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P32298

- GRK4_HUMAN

UniProt

P32298 - GRK4_HUMAN

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Protein

G protein-coupled receptor kinase 4

Gene

GRK4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2.2 Publications

Catalytic activityi

ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate.

Enzyme regulationi

Inhibited by heparin.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei216 – 2161ATPPROSITE-ProRule annotation
Active sitei312 – 3121Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi193 – 2019ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. G-protein coupled receptor kinase activity Source: UniProtKB-EC
  3. rhodopsin kinase activity Source: Ensembl

GO - Biological processi

  1. G-protein coupled receptor internalization Source: Ensembl
  2. receptor internalization Source: UniProtKB
  3. regulation of G-protein coupled receptor protein signaling pathway Source: ProtInc
  4. signal transduction Source: InterPro
  5. termination of G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.16. 2681.
SignaLinkiP32298.

Names & Taxonomyi

Protein namesi
Recommended name:
G protein-coupled receptor kinase 4 (EC:2.7.11.16)
Alternative name(s):
G protein-coupled receptor kinase GRK4
ITI1
Gene namesi
Name:GRK4
Synonyms:GPRK2L, GPRK4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:4543. GRK4.

Subcellular locationi

Cytoplasm. Cytoplasmcell cortex
Note: Both at the cell surface and dispersed in the cytoplasm under basal conditions. Receptor stimulation results in the internalization of GRK4 to the perinuclear area, where colocalization with DRD3 is observed strongly at 5 and 15 minutes. DRD3 and GRK4 colocalize in lipid rafts of renal proximal tubule cells.

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. dendrite Source: Ensembl
  3. neuronal cell body Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28941.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 578578G protein-coupled receptor kinase 4PRO_0000085967Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication

Post-translational modificationi

Palmitoylated.1 Publication

Keywords - PTMi

Acetylation, Lipoprotein, Palmitate

Proteomic databases

MaxQBiP32298.
PaxDbiP32298.
PRIDEiP32298.

PTM databases

PhosphoSiteiP32298.

Expressioni

Tissue specificityi

Isoform 1, isoform 2, isoform 3, and isoform 4 are expressed in testis. Isoform 4 is expressed in myometrium.2 Publications

Gene expression databases

BgeeiP32298.
ExpressionAtlasiP32298. baseline and differential.
GenevestigatoriP32298.

Organism-specific databases

HPAiCAB004421.
HPA028737.

Interactioni

Subunit structurei

Interacts with DRD3.1 Publication

Protein-protein interaction databases

BioGridi109126. 6 interactions.
IntActiP32298. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliP32298.
SMRiP32298. Positions 2-558.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini52 – 172121RGSPROSITE-ProRule annotationAdd
BLAST
Domaini187 – 449263Protein kinasePROSITE-ProRule annotationAdd
BLAST
Domaini450 – 51566AGC-kinase C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 154154N-terminalAdd
BLAST

Sequence similaritiesi

Contains 1 AGC-kinase C-terminal domain.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 RGS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000118793.
HOVERGENiHBG004532.
InParanoidiP32298.
KOiK08291.
OMAiHSIEKDY.
OrthoDBiEOG7V1FQK.
PhylomeDBiP32298.
TreeFamiTF313940.

Family and domain databases

InterProiIPR000961. AGC-kinase_C.
IPR000239. GPCR_kinase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR00717. GPCRKINASE.
SMARTiSM00315. RGS. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P32298-1) [UniParc]FASTAAdd to Basket

Also known as: GRK4-alpha, GRK4D

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELENIVANS LLLKARQGGY GKKSGRSKKW KEILTLPPVS QCSELRHSIE
60 70 80 90 100
KDYSSLCDKQ PIGRRLFRQF CDTKPTLKRH IEFLDAVAEY EVADDEDRSD
110 120 130 140 150
CGLSILDRFF NDKLAAPLPE IPPDVVTECR LGLKEENPSK KAFEECTRVA
160 170 180 190 200
HNYLRGEPFE EYQESSYFSQ FLQWKWLERQ PVTKNTFRHY RVLGKGGFGE
210 220 230 240 250
VCACQVRATG KMYACKKLQK KRIKKRKGEA MALNEKRILE KVQSRFVVSL
260 270 280 290 300
AYAYETKDAL CLVLTIMNGG DLKFHIYNLG NPGFDEQRAV FYAAELCCGL
310 320 330 340 350
EDLQRERIVY RDLKPENILL DDRGHIRISD LGLATEIPEG QRVRGRVGTV
360 370 380 390 400
GYMAPEVVNN EKYTFSPDWW GLGCLIYEMI QGHSPFKKYK EKVKWEEVDQ
410 420 430 440 450
RIKNDTEEYS EKFSEDAKSI CRMLLTKNPS KRLGCRGEGA AGVKQHPVFK
460 470 480 490 500
DINFRRLEAN MLEPPFCPDP HAVYCKDVLD IEQFSVVKGI YLDTADEDFY
510 520 530 540 550
ARFATGCVSI PWQNEMIESG CFKDINKSES EEALPLDLDK NIHTPVSRPN
560 570
RGFFYRLFRR GGCLTMVPSE KEVEPKQC
Length:578
Mass (Da):66,583
Last modified:April 3, 2007 - v3
Checksum:i72FCF94ED551F2D0
GO
Isoform 2 (identifier: P32298-2) [UniParc]FASTAAdd to Basket

