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Protein

Cytidine deaminase

Gene

CDA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

Catalytic activityi

Cytidine + H2O = uridine + NH3.
2'deoxycytidine + H2O = 2'-deoxyuridine + NH3.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi65Zinc; catalytic1
Active sitei67Proton donor1
Metal bindingi99Zinc; catalytic1
Metal bindingi102Zinc; catalytic1

GO - Molecular functioni

  • cytidine deaminase activity Source: UniProtKB
  • nucleoside binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • zinc ion binding Source: UniProtKB

GO - Biological processi

  • cell surface receptor signaling pathway Source: UniProtKB
  • cytidine deamination Source: UniProtKB
  • cytosine metabolic process Source: UniProtKB
  • negative regulation of cell growth Source: UniProtKB
  • negative regulation of nucleotide metabolic process Source: UniProtKB
  • protein homotetramerization Source: UniProtKB
  • pyrimidine-containing compound salvage Source: UniProtKB
  • pyrimidine nucleoside salvage Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciMetaCyc:HS08334-MONOMER.
ZFISH:HS08334-MONOMER.
BRENDAi3.5.4.5. 2681.
ReactomeiR-HSA-6798695. Neutrophil degranulation.
R-HSA-73614. Pyrimidine salvage reactions.
SABIO-RKP32320.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytidine deaminase (EC:3.5.4.5)
Alternative name(s):
Cytidine aminohydrolase
Gene namesi
Name:CDA
Synonyms:CDD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:1712. CDA.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: UniProtKB
  • extracellular region Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi978.
OpenTargetsiENSG00000158825.
PharmGKBiPA98.

Chemistry databases

ChEMBLiCHEMBL4502.
DrugBankiDB00928. Azacitidine.
DB01101. Capecitabine.
DB00987. Cytarabine.
DB00441. Gemcitabine.

Polymorphism and mutation databases

BioMutaiCDA.
DMDMi1705718.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001716821 – 146Cytidine deaminaseAdd BLAST146

Proteomic databases

EPDiP32320.
MaxQBiP32320.
PaxDbiP32320.
PeptideAtlasiP32320.
PRIDEiP32320.
TopDownProteomicsiP32320.

PTM databases

iPTMnetiP32320.
PhosphoSitePlusiP32320.

Expressioni

Tissue specificityi

Highly expressed in granulocytes while expression is very low in fibroblasts, chondrocytes, monocytes, and T- as well as B-cell lines.

Gene expression databases

BgeeiENSG00000158825.
CleanExiHS_CDA.
GenevisibleiP32320. HS.

Organism-specific databases

HPAiHPA064202.

Interactioni

Subunit structurei

Homotetramer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
C20orf195Q9BVV25EBI-9250559,EBI-744935
LNX1Q8TBB15EBI-9250559,EBI-739832
PLEKHB2Q96CS75EBI-9250559,EBI-373552
PSMA1P257863EBI-9250559,EBI-359352
PTGER3Q147X83EBI-9250559,EBI-10234038
SDCBPO005605EBI-9250559,EBI-727004
WDYHV1Q96HA85EBI-9250559,EBI-741158
ZBTB24O431675EBI-9250559,EBI-744471

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi107416. 36 interactors.
IntActiP32320. 11 interactors.
STRINGi9606.ENSP00000364212.

Chemistry databases

BindingDBiP32320.

Structurei

Secondary structure

1146
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi15 – 25Combined sources11
Helixi26 – 28Combined sources3
Turni32 – 34Combined sources3
Beta strandi38 – 43Combined sources6
Beta strandi49 – 53Combined sources5
Helixi60 – 62Combined sources3
Helixi66 – 76Combined sources11
Beta strandi83 – 90Combined sources8
Helixi100 – 107Combined sources8
Beta strandi111 – 118Combined sources8
Beta strandi124 – 128Combined sources5
Helixi129 – 132Combined sources4
Helixi139 – 141Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MQ0X-ray2.40A/B11-146[»]
ProteinModelPortaliP32320.
SMRiP32320.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP32320.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 140CMP/dCMP-type deaminasePROSITE-ProRule annotationAdd BLAST128

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni54 – 60Substrate binding7

Sequence similaritiesi

Contains 1 CMP/dCMP-type deaminase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0833. Eukaryota.
COG0295. LUCA.
GeneTreeiENSGT00390000000911.
HOGENOMiHOG000014707.
HOVERGENiHBG005294.
InParanoidiP32320.
KOiK01489.
OMAiKLVKMAL.
OrthoDBiEOG091G09D3.
PhylomeDBiP32320.
TreeFamiTF314486.

