Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

C-X-C chemokine receptor type 5

Gene

CXCR5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes. May have a regulatory function in Burkitt lymphoma (BL) lymphomagenesis and/or B-cell differentiation.

GO - Molecular functioni

  • C-X-C chemokine receptor activity Source: InterPro
  • G-protein coupled receptor activity Source: ProtInc

GO - Biological processi

  • B cell activation Source: UniProtKB-KW
  • G-protein coupled receptor signaling pathway Source: ProtInc
  • immune response Source: InterPro
  • leukocyte chemotaxis Source: Ensembl
  • lymph node development Source: Ensembl
  • movement of cell or subcellular component Source: ProtInc
  • positive regulation of cytokinesis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

B-cell activation

Enzyme and pathway databases

ReactomeiR-HSA-380108. Chemokine receptors bind chemokines.
R-HSA-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C chemokine receptor type 5
Short name:
CXC-R5
Short name:
CXCR-5
Alternative name(s):
Burkitt lymphoma receptor 1
Monocyte-derived receptor 15
Short name:
MDR-15
CD_antigen: CD185
Gene namesi
Name:CXCR5
Synonyms:BLR1, MDR15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:1060. CXCR5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 55ExtracellularSequence analysisAdd BLAST55
Transmembranei56 – 76Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini77 – 88CytoplasmicSequence analysisAdd BLAST12
Transmembranei89 – 109Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini110 – 124ExtracellularSequence analysisAdd BLAST15
Transmembranei125 – 145Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini146 – 167CytoplasmicSequence analysisAdd BLAST22
Transmembranei168 – 188Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini189 – 219ExtracellularSequence analysisAdd BLAST31
Transmembranei220 – 240Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini241 – 259CytoplasmicSequence analysisAdd BLAST19
Transmembranei260 – 280Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini281 – 304ExtracellularSequence analysisAdd BLAST24
Transmembranei305 – 325Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini326 – 372CytoplasmicSequence analysisAdd BLAST47

GO - Cellular componenti

  • external side of plasma membrane Source: Ensembl
  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi643.
OpenTargetsiENSG00000160683.
PharmGKBiPA162383046.

Chemistry databases

ChEMBLiCHEMBL1075315.
GuidetoPHARMACOLOGYi72.

Polymorphism and mutation databases

BioMutaiCXCR5.
DMDMi416718.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000693601 – 372C-X-C chemokine receptor type 5Add BLAST372

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi28N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi122 ↔ 202PROSITE-ProRule annotation
Glycosylationi196N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP32302.
PeptideAtlasiP32302.
PRIDEiP32302.

PTM databases

iPTMnetiP32302.
PhosphoSitePlusiP32302.

Expressioni

Tissue specificityi

Expression in mature B-cells and Burkitt lymphoma cells.

Gene expression databases

BgeeiENSG00000160683.
CleanExiHS_CXCR5.
ExpressionAtlasiP32302. baseline and differential.
GenevisibleiP32302. HS.

Organism-specific databases

HPAiCAB026149.
HPA042432.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CXCR4P610733EBI-2835269,EBI-489411
GNA13Q143449EBI-2835269,EBI-465387
GNAI2P048995EBI-2835269,EBI-353997
GNB3P165203EBI-2835269,EBI-2880663
GNG8Q9UK083EBI-2835269,EBI-9074207

Protein-protein interaction databases

BioGridi107112. 6 interactors.
DIPiDIP-5834N.
IntActiP32302. 7 interactors.
MINTiMINT-1203037.
STRINGi9606.ENSP00000292174.

Chemistry databases

BindingDBiP32302.

Structurei

3D structure databases

ProteinModelPortaliP32302.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE41. Eukaryota.
ENOG410YWPA. LUCA.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP32302.
KOiK04190.
OMAiLCQAQRR.
OrthoDBiEOG091G0EDT.
PhylomeDBiP32302.
TreeFamiTF330966.

Family and domain databases

InterProiIPR001053. Chemokine_CXCR5.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00564. CXCCHMKINER5.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: P32302-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNYPLTLEMD LENLEDLFWE LDRLDNYNDT SLVENHLCPA TEGPLMASFK
60 70 80 90 100
AVFVPVAYSL IFLLGVIGNV LVLVILERHR QTRSSTETFL FHLAVADLLL
110 120 130 140 150
VFILPFAVAE GSVGWVLGTF LCKTVIALHK VNFYCSSLLL ACIAVDRYLA
160 170 180 190 200
IVHAVHAYRH RRLLSIHITC GTIWLVGFLL ALPEILFAKV SQGHHNNSLP
210 220 230 240 250
RCTFSQENQA ETHAWFTSRF LYHVAGFLLP MLVMGWCYVG VVHRLRQAQR
260 270 280 290 300
RPQRQKAVRV AILVTSIFFL CWSPYHIVIF LDTLARLKAV DNTCKLNGSL
310 320 330 340 350
PVAITMCEFL GLAHCCLNPM LYTFAGVKFR SDLSRLLTKL GCTGPASLCQ
360 370
LFPSWRRSSL SESENATSLT TF
Length:372
Mass (Da):41,955
Last modified:October 1, 1993 - v1
Checksum:i6DF84C839492ACCF
GO
Isoform Short (identifier: P32302-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-45: Missing.

Show »
Length:327
Mass (Da):36,676
Checksum:i3D64E6893B517368
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03575734E → K in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_011838344G → S.Corresponds to variant rs665648dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0018921 – 45Missing in isoform Short. 1 PublicationAdd BLAST45

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68149 mRNA. Translation: CAA48252.1.
X68829 mRNA. Translation: CAA48723.1.
CCDSiCCDS8402.1. [P32302-1]
PIRiS26667.
RefSeqiNP_001707.1. NM_001716.4. [P32302-1]
NP_116743.1. NM_032966.2. [P32302-2]
UniGeneiHs.113916.

Genome annotation databases

EnsembliENST00000292174; ENSP00000292174; ENSG00000160683. [P32302-1]
GeneIDi643.
KEGGihsa:643.
UCSCiuc001pue.5. human. [P32302-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

CXC chemokine receptors entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68149 mRNA. Translation: CAA48252.1.
X68829 mRNA. Translation: CAA48723.1.
CCDSiCCDS8402.1. [P32302-1]
PIRiS26667.
RefSeqiNP_001707.1. NM_001716.4. [P32302-1]
NP_116743.1. NM_032966.2. [P32302-2]
UniGeneiHs.113916.

3D structure databases

ProteinModelPortaliP32302.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107112. 6 interactors.
DIPiDIP-5834N.
IntActiP32302. 7 interactors.
MINTiMINT-1203037.
STRINGi9606.ENSP00000292174.

Chemistry databases

BindingDBiP32302.
ChEMBLiCHEMBL1075315.
GuidetoPHARMACOLOGYi72.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP32302.
PhosphoSitePlusiP32302.

Polymorphism and mutation databases

BioMutaiCXCR5.
DMDMi416718.

Proteomic databases

PaxDbiP32302.
PeptideAtlasiP32302.
PRIDEiP32302.

Protocols and materials databases

DNASUi643.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000292174; ENSP00000292174; ENSG00000160683. [P32302-1]
GeneIDi643.
KEGGihsa:643.
UCSCiuc001pue.5. human. [P32302-1]

Organism-specific databases

CTDi643.
DisGeNETi643.
GeneCardsiCXCR5.
HGNCiHGNC:1060. CXCR5.
HPAiCAB026149.
HPA042432.
MIMi601613. gene.
neXtProtiNX_P32302.
OpenTargetsiENSG00000160683.
PharmGKBiPA162383046.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE41. Eukaryota.
ENOG410YWPA. LUCA.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP32302.
KOiK04190.
OMAiLCQAQRR.
OrthoDBiEOG091G0EDT.
PhylomeDBiP32302.
TreeFamiTF330966.

Enzyme and pathway databases

ReactomeiR-HSA-380108. Chemokine receptors bind chemokines.
R-HSA-418594. G alpha (i) signalling events.

Miscellaneous databases

ChiTaRSiCXCR5. human.
GeneWikiiCXCR5.
GenomeRNAii643.
PROiP32302.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000160683.
CleanExiHS_CXCR5.
ExpressionAtlasiP32302. baseline and differential.
GenevisibleiP32302. HS.

Family and domain databases

InterProiIPR001053. Chemokine_CXCR5.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00564. CXCCHMKINER5.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCXCR5_HUMAN
AccessioniPrimary (citable) accession number: P32302
Secondary accession number(s): Q14811
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: November 2, 2016
This is version 155 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.