Also known as: GRK4-beta, GRK4C

The sequence of this isoform differs from the canonical sequence as follows:
     18-49: Missing.

Show »
Length:546
Mass (Da):63,030
Checksum:iAD60D125A5839CA3
GO
Isoform 3 (identifier: P32298-3) [UniParc]FASTAAdd to Basket

Also known as: GRK4-delta, GRK4A

The sequence of this isoform differs from the canonical sequence as follows:
     18-49: Missing.
     516-561: Missing.

Show »
Length:500
Mass (Da):57,663
Checksum:i6AF0953E8D1F7A06
GO
Isoform 4 (identifier: P32298-4) [UniParc]FASTAAdd to Basket

Also known as: GRK4-gamma, GRK4B

The sequence of this isoform differs from the canonical sequence as follows:
     516-561: Missing.

Show »
Length:532
Mass (Da):61,216
Checksum:i1DD49402FCB381E5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti562 – 5621G → D in CAA66468. (PubMed:1338872)Curated
Sequence conflicti562 – 5621G → D in CAA66802. (PubMed:1338872)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti65 – 651R → L.1 Publication
Corresponds to variant rs2960306 [ dbSNP | Ensembl ].
VAR_024573
Natural varianti95 – 951D → H.
Corresponds to variant rs13305979 [ dbSNP | Ensembl ].
VAR_051621
Natural varianti116 – 1161A → T.1 Publication
Corresponds to variant rs34857805 [ dbSNP | Ensembl ].
VAR_046043
Natural varianti142 – 1421A → V.1 Publication
Corresponds to variant rs1024323 [ dbSNP | Ensembl ].
VAR_024574
Natural varianti183 – 1831T → R.
Corresponds to variant rs45538934 [ dbSNP | Ensembl ].
VAR_051622
Natural varianti247 – 2471V → I.1 Publication
Corresponds to variant rs35605687 [ dbSNP | Ensembl ].
VAR_007806
Natural varianti383 – 3831H → Q.1 Publication
Corresponds to variant rs55852353 [ dbSNP | Ensembl ].
VAR_046044
Natural varianti425 – 4251L → P.1 Publication
VAR_040516
Natural varianti440 – 4401A → V.
Corresponds to variant rs1801058 [ dbSNP | Ensembl ].
VAR_051623
Natural varianti473 – 4731V → I.1 Publication
Corresponds to variant rs35024854 [ dbSNP | Ensembl ].
VAR_046045
Natural varianti486 – 4861V → A.6 Publications
Corresponds to variant rs1801058 [ dbSNP | Ensembl ].
VAR_024575
Natural varianti495 – 4951A → T.1 Publication
Corresponds to variant rs35463176 [ dbSNP | Ensembl ].
VAR_046046

