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Protein

Forkhead box protein N2

Gene

FOXN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the purine-rich region in HTLV-I LTR.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi112 – 208Fork-headPROSITE-ProRule annotationAdd BLAST97

GO - Molecular functioni

  • sequence-specific DNA binding Source: GO_Central
  • transcription factor activity, sequence-specific DNA binding Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000170802-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein N2
Alternative name(s):
Human T-cell leukemia virus enhancer factor
Gene namesi
Name:FOXN2
Synonyms:HTLF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:5281. FOXN2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3344.
OpenTargetsiENSG00000170802.
PharmGKBiPA162388822.

Polymorphism and mutation databases

BioMutaiFOXN2.
DMDMi215274148.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000918681 – 431Forkhead box protein N2Add BLAST431

Proteomic databases

MaxQBiP32314.
PaxDbiP32314.
PeptideAtlasiP32314.
PRIDEiP32314.

PTM databases

iPTMnetiP32314.
PhosphoSitePlusiP32314.

Expressioni

Gene expression databases

BgeeiENSG00000170802.
CleanExiHS_FOXN2.
ExpressionAtlasiP32314. baseline and differential.
GenevisibleiP32314. HS.

Organism-specific databases

HPAiHPA003485.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FBXW11Q9UKB14EBI-10706164,EBI-355189
RFX1P226702EBI-10706164,EBI-716037

Protein-protein interaction databases

BioGridi109576. 11 interactors.
IntActiP32314. 7 interactors.
STRINGi9606.ENSP00000343633.

Structurei

3D structure databases

ProteinModelPortaliP32314.
SMRiP32314.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2294. Eukaryota.
COG5025. LUCA.
GeneTreeiENSGT00840000129742.
HOGENOMiHOG000095166.
HOVERGENiHBG051654.
InParanoidiP32314.
KOiK09407.
OMAiCADTSEK.
OrthoDBiEOG091G0EJR.
PhylomeDBiP32314.
TreeFamiTF105083.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. Fork_head_dom.
IPR018122. TF_fork_head_CS_1.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Forkhead. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P32314-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGPVIGMTPD KRAETPGAEK IAGLSQIYKM GSLPEAVDAA RPKATLVDSE
60 70 80 90 100
SADDELTNLN WLHESTNLLT NFSLGSEGLP IVSPLYDIEG DDVPSFGPAC
110 120 130 140 150
YQNPEKKSAT SKPPYSFSLL IYMAIEHSPN KCLPVKEIYS WILDHFPYFA
160 170 180 190 200
TAPTGWKNSV RHNLSLNKCF QKVERSHGKV NGKGSLWCVD PEYKPNLIQA
210 220 230 240 250
LKKQPFSSAS SQNGSLSPHY LSSVIKQNQV RNLKESDIDA AAAMMLLNTS
260 270 280 290 300
IEQGILECEK PLPLKTALQK KRSYGNAFHH PSAVRLQESD SLATSIDPKE
310 320 330 340 350
DHNYSASSMA AQRCASRSSV SSLSSVDEVY EFIPKNSHVG SDGSEGFHSE
360 370 380 390 400
EDTDVDYEDD PLGDSGYASQ PCAKISEKGQ SGKKMRKQTC QEIDEELKEA
410 420 430
AGSLLHLAGI RTCLGSLIST AKTQNQKQRK K
Length:431
Mass (Da):47,161
Last modified:November 25, 2008 - v3
Checksum:i5F71D3C0E4BA1797
GO
Isoform 2 (identifier: P32314-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-90: Missing.
     91-105: DDVPSFGPACYQNPE → MMCDPLDQLATRTQK

