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P32302

- CXCR5_HUMAN

UniProt

P32302 - CXCR5_HUMAN

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Protein
C-X-C chemokine receptor type 5
Gene
CXCR5, BLR1, MDR15
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes. May have a regulatory function in Burkitt lymphoma (BL) lymphomagenesis and/or B-cell differentiation.

GO - Molecular functioni

  1. C-X-C chemokine receptor activity Source: InterPro
  2. G-protein coupled receptor activity Source: ProtInc
  3. protein binding Source: IntAct
Complete GO annotation...

GO - Biological processi

  1. B cell activation Source: UniProtKB-KW
  2. G-protein coupled receptor signaling pathway Source: ProtInc
  3. cellular component movement Source: ProtInc
  4. chemotaxis Source: InterPro
  5. immune response Source: InterPro
  6. lymph node development Source: Ensembl
  7. positive regulation of cytokinesis Source: UniProt
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

B-cell activation

Enzyme and pathway databases

ReactomeiREACT_15344. Chemokine receptors bind chemokines.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C chemokine receptor type 5
Short name:
CXC-R5
Short name:
CXCR-5
Alternative name(s):
Burkitt lymphoma receptor 1
Monocyte-derived receptor 15
Short name:
MDR-15
CD_antigen: CD185
Gene namesi
Name:CXCR5
Synonyms:BLR1, MDR15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:1060. CXCR5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5555Extracellular Reviewed prediction
Add
BLAST
Transmembranei56 – 7621Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini77 – 8812Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei89 – 10921Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini110 – 12415Extracellular Reviewed prediction
Add
BLAST
Transmembranei125 – 14521Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini146 – 16722Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei168 – 18821Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini189 – 21931Extracellular Reviewed prediction
Add
BLAST
Transmembranei220 – 24021Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini241 – 25919Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei260 – 28021Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini281 – 30424Extracellular Reviewed prediction
Add
BLAST
Transmembranei305 – 32521Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini326 – 37247Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162383046.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 372372C-X-C chemokine receptor type 5
PRO_0000069360Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi28 – 281N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi122 ↔ 202 Reviewed prediction
Glycosylationi196 – 1961N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP32302.
PRIDEiP32302.

PTM databases

PhosphoSiteiP32302.

Expressioni

Tissue specificityi

Expression in mature B-cells and Burkitt lymphoma cells.

Gene expression databases

ArrayExpressiP32302.
BgeeiP32302.
CleanExiHS_CXCR5.
GenevestigatoriP32302.

Organism-specific databases

HPAiCAB026149.
HPA042432.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CXCR4P610733EBI-2835269,EBI-489411
GNA13Q143449EBI-2835269,EBI-465387
GNAI2P048994EBI-2835269,EBI-353997
GNB3P165203EBI-2835269,EBI-2880663
GNG8Q9UK083EBI-2835269,EBI-9074207

Protein-protein interaction databases

DIPiDIP-5834N.
IntActiP32302. 7 interactions.
MINTiMINT-1203037.
STRINGi9606.ENSP00000292174.

Structurei

3D structure databases

ProteinModelPortaliP32302.
SMRiP32302. Positions 54-341.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG146951.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP32302.
KOiK04190.
OMAiGLAHCCL.
OrthoDBiEOG7R8322.
PhylomeDBiP32302.
TreeFamiTF330966.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR001053. Chemokine_CXCR5.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PTHR24227:SF33. PTHR24227:SF33. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00564. CXCCHMKINER5.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform Long (identifier: P32302-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MNYPLTLEMD LENLEDLFWE LDRLDNYNDT SLVENHLCPA TEGPLMASFK    50
AVFVPVAYSL IFLLGVIGNV LVLVILERHR QTRSSTETFL FHLAVADLLL 100
VFILPFAVAE GSVGWVLGTF LCKTVIALHK VNFYCSSLLL ACIAVDRYLA 150
IVHAVHAYRH RRLLSIHITC GTIWLVGFLL ALPEILFAKV SQGHHNNSLP 200
RCTFSQENQA ETHAWFTSRF LYHVAGFLLP MLVMGWCYVG VVHRLRQAQR 250
RPQRQKAVRV AILVTSIFFL CWSPYHIVIF LDTLARLKAV DNTCKLNGSL 300
PVAITMCEFL GLAHCCLNPM LYTFAGVKFR SDLSRLLTKL GCTGPASLCQ 350
LFPSWRRSSL SESENATSLT TF 372
Length:372
Mass (Da):41,955
Last modified:October 1, 1993 - v1
Checksum:i6DF84C839492ACCF
GO
Isoform Short (identifier: P32302-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-45: Missing.

Show »
Length:327
Mass (Da):36,676
Checksum:i3D64E6893B517368
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti34 – 341E → K in a breast cancer sample; somatic mutation. 1 Publication
VAR_035757
Natural varianti344 – 3441G → S.
Corresponds to variant rs665648 [ dbSNP | Ensembl ].
VAR_011838

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4545Missing in isoform Short.
VSP_001892Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X68149 mRNA. Translation: CAA48252.1.
X68829 mRNA. Translation: CAA48723.1.
CCDSiCCDS8402.1. [P32302-1]
PIRiS26667.
RefSeqiNP_001707.1. NM_001716.4. [P32302-1]
NP_116743.1. NM_032966.2. [P32302-2]
UniGeneiHs.113916.

Genome annotation databases

EnsembliENST00000292174; ENSP00000292174; ENSG00000160683. [P32302-1]
GeneIDi643.
KEGGihsa:643.
UCSCiuc001pue.4. human. [P32302-1]

Polymorphism databases

DMDMi416718.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

CXC chemokine receptors entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X68149 mRNA. Translation: CAA48252.1 .
X68829 mRNA. Translation: CAA48723.1 .
CCDSi CCDS8402.1. [P32302-1 ]
PIRi S26667.
RefSeqi NP_001707.1. NM_001716.4. [P32302-1 ]
NP_116743.1. NM_032966.2. [P32302-2 ]
UniGenei Hs.113916.

3D structure databases

ProteinModelPortali P32302.
SMRi P32302. Positions 54-341.
ModBasei Search...

Protein-protein interaction databases

DIPi DIP-5834N.
IntActi P32302. 7 interactions.
MINTi MINT-1203037.
STRINGi 9606.ENSP00000292174.

Chemistry

ChEMBLi CHEMBL1075315.
GuidetoPHARMACOLOGYi 72.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P32302.

Polymorphism databases

DMDMi 416718.

Proteomic databases

PaxDbi P32302.
PRIDEi P32302.

Protocols and materials databases

DNASUi 643.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000292174 ; ENSP00000292174 ; ENSG00000160683 . [P32302-1 ]
GeneIDi 643.
KEGGi hsa:643.
UCSCi uc001pue.4. human. [P32302-1 ]

Organism-specific databases

CTDi 643.
GeneCardsi GC11P118754.
HGNCi HGNC:1060. CXCR5.
HPAi CAB026149.
HPA042432.
MIMi 601613. gene.
neXtProti NX_P32302.
PharmGKBi PA162383046.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG146951.
HOGENOMi HOG000234122.
HOVERGENi HBG106917.
InParanoidi P32302.
KOi K04190.
OMAi GLAHCCL.
OrthoDBi EOG7R8322.
PhylomeDBi P32302.
TreeFami TF330966.

Enzyme and pathway databases

Reactomei REACT_15344. Chemokine receptors bind chemokines.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikii CXCR5.
GenomeRNAii 643.
NextBioi 2608.
PROi P32302.
SOURCEi Search...

Gene expression databases

ArrayExpressi P32302.
Bgeei P32302.
CleanExi HS_CXCR5.
Genevestigatori P32302.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR001053. Chemokine_CXCR5.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24227. PTHR24227. 1 hit.
PTHR24227:SF33. PTHR24227:SF33. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00564. CXCCHMKINER5.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Differentiation-specific expression of a novel G protein-coupled receptor from Burkitt's lymphoma."
    Dobner T., Wolf I., Emrich T., Lipp M.
    Eur. J. Immunol. 22:2795-2799(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG).
    Tissue: Lymphocyte.
  2. "Sequence variation of a novel heptahelical leucocyte receptor through alternative transcript formation."
    Barella L., Loetscher M., Tobler A., Baggiolini M., Moser B.
    Biochem. J. 309:773-779(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
    Tissue: Blood.
  3. "B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5."
    Legler D.F., Loetscher M., Stuber Roos R., Clark-Lewis I., Baggiolini M., Moser B.
    J. Exp. Med. 187:655-660(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: LIGAND-BINDING.
  4. Cited for: VARIANT [LARGE SCALE ANALYSIS] LYS-34.

Entry informationi

Entry nameiCXCR5_HUMAN
AccessioniPrimary (citable) accession number: P32302
Secondary accession number(s): Q14811
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: September 3, 2014
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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