ID   5HT7R_MOUSE             Reviewed;         448 AA.
AC   P32304; Q14A50;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 2.
DT   27-MAR-2024, entry version 167.
DE   RecName: Full=5-hydroxytryptamine receptor 7;
DE            Short=5-HT-7;
DE            Short=5-HT7;
DE   AltName: Full=5-HT-X;
DE   AltName: Full=Serotonin receptor 7;
GN   Name=Htr7;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8394987;
RA   Plassat J.-L., Amlaiky N., Hen R.;
RT   "Molecular cloning of a mammalian serotonin receptor that activates
RT   adenylate cyclase.";
RL   Mol. Pharmacol. 44:229-236(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: This is one of the several different receptors for 5-
CC       hydroxytryptamine (serotonin), a biogenic hormone that functions as a
CC       neurotransmitter, a hormone, and a mitogen. The activity of this
CC       receptor is mediated by G proteins that stimulate adenylate cyclase.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; Z23107; CAA80654.1; -; mRNA.
DR   EMBL; CH466534; EDL41763.1; -; Genomic_DNA.
DR   EMBL; BC116986; AAI16987.1; -; mRNA.
DR   CCDS; CCDS29769.1; -.
DR   PIR; I48779; S36402.
DR   RefSeq; NP_032341.2; NM_008315.2.
DR   AlphaFoldDB; P32304; -.
DR   SMR; P32304; -.
DR   STRING; 10090.ENSMUSP00000097105; -.
DR   BindingDB; P32304; -.
DR   ChEMBL; CHEMBL4764; -.
DR   DrugCentral; P32304; -.
DR   GuidetoPHARMACOLOGY; 12; -.
DR   GlyCosmos; P32304; 2 sites, No reported glycans.
DR   GlyGen; P32304; 2 sites.
DR   iPTMnet; P32304; -.
DR   PhosphoSitePlus; P32304; -.
DR   SwissPalm; P32304; -.
DR   PaxDb; 10090-ENSMUSP00000126847; -.
DR   ProteomicsDB; 285691; -.
DR   Antibodypedia; 16324; 482 antibodies from 37 providers.
DR   DNASU; 15566; -.
DR   Ensembl; ENSMUST00000164639.8; ENSMUSP00000126847.2; ENSMUSG00000024798.16.
DR   GeneID; 15566; -.
DR   KEGG; mmu:15566; -.
DR   UCSC; uc008hhd.1; mouse.
DR   AGR; MGI:99841; -.
DR   CTD; 3363; -.
DR   MGI; MGI:99841; Htr7.
DR   VEuPathDB; HostDB:ENSMUSG00000024798; -.
DR   eggNOG; KOG3656; Eukaryota.
DR   GeneTree; ENSGT01010000222287; -.
DR   InParanoid; P32304; -.
DR   OMA; LXKTLTT; -.
DR   OrthoDB; 2999405at2759; -.
DR   PhylomeDB; P32304; -.
DR   TreeFam; TF331895; -.
DR   Reactome; R-MMU-390666; Serotonin receptors.
DR   Reactome; R-MMU-418555; G alpha (s) signalling events.
DR   Reactome; R-MMU-9706019; RHOBTB3 ATPase cycle.
DR   BioGRID-ORCS; 15566; 3 hits in 77 CRISPR screens.
DR   ChiTaRS; Htr7; mouse.
DR   PRO; PR:P32304; -.
DR   Proteomes; UP000000589; Chromosome 19.
DR   RNAct; P32304; Protein.
DR   Bgee; ENSMUSG00000024798; Expressed in medial dorsal nucleus of thalamus and 127 other cell types or tissues.
DR   ExpressionAtlas; P32304; baseline and differential.
DR   GO; GO:0043679; C:axon terminus; ISO:MGI.
DR   GO; GO:0030425; C:dendrite; ISO:MGI.
DR   GO; GO:0043025; C:neuronal cell body; ISO:MGI.
DR   GO; GO:0045211; C:postsynaptic membrane; ISO:MGI.
DR   GO; GO:0042734; C:presynaptic membrane; ISO:MGI.
DR   GO; GO:0008021; C:synaptic vesicle; ISO:MGI.
