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Protein

Forkhead box protein N2

Gene

FOXN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to the purine-rich region in HTLV-I LTR.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi112 – 208Fork-headPROSITE-ProRule annotationAdd BLAST97

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein N2
Alternative name(s):
Human T-cell leukemia virus enhancer factor
Gene namesi
Name:FOXN2
Synonyms:HTLF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000170802.15
HGNCiHGNC:5281 FOXN2
MIMi143089 gene
neXtProtiNX_P32314

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3344
OpenTargetsiENSG00000170802
PharmGKBiPA162388822

Polymorphism and mutation databases

BioMutaiFOXN2
DMDMi215274148

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000918681 – 431Forkhead box protein N2Add BLAST431

Proteomic databases

MaxQBiP32314
PaxDbiP32314
PeptideAtlasiP32314
PRIDEiP32314

PTM databases

iPTMnetiP32314
PhosphoSitePlusiP32314

Expressioni

Gene expression databases

BgeeiENSG00000170802
CleanExiHS_FOXN2
ExpressionAtlasiP32314 baseline and differential
GenevisibleiP32314 HS

Organism-specific databases

HPAiHPA003485

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi10957612 interactors.
IntActiP32314 7 interactors.
MINTiP32314
STRINGi9606.ENSP00000343633

Structurei

3D structure databases

ProteinModelPortaliP32314
SMRiP32314
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG2294 Eukaryota
COG5025 LUCA
GeneTreeiENSGT00910000144055
HOGENOMiHOG000095166
HOVERGENiHBG051654
InParanoidiP32314
KOiK09407
OMAiCADTSEK
OrthoDBiEOG091G0EJR
PhylomeDBiP32314
TreeFamiTF105083

Family and domain databases

CDDicd00059 FH, 1 hit
Gene3Di1.10.10.101 hit
InterProiView protein in InterPro
IPR001766 Fork_head_dom
IPR018122 TF_fork_head_CS_1
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00250 Forkhead, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00657 FORK_HEAD_1, 1 hit
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P32314-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGPVIGMTPD KRAETPGAEK IAGLSQIYKM GSLPEAVDAA RPKATLVDSE
60 70 80 90 100
SADDELTNLN WLHESTNLLT NFSLGSEGLP IVSPLYDIEG DDVPSFGPAC
110 120 130 140 150
YQNPEKKSAT SKPPYSFSLL IYMAIEHSPN KCLPVKEIYS WILDHFPYFA
160 170 180 190 200
TAPTGWKNSV RHNLSLNKCF QKVERSHGKV NGKGSLWCVD PEYKPNLIQA
210 220 230 240 250
LKKQPFSSAS SQNGSLSPHY LSSVIKQNQV RNLKESDIDA AAAMMLLNTS
260 270 280 290 300
IEQGILECEK PLPLKTALQK KRSYGNAFHH PSAVRLQESD SLATSIDPKE
310 320 330 340 350
DHNYSASSMA AQRCASRSSV SSLSSVDEVY EFIPKNSHVG SDGSEGFHSE
360 370 380 390 400
EDTDVDYEDD PLGDSGYASQ PCAKISEKGQ SGKKMRKQTC QEIDEELKEA
410 420 430
AGSLLHLAGI RTCLGSLIST AKTQNQKQRK K
Length:431
Mass (Da):47,161
Last modified:November 25, 2008 - v3
Checksum:i5F71D3C0E4BA1797
GO
Isoform 2 (identifier: P32314-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-90: Missing.
     91-105: DDVPSFGPACYQNPE → MMCDPLDQLATRTQK

Show »
Length:341
Mass (Da):37,735
Checksum:i693069650BF54A8B
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0357431 – 90Missing in isoform 2. 1 PublicationAdd BLAST90
Alternative sequenceiVSP_03574491 – 105DDVPS…YQNPE → MMCDPLDQLATRTQK in isoform 2. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57029 mRNA Translation: AAB03504.1
AC091485 Genomic DNA Translation: AAY14813.1
BC063305 mRNA Translation: AAH63305.1
CCDSiCCDS1838.1 [P32314-1]
RefSeqiNP_002149.2, NM_002158.3 [P32314-1]
XP_005264339.1, XM_005264282.2 [P32314-1]
XP_005264340.1, XM_005264283.2 [P32314-1]
XP_006712064.1, XM_006712001.3 [P32314-1]
XP_006712065.1, XM_006712002.3 [P32314-1]
XP_011531110.1, XM_011532808.2 [P32314-1]
XP_016859445.1, XM_017003956.1 [P32314-1]
XP_016859446.1, XM_017003957.1 [P32314-1]
XP_016859447.1, XM_017003958.1 [P32314-1]
XP_016859448.1, XM_017003959.1 [P32314-1]
UniGeneiHs.468478

Genome annotation databases

EnsembliENST00000340553; ENSP00000343633; ENSG00000170802 [P32314-1]
GeneIDi3344
KEGGihsa:3344
UCSCiuc002rwh.2 human [P32314-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiFOXN2_HUMAN
AccessioniPrimary (citable) accession number: P32314
Secondary accession number(s): Q15769, Q6P4Q2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: November 25, 2008
Last modified: April 25, 2018
This is version 154 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome