Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P32301

- GLP1R_RAT

UniProt

P32301 - GLP1R_RAT

Protein

Glucagon-like peptide 1 receptor

Gene

Glp1r

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 1 (01 Oct 1993)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    This is a receptor for glucagon-like peptide 1. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

    GO - Molecular functioni

    1. glucagon receptor activity Source: InterPro
    2. G-protein coupled peptide receptor activity Source: RGD
    3. G-protein coupled receptor activity Source: RGD
    4. peptide hormone binding Source: RGD
    5. peptide receptor activity Source: RGD

    GO - Biological processi

    1. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: RGD
    2. associative learning Source: RGD
    3. cAMP-mediated signaling Source: RGD
    4. feeding behavior Source: RGD
    5. hormone secretion Source: UniProtKB
    6. insulin secretion Source: UniProtKB
    7. learning or memory Source: UniProtKB
    8. memory Source: RGD
    9. negative regulation of apoptotic process Source: RGD
    10. negative regulation of neuron apoptotic process Source: RGD
    11. neuropeptide signaling pathway Source: RGD
    12. positive regulation of blood pressure Source: RGD
    13. positive regulation of cell differentiation Source: RGD
    14. positive regulation of cell proliferation Source: RGD
    15. positive regulation of heart contraction Source: RGD
    16. positive regulation of insulin secretion Source: RGD
    17. positive regulation of transcription from RNA polymerase II promoter Source: RGD
    18. regulation of calcium ion transport Source: RGD
    19. release of sequestered calcium ion into cytosol Source: RGD
    20. response to glucose Source: RGD

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucagon-like peptide 1 receptor
    Short name:
    GLP-1 receptor
    Short name:
    GLP-1-R
    Short name:
    GLP-1R
    Gene namesi
    Name:Glp1r
    Synonyms:Glpr
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi2703. Glp1r.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: RGD
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 463442Glucagon-like peptide 1 receptorPRO_0000012837Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi46 ↔ 71By similarity
    Disulfide bondi62 ↔ 104By similarity
    Glycosylationi63 – 631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi82 – 821N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi85 ↔ 126By similarity
    Glycosylationi115 – 1151N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi226 ↔ 296By similarity
    Modified residuei341 – 3411ADP-ribosylcysteineBy similarity
    Modified residuei348 – 3481ADP-ribosylarginineBy similarity

    Post-translational modificationi

    N-glycosylation enhances cell surface expression and lengthens receptor half-life by preventing degradation in the ER.By similarity

    Keywords - PTMi

    ADP-ribosylation, Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP32301.

    PTM databases

    PhosphoSiteiP32301.

    Expressioni

    Tissue specificityi

    Pancreatic islets, stomach, lung, rat insulinoma cell line.

    Gene expression databases

    GenevestigatoriP32301.

    Interactioni

    Subunit structurei

    May form homodimers and heterodimers with GIPR.By similarity

    Protein-protein interaction databases

    BioGridi247128. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP32301.
    SMRiP32301. Positions 28-131.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 139118ExtracellularBy similarityAdd
    BLAST
    Topological domaini165 – 17612CytoplasmicBy similarityAdd
    BLAST
    Topological domaini202 – 22726ExtracellularBy similarityAdd
    BLAST
    Topological domaini252 – 26514CytoplasmicBy similarityAdd
    BLAST
    Topological domaini288 – 30518ExtracellularBy similarityAdd
    BLAST
    Topological domaini329 – 35224CytoplasmicBy similarityAdd
    BLAST
    Topological domaini372 – 38312ExtracellularBy similarityAdd
    BLAST
    Topological domaini405 – 46359CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei140 – 16425Helical; Name=1By similarityAdd
    BLAST
    Transmembranei177 – 20125Helical; Name=2By similarityAdd
    BLAST
    Transmembranei228 – 25124Helical; Name=3By similarityAdd
    BLAST
    Transmembranei266 – 28722Helical; Name=4By similarityAdd
    BLAST
    Transmembranei306 – 32823Helical; Name=5By similarityAdd
    BLAST
    Transmembranei353 – 37119Helical; Name=6By similarityAdd
    BLAST
    Transmembranei384 – 40421Helical; Name=7By similarityAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG263329.
    HOGENOMiHOG000008250.
    HOVERGENiHBG008318.
    InParanoidiP32301.
    KOiK04581.

