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P32304 (5HT7R_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
5-hydroxytryptamine receptor 7

Short name=5-HT-7
Short name=5-HT7
Alternative name(s):
5-HT-X
Serotonin receptor 7
Gene names
Name:Htr7
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length448 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4484485-hydroxytryptamine receptor 7
PRO_0000068980

Regions

Topological domain1 – 8484Extracellular By similarity
Transmembrane85 – 11127Helical; Name=1; By similarity
Topological domain112 – 12110Cytoplasmic By similarity
Transmembrane122 – 14726Helical; Name=2; By similarity
Topological domain148 – 15912Extracellular By similarity
Transmembrane160 – 18122Helical; Name=3; By similarity
Topological domain182 – 20120Cytoplasmic By similarity
Transmembrane202 – 22524Helical; Name=4; By similarity
Topological domain226 – 24015Extracellular By similarity
Transmembrane241 – 26323Helical; Name=5; By similarity
Topological domain264 – 33168Cytoplasmic By similarity
Transmembrane332 – 35524Helical; Name=6; By similarity
Topological domain356 – 36712Extracellular By similarity
Transmembrane368 – 39023Helical; Name=7; By similarity
Topological domain391 – 44858Cytoplasmic By similarity

Amino acid modifications

Lipidation4041S-palmitoyl cysteine Potential
Glycosylation51N-linked (GlcNAc...) Potential
Glycosylation691N-linked (GlcNAc...) Potential
Disulfide bond158 ↔ 234 By similarity

Experimental info

Sequence conflict114 – 1152KL → NV in CAA80654. Ref.1
Sequence conflict2111L → P in CAA80654. Ref.1
Sequence conflict3211I → S in CAA80654. Ref.1
Sequence conflict3881A → S in CAA80654. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P32304 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 85A525FD90792CB1

FASTA44849,916
        10         20         30         40         50         60 
MMDVNSSGRP DLYGHLRSLI LPEVGRRLQD LSPDGGAHSV VSSWMPHLLS GFPEVTASPA 

        70         80         90        100        110        120 
PTWDAPPDNV SGCGEQINYG RVEKVVIGSI LTLITLLTIA GNCLVVISVC FVKKLRQPSN 

       130        140        150        160        170        180 
YLIVSLALAD LSVAVAVMPF VSVTDLIGGK WIFGHFFCNV FIAMDVMCCT ASIMTLCVIS 

       190        200        210        220        230        240 
IDRYLGITRP LTYPVRQNGK CMAKMILSVW LLSASITLPP LFGWAQNVND DKVCLISQDF 

       250        260        270        280        290        300 
GYTIYSTAVA FYIPMSVMLF MYYQIYKAAR KSAAKHKFSG FPRVQPESVI SLNGVVKLQK 

       310        320        330        340        350        360 
EVEECANLSR LLKHERKNIS IFKREQKAAT TLGIIVGAFT VCWLPFFLLS TARPFICGTS 

       370        380        390        400        410        420 
CSCIPLWVER TCLWLGYANS LINPFIYAFF NRDLRTTYRS LLQCQYRNIN RKLSAAGMHE 

       430        440 
ALKLAERPER SEFVLQNCDH CGKKGHDT 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of a mammalian serotonin receptor that activates adenylate cyclase."
Plassat J.-L., Amlaiky N., Hen R.
Mol. Pharmacol. 44:229-236(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z23107 mRNA. Translation: CAA80654.1.
CH466534 Genomic DNA. Translation: EDL41763.1.
BC116986 mRNA. Translation: AAI16987.1.
CCDSCCDS29769.1.
PIRS36402. I48779.
RefSeqNP_032341.2. NM_008315.2.
UniGeneMm.254266.

3D structure databases

ProteinModelPortalP32304.
SMRP32304. Positions 84-404.
ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBP32304.
ChEMBLCHEMBL4764.
GuidetoPHARMACOLOGY12.

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PRIDEP32304.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000164639; ENSMUSP00000126847; ENSMUSG00000024798.
GeneID15566.
KEGGmmu:15566.
UCSCuc008hhd.1. mouse.

Organism-specific databases

CTD3363.
MGIMGI:99841. Htr7.

Phylogenomic databases

eggNOGNOG249628.
GeneTreeENSGT00750000117429.
HOVERGENHBG106962.
InParanoidQ14A50.
KOK04163.
OrthoDBEOG7S7SDT.
PhylomeDBP32304.
TreeFamTF331895.

Gene expression databases

ArrayExpressP32304.
BgeeP32304.
CleanExMM_HTR7.
GenevestigatorP32304.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR001069. 5HT_7_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00652. 5HT7RECEPTR.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio288534.
PROP32304.
SOURCESearch...

Entry information

Entry name5HT7R_MOUSE
AccessionPrimary (citable) accession number: P32304
Secondary accession number(s): Q14A50
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries