P32302 (CXCR5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
C-X-C chemokine receptor type 5
Short name=CXC-R5
Short name=CXCR-5

Alternative name(s):
Burkitt lymphoma receptor 1
Monocyte-derived receptor 15
Short name=MDR-15
CD_antigen=CD185

Gene names

Name:	CXCR5
Synonyms:	BLR1, MDR15

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	372 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes. May have a regulatory function in Burkitt lymphoma (BL) lymphomagenesis and/or B-cell differentiation.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Expression in mature B-cells and Burkitt lymphoma cells.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	B-cell activation
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	B cell activation Inferred from electronic annotation. Source: UniProtKB-KW cellular component movement Traceable author statement Ref.1. Source: ProtInc chemotaxis Inferred from electronic annotation. Source: InterPro elevation of cytosolic calcium ion concentration Inferred from electronic annotation. Source: InterPro lymph node development Inferred from electronic annotation. Source: Compara
Cellular_component	integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc
Molecular_function	C-X-C chemokine receptor activity Inferred from electronic annotation. Source: InterPro G-protein coupled receptor activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform Long (identifier: P32302-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform Short (identifier: P32302-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-45: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 372	372	C-X-C chemokine receptor type 5		PRO_0000069360
Regions
	Topological domain	1 – 55	55	Extracellular Potential
	Transmembrane	56 – 76	21	Helical; Name=1; Potential
	Topological domain	77 – 88	12	Cytoplasmic Potential
	Transmembrane	89 – 109	21	Helical; Name=2; Potential
	Topological domain	110 – 124	15	Extracellular Potential
	Transmembrane	125 – 145	21	Helical; Name=3; Potential
	Topological domain	146 – 167	22	Cytoplasmic Potential
	Transmembrane	168 – 188	21	Helical; Name=4; Potential
	Topological domain	189 – 219	31	Extracellular Potential
	Transmembrane	220 – 240	21	Helical; Name=5; Potential
	Topological domain	241 – 259	19	Cytoplasmic Potential
	Transmembrane	260 – 280	21	Helical; Name=6; Potential
	Topological domain	281 – 304	24	Extracellular Potential
	Transmembrane	305 – 325	21	Helical; Name=7; Potential
	Topological domain	326 – 372	47	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	28	1	N-linked (GlcNAc...) Potential
	Glycosylation	196	1	N-linked (GlcNAc...) Potential
	Disulfide bond	122 ↔ 202		Potential
Natural variations
	Alternative sequence	1 – 45	45	Missing in isoform Short.		VSP_001892
	Natural variant	34	1	E → K in a breast cancer sample; somatic mutation. Ref.4		VAR_035757
	Natural variant	344	1	G → S. Corresponds to variant rs665648 [ dbSNP | Ensembl ].		VAR_011838