DR   GO; GO:0004993; F:G protein-coupled serotonin receptor activity; ISO:MGI.
DR   GO; GO:0030594; F:neurotransmitter receptor activity; ISO:MGI.
DR   GO; GO:0007192; P:adenylate cyclase-activating serotonin receptor signaling pathway; ISO:MGI.
DR   GO; GO:0048266; P:behavioral response to pain; ISO:MGI.
DR   GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR   GO; GO:0007623; P:circadian rhythm; IEA:InterPro.
DR   GO; GO:0050966; P:detection of mechanical stimulus involved in sensory perception of pain; ISO:MGI.
DR   GO; GO:0071542; P:dopaminergic neuron differentiation; ISO:MGI.
DR   GO; GO:0007187; P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; IBA:GO_Central.
DR   GO; GO:0060291; P:long-term synaptic potentiation; ISO:MGI.
DR   GO; GO:0007613; P:memory; ISO:MGI.
DR   GO; GO:0014063; P:negative regulation of serotonin secretion; ISO:MGI.
DR   GO; GO:0010976; P:positive regulation of neuron projection development; ISO:MGI.
DR   GO; GO:0099171; P:presynaptic modulation of chemical synaptic transmission; ISO:MGI.
DR   GO; GO:0062086; P:regulation of vein smooth muscle contraction; ISO:MGI.
DR   GO; GO:0051412; P:response to corticosterone; ISO:MGI.
DR   GO; GO:0007210; P:serotonin receptor signaling pathway; ISO:MGI.
DR   GO; GO:0014832; P:urinary bladder smooth muscle contraction; ISO:MGI.
DR   GO; GO:0042310; P:vasoconstriction; IEA:InterPro.
DR   CDD; cd15329; 7tmA_5-HT7; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR001069; 5HT_7_rcpt.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   PANTHER; PTHR24247; 5-HYDROXYTRYPTAMINE RECEPTOR; 1.
DR   PANTHER; PTHR24247:SF221; 5-HYDROXYTRYPTAMINE RECEPTOR 7; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00652; 5HT7RECEPTR.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   Genevisible; P32304; MM.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Lipoprotein; Membrane; Palmitate; Receptor; Reference proteome; Transducer;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..448
FT                   /note="5-hydroxytryptamine receptor 7"
FT                   /id="PRO_0000068980"
FT   TOPO_DOM        1..84
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        85..111
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        112..121
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        122..147
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        148..159
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        160..181
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        182..201
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        202..225
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        226..240
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        241..263
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        264..331
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        332..355
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        356..367
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        368..390
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        391..448
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   LIPID           404
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        69
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        158..234
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   CONFLICT        114..115
FT                   /note="KL -> NV (in Ref. 1; CAA80654)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        211
FT                   /note="L -> P (in Ref. 1; CAA80654)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        321
FT                   /note="I -> S (in Ref. 1; CAA80654)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        388
FT                   /note="A -> S (in Ref. 1; CAA80654)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   448 AA;  49916 MW;  85A525FD90792CB1 CRC64;
     MMDVNSSGRP DLYGHLRSLI LPEVGRRLQD LSPDGGAHSV VSSWMPHLLS GFPEVTASPA
     PTWDAPPDNV SGCGEQINYG RVEKVVIGSI LTLITLLTIA GNCLVVISVC FVKKLRQPSN
     YLIVSLALAD LSVAVAVMPF VSVTDLIGGK WIFGHFFCNV FIAMDVMCCT ASIMTLCVIS
     IDRYLGITRP LTYPVRQNGK CMAKMILSVW LLSASITLPP LFGWAQNVND DKVCLISQDF
     GYTIYSTAVA FYIPMSVMLF MYYQIYKAAR KSAAKHKFSG FPRVQPESVI SLNGVVKLQK
     EVEECANLSR LLKHERKNIS IFKREQKAAT TLGIIVGAFT VCWLPFFLLS TARPFICGTS
     CSCIPLWVER TCLWLGYANS LINPFIYAFF NRDLRTTYRS LLQCQYRNIN RKLSAAGMHE
     ALKLAERPER SEFVLQNCDH CGKKGHDT
//