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P32302 (CXCR5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 131. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-X-C chemokine receptor type 5

Short name=CXC-R5
Short name=CXCR-5
Alternative name(s):
Burkitt lymphoma receptor 1
Monocyte-derived receptor 15
Short name=MDR-15
CD_antigen=CD185
Gene names
Name:CXCR5
Synonyms:BLR1, MDR15
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length372 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes. May have a regulatory function in Burkitt lymphoma (BL) lymphomagenesis and/or B-cell differentiation.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expression in mature B-cells and Burkitt lymphoma cells.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform Long (identifier: P32302-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform Short (identifier: P32302-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-45: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 372372C-X-C chemokine receptor type 5
PRO_0000069360

Regions

Topological domain1 – 5555Extracellular Potential
Transmembrane56 – 7621Helical; Name=1; Potential
Topological domain77 – 8812Cytoplasmic Potential
Transmembrane89 – 10921Helical; Name=2; Potential
Topological domain110 – 12415Extracellular Potential
Transmembrane125 – 14521Helical; Name=3; Potential
Topological domain146 – 16722Cytoplasmic Potential
Transmembrane168 – 18821Helical; Name=4; Potential
Topological domain189 – 21931Extracellular Potential
Transmembrane220 – 24021Helical; Name=5; Potential
Topological domain241 – 25919Cytoplasmic Potential
Transmembrane260 – 28021Helical; Name=6; Potential
Topological domain281 – 30424Extracellular Potential
Transmembrane305 – 32521Helical; Name=7; Potential
Topological domain326 – 37247Cytoplasmic Potential

Amino acid modifications

Glycosylation281N-linked (GlcNAc...) Potential
Glycosylation1961N-linked (GlcNAc...) Potential
Disulfide bond122 ↔ 202 Potential

Natural variations

Alternative sequence1 – 4545Missing in isoform Short.
VSP_001892
Natural variant341E → K in a breast cancer sample; somatic mutation. Ref.4
VAR_035757
Natural variant3441G → S.
Corresponds to variant rs665648 [ dbSNP | Ensembl ].
VAR_011838

Sequences

Sequence LengthMass (Da)Tools
Isoform Long [UniParc].

Last modified October 1, 1993. Version 1.
Checksum: 6DF84C839492ACCF

FASTA37241,955
        10         20         30         40         50         60 
MNYPLTLEMD LENLEDLFWE LDRLDNYNDT SLVENHLCPA TEGPLMASFK AVFVPVAYSL 

        70         80         90        100        110        120 
IFLLGVIGNV LVLVILERHR QTRSSTETFL FHLAVADLLL VFILPFAVAE GSVGWVLGTF 

       130        140        150        160        170        180 
LCKTVIALHK VNFYCSSLLL ACIAVDRYLA IVHAVHAYRH RRLLSIHITC GTIWLVGFLL 

       190        200        210        220        230        240 
ALPEILFAKV SQGHHNNSLP RCTFSQENQA ETHAWFTSRF LYHVAGFLLP MLVMGWCYVG 

       250        260        270        280        290        300 
VVHRLRQAQR RPQRQKAVRV AILVTSIFFL CWSPYHIVIF LDTLARLKAV DNTCKLNGSL 

       310        320        330        340        350        360 
PVAITMCEFL GLAHCCLNPM LYTFAGVKFR SDLSRLLTKL GCTGPASLCQ LFPSWRRSSL 

       370 
SESENATSLT TF 

« Hide

Isoform Short [UniParc].

Checksum: 3D64E6893B517368
Show »

FASTA32736,676

References

« Hide 'large scale' references
[1]"Differentiation-specific expression of a novel G protein-coupled receptor from Burkitt's lymphoma."
Dobner T., Wolf I., Emrich T., Lipp M.
Eur. J. Immunol. 22:2795-2799(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG).
Tissue: Lymphocyte.
[2]"Sequence variation of a novel heptahelical leucocyte receptor through alternative transcript formation."
Barella L., Loetscher M., Tobler A., Baggiolini M., Moser B.
Biochem. J. 309:773-779(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
Tissue: Blood.
[3]"B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5."
Legler D.F., Loetscher M., Stuber Roos R., Clark-Lewis I., Baggiolini M., Moser B.
J. Exp. Med. 187:655-660(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: LIGAND-BINDING.
[4]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] LYS-34.
+Additional computationally mapped references.

Web resources

Wikipedia

CXC chemokine receptors entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X68149 mRNA. Translation: CAA48252.1.
X68829 mRNA. Translation: CAA48723.1.
PIRS26667.
RefSeqNP_001707.1. NM_001716.4.
NP_116743.1. NM_032966.2.
UniGeneHs.113916.

3D structure databases

ProteinModelPortalP32302.
SMRP32302. Positions 54-341.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-5834N.
IntActP32302. 7 interactions.
MINTMINT-1203037.
STRING9606.ENSP00000292174.

Chemistry

ChEMBLCHEMBL1075315.
GuidetoPHARMACOLOGY72.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP32302.

Polymorphism databases

DMDM416718.

Proteomic databases

PaxDbP32302.
PRIDEP32302.

Protocols and materials databases

DNASU643.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000292174; ENSP00000292174; ENSG00000160683. [P32302-1]
GeneID643.
KEGGhsa:643.
UCSCuc001pue.4. human. [P32302-1]

Organism-specific databases

CTD643.
GeneCardsGC11P118754.
HGNCHGNC:1060. CXCR5.
HPACAB026149.
HPA042432.
MIM601613. gene.
neXtProtNX_P32302.
PharmGKBPA162383046.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG146951.
HOGENOMHOG000234122.
HOVERGENHBG106917.
InParanoidP32302.
KOK04190.
OMAGLAHCCL.
OrthoDBEOG7R8322.
PhylomeDBP32302.
TreeFamTF330966.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressP32302.
BgeeP32302.
CleanExHS_CXCR5.
GenevestigatorP32302.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR001053. Chemokine_CXCR5.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERPTHR24227. PTHR24227. 1 hit.
PTHR24227:SF33. PTHR24227:SF33. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00564. CXCCHMKINER5.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiCXCR5.
GenomeRNAi643.
NextBio2608.
PROP32302.
SOURCESearch...

Entry information

Entry nameCXCR5_HUMAN
AccessionPrimary (citable) accession number: P32302
Secondary accession number(s): Q14811
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: April 16, 2014
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries