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P32301

- GLP1R_RAT

UniProt

P32301 - GLP1R_RAT

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Protein

Glucagon-like peptide 1 receptor

Gene

Glp1r

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

This is a receptor for glucagon-like peptide 1. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

GO - Molecular functioni

  1. glucagon receptor activity Source: InterPro
  2. G-protein coupled peptide receptor activity Source: RGD
  3. G-protein coupled receptor activity Source: RGD
  4. peptide hormone binding Source: RGD
  5. peptide receptor activity Source: RGD

GO - Biological processi

  1. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: RGD
  2. associative learning Source: RGD
  3. cAMP-mediated signaling Source: RGD
  4. feeding behavior Source: RGD
  5. hormone secretion Source: UniProtKB
  6. insulin secretion Source: UniProtKB
  7. learning or memory Source: UniProtKB
  8. memory Source: RGD
  9. negative regulation of apoptotic process Source: RGD
  10. negative regulation of neuron apoptotic process Source: RGD
  11. neuropeptide signaling pathway Source: RGD
  12. positive regulation of blood pressure Source: RGD
  13. positive regulation of cell differentiation Source: RGD
  14. positive regulation of cell proliferation Source: RGD
  15. positive regulation of heart contraction Source: RGD
  16. positive regulation of insulin secretion Source: RGD
  17. positive regulation of transcription from RNA polymerase II promoter Source: RGD
  18. regulation of calcium ion transport Source: RGD
  19. release of sequestered calcium ion into cytosol Source: RGD
  20. response to glucose Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Glucagon-like peptide 1 receptor
Short name:
GLP-1 receptor
Short name:
GLP-1-R
Short name:
GLP-1R
Gene namesi
Name:Glp1r
Synonyms:Glpr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi2703. Glp1r.

Subcellular locationi

GO - Cellular componenti

  1. integral component of plasma membrane Source: RGD
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 463442Glucagon-like peptide 1 receptorPRO_0000012837Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi46 ↔ 71By similarity
Disulfide bondi62 ↔ 104By similarity
Glycosylationi63 – 631N-linked (GlcNAc...)Sequence Analysis
Glycosylationi82 – 821N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi85 ↔ 126By similarity
Glycosylationi115 – 1151N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi226 ↔ 296By similarity
Modified residuei341 – 3411ADP-ribosylcysteineBy similarity
Modified residuei348 – 3481ADP-ribosylarginineBy similarity

Post-translational modificationi

N-glycosylation enhances cell surface expression and lengthens receptor half-life by preventing degradation in the ER.By similarity

Keywords - PTMi

ADP-ribosylation, Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP32301.

PTM databases

PhosphoSiteiP32301.

Expressioni

Tissue specificityi

Pancreatic islets, stomach, lung, rat insulinoma cell line.

Gene expression databases

GenevestigatoriP32301.