Family and domain databases

InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR006262. Cyt_deam_tetra.
IPR016193. Cytidine_deaminase-like.
[Graphical view]
PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
[Graphical view]
SUPFAMiSSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR01354. cyt_deam_tetra. 1 hit.
PROSITEiPS00903. CYT_DCMP_DEAMINASES_1. 1 hit.
PS51747. CYT_DCMP_DEAMINASES_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32320-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQKRPACTL KPECVQQLLV CSQEAKKSAY CPYSHFPVGA ALLTQEGRIF
60 70 80 90 100
KGCNIENACY PLGICAERTA IQKAVSEGYK DFRAIAIASD MQDDFISPCG
110 120 130 140
ACRQVMREFG TNWPVYMTKP DGTYIVMTVQ ELLPSSFGPE DLQKTQ
Length:146
Mass (Da):16,185
Last modified:October 1, 1996 - v2
Checksum:iAF33D09EE4E176B3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02155927K → Q.2 PublicationsCorresponds to variant rs2072671dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L27943 mRNA. Translation: AAA57254.1.
AF061658
, AF061655, AF061656, AF061657 Genomic DNA. Translation: AAD15828.1.
AJ000474 mRNA. Translation: CAA04113.1.
AL391357 Genomic DNA. Translation: CAH73474.1.
BC054036 mRNA. Translation: AAH54036.1.
S52873 mRNA. Translation: AAB24946.1.
CCDSiCCDS210.1.
PIRiI52710.
RefSeqiNP_001776.1. NM_001785.2.
UniGeneiHs.466910.

Genome annotation databases

EnsembliENST00000375071; ENSP00000364212; ENSG00000158825.
GeneIDi978.
KEGGihsa:978.
UCSCiuc001bdk.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L27943 mRNA. Translation: AAA57254.1.
AF061658
, AF061655, AF061656, AF061657 Genomic DNA. Translation: AAD15828.1.
AJ000474 mRNA. Translation: CAA04113.1.
AL391357 Genomic DNA. Translation: CAH73474.1.
BC054036 mRNA. Translation: AAH54036.1.
S52873 mRNA. Translation: AAB24946.1.
CCDSiCCDS210.1.
PIRiI52710.
RefSeqiNP_001776.1. NM_001785.2.
UniGeneiHs.466910.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MQ0X-ray2.40A/B11-146[»]
ProteinModelPortaliP32320.
SMRiP32320.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107416. 36 interactors.
IntActiP32320. 11 interactors.
STRINGi9606.ENSP00000364212.

Chemistry databases

BindingDBiP32320.
ChEMBLiCHEMBL4502.
DrugBankiDB00928. Azacitidine.
DB01101. Capecitabine.
DB00987. Cytarabine.
DB00441. Gemcitabine.

PTM databases

iPTMnetiP32320.
PhosphoSitePlusiP32320.

Polymorphism and mutation databases

BioMutaiCDA.
DMDMi1705718.

Proteomic databases

EPDiP32320.
MaxQBiP32320.
PaxDbiP32320.
PeptideAtlasiP32320.
PRIDEiP32320.
TopDownProteomicsiP32320.

Protocols and materials databases

DNASUi978.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375071; ENSP00000364212; ENSG00000158825.
GeneIDi978.
KEGGihsa:978.
UCSCiuc001bdk.4. human.

Organism-specific databases

CTDi978.
DisGeNETi978.
GeneCardsiCDA.
HGNCiHGNC:1712. CDA.
HPAiHPA064202.
MIMi123920. gene.
neXtProtiNX_P32320.
OpenTargetsiENSG00000158825.
PharmGKBiPA98.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0833. Eukaryota.
COG0295. LUCA.
GeneTreeiENSGT00390000000911.
HOGENOMiHOG000014707.
HOVERGENiHBG005294.
InParanoidiP32320.
KOiK01489.
OMAiKLVKMAL.
OrthoDBiEOG091G09D3.
PhylomeDBiP32320.
TreeFamiTF314486.

Enzyme and pathway databases

BioCyciMetaCyc:HS08334-MONOMER.
ZFISH:HS08334-MONOMER.
BRENDAi3.5.4.5. 2681.
ReactomeiR-HSA-6798695. Neutrophil degranulation.
R-HSA-73614. Pyrimidine salvage reactions.
SABIO-RKP32320.

Miscellaneous databases

ChiTaRSiCDA. human.
EvolutionaryTraceiP32320.
GeneWikiiCytidine_deaminase.
GenomeRNAii978.
PROiP32320.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000158825.
CleanExiHS_CDA.
GenevisibleiP32320. HS.

Family and domain databases

InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR006262. Cyt_deam_tetra.
IPR016193. Cytidine_deaminase-like.
[Graphical view]
PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
[Graphical view]
SUPFAMiSSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR01354. cyt_deam_tetra. 1 hit.
PROSITEiPS00903. CYT_DCMP_DEAMINASES_1. 1 hit.
PS51747. CYT_DCMP_DEAMINASES_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDD_HUMAN
AccessioniPrimary (citable) accession number: P32320
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 159 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.