    Family and domain databases

    InterProiIPR017981. GPCR_2-like.
    IPR001879. GPCR_2_extracellular_dom.
    IPR003290. GPCR_2_GLP1/glucagon_rcpt.
    IPR003292. GPCR_2_GLP1_rcpt.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    [Graphical view]
    PfamiPF00002. 7tm_2. 1 hit.
    PF02793. HRM. 1 hit.
    [Graphical view]
    PRINTSiPR01353. GLUCAGNFAMLY.
    PR01355. GLUCAGNLIKER.
    PR00249. GPCRSECRETIN.
    SMARTiSM00008. HormR. 1 hit.
    [Graphical view]
    PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
    PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P32301-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVTPSLLRL ALLLLGAVGR AGPRPQGATV SLSETVQKWR EYRHQCQRFL    50
    TEAPLLATGL FCNRTFDDYA CWPDGPPGSF VNVSCPWYLP WASSVLQGHV 100
    YRFCTAEGIW LHKDNSSLPW RDLSECEESK QGERNSPEEQ LLSLYIIYTV 150
    GYALSFSALV IASAILVSFR HLHCTRNYIH LNLFASFILR ALSVFIKDAA 200
    LKWMYSTAAQ QHQWDGLLSY QDSLGCRLVF LLMQYCVAAN YYWLLVEGVY 250
    LYTLLAFSVF SEQRIFKLYL SIGWGVPLLF VIPWGIVKYL YEDEGCWTRN 300
    SNMNYWLIIR LPILFAIGVN FLVFIRVICI VIAKLKANLM CKTDIKCRLA 350
    KSTLTLIPLL GTHEVIFAFV MDEHARGTLR FVKLFTELSF TSFQGFMVAV 400
    LYCFVNNEVQ MEFRKSWERW RLERLNIQRD SSMKPLKCPT SSVSSGATVG 450
    SSVYAATCQN SCS 463
    Length:463
    Mass (Da):52,877
    Last modified:October 1, 1993 - v1
    Checksum:iABE2183E8EBE621F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti323 – 3231V → I in AAP31860. (PubMed:7813606)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M97797 mRNA. Translation: AAA73377.1.
    S75952 mRNA. Translation: AAP31860.1.
    PIRiA46172.
    RefSeqiNP_036860.1. NM_012728.1.
    UniGeneiRn.11408.

    Genome annotation databases

    GeneIDi25051.
    KEGGirno:25051.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M97797 mRNA. Translation: AAA73377.1 .
    S75952 mRNA. Translation: AAP31860.1 .
    PIRi A46172.
    RefSeqi NP_036860.1. NM_012728.1.
    UniGenei Rn.11408.

    3D structure databases

    ProteinModelPortali P32301.
    SMRi P32301. Positions 28-131.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 247128. 1 interaction.

    Chemistry

    BindingDBi P32301.
    ChEMBLi CHEMBL5862.
    GuidetoPHARMACOLOGYi 249.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P32301.

    Proteomic databases

    PRIDEi P32301.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 25051.
    KEGGi rno:25051.

    Organism-specific databases

    CTDi 2740.
    RGDi 2703. Glp1r.

    Phylogenomic databases

    eggNOGi NOG263329.
    HOGENOMi HOG000008250.
    HOVERGENi HBG008318.
    InParanoidi P32301.
    KOi K04581.

    Miscellaneous databases

    NextBioi 605244.
    PROi P32301.

    Gene expression databases

    Genevestigatori P32301.

    Family and domain databases

    InterProi IPR017981. GPCR_2-like.
    IPR001879. GPCR_2_extracellular_dom.
    IPR003290. GPCR_2_GLP1/glucagon_rcpt.
    IPR003292. GPCR_2_GLP1_rcpt.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    [Graphical view ]
    Pfami PF00002. 7tm_2. 1 hit.
    PF02793. HRM. 1 hit.
    [Graphical view ]
    PRINTSi PR01353. GLUCAGNFAMLY.
    PR01355. GLUCAGNLIKER.
    PR00249. GPCRSECRETIN.
    SMARTi SM00008. HormR. 1 hit.
    [Graphical view ]
    PROSITEi PS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
    PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1."
      Thorens B.
      Proc. Natl. Acad. Sci. U.S.A. 89:8641-8645(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Pancreatic islet.
    2. "Molecular cloning of a cDNA encoding for the GLP-1 receptor expressed in rat lung."
      Lankat-Buttgereit B., Goke R., Fehmann H.C., Richter G., Goke B.
      Exp. Clin. Endocrinol. 102:341-347(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Lung.

    Entry informationi

    Entry nameiGLP1R_RAT
    AccessioniPrimary (citable) accession number: P32301
    Secondary accession number(s): Q64073, Q6LD83
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: October 1, 1993
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3