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Protein

Glucagon-like peptide 1 receptor

Gene

Glp1r

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

G-protein coupled receptor for glucagon-like peptide 1 (GLP-1) (PubMed:1326760, PubMed:7813606). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels (PubMed:1326760, PubMed:7813606). Plays a role in regulating insulin secretion in response to GLP-1 (By similarity).By similarity2 Publications

GO - Molecular functioni

  • glucagon-like peptide 1 receptor activity Source: UniProtKB
  • glucagon receptor activity Source: InterPro
  • G-protein coupled peptide receptor activity Source: RGD
  • G-protein coupled receptor activity Source: RGD
  • peptide hormone binding Source: RGD
  • peptide receptor activity Source: RGD

GO - Biological processi

  • adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: RGD
  • associative learning Source: RGD
  • cAMP-mediated signaling Source: RGD
  • cell surface receptor signaling pathway Source: InterPro
  • feeding behavior Source: RGD
  • hormone secretion Source: UniProtKB
  • insulin secretion Source: UniProtKB
  • learning or memory Source: UniProtKB
  • memory Source: RGD
  • negative regulation of apoptotic process Source: RGD
  • negative regulation of neuron apoptotic process Source: RGD
  • neuropeptide signaling pathway Source: RGD
  • positive regulation of blood pressure Source: RGD
  • positive regulation of cell differentiation Source: RGD
  • positive regulation of cell proliferation Source: RGD
  • positive regulation of heart contraction Source: RGD
  • positive regulation of insulin secretion Source: RGD
  • positive regulation of transcription from RNA polymerase II promoter Source: RGD
  • regulation of calcium ion transport Source: RGD
  • regulation of insulin secretion Source: Reactome
  • release of sequestered calcium ion into cytosol Source: RGD
  • response to glucose Source: RGD

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucagon-like peptide 1 receptor
Short name:
GLP-1 receptor
Short name:
GLP-1-R
Short name:
GLP-1R
Gene namesi
Name:Glp1r
Synonyms:Glpr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2703. Glp1r.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 139ExtracellularCuratedAdd BLAST118
Transmembranei140 – 164Helical; Name=1By similarityAdd BLAST25
Topological domaini165 – 175CytoplasmicCuratedAdd BLAST11
Transmembranei176 – 201Helical; Name=2By similarityAdd BLAST26
Topological domaini202 – 227ExtracellularCuratedAdd BLAST26
Transmembranei228 – 251Helical; Name=3By similarityAdd BLAST24
Topological domaini252 – 265CytoplasmicCuratedAdd BLAST14
Transmembranei266 – 290Helical; Name=4By similarityAdd BLAST25
Topological domaini291 – 305ExtracellularCuratedAdd BLAST15
Transmembranei306 – 328Helical; Name=5By similarityAdd BLAST23
Topological domaini329 – 348CytoplasmicCuratedAdd BLAST20
Transmembranei349 – 370Helical; Name=6By similarityAdd BLAST22
Topological domaini371 – 383ExtracellularCuratedAdd BLAST13
Transmembranei384 – 404Helical; Name=7By similarityAdd BLAST21
Topological domaini405 – 463CytoplasmicCuratedAdd BLAST59

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5862.
GuidetoPHARMACOLOGYi249.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001283722 – 463Glucagon-like peptide 1 receptorAdd BLAST442

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi46 ↔ 71By similarity
Disulfide bondi62 ↔ 104By similarity
Glycosylationi63N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi82N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi85 ↔ 126By similarity
Glycosylationi115N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi226 ↔ 296By similarity
Modified residuei341ADP-ribosylcysteineBy similarity1
Modified residuei348ADP-ribosylarginineBy similarity1

Post-translational modificationi

N-glycosylation enhances cell surface expression and lengthens receptor half-life by preventing degradation in the ER.By similarity

Keywords - PTMi

ADP-ribosylation, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP32301.
PRIDEiP32301.

PTM databases

iPTMnetiP32301.
PhosphoSitePlusiP32301.
SwissPalmiP32301.

Expressioni

Tissue specificityi

Pancreatic islets, stomach, lung, rat insulinoma cell line.1 Publication

Interactioni

Subunit structurei

May form homodimers and heterodimers with GIPR.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei121Interaction with the endogenous ligand GLP-1By similarity1
Sitei128Interaction with the endogenous ligand GLP-1By similarity1

Protein-protein interaction databases

BioGridi247128. 1 interactor.
STRINGi10116.ENSRNOP00000001527.

Chemistry databases

BindingDBiP32301.

Structurei

3D structure databases

ProteinModelPortaliP32301.
SMRiP32301.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni352 – 355Important for allosteric inhibitor bindingBy similarity4

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4564. Eukaryota.
ENOG410XRS2. LUCA.
HOGENOMiHOG000008250.
HOVERGENiHBG008318.
InParanoidiP32301.
KOiK04581.

Family and domain databases

CDDicd15268. 7tmB1_GLP1R. 1 hit.
Gene3Di4.10.1240.10. 1 hit.
InterProiView protein in InterPro
IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR003290. GPCR_2_GLP1/glucagon_rcpt.
IPR003292. GPCR_2_GLP1_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
PANTHERiPTHR12011:SF414. PTHR12011:SF414. 1 hit.
PfamiView protein in Pfam
PF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
PRINTSiPR01353. GLUCAGNFAMLY.
PR01355. GLUCAGNLIKER.
PR00249. GPCRSECRETIN.
SMARTiView protein in SMART
SM00008. HormR. 1 hit.
SUPFAMiSSF111418. SSF111418. 1 hit.
PROSITEiView protein in PROSITE
PS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P32301-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVTPSLLRL ALLLLGAVGR AGPRPQGATV SLSETVQKWR EYRHQCQRFL
60 70 80 90 100
TEAPLLATGL FCNRTFDDYA CWPDGPPGSF VNVSCPWYLP WASSVLQGHV
110 120 130 140 150
YRFCTAEGIW LHKDNSSLPW RDLSECEESK QGERNSPEEQ LLSLYIIYTV
160 170 180 190 200
GYALSFSALV IASAILVSFR HLHCTRNYIH LNLFASFILR ALSVFIKDAA
210 220 230 240 250
LKWMYSTAAQ QHQWDGLLSY QDSLGCRLVF LLMQYCVAAN YYWLLVEGVY
260 270 280 290 300
LYTLLAFSVF SEQRIFKLYL SIGWGVPLLF VIPWGIVKYL YEDEGCWTRN
310 320 330 340 350
SNMNYWLIIR LPILFAIGVN FLVFIRVICI VIAKLKANLM CKTDIKCRLA
360 370 380 390 400
KSTLTLIPLL GTHEVIFAFV MDEHARGTLR FVKLFTELSF TSFQGFMVAV
410 420 430 440 450
LYCFVNNEVQ MEFRKSWERW RLERLNIQRD SSMKPLKCPT SSVSSGATVG
460
SSVYAATCQN SCS
Length:463
Mass (Da):52,877
Last modified:October 1, 1993 - v1
Checksum:iABE2183E8EBE621F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti323V → I in AAP31860 (PubMed:7813606).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97797 mRNA. Translation: AAA73377.1.
S75952 mRNA. Translation: AAP31860.1.
PIRiA46172.
RefSeqiNP_036860.1. NM_012728.1.
UniGeneiRn.11408.

Genome annotation databases

GeneIDi25051.
KEGGirno:25051.

Similar proteinsi

Entry informationi

Entry nameiGLP1R_RAT
AccessioniPrimary (citable) accession number: P32301
Secondary accession number(s): Q64073, Q6LD83
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: August 30, 2017
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families