P32314 (FOXN2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Forkhead box protein N2

Alternative name(s):
Human T-cell leukemia virus enhancer factor

Gene names

Name:	FOXN2
Synonyms:	HTLF

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	431 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Binds to the purine-rich region in HTLV-I LTR.
Subcellular location	Nucleus.
Sequence similarities	Contains 1 fork-head DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	embryo development Inferred from Biological aspect of Ancestor. Source: RefGenome pattern specification process Inferred from Biological aspect of Ancestor. Source: RefGenome regulation of sequence-specific DNA binding transcription factor activity Inferred from Biological aspect of Ancestor. Source: RefGenome tissue development Inferred from Biological aspect of Ancestor. Source: RefGenome
Cellular_component	transcription factor complex Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	DNA binding, bending Inferred from Biological aspect of Ancestor. Source: RefGenome RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Inferred from Biological aspect of Ancestor. Source: RefGenome double-stranded DNA binding Inferred from Biological aspect of Ancestor. Source: RefGenome sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor binding Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P32314-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P32314-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-90: Missing.
     91-105: DDVPSFGPACYQNPE → MMCDPLDQLATRTQK

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 431	431	Forkhead box protein N2		PRO_0000091868
Regions
	DNA binding	112 – 208	97	Fork-head
Natural variations
	Alternative sequence	1 – 90	90	Missing in isoform 2.		VSP_035743
	Alternative sequence	91 – 105	15	DDVPS…YQNPE → MMCDPLDQLATRTQK in isoform 2.		VSP_035744

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 25, 2008. Version 3. Checksum: 5F71D3C0E4BA1797	FASTA	431	47,161
	10 20 30 40 50 60 MGPVIGMTPD KRAETPGAEK IAGLSQIYKM GSLPEAVDAA RPKATLVDSE SADDELTNLN 70 80 90 100 110 120 WLHESTNLLT NFSLGSEGLP IVSPLYDIEG DDVPSFGPAC YQNPEKKSAT SKPPYSFSLL 130 140 150 160 170 180 IYMAIEHSPN KCLPVKEIYS WILDHFPYFA TAPTGWKNSV RHNLSLNKCF QKVERSHGKV 190 200 210 220 230 240 NGKGSLWCVD PEYKPNLIQA LKKQPFSSAS SQNGSLSPHY LSSVIKQNQV RNLKESDIDA 250 260 270 280 290 300 AAAMMLLNTS IEQGILECEK PLPLKTALQK KRSYGNAFHH PSAVRLQESD SLATSIDPKE 310 320 330 340 350 360 DHNYSASSMA AQRCASRSSV SSLSSVDEVY EFIPKNSHVG SDGSEGFHSE EDTDVDYEDD 370 380 390 400 410 420 PLGDSGYASQ PCAKISEKGQ SGKKMRKQTC QEIDEELKEA AGSLLHLAGI RTCLGSLIST 430 AKTQNQKQRK K
	Isoform 2 [UniParc]. Checksum: 693069650BF54A8B	FASTA	341	37,735
	10 20 30 40 50 60 MMCDPLDQLA TRTQKKKSAT SKPPYSFSLL IYMAIEHSPN KCLPVKEIYS WILDHFPYFA 70 80 90 100 110 120 TAPTGWKNSV RHNLSLNKCF QKVERSHGKV NGKGSLWCVD PEYKPNLIQA LKKQPFSSAS 130 140 150 160 170 180 SQNGSLSPHY LSSVIKQNQV RNLKESDIDA AAAMMLLNTS IEQGILECEK PLPLKTALQK 190 200 210 220 230 240 KRSYGNAFHH PSAVRLQESD SLATSIDPKE DHNYSASSMA AQRCASRSSV SSLSSVDEVY 250 260 270 280 290 300 EFIPKNSHVG SDGSEGFHSE EDTDVDYEDD PLGDSGYASQ PCAKISEKGQ SGKKMRKQTC 310 320 330 340 QEIDEELKEA AGSLLHLAGI RTCLGSLIST AKTQNQKQRK K

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization and chromosomal mapping of the gene encoding the cellular DNA binding protein HTLF." Li C., Lusis A.J., Sparkes R., Tran S.-M., Gaynor R.B. Genomics 13:658-664(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Placenta.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U57029 mRNA. Translation: AAB03504.1. AC091485 Genomic DNA. Translation: AAY14813.1. BC063305 mRNA. Translation: AAH63305.1.
IPI	IPI00027968. IPI00413146.
RefSeq	NP_002149.2. NM_002158.3.
UniGene	Hs.468478.
3D structure databases
ProteinModelPortal	P32314.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000343633.
Polymorphism databases
DMDM	215274148.
Proteomic databases
PaxDb	P32314.
PRIDE	P32314.
Protocols and materials databases
DNASU	3344.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000340553; ENSP00000343633; ENSG00000170802.
GeneID	3344.
KEGG	hsa:3344.
UCSC	uc002rwh.1. human.
Organism-specific databases
CTD	3344.
GeneCards	GC02P048541.
HGNC	HGNC:5281. FOXN2.
HPA	HPA003485.
MIM	143089. gene.
neXtProt	NX_P32314.
PharmGKB	PA162388822.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5025.
HOGENOM	HOG000095166.
HOVERGEN	HBG051654.
KO	K09407.
OMA	FGSEGLP.
OrthoDB	EOG4M91RT.
PhylomeDB	P32314.
Gene expression databases
ArrayExpress	P32314.
Bgee	P32314.
CleanEx	HS_FOXN2.
Genevestigator	P32314.
GermOnline	ENSG00000170802. Homo sapiens.
Family and domain databases
Gene3D	1.10.10.10. 1 hit.
InterPro	IPR001766. TF_fork_head. IPR018122. TF_fork_head_CS. IPR011991. WHTH_DNA-bd_dom. [Graphical view]
Pfam	PF00250. Fork_head. 1 hit. [Graphical view]
PRINTS	PR00053. FORKHEAD.
SMART	SM00339. FH. 1 hit. [Graphical view]
PROSITE	PS00657. FORK_HEAD_1. 1 hit. PS00658. FORK_HEAD_2. 1 hit. PS50039. FORK_HEAD_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	FOXN2. human.
GenomeRNAi	3344.
NextBio	13230.
SOURCE	Search...

Entry information

Entry name

FOXN2_HUMAN

Accession

Primary (citable) accession number: P32314
Secondary accession number(s): Q15769, Q6P4Q2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
Last sequence update:	November 25, 2008
Last modified:	May 1, 2013
This is version 113 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.