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei18 – 4932Missing in isoform 2 and isoform 3. 3 PublicationsVSP_004936Add
BLAST
Alternative sequencei516 – 56146Missing in isoform 3 and isoform 4. 2 PublicationsVSP_004937Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L03718 Genomic DNA. Translation: AAB04045.1.
X97879 mRNA. Translation: CAA66468.1.
X97880 mRNA. Translation: CAA66469.1.
X97881 mRNA. Translation: CAA66470.1.
U33054 mRNA. Translation: AAC50406.1.
U33055 mRNA. Translation: AAC50407.1.
U33056 mRNA. Translation: AAC50408.1.
U33168
, U33153, U33155, U33156, U33157, U33158, U33159, U33160, U33161, U33162, U33163, U33164, U33165, U33166, U33167 Genomic DNA. Translation: AAC50409.1.
U33168
, U33153, U33154, U33155, U33156, U33157, U33158, U33159, U33160, U33161, U33162, U33163, U33164, U33165, U33166, U33167 Genomic DNA. Translation: AAC50410.1.
U33168
, U33153, U33154, U33155, U33156, U33157, U33158, U33159, U33160, U33161, U33162, U33163, U33164, U33165, U33166 Genomic DNA. Translation: AAC50411.1.
U33168
, U33153, U33155, U33156, U33157, U33158, U33159, U33160, U33161, U33162, U33163, U33164, U33165, U33166 Genomic DNA. Translation: AAC50412.1.
AK223581 mRNA. Translation: BAD97301.1.
X98118 mRNA. Translation: CAA66802.1.
X75897 mRNA. Translation: CAA53506.1.
Z68192 Genomic DNA. Translation: CAA92341.1.
BC117320 mRNA. Translation: AAI17321.1.
CCDSiCCDS33946.1. [P32298-1]
CCDS33947.1. [P32298-4]
CCDS47002.1. [P32298-2]
CCDS68656.1. [P32298-3]
PIRiI54326.
JC2127.
RefSeqiNP_001004056.1. NM_001004056.1. [P32298-2]
NP_001004057.1. NM_001004057.1. [P32298-4]
NP_005298.2. NM_005307.2. [P32298-3]
NP_892027.2. NM_182982.2. [P32298-1]
UniGeneiHs.32959.

Genome annotation databases

EnsembliENST00000345167; ENSP00000264764; ENSG00000125388. [P32298-2]
ENST00000398051; ENSP00000381128; ENSG00000125388. [P32298-3]
ENST00000398052; ENSP00000381129; ENSG00000125388. [P32298-1]
ENST00000504933; ENSP00000427445; ENSG00000125388. [P32298-4]
GeneIDi2868.
KEGGihsa:2868.
UCSCiuc003ggn.1. human. [P32298-1]
uc003ggo.1. human. [P32298-4]
uc003ggp.1. human. [P32298-2]
uc003ggq.1. human. [P32298-3]

Polymorphism databases

DMDMi143811400.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L03718 Genomic DNA. Translation: AAB04045.1 .
X97879 mRNA. Translation: CAA66468.1 .
X97880 mRNA. Translation: CAA66469.1 .
X97881 mRNA. Translation: CAA66470.1 .
U33054 mRNA. Translation: AAC50406.1 .
U33055 mRNA. Translation: AAC50407.1 .
U33056 mRNA. Translation: AAC50408.1 .
U33168
, U33153 , U33155 , U33156 , U33157 , U33158 , U33159 , U33160 , U33161 , U33162 , U33163 , U33164 , U33165 , U33166 , U33167 Genomic DNA. Translation: AAC50409.1 .
U33168
, U33153 , U33154 , U33155 , U33156 , U33157 , U33158 , U33159 , U33160 , U33161 , U33162 , U33163 , U33164 , U33165 , U33166 , U33167 Genomic DNA. Translation: AAC50410.1 .
U33168
, U33153 , U33154 , U33155 , U33156 , U33157 , U33158 , U33159 , U33160 , U33161 , U33162 , U33163 , U33164 , U33165 , U33166 Genomic DNA. Translation: AAC50411.1 .
U33168
, U33153 , U33155 , U33156 , U33157 , U33158 , U33159 , U33160 , U33161 , U33162 , U33163 , U33164 , U33165 , U33166 Genomic DNA. Translation: AAC50412.1 .
AK223581 mRNA. Translation: BAD97301.1 .
X98118 mRNA. Translation: CAA66802.1 .
X75897 mRNA. Translation: CAA53506.1 .
Z68192 Genomic DNA. Translation: CAA92341.1 .
BC117320 mRNA. Translation: AAI17321.1 .
CCDSi CCDS33946.1. [P32298-1 ]
CCDS33947.1. [P32298-4 ]
CCDS47002.1. [P32298-2 ]
CCDS68656.1. [P32298-3 ]
PIRi I54326.
JC2127.
RefSeqi NP_001004056.1. NM_001004056.1. [P32298-2 ]
NP_001004057.1. NM_001004057.1. [P32298-4 ]
NP_005298.2. NM_005307.2. [P32298-3 ]
NP_892027.2. NM_182982.2. [P32298-1 ]
UniGenei Hs.32959.

3D structure databases

ProteinModelPortali P32298.
SMRi P32298. Positions 2-558.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109126. 6 interactions.
IntActi P32298. 2 interactions.

Chemistry

BindingDBi P32298.
ChEMBLi CHEMBL5861.
GuidetoPHARMACOLOGYi 1468.

PTM databases

PhosphoSitei P32298.

Polymorphism databases

DMDMi 143811400.

