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P32314 (FOXN2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 124. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Forkhead box protein N2
Alternative name(s):
Human T-cell leukemia virus enhancer factor
Gene names
Name:FOXN2
Synonyms:HTLF
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length431 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Binds to the purine-rich region in HTLV-I LTR.

Subcellular location

Nucleus.

Sequence similarities

Contains 1 fork-head DNA-binding domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P32314-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P32314-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-90: Missing.
     91-105: DDVPSFGPACYQNPE → MMCDPLDQLATRTQK

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 431431Forkhead box protein N2
PRO_0000091868

Regions

DNA binding112 – 20897Fork-head

Natural variations

Alternative sequence1 – 9090Missing in isoform 2.
VSP_035743
Alternative sequence91 – 10515DDVPS…YQNPE → MMCDPLDQLATRTQK in isoform 2.
VSP_035744

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 25, 2008. Version 3.
Checksum: 5F71D3C0E4BA1797

FASTA43147,161
        10         20         30         40         50         60 
MGPVIGMTPD KRAETPGAEK IAGLSQIYKM GSLPEAVDAA RPKATLVDSE SADDELTNLN 

        70         80         90        100        110        120 
WLHESTNLLT NFSLGSEGLP IVSPLYDIEG DDVPSFGPAC YQNPEKKSAT SKPPYSFSLL 

       130        140        150        160        170        180 
IYMAIEHSPN KCLPVKEIYS WILDHFPYFA TAPTGWKNSV RHNLSLNKCF QKVERSHGKV 

       190        200        210        220        230        240 
NGKGSLWCVD PEYKPNLIQA LKKQPFSSAS SQNGSLSPHY LSSVIKQNQV RNLKESDIDA 

       250        260        270        280        290        300 
AAAMMLLNTS IEQGILECEK PLPLKTALQK KRSYGNAFHH PSAVRLQESD SLATSIDPKE 

       310        320        330        340        350        360 
DHNYSASSMA AQRCASRSSV SSLSSVDEVY EFIPKNSHVG SDGSEGFHSE EDTDVDYEDD 

       370        380        390        400        410        420 
PLGDSGYASQ PCAKISEKGQ SGKKMRKQTC QEIDEELKEA AGSLLHLAGI RTCLGSLIST 

       430 
AKTQNQKQRK K 

« Hide

Isoform 2 [UniParc].

Checksum: 693069650BF54A8B
Show »

FASTA34137,735

References

« Hide 'large scale' references
[1]"Characterization and chromosomal mapping of the gene encoding the cellular DNA binding protein HTLF."
Li C., Lusis A.J., Sparkes R., Tran S.-M., Gaynor R.B.
Genomics 13:658-664(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Placenta.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U57029 mRNA. Translation: AAB03504.1.
AC091485 Genomic DNA. Translation: AAY14813.1.
BC063305 mRNA. Translation: AAH63305.1.
CCDSCCDS1838.1. [P32314-1]
RefSeqNP_002149.2. NM_002158.3. [P32314-1]
XP_005264339.1. XM_005264282.1. [P32314-1]
XP_005264340.1. XM_005264283.1. [P32314-1]
XP_005264341.1. XM_005264284.1. [P32314-1]
XP_005264342.1. XM_005264285.2. [P32314-1]
XP_006712064.1. XM_006712001.1. [P32314-1]
XP_006712065.1. XM_006712002.1. [P32314-1]
UniGeneHs.468478.

3D structure databases

ProteinModelPortalP32314.
SMRP32314. Positions 111-191.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109576. 3 interactions.
STRING9606.ENSP00000343633.

Polymorphism databases

DMDM215274148.

Proteomic databases

PaxDbP32314.
PRIDEP32314.

Protocols and materials databases

DNASU3344.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000340553; ENSP00000343633; ENSG00000170802. [P32314-1]
GeneID3344.
KEGGhsa:3344.
UCSCuc002rwh.1. human. [P32314-1]

Organism-specific databases

CTD3344.
GeneCardsGC02P048541.
HGNCHGNC:5281. FOXN2.
HPAHPA003485.
MIM143089. gene.
neXtProtNX_P32314.
PharmGKBPA162388822.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5025.
HOGENOMHOG000095166.
HOVERGENHBG051654.
KOK09407.
OMACADTSEK.
PhylomeDBP32314.
TreeFamTF105083.

Gene expression databases

ArrayExpressP32314.
BgeeP32314.
CleanExHS_FOXN2.
GenevestigatorP32314.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
InterProIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSPR00053. FORKHEAD.
SMARTSM00339. FH. 1 hit.
[Graphical view]
PROSITEPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSFOXN2. human.
GenomeRNAi3344.
NextBio13230.
PROP32314.
SOURCESearch...

Entry information

Entry nameFOXN2_HUMAN
AccessionPrimary (citable) accession number: P32314
Secondary accession number(s): Q15769, Q6P4Q2
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: November 25, 2008
Last modified: July 9, 2014
This is version 124 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM