleiP32321. HS.

Organism-specific databases

HPAiHPA035894.

Interactioni

Subunit structurei

Homohexamer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
itself4EBI-739870,EBI-739870
FGF12P613283EBI-739870,EBI-6657662
GORASP2Q9H8Y85EBI-739870,EBI-739467
LNX1Q8TBB13EBI-739870,EBI-739832
MALSU1Q96EH33EBI-739870,EBI-2339737
SDCBPO005605EBI-739870,EBI-727004
TXN2Q997573EBI-739870,EBI-2932492

Protein-protein interaction databases

BioGridi108003. 12 interactors.
IntActiP32321. 13 interactors.
MINTiMINT-3013156.
STRINGi9606.ENSP00000349576.

Structurei

Secondary structure

1178
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi15 – 27Combined sources13
Beta strandi38 – 42Combined sources5
Beta strandi48 – 55Combined sources8
Turni62 – 64Combined sources3
Helixi74 – 76Combined sources3
Turni79 – 81Combined sources3
Helixi85 – 91Combined sources7
Beta strandi102 – 107Combined sources6
Helixi111 – 119Combined sources9
Beta strandi124 – 129Combined sources6
Turni131 – 134Combined sources4
Helixi136 – 148Combined sources13
Beta strandi151 – 154Combined sources4
Beta strandi160 – 165Combined sources6
Helixi166 – 168Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2W4LX-ray2.10A/B/C/D/E/F5-173[»]
ProteinModelPortaliP32321.
SMRiP32321.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP32321.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 145CMP/dCMP-type deaminasePROSITE-ProRule annotationAdd BLAST132

Sequence similaritiesi

Contains 1 CMP/dCMP-type deaminase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3127. Eukaryota.
COG2131. LUCA.
GeneTreeiENSGT00390000000501.
HOGENOMiHOG000015715.
HOVERGENiHBG025823.
InParanoidiP32321.
KOiK01493.
OMAiYRASKRM.
OrthoDBiEOG091G0JEC.
PhylomeDBiP32321.
TreeFamiTF105971.

Family and domain databases

CDDicd01286. deoxycytidylate_deaminase. 1 hit.
InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR016193. Cytidine_deaminase-like.
IPR016473. dCMP_deaminase.
IPR015517. dCMP_deaminase-rel.
[Graphical view]
PANTHERiPTHR11086. PTHR11086. 1 hit.
PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
[Graphical view]
PIRSFiPIRSF006019. dCMP_deaminase. 1 hit.
SUPFAMiSSF53927. SSF53927. 1 hit.
PROSITEiPS00903. CYT_DCMP_DEAMINASES_1. 1 hit.
PS51747. CYT_DCMP_DEAMINASES_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P32321-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSEVSCKKRD DYLEWPEYFM AVAFLSAQRS KDPNSQVGAC IVNSENKIVG
60 70 80 90 100
IGYNGMPNGC SDDVLPWRRT AENKLDTKYP YVCHAELNAI MNKNSTDVKG
110 120 130 140 150
CSMYVALFPC NECAKLIIQA GIKEVIFMSD KYHDSDEATA ARLLFNMAGV
160 170
TFRKFIPKCS KIVIDFDSIN SRPSQKLQ
Length:178
Mass (Da):20,016
Last modified:September 19, 2002 - v2
Checksum:i2B8DA5EAC85F3666
GO
Isoform 2 (identifier: P32321-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MVGGGQPCGPNM

Show »
Length:189
Mass (Da):21,014
Checksum:i973677A3294EBB97
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti95S → L in AAH01286 (PubMed:15489334).Curated1
Sequence conflicti128M → T in AAA35755 (PubMed:7685356).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0380941M → MVGGGQPCGPNM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12136 mRNA. Translation: AAA35755.1.
L39874 Genomic DNA. Translation: AAC37579.1.
AK313221 mRNA. Translation: BAG36033.1.
AC079766 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX04697.1.
CH471056 Genomic DNA. Translation: EAX04698.1.
CH471056 Genomic DNA. Translation: EAX04700.1.
CH471056 Genomic DNA. Translation: EAX04701.1.
BC001286 mRNA. Translation: AAH01286.1.
BC088357 mRNA. Translation: AAH88357.2.
CCDSiCCDS34108.1. [P32321-2]
CCDS3831.1. [P32321-1]
PIRiA47288.
I55434.
RefSeqiNP_001012750.1. NM_001012732.1. [P32321-2]
NP_001912.2. NM_001921.2. [P32321-1]
XP_005262836.1. XM_005262779.3. [P32321-1]
XP_005262837.1. XM_005262780.3. [P32321-1]
XP_011529976.1. XM_011531674.2. [P32321-1]
XP_016863305.1. XM_017007816.1. [P32321-1]
XP_016863306.1. XM_017007817.1. [P32321-1]
XP_016863307.1. XM_017007818.1. [P32321-1]
XP_016863308.1. XM_017007819.1. [P32321-1]
XP_016863309.1. XM_017007820.1. [P32321-1]
XP_016863310.1. XM_017007821.1. [P32321-1]
XP_016863311.1. XM_017007822.1. [P32321-1]
UniGeneiHs.183850.

