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Protein

5-hydroxytryptamine receptor 7

Gene

Htr7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.

GO - Molecular functioni

  1. serotonin receptor activity Source: InterPro

GO - Biological processi

  1. circadian rhythm Source: InterPro
  2. smooth muscle contraction Source: InterPro
  3. synaptic transmission Source: InterPro
  4. vasoconstriction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_232980. Serotonin receptors.
REACT_242871. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
5-hydroxytryptamine receptor 7
Short name:
5-HT-7
Short name:
5-HT7
Alternative name(s):
5-HT-X
Serotonin receptor 7
Gene namesi
Name:Htr7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:99841. Htr7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8484ExtracellularBy similarityAdd
BLAST
Transmembranei85 – 11127Helical; Name=1By similarityAdd
BLAST
Topological domaini112 – 12110CytoplasmicBy similarity
Transmembranei122 – 14726Helical; Name=2By similarityAdd
BLAST
Topological domaini148 – 15912ExtracellularBy similarityAdd
BLAST
Transmembranei160 – 18122Helical; Name=3By similarityAdd
BLAST
Topological domaini182 – 20120CytoplasmicBy similarityAdd
BLAST
Transmembranei202 – 22524Helical; Name=4By similarityAdd
BLAST
Topological domaini226 – 24015ExtracellularBy similarityAdd
BLAST
Transmembranei241 – 26323Helical; Name=5By similarityAdd
BLAST
Topological domaini264 – 33168CytoplasmicBy similarityAdd
BLAST
Transmembranei332 – 35524Helical; Name=6By similarityAdd
BLAST
Topological domaini356 – 36712ExtracellularBy similarityAdd
BLAST
Transmembranei368 – 39023Helical; Name=7By similarityAdd
BLAST
Topological domaini391 – 44858CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4484485-hydroxytryptamine receptor 7PRO_0000068980Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Glycosylationi69 – 691N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi158 ↔ 234PROSITE-ProRule annotation
Lipidationi404 – 4041S-palmitoyl cysteineSequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PRIDEiP32304.

Expressioni

Gene expression databases

BgeeiP32304.
CleanExiMM_HTR7.
ExpressionAtlasiP32304. baseline and differential.
GenevestigatoriP32304.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliP32304.
SMRiP32304. Positions 84-404.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG249628.
GeneTreeiENSGT00760000118795.
HOVERGENiHBG106962.
InParanoidiP32304.
KOiK04163.
OrthoDBiEOG7S7SDT.
PhylomeDBiP32304.
TreeFamiTF331895.

Family and domain databases

InterProiIPR001069. 5HT_7_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00652. 5HT7RECEPTR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32304-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMDVNSSGRP DLYGHLRSLI LPEVGRRLQD LSPDGGAHSV VSSWMPHLLS
60 70 80 90 100
GFPEVTASPA PTWDAPPDNV SGCGEQINYG RVEKVVIGSI LTLITLLTIA
110 120 130 140 150
GNCLVVISVC FVKKLRQPSN YLIVSLALAD LSVAVAVMPF VSVTDLIGGK
160 170 180 190 200
WIFGHFFCNV FIAMDVMCCT ASIMTLCVIS IDRYLGITRP LTYPVRQNGK
210 220 230 240 250
CMAKMILSVW LLSASITLPP LFGWAQNVND DKVCLISQDF GYTIYSTAVA
260 270 280 290 300
FYIPMSVMLF MYYQIYKAAR KSAAKHKFSG FPRVQPESVI SLNGVVKLQK
310 320 330 340 350
EVEECANLSR LLKHERKNIS IFKREQKAAT TLGIIVGAFT VCWLPFFLLS
360 370 380 390 400
TARPFICGTS CSCIPLWVER TCLWLGYANS LINPFIYAFF NRDLRTTYRS
410 420 430 440
LLQCQYRNIN RKLSAAGMHE ALKLAERPER SEFVLQNCDH CGKKGHDT
Length:448
Mass (Da):49,916
Last modified:July 27, 2011 - v2
Checksum:i85A525FD90792CB1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti114 – 1152KL → NV in CAA80654 (PubMed:8394987).Curated
Sequence conflicti211 – 2111L → P in CAA80654 (PubMed:8394987).Curated
Sequence conflicti321 – 3211I → S in CAA80654 (PubMed:8394987).Curated
Sequence conflicti388 – 3881A → S in CAA80654 (PubMed:8394987).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z23107 mRNA. Translation: CAA80654.1.
CH466534 Genomic DNA. Translation: EDL41763.1.
BC116986 mRNA. Translation: AAI16987.1.
CCDSiCCDS29769.1.
PIRiI48779. S36402.
RefSeqiNP_032341.2. NM_008315.2.
UniGeneiMm.254266.

Genome annotation databases

EnsembliENSMUST00000164639; ENSMUSP00000126847; ENSMUSG00000024798.
GeneIDi15566.
KEGGimmu:15566.
UCSCiuc008hhd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z23107 mRNA. Translation: CAA80654.1.
CH466534 Genomic DNA. Translation: EDL41763.1.
BC116986 mRNA. Translation: AAI16987.1.
CCDSiCCDS29769.1.
PIRiI48779. S36402.
RefSeqiNP_032341.2. NM_008315.2.
UniGeneiMm.254266.

3D structure databases

ProteinModelPortaliP32304.
SMRiP32304. Positions 84-404.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiP32304.
ChEMBLiCHEMBL4764.
GuidetoPHARMACOLOGYi12.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PRIDEiP32304.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000164639; ENSMUSP00000126847; ENSMUSG00000024798.
GeneIDi15566.
KEGGimmu:15566.
UCSCiuc008hhd.1. mouse.

Organism-specific databases

CTDi3363.
MGIiMGI:99841. Htr7.

Phylogenomic databases

eggNOGiNOG249628.
GeneTreeiENSGT00760000118795.
HOVERGENiHBG106962.
InParanoidiP32304.
KOiK04163.
OrthoDBiEOG7S7SDT.
PhylomeDBiP32304.
TreeFamiTF331895.

Enzyme and pathway databases

ReactomeiREACT_232980. Serotonin receptors.
REACT_242871. G alpha (s) signalling events.

Miscellaneous databases

NextBioi288534.
PROiP32304.
SOURCEiSearch...

Gene expression databases

BgeeiP32304.
CleanExiMM_HTR7.
ExpressionAtlasiP32304. baseline and differential.
GenevestigatoriP32304.

Family and domain databases

InterProiIPR001069. 5HT_7_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00652. 5HT7RECEPTR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a mammalian serotonin receptor that activates adenylate cyclase."
    Plassat J.-L., Amlaiky N., Hen R.
    Mol. Pharmacol. 44:229-236(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry namei5HT7R_MOUSE
AccessioniPrimary (citable) accession number: P32304
Secondary accession number(s): Q14A50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: July 27, 2011
Last modified: January 7, 2015
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.