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P32314

- FOXN2_HUMAN

UniProt

P32314 - FOXN2_HUMAN

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Protein

Forkhead box protein N2

Gene
FOXN2, HTLF
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Binds to the purine-rich region in HTLV-I LTR.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi112 – 20897Fork-headAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: ProtInc

GO - Biological processi

  1. skeletal muscle cell differentiation Source: Ensembl
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein N2
Alternative name(s):
Human T-cell leukemia virus enhancer factor
Gene namesi
Name:FOXN2
Synonyms:HTLF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:5281. FOXN2.

Subcellular locationi

GO - Cellular componenti

  1. intracellular membrane-bounded organelle Source: HPA
  2. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162388822.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 431431Forkhead box protein N2PRO_0000091868Add
BLAST

Proteomic databases

PaxDbiP32314.
PRIDEiP32314.

Expressioni

Gene expression databases

ArrayExpressiP32314.
BgeeiP32314.
CleanExiHS_FOXN2.
GenevestigatoriP32314.

Organism-specific databases

HPAiHPA003485.

Interactioni

Protein-protein interaction databases

BioGridi109576. 3 interactions.
STRINGi9606.ENSP00000343633.

Structurei

3D structure databases

ProteinModelPortaliP32314.
SMRiP32314. Positions 111-191.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5025.
HOGENOMiHOG000095166.
HOVERGENiHBG051654.
KOiK09407.
OMAiCADTSEK.
PhylomeDBiP32314.
TreeFamiTF105083.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P32314-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGPVIGMTPD KRAETPGAEK IAGLSQIYKM GSLPEAVDAA RPKATLVDSE    50
SADDELTNLN WLHESTNLLT NFSLGSEGLP IVSPLYDIEG DDVPSFGPAC 100
YQNPEKKSAT SKPPYSFSLL IYMAIEHSPN KCLPVKEIYS WILDHFPYFA 150
TAPTGWKNSV RHNLSLNKCF QKVERSHGKV NGKGSLWCVD PEYKPNLIQA 200
LKKQPFSSAS SQNGSLSPHY LSSVIKQNQV RNLKESDIDA AAAMMLLNTS 250
IEQGILECEK PLPLKTALQK KRSYGNAFHH PSAVRLQESD SLATSIDPKE 300
DHNYSASSMA AQRCASRSSV SSLSSVDEVY EFIPKNSHVG SDGSEGFHSE 350
EDTDVDYEDD PLGDSGYASQ PCAKISEKGQ SGKKMRKQTC QEIDEELKEA 400
AGSLLHLAGI RTCLGSLIST AKTQNQKQRK K 431
Length:431
Mass (Da):47,161
Last modified:November 25, 2008 - v3
Checksum:i5F71D3C0E4BA1797
GO
Isoform 2 (identifier: P32314-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-90: Missing.
     91-105: DDVPSFGPACYQNPE → MMCDPLDQLATRTQK

Show »
Length:341
Mass (Da):37,735
Checksum:i693069650BF54A8B
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9090Missing in isoform 2. VSP_035743Add
BLAST
Alternative sequencei91 – 10515DDVPS…YQNPE → MMCDPLDQLATRTQK in isoform 2. VSP_035744Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U57029 mRNA. Translation: AAB03504.1.
AC091485 Genomic DNA. Translation: AAY14813.1.
BC063305 mRNA. Translation: AAH63305.1.
CCDSiCCDS1838.1. [P32314-1]
RefSeqiNP_002149.2. NM_002158.3. [P32314-1]
XP_005264339.1. XM_005264282.1. [P32314-1]
XP_005264340.1. XM_005264283.1. [P32314-1]
XP_005264341.1. XM_005264284.1. [P32314-1]
XP_005264342.1. XM_005264285.2. [P32314-1]
XP_006712064.1. XM_006712001.1. [P32314-1]
XP_006712065.1. XM_006712002.1. [P32314-1]
UniGeneiHs.468478.

Genome annotation databases

EnsembliENST00000340553; ENSP00000343633; ENSG00000170802. [P32314-1]
GeneIDi3344.
KEGGihsa:3344.
UCSCiuc002rwh.1. human. [P32314-1]

Polymorphism databases

DMDMi215274148.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U57029 mRNA. Translation: AAB03504.1 .
AC091485 Genomic DNA. Translation: AAY14813.1 .
BC063305 mRNA. Translation: AAH63305.1 .
CCDSi CCDS1838.1. [P32314-1 ]
RefSeqi NP_002149.2. NM_002158.3. [P32314-1 ]
XP_005264339.1. XM_005264282.1. [P32314-1 ]
XP_005264340.1. XM_005264283.1. [P32314-1 ]
XP_005264341.1. XM_005264284.1. [P32314-1 ]
XP_005264342.1. XM_005264285.2. [P32314-1 ]
XP_006712064.1. XM_006712001.1. [P32314-1 ]
XP_006712065.1. XM_006712002.1. [P32314-1 ]
UniGenei Hs.468478.

3D structure databases

ProteinModelPortali P32314.
SMRi P32314. Positions 111-191.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109576. 3 interactions.
STRINGi 9606.ENSP00000343633.

Polymorphism databases

DMDMi 215274148.

Proteomic databases

PaxDbi P32314.
PRIDEi P32314.

Protocols and materials databases

DNASUi 3344.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000340553 ; ENSP00000343633 ; ENSG00000170802 . [P32314-1 ]
GeneIDi 3344.
KEGGi hsa:3344.
UCSCi uc002rwh.1. human. [P32314-1 ]

Organism-specific databases

CTDi 3344.
GeneCardsi GC02P048541.
HGNCi HGNC:5281. FOXN2.
HPAi HPA003485.
MIMi 143089. gene.
neXtProti NX_P32314.
PharmGKBi PA162388822.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5025.
HOGENOMi HOG000095166.
HOVERGENi HBG051654.
KOi K09407.
OMAi CADTSEK.
PhylomeDBi P32314.
TreeFami TF105083.

Miscellaneous databases

ChiTaRSi FOXN2. human.
GenomeRNAii 3344.
NextBioi 13230.
PROi P32314.
SOURCEi Search...

Gene expression databases

ArrayExpressi P32314.
Bgeei P32314.
CleanExi HS_FOXN2.
Genevestigatori P32314.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00250. Fork_head. 1 hit.
[Graphical view ]
PRINTSi PR00053. FORKHEAD.
SMARTi SM00339. FH. 1 hit.
[Graphical view ]
PROSITEi PS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization and chromosomal mapping of the gene encoding the cellular DNA binding protein HTLF."
    Li C., Lusis A.J., Sparkes R., Tran S.-M., Gaynor R.B.
    Genomics 13:658-664(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta.

Entry informationi

Entry nameiFOXN2_HUMAN
AccessioniPrimary (citable) accession number: P32314
Secondary accession number(s): Q15769, Q6P4Q2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: November 25, 2008
Last modified: July 9, 2014
This is version 124 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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