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Protein

Glucagon-like peptide 1 receptor

Gene

Glp1r

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

This is a receptor for glucagon-like peptide 1. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

GO - Molecular functioni

  • glucagon receptor activity Source: InterPro
  • G-protein coupled peptide receptor activity Source: RGD
  • G-protein coupled receptor activity Source: RGD
  • peptide hormone binding Source: RGD
  • peptide receptor activity Source: RGD

GO - Biological processi

  • adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: RGD
  • associative learning Source: RGD
  • cAMP-mediated signaling Source: RGD
  • cell surface receptor signaling pathway Source: InterPro
  • feeding behavior Source: RGD
  • hormone secretion Source: UniProtKB
  • insulin secretion Source: UniProtKB
  • learning or memory Source: UniProtKB
  • memory Source: RGD
  • negative regulation of apoptotic process Source: RGD
  • negative regulation of neuron apoptotic process Source: RGD
  • neuropeptide signaling pathway Source: RGD
  • positive regulation of blood pressure Source: RGD
  • positive regulation of cell differentiation Source: RGD
  • positive regulation of cell proliferation Source: RGD
  • positive regulation of heart contraction Source: RGD
  • positive regulation of insulin secretion Source: RGD
  • positive regulation of transcription from RNA polymerase II promoter Source: RGD
  • regulation of calcium ion transport Source: RGD
  • regulation of insulin secretion Source: Reactome
  • release of sequestered calcium ion into cytosol Source: RGD
  • response to glucose Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucagon-like peptide 1 receptor
Short name:
GLP-1 receptor
Short name:
GLP-1-R
Short name:
GLP-1R
Gene namesi
Name:Glp1r
Synonyms:Glpr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2703. Glp1r.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 139ExtracellularBy similarityAdd BLAST118
Transmembranei140 – 164Helical; Name=1By similarityAdd BLAST25
Topological domaini165 – 176CytoplasmicBy similarityAdd BLAST12
Transmembranei177 – 201Helical; Name=2By similarityAdd BLAST25
Topological domaini202 – 227ExtracellularBy similarityAdd BLAST26
Transmembranei228 – 251Helical; Name=3By similarityAdd BLAST24
Topological domaini252 – 265CytoplasmicBy similarityAdd BLAST14
Transmembranei266 – 287Helical; Name=4By similarityAdd BLAST22
Topological domaini288 – 305ExtracellularBy similarityAdd BLAST18
Transmembranei306 – 328Helical; Name=5By similarityAdd BLAST23
Topological domaini329 – 352CytoplasmicBy similarityAdd BLAST24
Transmembranei353 – 371Helical; Name=6By similarityAdd BLAST19
Topological domaini372 – 383ExtracellularBy similarityAdd BLAST12
Transmembranei384 – 404Helical; Name=7By similarityAdd BLAST21
Topological domaini405 – 463CytoplasmicBy similarityAdd BLAST59

GO - Cellular componenti

  • integral component of plasma membrane Source: RGD
  • intracellular Source: GOC
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5862.
GuidetoPHARMACOLOGYi249.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001283722 – 463Glucagon-like peptide 1 receptorAdd BLAST442

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi46 ↔ 71By similarity
Disulfide bondi62 ↔ 104By similarity
Glycosylationi63N-linked (GlcNAc...)Sequence analysis1
Glycosylationi82N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi85 ↔ 126By similarity
Glycosylationi115N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi226 ↔ 296By similarity
Modified residuei341ADP-ribosylcysteineBy similarity1
Modified residuei348ADP-ribosylarginineBy similarity1

Post-translational modificationi

N-glycosylation enhances cell surface expression and lengthens receptor half-life by preventing degradation in the ER.By similarity

Keywords - PTMi

ADP-ribosylation, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP32301.
PRIDEiP32301.

PTM databases

iPTMnetiP32301.
PhosphoSitePlusiP32301.
SwissPalmiP32301.

Expressioni

Tissue specificityi

Pancreatic islets, stomach, lung, rat insulinoma cell line.