Sequences

	Sequence		Length	Mass (Da)
	Isoform Long [UniParc]. Last modified October 1, 1993. Version 1. Checksum: 6DF84C839492ACCF	FASTA	372	41,955
	10 20 30 40 50 60 MNYPLTLEMD LENLEDLFWE LDRLDNYNDT SLVENHLCPA TEGPLMASFK AVFVPVAYSL 70 80 90 100 110 120 IFLLGVIGNV LVLVILERHR QTRSSTETFL FHLAVADLLL VFILPFAVAE GSVGWVLGTF 130 140 150 160 170 180 LCKTVIALHK VNFYCSSLLL ACIAVDRYLA IVHAVHAYRH RRLLSIHITC GTIWLVGFLL 190 200 210 220 230 240 ALPEILFAKV SQGHHNNSLP RCTFSQENQA ETHAWFTSRF LYHVAGFLLP MLVMGWCYVG 250 260 270 280 290 300 VVHRLRQAQR RPQRQKAVRV AILVTSIFFL CWSPYHIVIF LDTLARLKAV DNTCKLNGSL 310 320 330 340 350 360 PVAITMCEFL GLAHCCLNPM LYTFAGVKFR SDLSRLLTKL GCTGPASLCQ LFPSWRRSSL 370 SESENATSLT TF
	Isoform Short [UniParc]. Checksum: 3D64E6893B517368	FASTA	327	36,676
	10 20 30 40 50 60 MASFKAVFVP VAYSLIFLLG VIGNVLVLVI LERHRQTRSS TETFLFHLAV ADLLLVFILP 70 80 90 100 110 120 FAVAEGSVGW VLGTFLCKTV IALHKVNFYC SSLLLACIAV DRYLAIVHAV HAYRHRRLLS 130 140 150 160 170 180 IHITCGTIWL VGFLLALPEI LFAKVSQGHH NNSLPRCTFS QENQAETHAW FTSRFLYHVA 190 200 210 220 230 240 GFLLPMLVMG WCYVGVVHRL RQAQRRPQRQ KAVRVAILVT SIFFLCWSPY HIVIFLDTLA 250 260 270 280 290 300 RLKAVDNTCK LNGSLPVAIT MCEFLGLAHC CLNPMLYTFA GVKFRSDLSR LLTKLGCTGP 310 320 ASLCQLFPSW RRSSLSESEN ATSLTTF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Differentiation-specific expression of a novel G protein-coupled receptor from Burkitt's lymphoma." Dobner T., Wolf I., Emrich T., Lipp M. Eur. J. Immunol. 22:2795-2799(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG). Tissue: Lymphocyte.
[2]	"Sequence variation of a novel heptahelical leucocyte receptor through alternative transcript formation." Barella L., Loetscher M., Tobler A., Baggiolini M., Moser B. Biochem. J. 309:773-779(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT). Tissue: Blood.
[3]	"B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5." Legler D.F., Loetscher M., Stuber Roos R., Clark-Lewis I., Baggiolini M., Moser B. J. Exp. Med. 187:655-660(1998) [PubMed] [Europe PMC] [Abstract] Cited for: LIGAND-BINDING.
[4]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] LYS-34.
+	Additional computationally mapped references.

Web resources

Wikipedia

CXC chemokine receptors entry

Cross-references

Sequence databases
EMBL GenBank DDBJ	X68149 mRNA. Translation: CAA48252.1. X68829 mRNA. Translation: CAA48723.1.
IPI	IPI00018295. IPI00027955.
PIR	S26667.
RefSeq	NP_001707.1. NM_001716.4. NP_116743.1. NM_032966.2.
UniGene	Hs.113916.
3D structure databases
ProteinModelPortal	P32302.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-5834N.
IntAct	P32302. 2 interactions.
MINT	MINT-1203037.
STRING	9606.ENSP00000292174.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P32302.
Polymorphism databases
DMDM	416718.
Proteomic databases
PaxDb	P32302.
PRIDE	P32302.
Protocols and materials databases
DNASU	643.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000292174; ENSP00000292174; ENSG00000160683.
GeneID	643.
KEGG	hsa:643.
UCSC	uc001pue.4. human.
Organism-specific databases
CTD	643.
GeneCards	GC11P118754.
HGNC	HGNC:1060. CXCR5.
HPA	CAB026149.
MIM	601613. gene.
neXtProt	NX_P32302.
PharmGKB	PA162383046.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG146951.
HOGENOM	HOG000234122.
HOVERGEN	HBG106917.
InParanoid	P32302.
KO	K04190.
OMA	GLAHCCL.
OrthoDB	EOG4PZJ6X.
PhylomeDB	P32302.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	P32302.
Bgee	P32302.
CleanEx	HS_CXCR5.
Genevestigator	P32302.
GermOnline	ENSG00000160683. Homo sapiens.
Family and domain databases
InterPro	IPR001053. Chemokine_CXCR5. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00564. CXCCHMKINER5. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChEMBL	CHEMBL1075315.
GenomeRNAi	643.
NextBio	2608.
SOURCE	Search...

Entry information

Entry name

CXCR5_HUMAN

Accession

Primary (citable) accession number: P32302
Secondary accession number(s): Q14811

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
Last sequence update:	October 1, 1993
Last modified:	May 1, 2013
This is version 122 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.