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Protein

Vasopressin V2 receptor

Gene

AVPR2

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:8393786). Involved in renal water reabsorption (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-SSC-388479. Vasopressin-like receptors.
R-SSC-418555. G alpha (s) signalling events.
R-SSC-432040. Vasopressin regulates renal water homeostasis via Aquaporins.

Names & Taxonomyi

Protein namesi
Recommended name:
Vasopressin V2 receptor
Short name:
V2R
Alternative name(s):
AVPR V2
Antidiuretic hormone receptor
Renal-type arginine vasopressin receptor
Gene namesi
Name:AVPR2
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome X

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3737ExtracellularSequence analysisAdd
BLAST
Transmembranei38 – 6225Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini63 – 7614CytoplasmicSequence analysisAdd
BLAST
Transmembranei77 – 9721Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini98 – 11215ExtracellularSequence analysisAdd
BLAST
Transmembranei113 – 13422Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini135 – 15824CytoplasmicSequence analysisAdd
BLAST
Transmembranei159 – 17921Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini180 – 19920ExtracellularSequence analysisAdd
BLAST
Transmembranei200 – 21920Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini220 – 27051CytoplasmicSequence analysisAdd
BLAST
Transmembranei271 – 29222Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini293 – 30715ExtracellularSequence analysisAdd
BLAST
Transmembranei308 – 32720Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini328 – 37043CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL3944.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 370370Vasopressin V2 receptorPRO_0000070210Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi21 – 211N-linked (GlcNAc...)Sequence analysis
Lipidationi340 – 3401S-palmitoyl cysteineBy similarity
Lipidationi341 – 3411S-palmitoyl cysteineBy similarity

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP32307.

Expressioni

Gene expression databases

GenevisibleiP32307. SS.

Interactioni

Subunit structurei

Interacts with ARRDC4. Identified in a complex containing at least ARRDC4, V2R and HGS.By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000013598.

Chemistry

BindingDBiP32307.

Structurei

3D structure databases

ProteinModelPortaliP32307.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119156.
HOGENOMiHOG000237331.
HOVERGENiHBG105710.
InParanoidiP32307.
KOiK04228.
OMAiGGARWNR.
OrthoDBiEOG7Z69CP.
TreeFamiTF106499.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001817. Vasoprsn_rcpt.
IPR000161. Vprsn_rcpt_V2.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PR00898. VASOPRSNV2R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32307-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRATTSAVP RALSWPAAPG NGSEREPLDD RDPLLARVEL ALLSTVFVAV
60 70 80 90 100
ALSNGLVLGA LVRRGRRGRW APMHVFIGHL CLADLAVALF QVLPQLAWDA
110 120 130 140 150
TYRFRGPDAL CRAVKYLQMV GMYASSYMIL AMTLDRHRAI CRPMLAYRHG
160 170 180 190 200
GGARWNRPVL VAWAFSLLLS LPQLFIFAQR DVGDGSGVLD CWASFAEPWG
210 220 230 240 250
LRAYVTWIAL MVFVAPALGI AACQVLIFRE IHTSLVPGPA ERAGGHRGGR
260 270 280 290 300
RAGSPREGAR VSAAMAKTAR MTLVIVAVYV LCWAPFFLVQ LWSVWDPKAP
310 320 330 340 350
REGPPFVLLM LLASLNSCTN PWIYASFSSS ISSELRSLLC CPRRRTPPSL
360 370
RPQEESCATA SSFSARDTSS
Length:370
Mass (Da):40,537
Last modified:October 1, 1993 - v1
Checksum:i18079C128B689F2F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71795 mRNA. Translation: CAA50678.1.
PIRiS34042.
RefSeqiNP_999397.1. NM_214232.1.
UniGeneiSsc.16216.

Genome annotation databases

EnsembliENSSSCT00000013981; ENSSSCP00000013598; ENSSSCG00000012789.
GeneIDi397462.
KEGGissc:397462.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71795 mRNA. Translation: CAA50678.1.
PIRiS34042.
RefSeqiNP_999397.1. NM_214232.1.
UniGeneiSsc.16216.

3D structure databases

ProteinModelPortaliP32307.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000013598.

Chemistry

BindingDBiP32307.
ChEMBLiCHEMBL3944.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiP32307.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000013981; ENSSSCP00000013598; ENSSSCG00000012789.
GeneIDi397462.
KEGGissc:397462.

Organism-specific databases

CTDi554.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119156.
HOGENOMiHOG000237331.
HOVERGENiHBG105710.
InParanoidiP32307.
KOiK04228.
OMAiGGARWNR.
OrthoDBiEOG7Z69CP.
TreeFamiTF106499.

Enzyme and pathway databases

ReactomeiR-SSC-388479. Vasopressin-like receptors.
R-SSC-418555. G alpha (s) signalling events.
R-SSC-432040. Vasopressin regulates renal water homeostasis via Aquaporins.

Gene expression databases

GenevisibleiP32307. SS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001817. Vasoprsn_rcpt.
IPR000161. Vprsn_rcpt_V2.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PR00898. VASOPRSNV2R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and functional characterization of V2 [8-lysine] vasopressin and oxytocin receptors from a pig kidney cell line."
    Gorbulev V., Buechner H., Akhundova A., Fahrenholz F.
    Eur. J. Biochem. 215:1-7(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION.
    Tissue: Kidney.

Entry informationi

Entry nameiV2R_PIG
AccessioniPrimary (citable) accession number: P32307
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: February 17, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.