ID   FOXN2_HUMAN             Reviewed;         431 AA.
AC   P32314; Q15769; Q6P4Q2;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 3.
DT   27-MAR-2024, entry version 190.
DE   RecName: Full=Forkhead box protein N2;
DE   AltName: Full=Human T-cell leukemia virus enhancer factor;
GN   Name=FOXN2; Synonyms=HTLF;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RX   PubMed=1639393; DOI=10.1016/0888-7543(92)90138-i;
RA   Li C., Lusis A.J., Sparkes R., Tran S.-M., Gaynor R.B.;
RT   "Characterization and chromosomal mapping of the gene encoding the cellular
RT   DNA binding protein HTLF.";
RL   Genomics 13:658-664(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Binds to the purine-rich region in HTLV-I LTR.
CC   -!- INTERACTION:
CC       P32314; Q9UKB1: FBXW11; NbExp=4; IntAct=EBI-10706164, EBI-355189;
CC       P32314; P22670: RFX1; NbExp=3; IntAct=EBI-10706164, EBI-716037;
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=P32314-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=P32314-2; Sequence=VSP_035743, VSP_035744;
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DR   EMBL; U57029; AAB03504.1; -; mRNA.
DR   EMBL; AC091485; AAY14813.1; -; Genomic_DNA.
DR   EMBL; BC063305; AAH63305.1; -; mRNA.
DR   CCDS; CCDS1838.1; -. [P32314-1]
DR   RefSeq; NP_002149.2; NM_002158.3. [P32314-1]
DR   RefSeq; XP_005264339.1; XM_005264282.2.
DR   RefSeq; XP_005264340.1; XM_005264283.2. [P32314-1]
DR   RefSeq; XP_006712064.1; XM_006712001.3.
DR   RefSeq; XP_006712065.1; XM_006712002.3.
DR   RefSeq; XP_011531110.1; XM_011532808.2.
DR   RefSeq; XP_016859445.1; XM_017003956.1.
DR   RefSeq; XP_016859446.1; XM_017003957.1.
DR   RefSeq; XP_016859447.1; XM_017003958.1.
DR   RefSeq; XP_016859448.1; XM_017003959.1.
DR   AlphaFoldDB; P32314; -.
DR   SMR; P32314; -.
DR   BioGRID; 109576; 18.
DR   IntAct; P32314; 8.
DR   MINT; P32314; -.
DR   STRING; 9606.ENSP00000343633; -.
DR   GlyGen; P32314; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; P32314; -.
DR   PhosphoSitePlus; P32314; -.
DR   BioMuta; FOXN2; -.
DR   DMDM; 215274148; -.
DR   EPD; P32314; -.
DR   jPOST; P32314; -.
DR   MassIVE; P32314; -.
DR   MaxQB; P32314; -.
DR   PaxDb; 9606-ENSP00000343633; -.
DR   PeptideAtlas; P32314; -.
DR   ProteomicsDB; 54867; -. [P32314-1]
DR   ProteomicsDB; 54868; -. [P32314-2]
DR   Antibodypedia; 932; 324 antibodies from 27 providers.
DR   DNASU; 3344; -.
DR   Ensembl; ENST00000340553.8; ENSP00000343633.3; ENSG00000170802.17. [P32314-1]
DR   GeneID; 3344; -.
DR   KEGG; hsa:3344; -.
DR   MANE-Select; ENST00000340553.8; ENSP00000343633.3; NM_002158.4; NP_002149.2.
DR   UCSC; uc002rwh.2; human. [P32314-1]
DR   AGR; HGNC:5281; -.
DR   CTD; 3344; -.
DR   DisGeNET; 3344; -.
DR   GeneCards; FOXN2; -.
DR   HGNC; HGNC:5281; FOXN2.
DR   HPA; ENSG00000170802; Tissue enhanced (bone).
DR   MIM; 143089; gene.
DR   neXtProt; NX_P32314; -.
DR   OpenTargets; ENSG00000170802; -.
DR   PharmGKB; PA162388822; -.
DR   VEuPathDB; HostDB:ENSG00000170802; -.
DR   eggNOG; KOG2294; Eukaryota.
DR   GeneTree; ENSGT00940000159118; -.
DR   HOGENOM; CLU_032050_1_0_1; -.
DR   InParanoid; P32314; -.
DR   OMA; GYVSQPC; -.
DR   OrthoDB; 5385885at2759; -.
DR   PhylomeDB; P32314; -.
DR   TreeFam; TF105083; -.
DR   PathwayCommons; P32314; -.
DR   SignaLink; P32314; -.
DR   SIGNOR; P32314; -.
DR   BioGRID-ORCS; 3344; 18 hits in 1179 CRISPR screens.
DR   ChiTaRS; FOXN2; human.
DR   GenomeRNAi; 3344; -.
DR   Pharos; P32314; Tbio.
DR   PRO; PR:P32314; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   RNAct; P32314; Protein.
DR   Bgee; ENSG00000170802; Expressed in endothelial cell and 189 other cell types or tissues.
DR   ExpressionAtlas; P32314; baseline and differential.
DR   GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
DR   GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000987; F:cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IBA:GO_Central.
DR   GO; GO:0035914; P:skeletal muscle cell differentiation; IEA:Ensembl.
DR   CDD; cd20058; FH_FOXN2; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR047403; FH_FOXN2.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR047119; FOXN2/3-like.
DR   InterPro; IPR018122; TF_fork_head_CS_1.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR13962:SF19; FORKHEAD BOX PROTEIN N2; 1.
DR   PANTHER; PTHR13962; FORKHEAD BOX PROTEIN N3-LIKE PROTEIN-RELATED; 1.
DR   Pfam; PF00250; Forkhead; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS00657; FORK_HEAD_1; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
DR   Genevisible; P32314; HS.
PE   1: Evidence at protein level;
KW   Alternative splicing; DNA-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..431
FT                   /note="Forkhead box protein N2"
FT                   /id="PRO_0000091868"
FT   DNA_BIND        112..208
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT   REGION          364..387
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..90
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:1639393"
FT                   /id="VSP_035743"
FT   VAR_SEQ         91..105
FT                   /note="DDVPSFGPACYQNPE -> MMCDPLDQLATRTQK (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:1639393"
FT                   /id="VSP_035744"
SQ   SEQUENCE   431 AA;  47161 MW;  5F71D3C0E4BA1797 CRC64;
     MGPVIGMTPD KRAETPGAEK IAGLSQIYKM GSLPEAVDAA RPKATLVDSE SADDELTNLN
     WLHESTNLLT NFSLGSEGLP IVSPLYDIEG DDVPSFGPAC YQNPEKKSAT SKPPYSFSLL
     IYMAIEHSPN KCLPVKEIYS WILDHFPYFA TAPTGWKNSV RHNLSLNKCF QKVERSHGKV
     NGKGSLWCVD PEYKPNLIQA LKKQPFSSAS SQNGSLSPHY LSSVIKQNQV RNLKESDIDA
     AAAMMLLNTS IEQGILECEK PLPLKTALQK KRSYGNAFHH PSAVRLQESD SLATSIDPKE
     DHNYSASSMA AQRCASRSSV SSLSSVDEVY EFIPKNSHVG SDGSEGFHSE EDTDVDYEDD
     PLGDSGYASQ PCAKISEKGQ SGKKMRKQTC QEIDEELKEA AGSLLHLAGI RTCLGSLIST
     AKTQNQKQRK K
//