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P32298

- GRK4_HUMAN

UniProt

P32298 - GRK4_HUMAN

Protein

G protein-coupled receptor kinase 4

Gene

GRK4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 147 (01 Oct 2014)
      Sequence version 3 (03 Apr 2007)
      Previous versions | rss
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    Functioni

    Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2.2 Publications

    Catalytic activityi

    ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate.

    Enzyme regulationi

    Inhibited by heparin.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei216 – 2161ATPPROSITE-ProRule annotation
    Active sitei312 – 3121Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi193 – 2019ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. G-protein coupled receptor kinase activity Source: UniProtKB-EC
    3. rhodopsin kinase activity Source: Ensembl

    GO - Biological processi

    1. G-protein coupled receptor internalization Source: Ensembl
    2. receptor internalization Source: UniProtKB
    3. regulation of G-protein coupled receptor protein signaling pathway Source: ProtInc
    4. signal transduction Source: InterPro
    5. termination of G-protein coupled receptor signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.11.16. 2681.
    SignaLinkiP32298.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    G protein-coupled receptor kinase 4 (EC:2.7.11.16)
    Alternative name(s):
    G protein-coupled receptor kinase GRK4
    ITI1
    Gene namesi
    Name:GRK4
    Synonyms:GPRK2L, GPRK4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:4543. GRK4.

    Subcellular locationi

    Cytoplasm. Cytoplasmcell cortex
    Note: Both at the cell surface and dispersed in the cytoplasm under basal conditions. Receptor stimulation results in the internalization of GRK4 to the perinuclear area, where colocalization with DRD3 is observed strongly at 5 and 15 minutes. DRD3 and GRK4 colocalize in lipid rafts of renal proximal tubule cells.

    GO - Cellular componenti

    1. cell cortex Source: UniProtKB-SubCell
    2. cytosol Source: Ensembl
    3. dendrite Source: Ensembl
    4. neuronal cell body Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28941.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 578578G protein-coupled receptor kinase 4PRO_0000085967Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication

    Post-translational modificationi

    Palmitoylated.1 Publication

    Keywords - PTMi

    Acetylation, Lipoprotein, Palmitate

    Proteomic databases

    MaxQBiP32298.
    PaxDbiP32298.
    PRIDEiP32298.

    PTM databases

    PhosphoSiteiP32298.

    Expressioni

    Tissue specificityi

    Isoform 1, isoform 2, isoform 3, and isoform 4 are expressed in testis. Isoform 4 is expressed in myometrium.2 Publications

    Gene expression databases

    ArrayExpressiP32298.
    BgeeiP32298.
    GenevestigatoriP32298.

    Organism-specific databases

    HPAiCAB004421.
    HPA028737.

    Interactioni

    Subunit structurei

    Interacts with DRD3.1 Publication

    Protein-protein interaction databases

    BioGridi109126. 6 interactions.
    IntActiP32298. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP32298.
    SMRiP32298. Positions 2-558.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini52 – 172121RGSPROSITE-ProRule annotationAdd
    BLAST
    Domaini187 – 449263Protein kinasePROSITE-ProRule annotationAdd
    BLAST
    Domaini450 – 51566AGC-kinase C-terminalAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 154154N-terminalAdd
    BLAST

    Sequence similaritiesi

    Contains 1 AGC-kinase C-terminal domain.Curated
    Contains 1 protein kinase domain.PROSITE-ProRule annotation
    Contains 1 RGS domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOVERGENiHBG004532.
    KOiK08291.
    OMAiHSIEKDY.
    OrthoDBiEOG7V1FQK.
    PhylomeDBiP32298.
    TreeFamiTF313940.

