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P32314

- FOXN2_HUMAN

UniProt

P32314 - FOXN2_HUMAN

Protein

Forkhead box protein N2

Gene

FOXN2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 3 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    Binds to the purine-rich region in HTLV-I LTR.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi112 – 20897Fork-headPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: ProtInc

    GO - Biological processi

    1. skeletal muscle cell differentiation Source: Ensembl
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Forkhead box protein N2
    Alternative name(s):
    Human T-cell leukemia virus enhancer factor
    Gene namesi
    Name:FOXN2
    Synonyms:HTLF
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:5281. FOXN2.

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular membrane-bounded organelle Source: HPA
    2. nucleus Source: HPA

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162388822.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 431431Forkhead box protein N2PRO_0000091868Add
    BLAST

    Proteomic databases

    PaxDbiP32314.
    PRIDEiP32314.

    Expressioni

    Gene expression databases

    ArrayExpressiP32314.
    BgeeiP32314.
    CleanExiHS_FOXN2.
    GenevestigatoriP32314.

    Organism-specific databases

    HPAiHPA003485.

    Interactioni

    Protein-protein interaction databases

    BioGridi109576. 3 interactions.
    STRINGi9606.ENSP00000343633.

    Structurei

    3D structure databases

    ProteinModelPortaliP32314.
    SMRiP32314. Positions 111-191.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5025.
    HOGENOMiHOG000095166.
    HOVERGENiHBG051654.
    KOiK09407.
    OMAiCADTSEK.
    PhylomeDBiP32314.
    TreeFamiTF105083.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00250. Fork_head. 1 hit.
    [Graphical view]
    PRINTSiPR00053. FORKHEAD.
    SMARTiSM00339. FH. 1 hit.
    [Graphical view]
    PROSITEiPS00657. FORK_HEAD_1. 1 hit.
    PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P32314-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGPVIGMTPD KRAETPGAEK IAGLSQIYKM GSLPEAVDAA RPKATLVDSE    50
    SADDELTNLN WLHESTNLLT NFSLGSEGLP IVSPLYDIEG DDVPSFGPAC 100
    YQNPEKKSAT SKPPYSFSLL IYMAIEHSPN KCLPVKEIYS WILDHFPYFA 150
    TAPTGWKNSV RHNLSLNKCF QKVERSHGKV NGKGSLWCVD PEYKPNLIQA 200
    LKKQPFSSAS SQNGSLSPHY LSSVIKQNQV RNLKESDIDA AAAMMLLNTS 250
    IEQGILECEK PLPLKTALQK KRSYGNAFHH PSAVRLQESD SLATSIDPKE 300
    DHNYSASSMA AQRCASRSSV SSLSSVDEVY EFIPKNSHVG SDGSEGFHSE 350
    EDTDVDYEDD PLGDSGYASQ PCAKISEKGQ SGKKMRKQTC QEIDEELKEA 400
    AGSLLHLAGI RTCLGSLIST AKTQNQKQRK K 431
    Length:431
    Mass (Da):47,161
    Last modified:November 25, 2008 - v3
    Checksum:i5F71D3C0E4BA1797
    GO
    Isoform 2 (identifier: P32314-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-90: Missing.
         91-105: DDVPSFGPACYQNPE → MMCDPLDQLATRTQK

    Show »
    Length:341
    Mass (Da):37,735
    Checksum:i693069650BF54A8B
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 9090Missing in isoform 2. 1 PublicationVSP_035743Add
    BLAST
    Alternative sequencei91 – 10515DDVPS…YQNPE → MMCDPLDQLATRTQK in isoform 2. 1 PublicationVSP_035744Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U57029 mRNA. Translation: AAB03504.1.
    AC091485 Genomic DNA. Translation: AAY14813.1.
    BC063305 mRNA. Translation: AAH63305.1.
    CCDSiCCDS1838.1. [P32314-1]
    RefSeqiNP_002149.2. NM_002158.3. [P32314-1]
    XP_005264339.1. XM_005264282.1. [P32314-1]
    XP_005264340.1. XM_005264283.1. [P32314-1]
    XP_005264341.1. XM_005264284.1. [P32314-1]
    XP_005264342.1. XM_005264285.2. [P32314-1]
    XP_006712064.1. XM_006712001.1. [P32314-1]
    XP_006712065.1. XM_006712002.1. [P32314-1]
    UniGeneiHs.468478.

    Genome annotation databases

    EnsembliENST00000340553; ENSP00000343633; ENSG00000170802. [P32314-1]
    GeneIDi3344.
    KEGGihsa:3344.
    UCSCiuc002rwh.1. human. [P32314-1]

    Polymorphism databases

    DMDMi215274148.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U57029 mRNA. Translation: AAB03504.1 .
    AC091485 Genomic DNA. Translation: AAY14813.1 .
    BC063305 mRNA. Translation: AAH63305.1 .
    CCDSi CCDS1838.1. [P32314-1 ]
    RefSeqi NP_002149.2. NM_002158.3. [P32314-1 ]
    XP_005264339.1. XM_005264282.1. [P32314-1 ]
    XP_005264340.1. XM_005264283.1. [P32314-1 ]
    XP_005264341.1. XM_005264284.1. [P32314-1 ]
    XP_005264342.1. XM_005264285.2. [P32314-1 ]
    XP_006712064.1. XM_006712001.1. [P32314-1 ]
    XP_006712065.1. XM_006712002.1. [P32314-1 ]
    UniGenei Hs.468478.

    3D structure databases

    ProteinModelPortali P32314.
    SMRi P32314. Positions 111-191.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109576. 3 interactions.
    STRINGi 9606.ENSP00000343633.

    Polymorphism databases

    DMDMi 215274148.

    Proteomic databases

    PaxDbi P32314.
    PRIDEi P32314.

    Protocols and materials databases

    DNASUi 3344.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000340553 ; ENSP00000343633 ; ENSG00000170802 . [P32314-1 ]
    GeneIDi 3344.
    KEGGi hsa:3344.
    UCSCi uc002rwh.1. human. [P32314-1 ]

    Organism-specific databases

    CTDi 3344.
    GeneCardsi GC02P048541.
    HGNCi HGNC:5281. FOXN2.
    HPAi HPA003485.
    MIMi 143089. gene.
    neXtProti NX_P32314.
    PharmGKBi PA162388822.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5025.
    HOGENOMi HOG000095166.
    HOVERGENi HBG051654.
    KOi K09407.
    OMAi CADTSEK.
    PhylomeDBi P32314.
    TreeFami TF105083.

    Miscellaneous databases

    ChiTaRSi FOXN2. human.
    GenomeRNAii 3344.
    NextBioi 13230.
    PROi P32314.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P32314.
    Bgeei P32314.
    CleanExi HS_FOXN2.
    Genevestigatori P32314.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00250. Fork_head. 1 hit.
    [Graphical view ]
    PRINTSi PR00053. FORKHEAD.
    SMARTi SM00339. FH. 1 hit.
    [Graphical view ]
    PROSITEi PS00657. FORK_HEAD_1. 1 hit.
    PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization and chromosomal mapping of the gene encoding the cellular DNA binding protein HTLF."
      Li C., Lusis A.J., Sparkes R., Tran S.-M., Gaynor R.B.
      Genomics 13:658-664(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Placenta.

    Entry informationi

    Entry nameiFOXN2_HUMAN
    AccessioniPrimary (citable) accession number: P32314
    Secondary accession number(s): Q15769, Q6P4Q2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 125 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3