P32298 (GRK4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
G protein-coupled receptor kinase 4
EC=2.7.11.16

Alternative name(s):
G protein-coupled receptor kinase GRK4
ITI1

Gene names

Name:	GRK4
Synonyms:	GPRK2L, GPRK4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	578 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2. Ref.3 Ref.9
Catalytic activity	ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate.
Enzyme regulation	Inhibited by heparin. Ref.9
Subunit structure	Interacts with DRD3. Ref.9
Subcellular location	Cytoplasm. Cytoplasm › cell cortex. Note: Both at the cell surface and dispersed in the cytoplasm under basal conditions. Receptor stimulation results in the internalization of GRK4 to the perinuclear area, where co-localization with DRD3 is observed strongly at 5 and 15 minutes. DRD3 and GRK4 co-localize in lipid rafts of renal proximal tubule cells. Ref.3 Ref.9
Tissue specificity	Isoform 1, isoform 2, isoform 3, and isoform 4 are expressed in testis. Isoform 4 is expressed in myometrium. Ref.3 Ref.8
Post-translational modification	Palmitoylated. Ref.3
Sequence similarities	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. Contains 1 AGC-kinase C-terminal domain. Contains 1 protein kinase domain. Contains 1 RGS domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Lipoprotein Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G-protein coupled receptor internalization Inferred from electronic annotation. Source: Compara receptor internalization Inferred from direct assay PubMed 20074556. Source: UniProtKB regulation of G-protein coupled receptor protein signaling pathway Traceable author statement Ref.1. Source: ProtInc signal transduction Inferred from electronic annotation. Source: InterPro termination of G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular_component	cell cortex Inferred from electronic annotation. Source: UniProtKB-SubCell cytosol Inferred from electronic annotation. Source: Compara dendrite Inferred from electronic annotation. Source: Compara neuronal cell body Inferred from electronic annotation. Source: Compara
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW G-protein coupled receptor kinase activity Inferred from electronic annotation. Source: EC rhodopsin kinase activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P32298-1)

Also known as: GRK4-alpha; GRK4D;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P32298-2)

Also known as: GRK4-beta; GRK4C;

The sequence of this isoform differs from the canonical sequence as follows:
     18-49: Missing.

Isoform 3 (identifier: P32298-3)

Also known as: GRK4-delta; GRK4A;

The sequence of this isoform differs from the canonical sequence as follows:
     18-49: Missing.
     516-561: Missing.

Isoform 4 (identifier: P32298-4)

Also known as: GRK4-gamma; GRK4B;