    Family and domain databases

    InterProiIPR000961. AGC-kinase_C.
    IPR000239. GPCR_kinase.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    PF00615. RGS. 1 hit.
    [Graphical view]
    PRINTSiPR00717. GPCRKINASE.
    SMARTiSM00315. RGS. 1 hit.
    SM00133. S_TK_X. 1 hit.
    SM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF48097. SSF48097. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    PS50132. RGS. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P32298-1) [UniParc]FASTAAdd to Basket

    Also known as: GRK4-alpha, GRK4D

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MELENIVANS LLLKARQGGY GKKSGRSKKW KEILTLPPVS QCSELRHSIE    50
    KDYSSLCDKQ PIGRRLFRQF CDTKPTLKRH IEFLDAVAEY EVADDEDRSD 100
    CGLSILDRFF NDKLAAPLPE IPPDVVTECR LGLKEENPSK KAFEECTRVA 150
    HNYLRGEPFE EYQESSYFSQ FLQWKWLERQ PVTKNTFRHY RVLGKGGFGE 200
    VCACQVRATG KMYACKKLQK KRIKKRKGEA MALNEKRILE KVQSRFVVSL 250
    AYAYETKDAL CLVLTIMNGG DLKFHIYNLG NPGFDEQRAV FYAAELCCGL 300
    EDLQRERIVY RDLKPENILL DDRGHIRISD LGLATEIPEG QRVRGRVGTV 350
    GYMAPEVVNN EKYTFSPDWW GLGCLIYEMI QGHSPFKKYK EKVKWEEVDQ 400
    RIKNDTEEYS EKFSEDAKSI CRMLLTKNPS KRLGCRGEGA AGVKQHPVFK 450
    DINFRRLEAN MLEPPFCPDP HAVYCKDVLD IEQFSVVKGI YLDTADEDFY 500
    ARFATGCVSI PWQNEMIESG CFKDINKSES EEALPLDLDK NIHTPVSRPN 550
    RGFFYRLFRR GGCLTMVPSE KEVEPKQC 578
    Length:578
    Mass (Da):66,583
    Last modified:April 3, 2007 - v3
    Checksum:i72FCF94ED551F2D0
    GO
    Isoform 2 (identifier: P32298-2) [UniParc]FASTAAdd to Basket

    Also known as: GRK4-beta, GRK4C

    The sequence of this isoform differs from the canonical sequence as follows:
         18-49: Missing.

    Show »
    Length:546
    Mass (Da):63,030
    Checksum:iAD60D125A5839CA3
    GO
    Isoform 3 (identifier: P32298-3) [UniParc]FASTAAdd to Basket

    Also known as: GRK4-delta, GRK4A

    The sequence of this isoform differs from the canonical sequence as follows:
         18-49: Missing.
         516-561: Missing.

    Show »
    Length:500
    Mass (Da):57,663
    Checksum:i6AF0953E8D1F7A06
    GO
    Isoform 4 (identifier: P32298-4) [UniParc]FASTAAdd to Basket

    Also known as: GRK4-gamma, GRK4B

    The sequence of this isoform differs from the canonical sequence as follows:
         516-561: Missing.

    Show »
    Length:532
    Mass (Da):61,216
    Checksum:i1DD49402FCB381E5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti562 – 5621G → D in CAA66468. (PubMed:1338872)Curated
    Sequence conflicti562 – 5621G → D in CAA66802. (PubMed:1338872)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti65 – 651R → L.1 Publication
    Corresponds to variant rs2960306 [ dbSNP | Ensembl ].
    VAR_024573
    Natural varianti95 – 951D → H.
    Corresponds to variant rs13305979 [ dbSNP | Ensembl ].
    VAR_051621
    Natural varianti116 – 1161A → T.1 Publication
    Corresponds to variant rs34857805 [ dbSNP | Ensembl ].
    VAR_046043
    Natural varianti142 – 1421A → V.1 Publication
    Corresponds to variant rs1024323 [ dbSNP | Ensembl ].
    VAR_024574
    Natural varianti183 – 1831T → R.
    Corresponds to variant rs45538934 [ dbSNP | Ensembl ].
    VAR_051622
    Natural varianti247 – 2471V → I.1 Publication
    Corresponds to variant rs35605687 [ dbSNP | Ensembl ].
    VAR_007806
    Natural varianti383 – 3831H → Q.1 Publication
    Corresponds to variant rs55852353 [ dbSNP | Ensembl ].
    VAR_046044
    Natural varianti425 – 4251L → P.1 Publication
    VAR_040516
    Natural varianti440 – 4401A → V.
    Corresponds to variant rs1801058 [ dbSNP | Ensembl ].
    VAR_051623
    Natural varianti473 – 4731V → I.1 Publication
    Corresponds to variant rs35024854 [ dbSNP | Ensembl ].
    VAR_046045
    Natural varianti486 – 4861V → A.6 Publications
    Corresponds to variant rs1801058 [ dbSNP | Ensembl ].
    VAR_024575
    Natural varianti495 – 4951A → T.1 Publication
    Corresponds to variant rs35463176 [ dbSNP | Ensembl ].
    VAR_046046

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei18 – 4932Missing in isoform 2 and isoform 3. 3 PublicationsVSP_004936Add
    BLAST
    Alternative sequencei516 – 56146Missing in isoform 3 and isoform 4. 2 PublicationsVSP_004937Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L03718 Genomic DNA. Translation: AAB04045.1.
    X97879 mRNA. Translation: CAA66468.1.
    X97880 mRNA. Translation: CAA66469.1.
    X97881 mRNA. Translation: CAA66470.1.
    U33054 mRNA. Translation: AAC50406.1.
    U33055 mRNA. Translation: AAC50407.1.
    U33056 mRNA. Translation: AAC50408.1.
    U33168
    , U33153, U33155, U33156, U33157, U33158, U33159, U33160, U33161, U33162, U33163, U33164, U33165, U33166, U33167 Genomic DNA. Translation: AAC50409.1.
    U33168
    , U33153, U33154, U33155, U33156, U33157, U33158, U33159, U33160, U33161, U33162, U33163, U33164, U33165, U33166, U33167 Genomic DNA. Translation: AAC50410.1.
    U33168
    , U33153, U33154, U33155, U33156, U33157, U33158, U33159, U33160, U33161, U33162, U33163, U33164, U33165, U33166 Genomic DNA. Translation: AAC50411.1.
    U33168
    , U33153, U33155, U33156, U33157, U33158, U33159, U33160, U33161, U33162, U33163, U33164, U33165, U33166 Genomic DNA. Translation: AAC50412.1.
    AK223581 mRNA. Translation: BAD97301.1.
    X98118 mRNA. Translation: CAA66802.1.
    X75897 mRNA. Translation: CAA53506.1.
    Z68192 Genomic DNA. Translation: CAA92341.1.
    BC117320 mRNA. Translation: AAI17321.1.
    CCDSiCCDS33946.1. [P32298-1]
    CCDS33947.1. [P32298-4]
    CCDS47002.1. [P32298-2]
    CCDS68656.1. [P32298-3]
    PIRiI54326.
    JC2127.
    RefSeqiNP_001004056.1. NM_001004056.1. [P32298-2]
    NP_001004057.1. NM_001004057.1. [P32298-4]
    NP_005298.2. NM_005307.2. [P32298-3]
    NP_892027.2. NM_182982.2. [P32298-1]
    UniGeneiHs.32959.

    Genome annotation databases

    EnsembliENST00000345167; ENSP00000264764; ENSG00000125388. [P32298-2]
    ENST00000398051; ENSP00000381128; ENSG00000125388. [P32298-3]
    ENST00000398052; ENSP00000381129; ENSG00000125388. [P32298-1]
    ENST00000504933; ENSP00000427445; ENSG00000125388. [P32298-4]
    GeneIDi2868.
    KEGGihsa:2868.
    UCSCiuc003ggn.1. human. [P32298-1]
    uc003ggo.1. human. [P32298-4]
    uc003ggp.1. human. [P32298-2]
    uc003ggq.1. human. [P32298-3]

    Polymorphism databases

    DMDMi143811400.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L03718 Genomic DNA. Translation: AAB04045.1 .
    X97879 mRNA. Translation: CAA66468.1 .
    X97880 mRNA. Translation: CAA66469.1 .
    X97881 mRNA. Translation: CAA66470.1 .
    U33054 mRNA. Translation: AAC50406.1 .
    U33055 mRNA. Translation: AAC50407.1 .
    U33056 mRNA. Translation: AAC50408.1 .
    U33168
    , U33153 , U33155 , U33156 , U33157 , U33158 , U33159 , U33160 , U33161 , U33162 , U33163 , U33164 , U33165 , U33166 , U33167 Genomic DNA. Translation: AAC50409.1 .
    U33168
    , U33153 , U33154 , U33155 , U33156 , U33157 , U33158 , U33159 , U33160 , U33161 , U33162 , U33163 , U33164 , U33165 , U33166 , U33167 Genomic DNA. Translation: AAC50410.1 .
    U33168
    , U33153 , U33154 , U33155 , U33156 , U33157 , U33158 , U33159 , U33160 , U33161 , U33162 , U33163 , U33164 , U33165 , U33166 Genomic DNA. Translation: AAC50411.1 .
    U33168
    , U33153 , U33155 , U33156 , U33157 , U33158 , U33159 , U33160 , U33161 , U33162 , U33163 , U33164 , U33165 , U33166 Genomic DNA. Translation: AAC50412.1 .
    AK223581 mRNA. Translation: BAD97301.1 .
    X98118 mRNA. Translation: CAA66802.1 .
    X75897 mRNA. Translation: CAA53506.1 .
    Z68192 Genomic DNA. Translation: CAA92341.1 .
    BC117320 mRNA. Translation: AAI17321.1 .
    CCDSi CCDS33946.1. [P32298-1 ]
    CCDS33947.1. [P32298-4 ]
    CCDS47002.1. [P32298-2 ]
    CCDS68656.1. [P32298-3 ]
    PIRi I54326.
    JC2127.
    RefSeqi NP_001004056.1. NM_001004056.1. [P32298-2 ]
    NP_001004057.1. NM_001004057.1. [P32298-4 ]
    NP_005298.2. NM_005307.2. [P32298-3 ]
    NP_892027.2. NM_182982.2. [P32298-1 ]
    UniGenei Hs.32959.

    3D structure databases

    ProteinModelPortali P32298.
    SMRi P32298. Positions 2-558.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109126. 6 interactions.
    IntActi P32298. 2 interactions.

    Chemistry

    BindingDBi P32298.
    ChEMBLi CHEMBL5861.
    GuidetoPHARMACOLOGYi 1468.

    PTM databases

    PhosphoSitei P32298.

    Polymorphism databases

    DMDMi 143811400.

    Proteomic databases

    MaxQBi P32298.
    PaxDbi P32298.
    PRIDEi P32298.

    Protocols and materials databases

    DNASUi 2868.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000345167 ; ENSP00000264764 ; ENSG00000125388 . [P32298-2 ]
    ENST00000398051 ; ENSP00000381128 ; ENSG00000125388 . [P32298-3 ]
    ENST00000398052 ; ENSP00000381129 ; ENSG00000125388 . [P32298-1 ]
    ENST00000504933 ; ENSP00000427445 ; ENSG00000125388 . [P32298-4 ]
    GeneIDi 2868.
    KEGGi hsa:2868.
    UCSCi uc003ggn.1. human. [P32298-1 ]
    uc003ggo.1. human. [P32298-4 ]
    uc003ggp.1. human. [P32298-2 ]
    uc003ggq.1. human. [P32298-3 ]

    Organism-specific databases

    CTDi 2868.
    GeneCardsi GC04P002967.
    HGNCi HGNC:4543. GRK4.
    HPAi CAB004421.
    HPA028737.
    MIMi 137026. gene.
    neXtProti NX_P32298.
    PharmGKBi PA28941.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOVERGENi HBG004532.
    KOi K08291.
    OMAi HSIEKDY.
    OrthoDBi EOG7V1FQK.
    PhylomeDBi P32298.
    TreeFami TF313940.

    Enzyme and pathway databases

    BRENDAi 2.7.11.16. 2681.
    SignaLinki P32298.

    Miscellaneous databases

    GeneWikii GRK4.
    GenomeRNAii 2868.
    NextBioi 11309.
    PROi P32298.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P32298.
    Bgeei P32298.
    Genevestigatori P32298.

    Family and domain databases

    InterProi IPR000961. AGC-kinase_C.
    IPR000239. GPCR_kinase.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    PF00615. RGS. 1 hit.
    [Graphical view ]
    PRINTSi PR00717. GPCRKINASE.
    SMARTi SM00315. RGS. 1 hit.
    SM00133. S_TK_X. 1 hit.
    SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48097. SSF48097. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS51285. AGC_KINASE_CTER. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    PS50132. RGS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 3), VARIANT ALA-486.
    2. "G protein-coupled receptor kinase GRK4. Molecular analysis of the four isoforms and ultrastructural localization in spermatozoa and germinal cells."
      Sallese M., Mariggio S., Collodel G., Moretti E., Piomboni P., Baccetti B., de Blasi A.
      J. Biol. Chem. 272:10188-10195(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), VARIANT ALA-486.
      Tissue: Testis.
    3. "Characterization of the G protein-coupled receptor kinase GRK4. Identification of four splice variants."
      Premont R.T., Macrae A.D., Stoffel R.H., Chung N., Pitcher J.A., Ambrose C., Inglese J., MacDonald M.E., Lefkowitz R.J.
      J. Biol. Chem. 271:6403-6410(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], ALTERNATIVE SPLICING, FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, PALMITOYLATION, VARIANT ALA-486.
      Tissue: Testis.
    4. "Two isoforms of G protein-coupled receptor kinase 4 identified by molecular cloning."
      Sallese M., Lombardi M.S., de Blasi A.
      Biochem. Biophys. Res. Commun. 199:848-854(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANT ALA-486.
      Tissue: Brain.
    5. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Kidney.
    6. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-486.
    8. "Amelioration of genetic hypertension by suppression of renal G protein-coupled receptor kinase type 4 expression."
      Sanada H., Yatabe J., Midorikawa S., Katoh T., Hashimoto S., Watanabe T., Xu J., Luo Y., Wang X., Zeng C., Armando I., Felder R.A., Jose P.A.
      Hypertension 47:1131-1139(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    9. "G protein-coupled receptor kinase 4 (GRK4) regulates the phosphorylation and function of the dopamine D3 receptor."
      Villar V.A.M., Jones J.E., Armando I., Palmes-Saloma C., Yu P., Pascua A.M., Keever L., Arnaldo F.B., Wang Z., Luo Y., Felder R.A., Jose P.A.
      J. Biol. Chem. 284:21425-21434(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, ENZYME REGULATION, SUBCELLULAR LOCATION, INTERACTION WITH DRD3.
    10. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] LEU-65; THR-116; VAL-142; ILE-247; GLN-383; PRO-425; ILE-473; ALA-486 AND THR-495.

    Entry informationi

    Entry nameiGRK4_HUMAN
    AccessioniPrimary (citable) accession number: P32298
    Secondary accession number(s): O00641
    , O00642, Q13293, Q13294, Q13295, Q14453, Q14725, Q15313, Q15314, Q15315, Q15316, Q17RH6, Q53EQ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 147 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3