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P32302

- CXCR5_HUMAN

UniProt

P32302 - CXCR5_HUMAN

Protein

C-X-C chemokine receptor type 5

Gene

CXCR5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 136 (01 Oct 2014)
      Sequence version 1 (01 Oct 1993)
      Previous versions | rss
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    Functioni

    Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes. May have a regulatory function in Burkitt lymphoma (BL) lymphomagenesis and/or B-cell differentiation.

    GO - Molecular functioni

    1. C-X-C chemokine receptor activity Source: InterPro
    2. G-protein coupled receptor activity Source: ProtInc
    3. protein binding Source: IntAct

    GO - Biological processi

    1. B cell activation Source: UniProtKB-KW
    2. cellular component movement Source: ProtInc
    3. chemotaxis Source: InterPro
    4. G-protein coupled receptor signaling pathway Source: ProtInc
    5. immune response Source: InterPro
    6. lymph node development Source: Ensembl
    7. positive regulation of cytokinesis Source: UniProt

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    B-cell activation

    Enzyme and pathway databases

    ReactomeiREACT_15344. Chemokine receptors bind chemokines.
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-X-C chemokine receptor type 5
    Short name:
    CXC-R5
    Short name:
    CXCR-5
    Alternative name(s):
    Burkitt lymphoma receptor 1
    Monocyte-derived receptor 15
    Short name:
    MDR-15
    CD_antigen: CD185
    Gene namesi
    Name:CXCR5
    Synonyms:BLR1, MDR15
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:1060. CXCR5.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162383046.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 372372C-X-C chemokine receptor type 5PRO_0000069360Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi28 – 281N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi122 ↔ 202PROSITE-ProRule annotation
    Glycosylationi196 – 1961N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP32302.
    PRIDEiP32302.

    PTM databases

    PhosphoSiteiP32302.

    Expressioni

    Tissue specificityi

    Expression in mature B-cells and Burkitt lymphoma cells.

    Gene expression databases

    ArrayExpressiP32302.
    BgeeiP32302.
    CleanExiHS_CXCR5.
    GenevestigatoriP32302.

    Organism-specific databases

    HPAiCAB026149.
    HPA042432.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CXCR4P610733EBI-2835269,EBI-489411
    GNA13Q143449EBI-2835269,EBI-465387
    GNAI2P048995EBI-2835269,EBI-353997
    GNB3P165203EBI-2835269,EBI-2880663
    GNG8Q9UK083EBI-2835269,EBI-9074207

    Protein-protein interaction databases

    DIPiDIP-5834N.
    IntActiP32302. 7 interactions.
    MINTiMINT-1203037.
    STRINGi9606.ENSP00000292174.

    Structurei

    3D structure databases

    ProteinModelPortaliP32302.
    SMRiP32302. Positions 54-341.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5555ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini77 – 8812CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini110 – 12415ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini146 – 16722CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini189 – 21931ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini241 – 25919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini281 – 30424ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini326 – 37247CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei56 – 7621Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei89 – 10921Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei125 – 14521Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei168 – 18821Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei220 – 24021Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei260 – 28021Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei305 – 32521Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG146951.
    HOGENOMiHOG000234122.
    HOVERGENiHBG106917.
    InParanoidiP32302.
    KOiK04190.
    OMAiGLAHCCL.
    OrthoDBiEOG7R8322.
    PhylomeDBiP32302.
    TreeFamiTF330966.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR001053. Chemokine_CXCR5.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24227. PTHR24227. 1 hit.
    PTHR24227:SF33. PTHR24227:SF33. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00564. CXCCHMKINER5.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform Long (identifier: P32302-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNYPLTLEMD LENLEDLFWE LDRLDNYNDT SLVENHLCPA TEGPLMASFK    50
    AVFVPVAYSL IFLLGVIGNV LVLVILERHR QTRSSTETFL FHLAVADLLL 100
    VFILPFAVAE GSVGWVLGTF LCKTVIALHK VNFYCSSLLL ACIAVDRYLA 150
    IVHAVHAYRH RRLLSIHITC GTIWLVGFLL ALPEILFAKV SQGHHNNSLP 200
    RCTFSQENQA ETHAWFTSRF LYHVAGFLLP MLVMGWCYVG VVHRLRQAQR 250
    RPQRQKAVRV AILVTSIFFL CWSPYHIVIF LDTLARLKAV DNTCKLNGSL 300
    PVAITMCEFL GLAHCCLNPM LYTFAGVKFR SDLSRLLTKL GCTGPASLCQ 350
    LFPSWRRSSL SESENATSLT TF 372
    Length:372
    Mass (Da):41,955
    Last modified:October 1, 1993 - v1
    Checksum:i6DF84C839492ACCF
    GO
    Isoform Short (identifier: P32302-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-45: Missing.

