Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

C-X-C chemokine receptor type 5

Gene

CXCR5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes. May have a regulatory function in Burkitt lymphoma (BL) lymphomagenesis and/or B-cell differentiation.

GO - Molecular functioni

  • C-X-C chemokine receptor activity Source: InterPro
  • G-protein coupled receptor activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processB-cell activation

Enzyme and pathway databases

ReactomeiR-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C chemokine receptor type 5
Short name:
CXC-R5
Short name:
CXCR-5
Alternative name(s):
Burkitt lymphoma receptor 1
Monocyte-derived receptor 15
Short name:
MDR-15
CD_antigen: CD185
Gene namesi
Name:CXCR5
Synonyms:BLR1, MDR15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000160683.4
HGNCiHGNC:1060 CXCR5
MIMi601613 gene
neXtProtiNX_P32302

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 55ExtracellularSequence analysisAdd BLAST55
Transmembranei56 – 76Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini77 – 88CytoplasmicSequence analysisAdd BLAST12
Transmembranei89 – 109Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini110 – 124ExtracellularSequence analysisAdd BLAST15
Transmembranei125 – 145Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini146 – 167CytoplasmicSequence analysisAdd BLAST22
Transmembranei168 – 188Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini189 – 219ExtracellularSequence analysisAdd BLAST31
Transmembranei220 – 240Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini241 – 259CytoplasmicSequence analysisAdd BLAST19
Transmembranei260 – 280Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini281 – 304ExtracellularSequence analysisAdd BLAST24
Transmembranei305 – 325Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini326 – 372CytoplasmicSequence analysisAdd BLAST47

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi643
OpenTargetsiENSG00000160683
PharmGKBiPA162383046

Chemistry databases

ChEMBLiCHEMBL1075315
GuidetoPHARMACOLOGYi72

Polymorphism and mutation databases

BioMutaiCXCR5
DMDMi416718

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000693601 – 372C-X-C chemokine receptor type 5Add BLAST372

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi28N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi122 ↔ 202PROSITE-ProRule annotation
Glycosylationi196N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP32302
PeptideAtlasiP32302
PRIDEiP32302

PTM databases

iPTMnetiP32302
PhosphoSitePlusiP32302

Expressioni

Tissue specificityi

Expression in mature B-cells and Burkitt lymphoma cells.

Gene expression databases

BgeeiENSG00000160683
CleanExiHS_CXCR5
ExpressionAtlasiP32302 baseline and differential
GenevisibleiP32302 HS

Organism-specific databases

HPAiCAB026149
HPA042432

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi107112, 6 interactors
DIPiDIP-5834N
IntActiP32302, 7 interactors
MINTiP32302
STRINGi9606.ENSP00000292174

Chemistry databases

BindingDBiP32302

Structurei

3D structure databases

ProteinModelPortaliP32302
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE41 Eukaryota
ENOG410YWPA LUCA
GeneTreeiENSGT00760000118785
HOGENOMiHOG000234122
HOVERGENiHBG106917
InParanoidiP32302
KOiK04190
OMAiINFYCSS
OrthoDBiEOG091G0EDT
PhylomeDBiP32302
TreeFamiTF330966

Family and domain databases

CDDicd15181 7tmA_CXCR5, 1 hit
InterProiView protein in InterPro
IPR001053 Chemokine_CXCR5
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00564 CXCCHMKINER5
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: P32302-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNYPLTLEMD LENLEDLFWE LDRLDNYNDT SLVENHLCPA TEGPLMASFK
60 70 80 90 100
AVFVPVAYSL IFLLGVIGNV LVLVILERHR QTRSSTETFL FHLAVADLLL
110 120 130 140 150
VFILPFAVAE GSVGWVLGTF LCKTVIALHK VNFYCSSLLL ACIAVDRYLA
160 170 180 190 200
IVHAVHAYRH RRLLSIHITC GTIWLVGFLL ALPEILFAKV SQGHHNNSLP
210 220 230 240 250
RCTFSQENQA ETHAWFTSRF LYHVAGFLLP MLVMGWCYVG VVHRLRQAQR
260 270 280 290 300
RPQRQKAVRV AILVTSIFFL CWSPYHIVIF LDTLARLKAV DNTCKLNGSL
310 320 330 340 350
PVAITMCEFL GLAHCCLNPM LYTFAGVKFR SDLSRLLTKL GCTGPASLCQ
360 370
LFPSWRRSSL SESENATSLT TF
Length:372
Mass (Da):41,955
Last modified:October 1, 1993 - v1
Checksum:i6DF84C839492ACCF
GO
Isoform Short (identifier: P32302-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-45: Missing.

Show »
Length:327
Mass (Da):36,676
Checksum:i3D64E6893B517368
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03575734E → K in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_011838344G → S. Corresponds to variant dbSNP:rs665648Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0018921 – 45Missing in isoform Short. 1 PublicationAdd BLAST45

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68149 mRNA Translation: CAA48252.1
X68829 mRNA Translation: CAA48723.1
CCDSiCCDS8402.1 [P32302-1]
PIRiS26667
RefSeqiNP_001707.1, NM_001716.4 [P32302-1]
NP_116743.1, NM_032966.2 [P32302-2]
UniGeneiHs.113916

Genome annotation databases

EnsembliENST00000292174; ENSP00000292174; ENSG00000160683 [P32302-1]
GeneIDi643
KEGGihsa:643
UCSCiuc001pue.5 human [P32302-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCXCR5_HUMAN
AccessioniPrimary (citable) accession number: P32302
Secondary accession number(s): Q14811
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: May 23, 2018
This is version 167 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health