Genome annotation databases

EnsembliENST00000357067; ENSP00000349576; ENSG00000129187. [P32321-2]
ENST00000438320; ENSP00000398194; ENSG00000129187. [P32321-1]
ENST00000510370; ENSP00000424017; ENSG00000129187. [P32321-1]
GeneIDi1635.
KEGGihsa:1635.
UCSCiuc003ivf.4. human. [P32321-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12136 mRNA. Translation: AAA35755.1.
L39874 Genomic DNA. Translation: AAC37579.1.
AK313221 mRNA. Translation: BAG36033.1.
AC079766 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX04697.1.
CH471056 Genomic DNA. Translation: EAX04698.1.
CH471056 Genomic DNA. Translation: EAX04700.1.
CH471056 Genomic DNA. Translation: EAX04701.1.
BC001286 mRNA. Translation: AAH01286.1.
BC088357 mRNA. Translation: AAH88357.2.
CCDSiCCDS34108.1. [P32321-2]
CCDS3831.1. [P32321-1]
PIRiA47288.
I55434.
RefSeqiNP_001012750.1. NM_001012732.1. [P32321-2]
NP_001912.2. NM_001921.2. [P32321-1]
XP_005262836.1. XM_005262779.3. [P32321-1]
XP_005262837.1. XM_005262780.3. [P32321-1]
XP_011529976.1. XM_011531674.2. [P32321-1]
XP_016863305.1. XM_017007816.1. [P32321-1]
XP_016863306.1. XM_017007817.1. [P32321-1]
XP_016863307.1. XM_017007818.1. [P32321-1]
XP_016863308.1. XM_017007819.1. [P32321-1]
XP_016863309.1. XM_017007820.1. [P32321-1]
XP_016863310.1. XM_017007821.1. [P32321-1]
XP_016863311.1. XM_017007822.1. [P32321-1]
UniGeneiHs.183850.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2W4LX-ray2.10A/B/C/D/E/F5-173[»]
ProteinModelPortaliP32321.
SMRiP32321.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108003. 12 interactors.
IntActiP32321. 13 interactors.
MINTiMINT-3013156.
STRINGi9606.ENSP00000349576.

Chemistry databases

ChEMBLiCHEMBL5675.
DrugBankiDB00987. Cytarabine.

PTM databases

iPTMnetiP32321.
PhosphoSitePlusiP32321.

Polymorphism and mutation databases

BioMutaiDCTD.
DMDMi23503055.

Proteomic databases

EPDiP32321.
MaxQBiP32321.
PaxDbiP32321.
PeptideAtlasiP32321.
PRIDEiP32321.

Protocols and materials databases

DNASUi1635.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357067; ENSP00000349576; ENSG00000129187. [P32321-2]
ENST00000438320; ENSP00000398194; ENSG00000129187. [P32321-1]
ENST00000510370; ENSP00000424017; ENSG00000129187. [P32321-1]
GeneIDi1635.
KEGGihsa:1635.
UCSCiuc003ivf.4. human. [P32321-1]

Organism-specific databases

CTDi1635.
DisGeNETi1635.
GeneCardsiDCTD.
HGNCiHGNC:2710. DCTD.
HPAiHPA035894.
MIMi607638. gene.
neXtProtiNX_P32321.
OpenTargetsiENSG00000129187.
PharmGKBiPA138.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3127. Eukaryota.
COG2131. LUCA.
GeneTreeiENSGT00390000000501.
HOGENOMiHOG000015715.
HOVERGENiHBG025823.
InParanoidiP32321.
KOiK01493.
OMAiYRASKRM.
OrthoDBiEOG091G0JEC.
PhylomeDBiP32321.
TreeFamiTF105971.

Enzyme and pathway databases

BioCyciMetaCyc:HS05252-MONOMER.
ZFISH:HS05252-MONOMER.
ReactomeiR-HSA-500753. Pyrimidine biosynthesis.
SABIO-RKP32321.

Miscellaneous databases

ChiTaRSiDCTD. human.
EvolutionaryTraceiP32321.
GenomeRNAii1635.
PROiP32321.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000129187.
CleanExiHS_DCTD.
ExpressionAtlasiP32321. baseline and differential.
GenevisibleiP32321. HS.

Family and domain databases

CDDicd01286. deoxycytidylate_deaminase. 1 hit.
InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR016193. Cytidine_deaminase-like.
IPR016473. dCMP_deaminase.
IPR015517. dCMP_deaminase-rel.
[Graphical view]
PANTHERiPTHR11086. PTHR11086. 1 hit.
PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
[Graphical view]
PIRSFiPIRSF006019. dCMP_deaminase. 1 hit.
SUPFAMiSSF53927. SSF53927. 1 hit.
PROSITEiPS00903. CYT_DCMP_DEAMINASES_1. 1 hit.
PS51747. CYT_DCMP_DEAMINASES_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDCTD_HUMAN
AccessioniPrimary (citable) accession number: P32321
Secondary accession number(s): B2R836
, D3DP49, D3DP50, Q5M7Z8, Q9BVD8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: September 19, 2002
Last modified: November 30, 2016
This is version 162 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Allosteric enzyme, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.