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Protein

5-hydroxytryptamine receptor 7

Gene

Htr7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-390666. Serotonin receptors.
R-MMU-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
5-hydroxytryptamine receptor 7
Short name:
5-HT-7
Short name:
5-HT7
Alternative name(s):
5-HT-X
Serotonin receptor 7
Gene namesi
Name:Htr7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:99841. Htr7.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 84ExtracellularBy similarityAdd BLAST84
Transmembranei85 – 111Helical; Name=1By similarityAdd BLAST27
Topological domaini112 – 121CytoplasmicBy similarity10
Transmembranei122 – 147Helical; Name=2By similarityAdd BLAST26
Topological domaini148 – 159ExtracellularBy similarityAdd BLAST12
Transmembranei160 – 181Helical; Name=3By similarityAdd BLAST22
Topological domaini182 – 201CytoplasmicBy similarityAdd BLAST20
Transmembranei202 – 225Helical; Name=4By similarityAdd BLAST24
Topological domaini226 – 240ExtracellularBy similarityAdd BLAST15
Transmembranei241 – 263Helical; Name=5By similarityAdd BLAST23
Topological domaini264 – 331CytoplasmicBy similarityAdd BLAST68
Transmembranei332 – 355Helical; Name=6By similarityAdd BLAST24
Topological domaini356 – 367ExtracellularBy similarityAdd BLAST12
Transmembranei368 – 390Helical; Name=7By similarityAdd BLAST23
Topological domaini391 – 448CytoplasmicBy similarityAdd BLAST58

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4764.
GuidetoPHARMACOLOGYi12.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000689801 – 4485-hydroxytryptamine receptor 7Add BLAST448

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Glycosylationi69N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi158 ↔ 234PROSITE-ProRule annotation
Lipidationi404S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP32304.
PRIDEiP32304.

PTM databases

iPTMnetiP32304.
PhosphoSitePlusiP32304.
SwissPalmiP32304.

Expressioni

Gene expression databases

BgeeiENSMUSG00000024798.
CleanExiMM_HTR7.
ExpressionAtlasiP32304. baseline and differential.
GenevisibleiP32304. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000126847.

Structurei

3D structure databases

ProteinModelPortaliP32304.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118795.
HOVERGENiHBG106962.
InParanoidiP32304.
KOiK04163.
PhylomeDBiP32304.
TreeFamiTF331895.

Family and domain databases

InterProiIPR001069. 5HT_7_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00652. 5HT7RECEPTR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32304-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMDVNSSGRP DLYGHLRSLI LPEVGRRLQD LSPDGGAHSV VSSWMPHLLS
60 70 80 90 100
GFPEVTASPA PTWDAPPDNV SGCGEQINYG RVEKVVIGSI LTLITLLTIA
110 120 130 140 150
GNCLVVISVC FVKKLRQPSN YLIVSLALAD LSVAVAVMPF VSVTDLIGGK
160 170 180 190 200
WIFGHFFCNV FIAMDVMCCT ASIMTLCVIS IDRYLGITRP LTYPVRQNGK
210 220 230 240 250
CMAKMILSVW LLSASITLPP LFGWAQNVND DKVCLISQDF GYTIYSTAVA
260 270 280 290 300
FYIPMSVMLF MYYQIYKAAR KSAAKHKFSG FPRVQPESVI SLNGVVKLQK
310 320 330 340 350
EVEECANLSR LLKHERKNIS IFKREQKAAT TLGIIVGAFT VCWLPFFLLS
360 370 380 390 400
TARPFICGTS CSCIPLWVER TCLWLGYANS LINPFIYAFF NRDLRTTYRS
410 420 430 440
LLQCQYRNIN RKLSAAGMHE ALKLAERPER SEFVLQNCDH CGKKGHDT
Length:448
Mass (Da):49,916
Last modified:July 27, 2011 - v2
Checksum:i85A525FD90792CB1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti114 – 115KL → NV in CAA80654 (PubMed:8394987).Curated2
Sequence conflicti211L → P in CAA80654 (PubMed:8394987).Curated1
Sequence conflicti321I → S in CAA80654 (PubMed:8394987).Curated1
Sequence conflicti388A → S in CAA80654 (PubMed:8394987).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z23107 mRNA. Translation: CAA80654.1.
CH466534 Genomic DNA. Translation: EDL41763.1.
BC116986 mRNA. Translation: AAI16987.1.
CCDSiCCDS29769.1.
PIRiI48779. S36402.
RefSeqiNP_032341.2. NM_008315.2.
UniGeneiMm.254266.

Genome annotation databases

EnsembliENSMUST00000164639; ENSMUSP00000126847; ENSMUSG00000024798.
GeneIDi15566.
KEGGimmu:15566.
UCSCiuc008hhd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z23107 mRNA. Translation: CAA80654.1.
CH466534 Genomic DNA. Translation: EDL41763.1.
BC116986 mRNA. Translation: AAI16987.1.
CCDSiCCDS29769.1.
PIRiI48779. S36402.
RefSeqiNP_032341.2. NM_008315.2.
UniGeneiMm.254266.

3D structure databases

ProteinModelPortaliP32304.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000126847.

Chemistry databases

ChEMBLiCHEMBL4764.
GuidetoPHARMACOLOGYi12.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP32304.
PhosphoSitePlusiP32304.
SwissPalmiP32304.

Proteomic databases

PaxDbiP32304.
PRIDEiP32304.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000164639; ENSMUSP00000126847; ENSMUSG00000024798.
GeneIDi15566.
KEGGimmu:15566.
UCSCiuc008hhd.1. mouse.

Organism-specific databases

CTDi3363.
MGIiMGI:99841. Htr7.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118795.
HOVERGENiHBG106962.
InParanoidiP32304.
KOiK04163.
PhylomeDBiP32304.
TreeFamiTF331895.

Enzyme and pathway databases

ReactomeiR-MMU-390666. Serotonin receptors.
R-MMU-418555. G alpha (s) signalling events.

Miscellaneous databases

PROiP32304.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024798.
CleanExiMM_HTR7.
ExpressionAtlasiP32304. baseline and differential.
GenevisibleiP32304. MM.

Family and domain databases

InterProiIPR001069. 5HT_7_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00652. 5HT7RECEPTR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry namei5HT7R_MOUSE
AccessioniPrimary (citable) accession number: P32304
Secondary accession number(s): Q14A50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.