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P32304

- 5HT7R_MOUSE

UniProt

P32304 - 5HT7R_MOUSE

Protein

5-hydroxytryptamine receptor 7

Gene

Htr7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.

    GO - Molecular functioni

    1. serotonin receptor activity Source: InterPro

    GO - Biological processi

    1. circadian rhythm Source: InterPro
    2. smooth muscle contraction Source: InterPro
    3. synaptic transmission Source: InterPro
    4. vasoconstriction Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    5-hydroxytryptamine receptor 7
    Short name:
    5-HT-7
    Short name:
    5-HT7
    Alternative name(s):
    5-HT-X
    Serotonin receptor 7
    Gene namesi
    Name:Htr7
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:99841. Htr7.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 4484485-hydroxytryptamine receptor 7PRO_0000068980Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi69 – 691N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi158 ↔ 234PROSITE-ProRule annotation
    Lipidationi404 – 4041S-palmitoyl cysteineSequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PRIDEiP32304.

    Expressioni

    Gene expression databases

    ArrayExpressiP32304.
    BgeeiP32304.
    CleanExiMM_HTR7.
    GenevestigatoriP32304.

    Interactioni

    Structurei

    3D structure databases

    ProteinModelPortaliP32304.
    SMRiP32304. Positions 84-404.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 8484ExtracellularBy similarityAdd
    BLAST
    Topological domaini112 – 12110CytoplasmicBy similarity
    Topological domaini148 – 15912ExtracellularBy similarityAdd
    BLAST
    Topological domaini182 – 20120CytoplasmicBy similarityAdd
    BLAST
    Topological domaini226 – 24015ExtracellularBy similarityAdd
    BLAST
    Topological domaini264 – 33168CytoplasmicBy similarityAdd
    BLAST
    Topological domaini356 – 36712ExtracellularBy similarityAdd
    BLAST
    Topological domaini391 – 44858CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei85 – 11127Helical; Name=1By similarityAdd
    BLAST
    Transmembranei122 – 14726Helical; Name=2By similarityAdd
    BLAST
    Transmembranei160 – 18122Helical; Name=3By similarityAdd
    BLAST
    Transmembranei202 – 22524Helical; Name=4By similarityAdd
    BLAST
    Transmembranei241 – 26323Helical; Name=5By similarityAdd
    BLAST
    Transmembranei332 – 35524Helical; Name=6By similarityAdd
    BLAST
    Transmembranei368 – 39023Helical; Name=7By similarityAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG249628.
    GeneTreeiENSGT00750000117429.
    HOVERGENiHBG106962.
    InParanoidiQ14A50.
    KOiK04163.
    OrthoDBiEOG7S7SDT.
    PhylomeDBiP32304.
    TreeFamiTF331895.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR001069. 5HT_7_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00652. 5HT7RECEPTR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P32304-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMDVNSSGRP DLYGHLRSLI LPEVGRRLQD LSPDGGAHSV VSSWMPHLLS    50
    GFPEVTASPA PTWDAPPDNV SGCGEQINYG RVEKVVIGSI LTLITLLTIA 100
    GNCLVVISVC FVKKLRQPSN YLIVSLALAD LSVAVAVMPF VSVTDLIGGK 150
    WIFGHFFCNV FIAMDVMCCT ASIMTLCVIS IDRYLGITRP LTYPVRQNGK 200
    CMAKMILSVW LLSASITLPP LFGWAQNVND DKVCLISQDF GYTIYSTAVA 250
    FYIPMSVMLF MYYQIYKAAR KSAAKHKFSG FPRVQPESVI SLNGVVKLQK 300
    EVEECANLSR LLKHERKNIS IFKREQKAAT TLGIIVGAFT VCWLPFFLLS 350
    TARPFICGTS CSCIPLWVER TCLWLGYANS LINPFIYAFF NRDLRTTYRS 400
    LLQCQYRNIN RKLSAAGMHE ALKLAERPER SEFVLQNCDH CGKKGHDT 448
    Length:448
    Mass (Da):49,916
    Last modified:July 27, 2011 - v2
    Checksum:i85A525FD90792CB1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti114 – 1152KL → NV in CAA80654. (PubMed:8394987)Curated
    Sequence conflicti211 – 2111L → P in CAA80654. (PubMed:8394987)Curated
    Sequence conflicti321 – 3211I → S in CAA80654. (PubMed:8394987)Curated
    Sequence conflicti388 – 3881A → S in CAA80654. (PubMed:8394987)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z23107 mRNA. Translation: CAA80654.1.
    CH466534 Genomic DNA. Translation: EDL41763.1.
    BC116986 mRNA. Translation: AAI16987.1.
    CCDSiCCDS29769.1.
    PIRiI48779. S36402.
    RefSeqiNP_032341.2. NM_008315.2.
    UniGeneiMm.254266.

    Genome annotation databases

    EnsembliENSMUST00000164639; ENSMUSP00000126847; ENSMUSG00000024798.
    GeneIDi15566.
    KEGGimmu:15566.
    UCSCiuc008hhd.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z23107 mRNA. Translation: CAA80654.1 .
    CH466534 Genomic DNA. Translation: EDL41763.1 .
    BC116986 mRNA. Translation: AAI16987.1 .
    CCDSi CCDS29769.1.
    PIRi I48779. S36402.
    RefSeqi NP_032341.2. NM_008315.2.
    UniGenei Mm.254266.

    3D structure databases

    ProteinModelPortali P32304.
    SMRi P32304. Positions 84-404.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi P32304.
    ChEMBLi CHEMBL4764.
    GuidetoPHARMACOLOGYi 12.

    Protein family/group databases

    GPCRDBi Search...

    Proteomic databases

    PRIDEi P32304.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000164639 ; ENSMUSP00000126847 ; ENSMUSG00000024798 .
    GeneIDi 15566.
    KEGGi mmu:15566.
    UCSCi uc008hhd.1. mouse.

    Organism-specific databases

    CTDi 3363.
    MGIi MGI:99841. Htr7.

    Phylogenomic databases

    eggNOGi NOG249628.
    GeneTreei ENSGT00750000117429.
    HOVERGENi HBG106962.
    InParanoidi Q14A50.
    KOi K04163.
    OrthoDBi EOG7S7SDT.
    PhylomeDBi P32304.
    TreeFami TF331895.

    Miscellaneous databases

    NextBioi 288534.
    PROi P32304.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P32304.
    Bgeei P32304.
    CleanExi MM_HTR7.
    Genevestigatori P32304.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR001069. 5HT_7_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00652. 5HT7RECEPTR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of a mammalian serotonin receptor that activates adenylate cyclase."
      Plassat J.-L., Amlaiky N., Hen R.
      Mol. Pharmacol. 44:229-236(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry namei5HT7R_MOUSE
    AccessioniPrimary (citable) accession number: P32304
    Secondary accession number(s): Q14A50
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 117 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3