Reviewed,
UniProtKB/Swiss-Prot P32321 (DCTD_HUMAN)
Last modified
June 16, 2009.
Version 82.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Deoxycytidylate deaminase EC=3.5.4.12 Alternative name(s): dCMP deaminase | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 178 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Supplies the nucleotide substrate for thymidylate synthetase. |
| Catalytic activity | dCMP + H2O = dUMP + NH3. |
| Cofactor | Zinc. |
| Enzyme regulation | Allosteric enzyme whose activity is greatly influenced by the end products of its metabolic pathway, dCTP and dTTP. |
| Subunit structure | Homohexamer. |
| Sequence similarities | Belongs to the cytidine and deoxycytidylate deaminase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Nucleotide biosynthesis |
| Ligand | Metal-binding Zinc |
| Molecular function | Hydrolase |
| PTM | Phosphoprotein |
| Technical term | 3D-structure Allosteric enzyme Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW pyrimidine nucleotide metabolic process Ref.1Traceable author statement. Source: ProtInc |
| Cellular component | cytosol Ref.1 Inferred from Experiment. Source: Reactome |
| Molecular function | dCMP deaminase activity Ref.1 Inferred from Experiment. Source: Reactome zinc ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 178 | 178 | Deoxycytidylate deaminase | PRO_0000171691 | |||||
Sites | |||||||||
| Active site | 86 | 1 | Proton donor By similarity | ||||||
| Metal binding | 84 | 1 | Zinc; catalytic By similarity | ||||||
| Metal binding | 110 | 1 | Zinc; catalytic By similarity | ||||||
| Metal binding | 113 | 1 | Zinc; catalytic By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 79 | 1 | Phosphotyrosine Ref.4 | ||||||
Experimental info | |||||||||
| Sequence conflict | 95 | 1 | S → L in AAH01286. Ref.3 | ||||||
| Sequence conflict | 128 | 1 | M → T in AAA35755. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Primary structure of human deoxycytidylate deaminase and overexpression of its functional protein in Escherichia coli." Weiner K.X., Weiner R.S., Maley F., Maley G.F. J. Biol. Chem. 268:12983-12989(1993) [PubMed: 7685356] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE. |
| [2] | "Chromosomal location and structural organization of the human deoxycytidylate deaminase gene." Weiner K.X., Ciesla J., Jaffe A.B., Ketring R., Maley F., Maley G.F. J. Biol. Chem. 270:18727-18729(1995) [PubMed: 7642519] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Lung. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Cervix. |
| [4] | "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells." Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J. Nat. Biotechnol. 23:94-101(2005) [PubMed: 15592455] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-79, MASS SPECTROMETRY. |
| [5] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| L12136 mRNA. Translation: AAA35755.1. L39874 Genomic DNA. Translation: AAC37579.1. BC001286 mRNA. Translation: AAH01286.1. | |||||||||||||
| IPI | IPI00296863. | ||||||||||||
| PIR | A47288. I55434. | ||||||||||||
| RefSeq | NP_001912.2. | ||||||||||||
| UniGene | Hs.183850 | ||||||||||||
3D structure databases | |||||||||||||
| |||||||||||||
| ModBase | Search... | ||||||||||||
Protein-protein interaction databases | |||||||||||||
| IntAct | P32321. 5 interactions. | ||||||||||||
PTM databases | |||||||||||||
| PhosphoSite | P32321. | ||||||||||||
Proteomic databases | |||||||||||||
| PRIDE | P32321. | ||||||||||||
Genome annotation databases | |||||||||||||
| Ensembl | ENSG00000129187. Homo sapiens. [Contig view] | ||||||||||||
| GeneID | 1635. | ||||||||||||
Organism-specific databases | |||||||||||||
| GeneCards | GC04M184048. | ||||||||||||
| H-InvDB | HIX0004657. | ||||||||||||
| HGNC | HGNC:2710. DCTD. | ||||||||||||
| MIM | 607638. gene. | ||||||||||||
| PharmGKB | PA138. | ||||||||||||
| GenAtlas | Search... | ||||||||||||
Phylogenomic databases | |||||||||||||
| HOVERGEN | P32321. | ||||||||||||
Enzyme and pathway databases | |||||||||||||
| BRENDA | 3.5.4.12. 247. | ||||||||||||
| Reactome | REACT_1698. Nucleotide metabolism. | ||||||||||||
Gene expression databases | |||||||||||||
| ArrayExpress | P32321. | ||||||||||||
| Bgee | P32321. | ||||||||||||
| CleanEx | HS_DCTD. | ||||||||||||
| GermOnline | ENSG00000129187. Homo sapiens. | ||||||||||||
Family and domain databases | |||||||||||||
| InterPro | IPR016192. APOBEC/CMP_deaminase_Zn-bd. IPR002125. CMP_dCMP_Zn_bd. IPR015517. Cyt_deaminase. IPR016473. dCMP_deaminase. [Graphical view] | ||||||||||||
| PANTHER | PTHR11086. Cyt_deaminase. 1 hit. | ||||||||||||
| Pfam | PF00383. dCMP_cyt_deam_1. 1 hit. [Graphical view] | ||||||||||||
| PIRSF | PIRSF006019. dCMP_deaminase. 1 hit. | ||||||||||||
| PROSITE | PS00903. CYT_DCMP_DEAMINASES. 1 hit. [Graphical view] | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Other Resources | |||||||||||||
| NextBio | 6716. | ||||||||||||
| SOURCE | Search... | ||||||||||||
Entry information
| Entry name | DCTD_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P32321 Secondary accession number(s): Q9BVD8 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 4 Human chromosome 4: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with


