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Protein

Acetyl-CoA hydrolase

Gene

ACH1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Presumably involved in regulating the intracellular acetyl-CoA pool for fatty acid and cholesterol synthesis and fatty acid oxidation. It may be involved in overall regulation of acetylation during melatonin synthesis.

Miscellaneous

Present with 4890 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

Acetyl-CoA + H2O = CoA + acetate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei3025-glutamyl coenzyme A thioester intermediateBy similarity1
Binding sitei392Coenzyme ABy similarity1
Binding sitei396Coenzyme A; via amide nitrogenBy similarity1

GO - Molecular functioni

  • acetate CoA-transferase activity Source: SGD
  • acetyl-CoA hydrolase activity Source: SGD

GO - Biological processi

  • acetate metabolic process Source: SGD
  • acetyl-CoA metabolic process Source: InterPro
  • propionate metabolic process, methylcitrate cycle Source: GO_Central

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BioCyciMetaCyc:YBL015W-MONOMER
YEAST:YBL015W-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-CoA hydrolase (EC:3.1.2.1)
Alternative name(s):
Acetyl-CoA deacylase
Short name:
Acetyl-CoA acylase
Gene namesi
Name:ACH1
Ordered Locus Names:YBL015W
ORF Names:YBL03.18, YBL0304
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBL015W
SGDiS000000111 ACH1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00002155242 – 526Acetyl-CoA hydrolaseAdd BLAST525

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonine1 Publication1
Modified residuei350PhosphoserineCombined sources1

Post-translational modificationi

Glycosylated; contains mannose.

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP32316
PaxDbiP32316
PRIDEiP32316

PTM databases

iPTMnetiP32316

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

BioGridi32683, 143 interactors
DIPiDIP-6548N
IntActiP32316, 5 interactors
STRINGi4932.YBL015W

Structurei

3D structure databases

ProteinModelPortaliP32316
SMRiP32316
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni277 – 281Coenzyme A bindingBy similarity5

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000011259
HOGENOMiHOG000172597
InParanoidiP32316
KOiK01067
OMAiDEALSWH
OrthoDBiEOG092C1EVJ

Family and domain databases

Gene3Di3.40.1080.20, 1 hit
InterProiView protein in InterPro
IPR026888 AcetylCoA_hyd_C
IPR038460 AcetylCoA_hyd_C_sf
IPR003702 ActCoA_hydro
IPR037171 NagB/RpiA_transferase-like
PfamiView protein in Pfam
PF13336 AcetylCoA_hyd_C, 1 hit
PF02550 AcetylCoA_hydro, 1 hit
SUPFAMiSSF100950 SSF100950, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P32316-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTISNLLKQR VRYAPYLKKV KEAHELIPLF KNGQYLGWSG FTGVGTPKAV
60 70 80 90 100
PEALIDHVEK NNLQGKLRFN LFVGASAGPE ENRWAEHDMI IKRAPHQVGK
110 120 130 140 150
PIAKAINQGR IEFFDKHLSM FPQDLTYGFY TRERKDNKIL DYTIIEATAI
160 170 180 190 200
KEDGSIVPGP SVGGSPEFIT VSDKVIIEVN TATPSFEGIH DIDMPVNPPF
210 220 230 240 250
RKPYPYLKVD DKCGVDSIPV DPEKVVAIVE STMRDQVPPN TPSDDMSRAI
260 270 280 290 300
AGHLVEFFRN EVKHGRLPEN LLPLQSGIGN IANAVIEGLA GAQFKHLTVW
310 320 330 340 350
TEVLQDSFLD LFENGSLDYA TATSVRLTEK GFDRAFANWE NFKHRLCLRS
360 370 380 390 400
QVVSNNPEMI RRLGVIAMNT PVEVDIYAHA NSTNVNGSRM LNGLGGSADF
410 420 430 440 450
LRNAKLSIMH APSARPTKVD PTGISTIVPM ASHVDQTEHD LDILVTDQGL
460 470 480 490 500
ADLRGLSPKE RAREIINKCA HPDYQALLTD YLDRAEHYAK KHNCLHEPHM
510 520
LKNAFKFHTN LAEKGTMKVD SWEPVD
Length:526
Mass (Da):58,712
Last modified:January 4, 2005 - v2
Checksum:i7133A291F18AA1E4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti308F → L in AAA34388 (PubMed:1970569).Curated1
Sequence conflicti320A → S in AAA34388 (PubMed:1970569).Curated1
Sequence conflicti363 – 364LG → FP in AAA34388 (PubMed:1970569).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31036 mRNA Translation: AAA34388.1
X68577 Genomic DNA Translation: CAA48570.1
Z35776 Genomic DNA Translation: CAA84834.1
BK006936 Genomic DNA Translation: DAA07105.1
PIRiS28549
RefSeqiNP_009538.1, NM_001178255.1

Genome annotation databases

EnsemblFungiiYBL015W; YBL015W; YBL015W
GeneIDi852266
KEGGisce:YBL015W

Similar proteinsi

Entry informationi

Entry nameiACH1_YEAST
AccessioniPrimary (citable) accession number: P32316
Secondary accession number(s): D6VPY5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: January 4, 2005
Last modified: May 23, 2018
This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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