Show »
Length:341
Mass (Da):37,735
Checksum:i693069650BF54A8B
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0357431 – 90Missing in isoform 2. 1 PublicationAdd BLAST90
Alternative sequenceiVSP_03574491 – 105DDVPS…YQNPE → MMCDPLDQLATRTQK in isoform 2. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57029 mRNA. Translation: AAB03504.1.
AC091485 Genomic DNA. Translation: AAY14813.1.
BC063305 mRNA. Translation: AAH63305.1.
CCDSiCCDS1838.1. [P32314-1]
RefSeqiNP_002149.2. NM_002158.3. [P32314-1]
XP_005264339.1. XM_005264282.2. [P32314-1]
XP_005264340.1. XM_005264283.2. [P32314-1]
XP_006712064.1. XM_006712001.3. [P32314-1]
XP_006712065.1. XM_006712002.3. [P32314-1]
XP_011531110.1. XM_011532808.2. [P32314-1]
XP_016859445.1. XM_017003956.1. [P32314-1]
XP_016859446.1. XM_017003957.1. [P32314-1]
XP_016859447.1. XM_017003958.1. [P32314-1]
XP_016859448.1. XM_017003959.1. [P32314-1]
UniGeneiHs.468478.

Genome annotation databases

EnsembliENST00000340553; ENSP00000343633; ENSG00000170802. [P32314-1]
GeneIDi3344.
KEGGihsa:3344.
UCSCiuc002rwh.2. human. [P32314-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57029 mRNA. Translation: AAB03504.1.
AC091485 Genomic DNA. Translation: AAY14813.1.
BC063305 mRNA. Translation: AAH63305.1.
CCDSiCCDS1838.1. [P32314-1]
RefSeqiNP_002149.2. NM_002158.3. [P32314-1]
XP_005264339.1. XM_005264282.2. [P32314-1]
XP_005264340.1. XM_005264283.2. [P32314-1]
XP_006712064.1. XM_006712001.3. [P32314-1]
XP_006712065.1. XM_006712002.3. [P32314-1]
XP_011531110.1. XM_011532808.2. [P32314-1]
XP_016859445.1. XM_017003956.1. [P32314-1]
XP_016859446.1. XM_017003957.1. [P32314-1]
XP_016859447.1. XM_017003958.1. [P32314-1]
XP_016859448.1. XM_017003959.1. [P32314-1]
UniGeneiHs.468478.

3D structure databases

ProteinModelPortaliP32314.
SMRiP32314.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109576. 11 interactors.
IntActiP32314. 7 interactors.
STRINGi9606.ENSP00000343633.

PTM databases

iPTMnetiP32314.
PhosphoSitePlusiP32314.

Polymorphism and mutation databases

BioMutaiFOXN2.
DMDMi215274148.

Proteomic databases

MaxQBiP32314.
PaxDbiP32314.
PeptideAtlasiP32314.
PRIDEiP32314.

Protocols and materials databases

DNASUi3344.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340553; ENSP00000343633; ENSG00000170802. [P32314-1]
GeneIDi3344.
KEGGihsa:3344.
UCSCiuc002rwh.2. human. [P32314-1]

Organism-specific databases

CTDi3344.
DisGeNETi3344.
GeneCardsiFOXN2.
HGNCiHGNC:5281. FOXN2.
HPAiHPA003485.
MIMi143089. gene.
neXtProtiNX_P32314.
OpenTargetsiENSG00000170802.
PharmGKBiPA162388822.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2294. Eukaryota.
COG5025. LUCA.
GeneTreeiENSGT00840000129742.
HOGENOMiHOG000095166.
HOVERGENiHBG051654.
InParanoidiP32314.
KOiK09407.
OMAiCADTSEK.
OrthoDBiEOG091G0EJR.
PhylomeDBiP32314.
TreeFamiTF105083.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000170802-MONOMER.

Miscellaneous databases

ChiTaRSiFOXN2. human.
GenomeRNAii3344.
PROiP32314.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170802.
CleanExiHS_FOXN2.
ExpressionAtlasiP32314. baseline and differential.
GenevisibleiP32314. HS.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. Fork_head_dom.
IPR018122. TF_fork_head_CS_1.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Forkhead. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFOXN2_HUMAN
AccessioniPrimary (citable) accession number: P32314
Secondary accession number(s): Q15769, Q6P4Q2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: November 25, 2008
Last modified: November 2, 2016
This is version 145 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.