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Protein

B2 bradykinin receptor

Gene

Bdkrb2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

GO - Biological processi

  • arachidonic acid secretion Source: MGI
  • negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress Source: MGI
  • negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator Source: MGI
  • negative regulation of peptidyl-serine phosphorylation Source: MGI
  • response to salt stress Source: MGI
  • smooth muscle contraction Source: InterPro
  • vasoconstriction Source: InterPro
  • vasodilation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-416476. G alpha (q) signalling events.
R-MMU-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
B2 bradykinin receptor
Short name:
B2R
Short name:
BK-2 receptor
Gene namesi
Name:Bdkrb2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:102845. Bdkrb2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 61ExtracellularSequence analysisAdd BLAST61
Transmembranei62 – 85Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini86 – 94CytoplasmicSequence analysis9
Transmembranei95 – 119Helical; Name=2Sequence analysisAdd BLAST25
Topological domaini120 – 132ExtracellularSequence analysisAdd BLAST13
Transmembranei133 – 154Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini155 – 176CytoplasmicSequence analysisAdd BLAST22
Transmembranei177 – 199Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini200 – 222ExtracellularSequence analysisAdd BLAST23
Transmembranei223 – 249Helical; Name=5Sequence analysisAdd BLAST27
Topological domaini250 – 268CytoplasmicSequence analysisAdd BLAST19
Transmembranei269 – 293Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini294 – 312ExtracellularSequence analysisAdd BLAST19
Transmembranei313 – 336Helical; Name=7Sequence analysisAdd BLAST24
Topological domaini337 – 392CytoplasmicSequence analysisAdd BLAST56

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

GuidetoPHARMACOLOGYi42.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000691911 – 392B2 bradykinin receptorAdd BLAST392

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi29N-linked (GlcNAc...)Sequence analysis1
Glycosylationi40N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi131 ↔ 212PROSITE-ProRule annotation
Modified residuei157PhosphotyrosineBy similarity1
Glycosylationi208N-linked (GlcNAc...)Sequence analysis1
Modified residuei348PhosphotyrosineBy similarity1
Lipidationi352S-palmitoyl cysteineSequence analysis1
Modified residuei367PhosphoserineBy similarity1
Modified residuei370PhosphothreonineBy similarity1
Modified residuei374Phosphoserine; by GRK6By similarity1
Modified residuei376Phosphoserine; by GRK6By similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP32299.
PRIDEiP32299.

PTM databases

iPTMnetiP32299.
PhosphoSitePlusiP32299.

Expressioni

Gene expression databases

BgeeiENSMUSG00000021070.
CleanExiMM_BDKRB2.
GenevisibleiP32299. MM.

Interactioni

Subunit structurei

Forms a complex with PECAM1 and GNAQ. Interacts with PECAM1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000001652.

Structurei

3D structure databases

ProteinModelPortaliP32299.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB2 sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410INT3. Eukaryota.
ENOG41117RA. LUCA.
GeneTreeiENSGT00760000119055.
HOGENOMiHOG000010314.
HOVERGENiHBG103183.
InParanoidiP32299.
KOiK03916.
OMAiENSMGTL.
OrthoDBiEOG091G0AAK.
PhylomeDBiP32299.
TreeFamiTF330024.

Family and domain databases

InterProiIPR001504. Brdyknn_2_rcpt.
IPR000496. Brdyknn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00425. BRADYKININR.
PR00994. BRADYKINNB2R.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: P32299-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPCSWKLLGF LSVHEPMPTA ASFGIEMFNV TTQVLGSALN GTLSKDNCPD
60 70 80 90 100
TEWWSWLNAI QAPFLWVLFL LAALENLFVL SVFFLHKNSC TVAEIYLGNL
110 120 130 140 150
AAADLILACG LPFWAITIAN NFDWVFGEVL CRVVNTMIYM NLYSSICFLM
160 170 180 190 200
LVSIDRYLAL VKTMSMGRMR GVRWAKLYSL VIWGCTLLLS SPMLVFRTMR
210 220 230 240 250
EYSEEGHNVT ACVIVYPSRS WEVFTNVLLN LVGFLLPLSV ITFCTVRILQ
260 270 280 290 300
VLRNNEMKKF KEVQTERKAT VLVLAVLGLF VLCWVPFQIS TFLDTLLRLG
310 320 330 340 350
VLSGCWDEHA VDVITQISSY VAYSNSGLNP LVYVIVGKRF RKKSREVYRV
360 370 380 390
LCQKGGCMGE PVQMENSMGT LRTSISVERQ IHKLQDWAGK KQ
Length:392
Mass (Da):44,389
Last modified:May 30, 2000 - v4
Checksum:iFB1AA59BCBFFF5F9
GO
Isoform Short (identifier: P32299-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-26: Missing.

