true
1993-10-01
2024-01-24
209
GRK4_HUMAN
A novel G protein-coupled receptor kinase gene cloned from 4p16.3.
Ambrose C.
James M.
Barnes G.
Lin C.
Bates G.
Altherr M.
Duyao M.
Groot N.
Church D.
Wasmuth J.J.
Lehrach H.
Housman D.
Buckler A.J.
Gusella J.F.
McDonald M.E.
doi:10.1093/hmg/1.9.697
1992
Hum. Mol. Genet.
1
697-703
NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 3)
VARIANT ALA-486
G protein-coupled receptor kinase GRK4. Molecular analysis of the four isoforms and ultrastructural localization in spermatozoa and germinal cells.
Sallese M.
Mariggio S.
Collodel G.
Moretti E.
Piomboni P.
Baccetti B.
de Blasi A.
doi:10.1074/jbc.272.15.10188
1997
J. Biol. Chem.
272
10188-10195
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4)
VARIANT ALA-486
Testis
Characterization of the G protein-coupled receptor kinase GRK4. Identification of four splice variants.
Premont R.T.
Macrae A.D.
Stoffel R.H.
Chung N.
Pitcher J.A.
Ambrose C.
Inglese J.
MacDonald M.E.
Lefkowitz R.J.
doi:10.1074/jbc.271.11.6403
1996
J. Biol. Chem.
271
6403-6410
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]
ALTERNATIVE SPLICING
FUNCTION
TISSUE SPECIFICITY
SUBCELLULAR LOCATION
PALMITOYLATION
VARIANT ALA-486
Two isoforms of G protein-coupled receptor kinase 4 identified by molecular cloning.
Sallese M.
Lombardi M.S.
de Blasi A.
doi:10.1006/bbrc.1994.1306
1994
Biochem. Biophys. Res. Commun.
199
848-854
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
VARIANT ALA-486
Brain
Totoki Y.
Toyoda A.
Takeda T.
Sakaki Y.
Tanaka A.
Yokoyama S.
2005-04
EMBL/GenBank/DDBJ
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
Kidney
Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
Hillier L.W.
Graves T.A.
Fulton R.S.
Fulton L.A.
Pepin K.H.
Minx P.
Wagner-McPherson C.
Layman D.
Wylie K.
Sekhon M.
Becker M.C.
Fewell G.A.
Delehaunty K.D.
Miner T.L.
Nash W.E.
Kremitzki C.
Oddy L.
Du H.
Sun H.
Bradshaw-Cordum H.
Ali J.
Carter J.
Cordes M.
Harris A.
Isak A.
van Brunt A.
Nguyen C.
Du F.
Courtney L.
Kalicki J.
Ozersky P.
Abbott S.
Armstrong J.
Belter E.A.
Caruso L.
Cedroni M.
Cotton M.
Davidson T.
Desai A.
Elliott G.
Erb T.
Fronick C.
Gaige T.
Haakenson W.
Haglund K.
Holmes A.
Harkins R.
Kim K.
Kruchowski S.S.
Strong C.M.
Grewal N.
Goyea E.
Hou S.
Levy A.
Martinka S.
Mead K.
McLellan M.D.
Meyer R.
Randall-Maher J.
Tomlinson C.
Dauphin-Kohlberg S.
Kozlowicz-Reilly A.
Shah N.
Swearengen-Shahid S.
Snider J.
Strong J.T.
Thompson J.
Yoakum M.
Leonard S.
Pearman C.
Trani L.
Radionenko M.
Waligorski J.E.
Wang C.
Rock S.M.
Tin-Wollam A.-M.
Maupin R.
Latreille P.
Wendl M.C.
Yang S.-P.
Pohl C.
Wallis J.W.
Spieth J.
Bieri T.A.
Berkowicz N.
Nelson J.O.
Osborne J.
Ding L.
Meyer R.'
Sabo A.
Shotland Y.
Sinha P.
Wohldmann P.E.
Cook L.L.
Hickenbotham M.T.
Eldred J.
Williams D.
Jones T.A.
She X.
Ciccarelli F.D.
Izaurralde E.
Taylor J.
Schmutz J.
Myers R.M.
Cox D.R.
Huang X.
McPherson J.D.
Mardis E.R.
Clifton S.W.
Warren W.C.
Chinwalla A.T.
Eddy S.R.
Marra M.A.
Ovcharenko I.
Furey T.S.
Miller W.
Eichler E.E.
Bork P.
Suyama M.
Torrents D.
Waterston R.H.
Wilson R.K.
doi:10.1038/nature03466
2005
Nature
434
724-731
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team
doi:10.1101/gr.2596504
2004
Genome Res.
14
2121-2127
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
VARIANT ALA-486
Amelioration of genetic hypertension by suppression of renal G protein-coupled receptor kinase type 4 expression.
Sanada H.
Yatabe J.
Midorikawa S.
Katoh T.
Hashimoto S.
Watanabe T.
Xu J.
Luo Y.
Wang X.
Zeng C.
Armando I.
Felder R.A.
Jose P.A.
doi:10.1161/01.hyp.0000222004.74872.17
2006
Hypertension
47
1131-1139
TISSUE SPECIFICITY
G protein-coupled receptor kinase 4 (GRK4) regulates the phosphorylation and function of the dopamine D3 receptor.
Villar V.A.M.
Jones J.E.
Armando I.
Palmes-Saloma C.
Yu P.
Pascua A.M.
Keever L.
Arnaldo F.B.
Wang Z.
Luo Y.
Felder R.A.
Jose P.A.
doi:10.1074/jbc.m109.003665
2009
J. Biol. Chem.
284
21425-21434
FUNCTION
ACTIVITY REGULATION
SUBCELLULAR LOCATION
INTERACTION WITH DRD3
Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
Bienvenut W.V.
