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Reviewed, UniProtKB/Swiss-Prot P32299 (BKRB2_MOUSE)

Last modified June 16, 2009. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    B2 bradykinin receptor
Alternative name(s):
    BK-2 receptor
      Short name=B2R
Gene names
Name: Bdkrb2
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length392 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

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Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform Long (identifier: P32299-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform Short (identifier: P32299-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-26: Missing.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 392392B2 bradykinin receptor
PRO_0000069191

Regions

Topological domain1 – 6161Extracellular Potential
Transmembrane62 – 85241 Potential
Topological domain86 – 949Cytoplasmic Potential
Transmembrane95 – 119252 Potential
Topological domain120 – 13213Extracellular Potential
Transmembrane133 – 154223 Potential
Topological domain155 – 17622Cytoplasmic Potential
Transmembrane177 – 199234 Potential
Topological domain200 – 22223Extracellular Potential
Transmembrane223 – 249275 Potential
Topological domain250 – 26819Cytoplasmic Potential
Transmembrane269 – 293256 Potential
Topological domain294 – 31219Extracellular Potential
Transmembrane313 – 336247 Potential
Topological domain337 – 39256Cytoplasmic Potential

Amino acid modifications

Lipidation3521S-palmitoyl cysteine Potential
Glycosylation291N-linked (GlcNAc...) Potential
Glycosylation401N-linked (GlcNAc...) Potential
Glycosylation2081N-linked (GlcNAc...) Potential
Disulfide bond131 ↔ 212 By similarity

Natural variations

Alternative sequence1 – 2626Missing in isoform Short.
VSP_001866

Experimental info

Sequence conflict2981R → A Ref.1
Sequence conflict2981R → A Ref.4

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Sequences

Sequence LengthMass (Da)Tools
Isoform Long [UniParc].

Last modified May 30, 2000. Version 4.
Checksum: FB1AA59BCBFFF5F9

FASTA39244,389
        10         20         30         40         50         60 
MPCSWKLLGF LSVHEPMPTA ASFGIEMFNV TTQVLGSALN GTLSKDNCPD TEWWSWLNAI 

        70         80         90        100        110        120 
QAPFLWVLFL LAALENLFVL SVFFLHKNSC TVAEIYLGNL AAADLILACG LPFWAITIAN 

       130        140        150        160        170        180 
NFDWVFGEVL CRVVNTMIYM NLYSSICFLM LVSIDRYLAL VKTMSMGRMR GVRWAKLYSL 

       190        200        210        220        230        240 
VIWGCTLLLS SPMLVFRTMR EYSEEGHNVT ACVIVYPSRS WEVFTNVLLN LVGFLLPLSV 

       250        260        270        280        290        300 
ITFCTVRILQ VLRNNEMKKF KEVQTERKAT VLVLAVLGLF VLCWVPFQIS TFLDTLLRLG 

       310        320        330        340        350        360 
VLSGCWDEHA VDVITQISSY VAYSNSGLNP LVYVIVGKRF RKKSREVYRV LCQKGGCMGE 

       370        380        390 
PVQMENSMGT LRTSISVERQ IHKLQDWAGK KQ

« Hide

Isoform Short.

Checksum: 9276DBA985F42379
Show »

FASTA36641,558

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References

[1]"Cloned murine bradykinin receptor exhibits a mixed B1 and B2 pharmacological selectivity."
McIntyre P., Phillips E., Skidmore E., Brown M., Webb M.
Mol. Pharmacol. 44:346-355(1993) [PubMed: 8394991] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM SHORT).
Strain: C57BL/6.
[2]"Differential pharmacology of cloned human and mouse B2 bradykinin receptors."
Hess J.F.R., Borkowski J.A., Macneil T., Stonesifer G.Y., Fraher J., Strader C.D., Ransom R.W.
Mol. Pharmacol. 45:1-8(1994) [PubMed: 8302267] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE (ISOFORM SHORT).
Strain: 129/J.
[3]"B2 bradykinin receptors in NG108-15 cells: cDNA cloning and functional expression."
Yokoyama S., Kimura Y., Taketo M., Black J.A., Ransom B.R., Higashida H.
Biochem. Biophys. Res. Commun. 200:634-641(1994) [PubMed: 8166739] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
Strain: A/J.
[4]"Cloning, sequence analysis and expression of the gene encoding the mouse bradykinin B2 receptor."
Ma J.X., Wang D.Z., Chao L., Chao J.
Gene 149:283-288(1994) [PubMed: 7959003] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]"Structure of the bradykinin B2 receptors' amino terminus."
Abdalla S., Godovac-Zimmermann J., Braun A., Roscher A.A., Mueller-Esterl W., Quitterer U.
Biochemistry 35:7514-7519(1996) [PubMed: 8652530] [Abstract]
Cited for: IDENTIFICATION OF LONG FORM.
+Additional computationally mapped references.

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Cross-references

Sequence databases

X69676 Genomic DNA. Translation: CAA49357.1.
X69682 mRNA. Translation: CAA49362.1.
L26047 Unassigned DNA. Translation: AAA19797.1.
X78438 mRNA. Translation: CAA55202.1.
L27595 Genomic DNA. Translation: AAA62616.1.
IPIIPI00136814.
IPI00226768.
PIRI49519.
RefSeqNP_033877.3.
UniGeneMm.390475

3D structure databases

ModBaseSearch...

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP32299.

Genome annotation databases

EnsemblENSMUSG00000021070. Mus musculus. [Contig view]
GeneID12062.
KEGGmmu:12062.

Organism-specific databases

MGIMGI:102845. Bdkrb2.

Phylogenomic databases

HOGENOMP32299.
HOVERGENP32299.
OMAP32299. MENSMGT.

Gene expression databases

ArrayExpressP32299.
BgeeP32299.
CleanExMM_BDKRB2.
GermOnlineENSMUSG00000021070. Mus musculus.

Family and domain databases

InterProIPR000276. 7TM_GPCR_Rhodpsn.
IPR001504. B2_bradkn_rcpt.
IPR000496. Brdyknn_rcpt.
IPR017452. GPCR_Rhodpsn_supfam.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00425. BRADYKININR.
PR00994. BRADYKINNB2R.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio280373.
SOURCESearch...

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Entry information

Entry nameBKRB2_MOUSE
AccessionPrimary (citable) accession number: P32299
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: May 30, 2000
Last modified: June 16, 2009
This is version 78 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents