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P32304

- 5HT7R_MOUSE

UniProt

P32304 - 5HT7R_MOUSE

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Protein

5-hydroxytryptamine receptor 7

Gene

Htr7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.

GO - Molecular functioni

  1. serotonin receptor activity Source: InterPro

GO - Biological processi

  1. circadian rhythm Source: InterPro
  2. smooth muscle contraction Source: InterPro
  3. synaptic transmission Source: InterPro
  4. vasoconstriction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
5-hydroxytryptamine receptor 7
Short name:
5-HT-7
Short name:
5-HT7
Alternative name(s):
5-HT-X
Serotonin receptor 7
Gene namesi
Name:Htr7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:99841. Htr7.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4484485-hydroxytryptamine receptor 7PRO_0000068980Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Glycosylationi69 – 691N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi158 ↔ 234PROSITE-ProRule annotation
Lipidationi404 – 4041S-palmitoyl cysteineSequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PRIDEiP32304.

Expressioni

Gene expression databases

BgeeiP32304.
CleanExiMM_HTR7.
ExpressionAtlasiP32304. baseline and differential.
GenevestigatoriP32304.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliP32304.
SMRiP32304. Positions 84-404.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8484ExtracellularBy similarityAdd
BLAST
Topological domaini112 – 12110CytoplasmicBy similarity
Topological domaini148 – 15912ExtracellularBy similarityAdd
BLAST
Topological domaini182 – 20120CytoplasmicBy similarityAdd
BLAST
Topological domaini226 – 24015ExtracellularBy similarityAdd
BLAST
Topological domaini264 – 33168CytoplasmicBy similarityAdd
BLAST
Topological domaini356 – 36712ExtracellularBy similarityAdd
BLAST
Topological domaini391 – 44858CytoplasmicBy similarityAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei85 – 11127Helical; Name=1By similarityAdd
BLAST
Transmembranei122 – 14726Helical; Name=2By similarityAdd
BLAST
Transmembranei160 – 18122Helical; Name=3By similarityAdd
BLAST
Transmembranei202 – 22524Helical; Name=4By similarityAdd
BLAST
Transmembranei241 – 26323Helical; Name=5By similarityAdd
BLAST
Transmembranei332 – 35524Helical; Name=6By similarityAdd
BLAST
Transmembranei368 – 39023Helical; Name=7By similarityAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG249628.
GeneTreeiENSGT00760000118795.
HOVERGENiHBG106962.
InParanoidiP32304.
KOiK04163.
OrthoDBiEOG7S7SDT.
PhylomeDBiP32304.
TreeFamiTF331895.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR001069. 5HT_7_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00652. 5HT7RECEPTR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32304-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMDVNSSGRP DLYGHLRSLI LPEVGRRLQD LSPDGGAHSV VSSWMPHLLS
60 70 80 90 100
GFPEVTASPA PTWDAPPDNV SGCGEQINYG RVEKVVIGSI LTLITLLTIA
110 120 130 140 150
GNCLVVISVC FVKKLRQPSN YLIVSLALAD LSVAVAVMPF VSVTDLIGGK
160 170 180 190 200
WIFGHFFCNV FIAMDVMCCT ASIMTLCVIS IDRYLGITRP LTYPVRQNGK
210 220 230 240 250
CMAKMILSVW LLSASITLPP LFGWAQNVND DKVCLISQDF GYTIYSTAVA
260 270 280 290 300
FYIPMSVMLF MYYQIYKAAR KSAAKHKFSG FPRVQPESVI SLNGVVKLQK
310 320 330 340 350
EVEECANLSR LLKHERKNIS IFKREQKAAT TLGIIVGAFT VCWLPFFLLS
360 370 380 390 400
TARPFICGTS CSCIPLWVER TCLWLGYANS LINPFIYAFF NRDLRTTYRS
410 420 430 440
LLQCQYRNIN RKLSAAGMHE ALKLAERPER SEFVLQNCDH CGKKGHDT
Length:448
Mass (Da):49,916
Last modified:July 27, 2011 - v2
Checksum:i85A525FD90792CB1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti114 – 1152KL → NV in CAA80654. (PubMed:8394987)Curated
Sequence conflicti211 – 2111L → P in CAA80654. (PubMed:8394987)Curated
Sequence conflicti321 – 3211I → S in CAA80654. (PubMed:8394987)Curated
Sequence conflicti388 – 3881A → S in CAA80654. (PubMed:8394987)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z23107 mRNA. Translation: CAA80654.1.
CH466534 Genomic DNA. Translation: EDL41763.1.
BC116986 mRNA. Translation: AAI16987.1.
CCDSiCCDS29769.1.
PIRiI48779. S36402.
RefSeqiNP_032341.2. NM_008315.2.
UniGeneiMm.254266.

Genome annotation databases

EnsembliENSMUST00000164639; ENSMUSP00000126847; ENSMUSG00000024798.
GeneIDi15566.
KEGGimmu:15566.
UCSCiuc008hhd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z23107 mRNA. Translation: CAA80654.1 .
CH466534 Genomic DNA. Translation: EDL41763.1 .
BC116986 mRNA. Translation: AAI16987.1 .
CCDSi CCDS29769.1.
PIRi I48779. S36402.
RefSeqi NP_032341.2. NM_008315.2.
UniGenei Mm.254266.

3D structure databases

ProteinModelPortali P32304.
SMRi P32304. Positions 84-404.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi P32304.
ChEMBLi CHEMBL4764.
GuidetoPHARMACOLOGYi 12.

Protein family/group databases

GPCRDBi Search...

Proteomic databases

PRIDEi P32304.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000164639 ; ENSMUSP00000126847 ; ENSMUSG00000024798 .
GeneIDi 15566.
KEGGi mmu:15566.
UCSCi uc008hhd.1. mouse.

Organism-specific databases

CTDi 3363.
MGIi MGI:99841. Htr7.

Phylogenomic databases

eggNOGi NOG249628.
GeneTreei ENSGT00760000118795.
HOVERGENi HBG106962.
InParanoidi P32304.
KOi K04163.
OrthoDBi EOG7S7SDT.
PhylomeDBi P32304.
TreeFami TF331895.

Miscellaneous databases

NextBioi 288534.
PROi P32304.
SOURCEi Search...

Gene expression databases

Bgeei P32304.
CleanExi MM_HTR7.
ExpressionAtlasi P32304. baseline and differential.
Genevestigatori P32304.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR001069. 5HT_7_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00652. 5HT7RECEPTR.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a mammalian serotonin receptor that activates adenylate cyclase."
    Plassat J.-L., Amlaiky N., Hen R.
    Mol. Pharmacol. 44:229-236(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry namei5HT7R_MOUSE
AccessioniPrimary (citable) accession number: P32304
Secondary accession number(s): Q14A50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3