    Show »
    Length:327
    Mass (Da):36,676
    Checksum:i3D64E6893B517368
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti34 – 341E → K in a breast cancer sample; somatic mutation. 1 Publication
    VAR_035757
    Natural varianti344 – 3441G → S.
    Corresponds to variant rs665648 [ dbSNP | Ensembl ].
    VAR_011838

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 4545Missing in isoform Short. 1 PublicationVSP_001892Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X68149 mRNA. Translation: CAA48252.1.
    X68829 mRNA. Translation: CAA48723.1.
    CCDSiCCDS8402.1. [P32302-1]
    PIRiS26667.
    RefSeqiNP_001707.1. NM_001716.4. [P32302-1]
    NP_116743.1. NM_032966.2. [P32302-2]
    UniGeneiHs.113916.

    Genome annotation databases

    EnsembliENST00000292174; ENSP00000292174; ENSG00000160683. [P32302-1]
    GeneIDi643.
    KEGGihsa:643.
    UCSCiuc001pue.4. human. [P32302-1]

    Polymorphism databases

    DMDMi416718.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    CXC chemokine receptors entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X68149 mRNA. Translation: CAA48252.1 .
    X68829 mRNA. Translation: CAA48723.1 .
    CCDSi CCDS8402.1. [P32302-1 ]
    PIRi S26667.
    RefSeqi NP_001707.1. NM_001716.4. [P32302-1 ]
    NP_116743.1. NM_032966.2. [P32302-2 ]
    UniGenei Hs.113916.

    3D structure databases

    ProteinModelPortali P32302.
    SMRi P32302. Positions 54-341.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-5834N.
    IntActi P32302. 7 interactions.
    MINTi MINT-1203037.
    STRINGi 9606.ENSP00000292174.

    Chemistry

    ChEMBLi CHEMBL1075315.
    GuidetoPHARMACOLOGYi 72.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P32302.

    Polymorphism databases

    DMDMi 416718.

    Proteomic databases

    PaxDbi P32302.
    PRIDEi P32302.

    Protocols and materials databases

    DNASUi 643.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000292174 ; ENSP00000292174 ; ENSG00000160683 . [P32302-1 ]
    GeneIDi 643.
    KEGGi hsa:643.
    UCSCi uc001pue.4. human. [P32302-1 ]

    Organism-specific databases

    CTDi 643.
    GeneCardsi GC11P118754.
    HGNCi HGNC:1060. CXCR5.
    HPAi CAB026149.
    HPA042432.
    MIMi 601613. gene.
    neXtProti NX_P32302.
    PharmGKBi PA162383046.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG146951.
    HOGENOMi HOG000234122.
    HOVERGENi HBG106917.
    InParanoidi P32302.
    KOi K04190.
    OMAi GLAHCCL.
    OrthoDBi EOG7R8322.
    PhylomeDBi P32302.
    TreeFami TF330966.

    Enzyme and pathway databases

    Reactomei REACT_15344. Chemokine receptors bind chemokines.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GeneWikii CXCR5.
    GenomeRNAii 643.
    NextBioi 2608.
    PROi P32302.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P32302.
    Bgeei P32302.
    CleanExi HS_CXCR5.
    Genevestigatori P32302.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR001053. Chemokine_CXCR5.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24227. PTHR24227. 1 hit.
    PTHR24227:SF33. PTHR24227:SF33. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00564. CXCCHMKINER5.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Differentiation-specific expression of a novel G protein-coupled receptor from Burkitt's lymphoma."
      Dobner T., Wolf I., Emrich T., Lipp M.
      Eur. J. Immunol. 22:2795-2799(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG).
      Tissue: Lymphocyte.
    2. "Sequence variation of a novel heptahelical leucocyte receptor through alternative transcript formation."
      Barella L., Loetscher M., Tobler A., Baggiolini M., Moser B.
      Biochem. J. 309:773-779(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
      Tissue: Blood.
    3. "B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5."
      Legler D.F., Loetscher M., Stuber Roos R., Clark-Lewis I., Baggiolini M., Moser B.
      J. Exp. Med. 187:655-660(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: LIGAND-BINDING.
    4. Cited for: VARIANT [LARGE SCALE ANALYSIS] LYS-34.

    Entry informationi

    Entry nameiCXCR5_HUMAN
    AccessioniPrimary (citable) accession number: P32302
    Secondary accession number(s): Q14811
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: October 1, 1993
    Last modified: October 1, 2014
    This is version 136 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    3. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    4. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    5. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    6. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3