Sumpton D.
Martinez A.
Lilla S.
Espagne C.
Meinnel T.
Giglione C.
doi:10.1074/mcp.m111.015131
2012
Mol. Cell. Proteomics
11
M111.015131
ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
Patterns of somatic mutation in human cancer genomes.
Greenman C.
Stephens P.
Smith R.
Dalgliesh G.L.
Hunter C.
Bignell G.
Davies H.
Teague J.
Butler A.
Stevens C.
Edkins S.
O'Meara S.
Vastrik I.
Schmidt E.E.
Avis T.
Barthorpe S.
Bhamra G.
Buck G.
Choudhury B.
Clements J.
Cole J.
Dicks E.
Forbes S.
Gray K.
Halliday K.
Harrison R.
Hills K.
Hinton J.
Jenkinson A.
Jones D.
Menzies A.
Mironenko T.
Perry J.
Raine K.
Richardson D.
Shepherd R.
Small A.
Tofts C.
Varian J.
Webb T.
West S.
Widaa S.
Yates A.
Cahill D.P.
Louis D.N.
Goldstraw P.
Nicholson A.G.
Brasseur F.
Looijenga L.
Weber B.L.
Chiew Y.-E.
DeFazio A.
Greaves M.F.
Green A.R.
Campbell P.
Birney E.
Easton D.F.
Chenevix-Trench G.
Tan M.-H.
Khoo S.K.
Teh B.T.
Yuen S.T.
Leung S.Y.
Wooster R.
Futreal P.A.
Stratton M.R.
doi:10.1038/nature05610
2007
Nature
446
153-158
VARIANTS [LARGE SCALE ANALYSIS] LEU-65; THR-116; VAL-142; ILE-247; GLN-383; PRO-425; ILE-473; ALA-486 AND THR-495
2.60
A/B=1-578
29
18
301 antibodies from 29 providers
human
GRK4
Tissue enhanced (testis)
gene
Eukaryota
2681
Inactivation, recovery and regulation of the phototransduction cascade
7 hits in 1173 CRISPR screens
human
Tchem
Protein
Expressed in left testis and 112 other cell types or tissues
baseline and differential
STKc_GRK4
Regulator of G-protein Signalling 4, domain 2
Transferase(Phosphotransferase) domain 1
AGC-kinase_C
GPCR_kinase
Kinase-like_dom_sf
Prot_kinase_dom
Protein_kinase_ATP_BS
RGS
RGS_sf
RGS_subdomain_2
Ser/Thr_kinase_AS
G PROTEIN-COUPLED RECEPTOR KINASE 4
G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE
Pkinase
RGS
GPCRKINASE
RGS
S_TK_X
S_TKc
Protein kinase-like (PK-like)
Regulator of G-protein signaling, RGS
AGC_KINASE_CTER
PROTEIN_KINASE_ATP
PROTEIN_KINASE_DOM
PROTEIN_KINASE_ST
RGS
HS
G protein-coupled receptor kinase 4
2.7.11.16
G protein-coupled receptor kinase GRK4
ITI1
GRK4
GPRK2L
GPRK4
Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2.
Inhibited by heparin.
Interacts with DRD3.
Both at the cell surface and dispersed in the cytoplasm under basal conditions. Receptor stimulation results in the internalization of GRK4 to the perinuclear area, where colocalization with DRD3 is observed strongly at 5 and 15 minutes. DRD3 and GRK4 colocalize in lipid rafts of renal proximal tubule cells.
Isoform 1, isoform 2, isoform 3, and isoform 4 are expressed in testis. Isoform 4 is expressed in myometrium.
Palmitoylated.
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
G protein-coupled receptor kinase 4
66583
1
578
RGS
52
172
Protein kinase
187
449
AGC-kinase C-terminal
450
515
N-terminal
154
Proton acceptor
312
193
201
216
N-acetylmethionine
Phosphoserine
485
In isoform 2 and isoform 3.
18
49
In isoform 3 and isoform 4.
516
561
L
65
H
95
T
116
V
142
R
183
I
247
Q
383
P
425
V
440
I
473
A
486
T
495
D
562
D
30
33
39
42
43
48
53
57
61
71
75
91
97
98
109
113
115
123
132
135
137
140
143
144
157
162
166
178
184
186
195
197
206
207
209
212
219
220
226
229
241
250
255
257
264
272
276
277
279
280
283
286
304
305
307
315
317
318
320
326
328
341
343
350
352
355
358
363
365
366
381
382
384
395
403
415
424
429
431
433
438
439
444
447
454
458
494
500
505
507
509
518
519
524
2007-04-03
3
66583
95b0e4752620561e87cdd738298d457c
1
GRK4-alpha
GRK4D
MELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQPIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPEIPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQPVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLDIEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDINKSESEEALPLDLDKNIHTPVSRPNRGFFYRLFRRGGCLTMVPSEKEVEPKQC
2
GRK4-beta
GRK4C
MELENIVANSLLLKARQEKDYSSLCDKQPIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPEIPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQPVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLDIEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDINKSESEEALPLDLDKNIHTPVSRPNRGFFYRLFRRGGCLTMVPSEKEVEPKQC
3
GRK4-delta
GRK4A
MELENIVANSLLLKARQEKDYSSLCDKQPIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPEIPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQPVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLDIEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEGCLTMVPSEKEVEPKQC
4
GRK4-gamma
GRK4B
MELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQPIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPEIPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQPVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLDIEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEGCLTMVPSEKEVEPKQC
true
true
true
true
true
true
true
true
true
true
true
true
true
true
true
true
true
true
true
true
true
true
true