Interactioni

Subunit structurei

May form homodimers and heterodimers with GIPR.By similarity

Protein-protein interaction databases

BioGridi247128. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP32301.
SMRiP32301. Positions 28-131.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 139118ExtracellularBy similarityAdd
BLAST
Topological domaini165 – 17612CytoplasmicBy similarityAdd
BLAST
Topological domaini202 – 22726ExtracellularBy similarityAdd
BLAST
Topological domaini252 – 26514CytoplasmicBy similarityAdd
BLAST
Topological domaini288 – 30518ExtracellularBy similarityAdd
BLAST
Topological domaini329 – 35224CytoplasmicBy similarityAdd
BLAST
Topological domaini372 – 38312ExtracellularBy similarityAdd
BLAST
Topological domaini405 – 46359CytoplasmicBy similarityAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei140 – 16425Helical; Name=1By similarityAdd
BLAST
Transmembranei177 – 20125Helical; Name=2By similarityAdd
BLAST
Transmembranei228 – 25124Helical; Name=3By similarityAdd
BLAST
Transmembranei266 – 28722Helical; Name=4By similarityAdd
BLAST
Transmembranei306 – 32823Helical; Name=5By similarityAdd
BLAST
Transmembranei353 – 37119Helical; Name=6By similarityAdd
BLAST
Transmembranei384 – 40421Helical; Name=7By similarityAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG263329.
HOGENOMiHOG000008250.
HOVERGENiHBG008318.
InParanoidiP32301.
KOiK04581.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR003290. GPCR_2_GLP1/glucagon_rcpt.
IPR003292. GPCR_2_GLP1_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR01353. GLUCAGNFAMLY.
PR01355. GLUCAGNLIKER.
PR00249. GPCRSECRETIN.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P32301-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAVTPSLLRL ALLLLGAVGR AGPRPQGATV SLSETVQKWR EYRHQCQRFL
60 70 80 90 100
TEAPLLATGL FCNRTFDDYA CWPDGPPGSF VNVSCPWYLP WASSVLQGHV
110 120 130 140 150
YRFCTAEGIW LHKDNSSLPW RDLSECEESK QGERNSPEEQ LLSLYIIYTV
160 170 180 190 200
GYALSFSALV IASAILVSFR HLHCTRNYIH LNLFASFILR ALSVFIKDAA
210 220 230 240 250
LKWMYSTAAQ QHQWDGLLSY QDSLGCRLVF LLMQYCVAAN YYWLLVEGVY
260 270 280 290 300
LYTLLAFSVF SEQRIFKLYL SIGWGVPLLF VIPWGIVKYL YEDEGCWTRN
310 320 330 340 350
SNMNYWLIIR LPILFAIGVN FLVFIRVICI VIAKLKANLM CKTDIKCRLA
360 370 380 390 400
KSTLTLIPLL GTHEVIFAFV MDEHARGTLR FVKLFTELSF TSFQGFMVAV
410 420 430 440 450
LYCFVNNEVQ MEFRKSWERW RLERLNIQRD SSMKPLKCPT SSVSSGATVG
460
SSVYAATCQN SCS
Length:463
Mass (Da):52,877
Last modified:October 1, 1993 - v1
Checksum:iABE2183E8EBE621F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti323 – 3231V → I in AAP31860. (PubMed:7813606)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M97797 mRNA. Translation: AAA73377.1.
S75952 mRNA. Translation: AAP31860.1.
PIRiA46172.
RefSeqiNP_036860.1. NM_012728.1.
UniGeneiRn.11408.

Genome annotation databases

GeneIDi25051.
KEGGirno:25051.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M97797 mRNA. Translation: AAA73377.1 .
S75952 mRNA. Translation: AAP31860.1 .
PIRi A46172.
RefSeqi NP_036860.1. NM_012728.1.
UniGenei Rn.11408.

3D structure databases

ProteinModelPortali P32301.
SMRi P32301. Positions 28-131.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 247128. 1 interaction.

Chemistry

BindingDBi P32301.
ChEMBLi CHEMBL5862.
GuidetoPHARMACOLOGYi 249.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P32301.

Proteomic databases

PRIDEi P32301.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 25051.
KEGGi rno:25051.

Organism-specific databases

CTDi 2740.
RGDi 2703. Glp1r.

Phylogenomic databases

eggNOGi NOG263329.
HOGENOMi HOG000008250.
HOVERGENi HBG008318.
InParanoidi P32301.
KOi K04581.

Miscellaneous databases

NextBioi 605244.
PROi P32301.

Gene expression databases

Genevestigatori P32301.

Family and domain databases

InterProi IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR003290. GPCR_2_GLP1/glucagon_rcpt.
IPR003292. GPCR_2_GLP1_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view ]
Pfami PF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view ]
PRINTSi PR01353. GLUCAGNFAMLY.
PR01355. GLUCAGNLIKER.
PR00249. GPCRSECRETIN.
SMARTi SM00008. HormR. 1 hit.
[Graphical view ]
PROSITEi PS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1."
    Thorens B.
    Proc. Natl. Acad. Sci. U.S.A. 89:8641-8645(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Pancreatic islet.
  2. "Molecular cloning of a cDNA encoding for the GLP-1 receptor expressed in rat lung."
    Lankat-Buttgereit B., Goke R., Fehmann H.C., Richter G., Goke B.
    Exp. Clin. Endocrinol. 102:341-347(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiGLP1R_RAT
AccessioniPrimary (citable) accession number: P32301
Secondary accession number(s): Q64073, Q6LD83
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: October 1, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3