Proteomic databases

MaxQBi P32298.
PaxDbi P32298.
PRIDEi P32298.

Protocols and materials databases

DNASUi 2868.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000345167 ; ENSP00000264764 ; ENSG00000125388 . [P32298-2 ]
ENST00000398051 ; ENSP00000381128 ; ENSG00000125388 . [P32298-3 ]
ENST00000398052 ; ENSP00000381129 ; ENSG00000125388 . [P32298-1 ]
ENST00000504933 ; ENSP00000427445 ; ENSG00000125388 . [P32298-4 ]
GeneIDi 2868.
KEGGi hsa:2868.
UCSCi uc003ggn.1. human. [P32298-1 ]
uc003ggo.1. human. [P32298-4 ]
uc003ggp.1. human. [P32298-2 ]
uc003ggq.1. human. [P32298-3 ]

Organism-specific databases

CTDi 2868.
GeneCardsi GC04P002967.
HGNCi HGNC:4543. GRK4.
HPAi CAB004421.
HPA028737.
MIMi 137026. gene.
neXtProti NX_P32298.
PharmGKBi PA28941.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00760000118793.
HOVERGENi HBG004532.
InParanoidi P32298.
KOi K08291.
OMAi HSIEKDY.
OrthoDBi EOG7V1FQK.
PhylomeDBi P32298.
TreeFami TF313940.

Enzyme and pathway databases

BRENDAi 2.7.11.16. 2681.
SignaLinki P32298.

Miscellaneous databases

GeneWikii GRK4.
GenomeRNAii 2868.
NextBioi 11309.
PROi P32298.
SOURCEi Search...

Gene expression databases

Bgeei P32298.
ExpressionAtlasi P32298. baseline and differential.
Genevestigatori P32298.

Family and domain databases

InterProi IPR000961. AGC-kinase_C.
IPR000239. GPCR_kinase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view ]
PRINTSi PR00717. GPCRKINASE.
SMARTi SM00315. RGS. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF48097. SSF48097. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 3), VARIANT ALA-486.
  2. "G protein-coupled receptor kinase GRK4. Molecular analysis of the four isoforms and ultrastructural localization in spermatozoa and germinal cells."
    Sallese M., Mariggio S., Collodel G., Moretti E., Piomboni P., Baccetti B., de Blasi A.
    J. Biol. Chem. 272:10188-10195(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), VARIANT ALA-486.
    Tissue: Testis.
  3. "Characterization of the G protein-coupled receptor kinase GRK4. Identification of four splice variants."
    Premont R.T., Macrae A.D., Stoffel R.H., Chung N., Pitcher J.A., Ambrose C., Inglese J., MacDonald M.E., Lefkowitz R.J.
    J. Biol. Chem. 271:6403-6410(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], ALTERNATIVE SPLICING, FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, PALMITOYLATION, VARIANT ALA-486.
    Tissue: Testis.
  4. "Two isoforms of G protein-coupled receptor kinase 4 identified by molecular cloning."
    Sallese M., Lombardi M.S., de Blasi A.
    Biochem. Biophys. Res. Commun. 199:848-854(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANT ALA-486.
    Tissue: Brain.
  5. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Kidney.
  6. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-486.
  8. "Amelioration of genetic hypertension by suppression of renal G protein-coupled receptor kinase type 4 expression."
    Sanada H., Yatabe J., Midorikawa S., Katoh T., Hashimoto S., Watanabe T., Xu J., Luo Y., Wang X., Zeng C., Armando I., Felder R.A., Jose P.A.
    Hypertension 47:1131-1139(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  9. "G protein-coupled receptor kinase 4 (GRK4) regulates the phosphorylation and function of the dopamine D3 receptor."
    Villar V.A.M., Jones J.E., Armando I., Palmes-Saloma C., Yu P., Pascua A.M., Keever L., Arnaldo F.B., Wang Z., Luo Y., Felder R.A., Jose P.A.
    J. Biol. Chem. 284:21425-21434(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, ENZYME REGULATION, SUBCELLULAR LOCATION, INTERACTION WITH DRD3.
  10. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] LEU-65; THR-116; VAL-142; ILE-247; GLN-383; PRO-425; ILE-473; ALA-486 AND THR-495.

Entry informationi

Entry nameiGRK4_HUMAN
AccessioniPrimary (citable) accession number: P32298
Secondary accession number(s): O00641
, O00642, Q13293, Q13294, Q13295, Q14453, Q14725, Q15313, Q15314, Q15315, Q15316, Q17RH6, Q53EQ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: April 3, 2007
Last modified: October 29, 2014
This is version 148 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3