Show »
Length:366
Mass (Da):41,558
Checksum:i9276DBA985F42379
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti298R → A (PubMed:8394991).Curated1
Sequence conflicti298R → A (PubMed:7959003).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0018661 – 26Missing in isoform Short. 2 PublicationsAdd BLAST26

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69676 Genomic DNA. Translation: CAA49357.1.
X69682 mRNA. Translation: CAA49362.1.
L26047 Unassigned DNA. Translation: AAA19797.1.
X78438 mRNA. Translation: CAA55202.1.
L27595 Genomic DNA. Translation: AAA62616.1.
BC137755 mRNA. Translation: AAI37756.1.
CCDSiCCDS49160.1. [P32299-1]
PIRiI49519.
RefSeqiNP_033877.3. NM_009747.2. [P32299-1]
XP_006515505.1. XM_006515442.3. [P32299-1]
UniGeneiMm.390475.

Genome annotation databases

EnsembliENSMUST00000001652; ENSMUSP00000001652; ENSMUSG00000021070. [P32299-1]
GeneIDi12062.
KEGGimmu:12062.
UCSCiuc007oym.1. mouse. [P32299-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69676 Genomic DNA. Translation: CAA49357.1.
X69682 mRNA. Translation: CAA49362.1.
L26047 Unassigned DNA. Translation: AAA19797.1.
X78438 mRNA. Translation: CAA55202.1.
L27595 Genomic DNA. Translation: AAA62616.1.
BC137755 mRNA. Translation: AAI37756.1.
CCDSiCCDS49160.1. [P32299-1]
PIRiI49519.
RefSeqiNP_033877.3. NM_009747.2. [P32299-1]
XP_006515505.1. XM_006515442.3. [P32299-1]
UniGeneiMm.390475.

3D structure databases

ProteinModelPortaliP32299.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000001652.

Chemistry databases

GuidetoPHARMACOLOGYi42.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP32299.
PhosphoSitePlusiP32299.

Proteomic databases

PaxDbiP32299.
PRIDEiP32299.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001652; ENSMUSP00000001652; ENSMUSG00000021070. [P32299-1]
GeneIDi12062.
KEGGimmu:12062.
UCSCiuc007oym.1. mouse. [P32299-1]

Organism-specific databases

CTDi624.
MGIiMGI:102845. Bdkrb2.

Phylogenomic databases

eggNOGiENOG410INT3. Eukaryota.
ENOG41117RA. LUCA.
GeneTreeiENSGT00760000119055.
HOGENOMiHOG000010314.
HOVERGENiHBG103183.
InParanoidiP32299.
KOiK03916.
OMAiENSMGTL.
OrthoDBiEOG091G0AAK.
PhylomeDBiP32299.
TreeFamiTF330024.

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-416476. G alpha (q) signalling events.
R-MMU-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiP32299.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021070.
CleanExiMM_BDKRB2.
GenevisibleiP32299. MM.

Family and domain databases

InterProiIPR001504. Brdyknn_2_rcpt.
IPR000496. Brdyknn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00425. BRADYKININR.
PR00994. BRADYKINNB2R.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBKRB2_MOUSE
AccessioniPrimary (citable) accession number: P32299
Secondary accession number(s): B9EHE3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: May 30, 2000
Last modified: November 2, 2016
This is version 144 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.