Interactioni

Subunit structurei

May form homodimers and heterodimers with GIPR.By similarity

Protein-protein interaction databases

BioGridi247128. 1 interactor.
STRINGi10116.ENSRNOP00000001527.

Chemistry databases

BindingDBiP32301.

Structurei

3D structure databases

ProteinModelPortaliP32301.
SMRiP32301.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4564. Eukaryota.
ENOG410XRS2. LUCA.
HOGENOMiHOG000008250.
HOVERGENiHBG008318.
InParanoidiP32301.
KOiK04581.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR003290. GPCR_2_GLP1/glucagon_rcpt.
IPR003292. GPCR_2_GLP1_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR01353. GLUCAGNFAMLY.
PR01355. GLUCAGNLIKER.
PR00249. GPCRSECRETIN.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P32301-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVTPSLLRL ALLLLGAVGR AGPRPQGATV SLSETVQKWR EYRHQCQRFL
60 70 80 90 100
TEAPLLATGL FCNRTFDDYA CWPDGPPGSF VNVSCPWYLP WASSVLQGHV
110 120 130 140 150
YRFCTAEGIW LHKDNSSLPW RDLSECEESK QGERNSPEEQ LLSLYIIYTV
160 170 180 190 200
GYALSFSALV IASAILVSFR HLHCTRNYIH LNLFASFILR ALSVFIKDAA
210 220 230 240 250
LKWMYSTAAQ QHQWDGLLSY QDSLGCRLVF LLMQYCVAAN YYWLLVEGVY
260 270 280 290 300
LYTLLAFSVF SEQRIFKLYL SIGWGVPLLF VIPWGIVKYL YEDEGCWTRN
310 320 330 340 350
SNMNYWLIIR LPILFAIGVN FLVFIRVICI VIAKLKANLM CKTDIKCRLA
360 370 380 390 400
KSTLTLIPLL GTHEVIFAFV MDEHARGTLR FVKLFTELSF TSFQGFMVAV
410 420 430 440 450
LYCFVNNEVQ MEFRKSWERW RLERLNIQRD SSMKPLKCPT SSVSSGATVG
460
SSVYAATCQN SCS
Length:463
Mass (Da):52,877
Last modified:October 1, 1993 - v1
Checksum:iABE2183E8EBE621F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti323V → I in AAP31860 (PubMed:7813606).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97797 mRNA. Translation: AAA73377.1.
S75952 mRNA. Translation: AAP31860.1.
PIRiA46172.
RefSeqiNP_036860.1. NM_012728.1.
UniGeneiRn.11408.

Genome annotation databases

GeneIDi25051.
KEGGirno:25051.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97797 mRNA. Translation: AAA73377.1.
S75952 mRNA. Translation: AAP31860.1.
PIRiA46172.
RefSeqiNP_036860.1. NM_012728.1.
UniGeneiRn.11408.

3D structure databases

ProteinModelPortaliP32301.
SMRiP32301.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi247128. 1 interactor.
STRINGi10116.ENSRNOP00000001527.

Chemistry databases

BindingDBiP32301.
ChEMBLiCHEMBL5862.
GuidetoPHARMACOLOGYi249.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP32301.
PhosphoSitePlusiP32301.
SwissPalmiP32301.

Proteomic databases

PaxDbiP32301.
PRIDEiP32301.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25051.
KEGGirno:25051.

Organism-specific databases

CTDi2740.
RGDi2703. Glp1r.

Phylogenomic databases

eggNOGiKOG4564. Eukaryota.
ENOG410XRS2. LUCA.
HOGENOMiHOG000008250.
HOVERGENiHBG008318.
InParanoidiP32301.
KOiK04581.

Enzyme and pathway databases

ReactomeiR-RNO-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.

Miscellaneous databases

PROiP32301.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR003290. GPCR_2_GLP1/glucagon_rcpt.
IPR003292. GPCR_2_GLP1_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR01353. GLUCAGNFAMLY.
PR01355. GLUCAGNLIKER.
PR00249. GPCRSECRETIN.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGLP1R_RAT
AccessioniPrimary (citable) accession number: P32301
Secondary accession number(s): Q64073, Q6LD83
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: November 2, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.