The sequence of this isoform differs from the canonical sequence as follows:
     516-561: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 578	578	G protein-coupled receptor kinase 4		PRO_0000085967
Regions
	Domain	52 – 172	121	RGS
	Domain	187 – 449	263	Protein kinase
	Domain	450 – 515	66	AGC-kinase C-terminal
	Nucleotide binding	193 – 201	9	ATP By similarity
	Region	1 – 154	154	N-terminal
Sites
	Active site	312	1	Proton acceptor By similarity
	Binding site	216	1	ATP By similarity
Natural variations
	Alternative sequence	18 – 49	32	Missing in isoform 2 and isoform 3.		VSP_004936
	Alternative sequence	516 – 561	46	Missing in isoform 3 and isoform 4.		VSP_004937
	Natural variant	65	1	R → L. Ref.10 Corresponds to variant rs2960306 [ dbSNP | Ensembl ].		VAR_024573
	Natural variant	95	1	D → H. Corresponds to variant rs13305979 [ dbSNP | Ensembl ].		VAR_051621
	Natural variant	116	1	A → T. Ref.10 Corresponds to variant rs34857805 [ dbSNP | Ensembl ].		VAR_046043
	Natural variant	142	1	A → V. Ref.10 Corresponds to variant rs1024323 [ dbSNP | Ensembl ].		VAR_024574
	Natural variant	183	1	T → R. Corresponds to variant rs45538934 [ dbSNP | Ensembl ].		VAR_051622
	Natural variant	247	1	V → I. Ref.10 Corresponds to variant rs35605687 [ dbSNP | Ensembl ].		VAR_007806
	Natural variant	383	1	H → Q. Ref.10 Corresponds to variant rs55852353 [ dbSNP | Ensembl ].		VAR_046044
	Natural variant	425	1	L → P. Ref.10		VAR_040516
	Natural variant	440	1	A → V. Corresponds to variant rs1801058 [ dbSNP | Ensembl ].		VAR_051623
	Natural variant	473	1	V → I. Ref.10 Corresponds to variant rs35024854 [ dbSNP | Ensembl ].		VAR_046045
	Natural variant	486	1	V → A. Ref.1 Ref.2 Ref.3 Ref.4 Ref.7 Ref.10 Corresponds to variant rs1801058 [ dbSNP | Ensembl ].		VAR_024575
	Natural variant	495	1	A → T. Ref.10 Corresponds to variant rs35463176 [ dbSNP | Ensembl ].		VAR_046046
Experimental info
	Sequence conflict	562	1	G → D in CAA66468. Ref.1
	Sequence conflict	562	1	G → D in CAA66802. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (GRK4-alpha) (GRK4D) [UniParc]. Last modified April 3, 2007. Version 3. Checksum: 72FCF94ED551F2D0	FASTA	578	66,583
	10 20 30 40 50 60 MELENIVANS LLLKARQGGY GKKSGRSKKW KEILTLPPVS QCSELRHSIE KDYSSLCDKQ 70 80 90 100 110 120 PIGRRLFRQF CDTKPTLKRH IEFLDAVAEY EVADDEDRSD CGLSILDRFF NDKLAAPLPE 130 140 150 160 170 180 IPPDVVTECR LGLKEENPSK KAFEECTRVA HNYLRGEPFE EYQESSYFSQ FLQWKWLERQ 190 200 210 220 230 240 PVTKNTFRHY RVLGKGGFGE VCACQVRATG KMYACKKLQK KRIKKRKGEA MALNEKRILE 250 260 270 280 290 300 KVQSRFVVSL AYAYETKDAL CLVLTIMNGG DLKFHIYNLG NPGFDEQRAV FYAAELCCGL 310 320 330 340 350 360 EDLQRERIVY RDLKPENILL DDRGHIRISD LGLATEIPEG QRVRGRVGTV GYMAPEVVNN 370 380 390 400 410 420 EKYTFSPDWW GLGCLIYEMI QGHSPFKKYK EKVKWEEVDQ RIKNDTEEYS EKFSEDAKSI 430 440 450 460 470 480 CRMLLTKNPS KRLGCRGEGA AGVKQHPVFK DINFRRLEAN MLEPPFCPDP HAVYCKDVLD 490 500 510 520 530 540 IEQFSVVKGI YLDTADEDFY ARFATGCVSI PWQNEMIESG CFKDINKSES EEALPLDLDK 550 560 570 NIHTPVSRPN RGFFYRLFRR GGCLTMVPSE KEVEPKQC
	Isoform 2 (GRK4-beta) (GRK4C) [UniParc]. Checksum: AD60D125A5839CA3	FASTA	546	63,030
	10 20 30 40 50 60 MELENIVANS LLLKARQEKD YSSLCDKQPI GRRLFRQFCD TKPTLKRHIE FLDAVAEYEV 70 80 90 100 110 120 ADDEDRSDCG LSILDRFFND KLAAPLPEIP PDVVTECRLG LKEENPSKKA FEECTRVAHN 130 140 150 160 170 180 YLRGEPFEEY QESSYFSQFL QWKWLERQPV TKNTFRHYRV LGKGGFGEVC ACQVRATGKM 190 200 210 220 230 240 YACKKLQKKR IKKRKGEAMA LNEKRILEKV QSRFVVSLAY AYETKDALCL VLTIMNGGDL 250 260 270 280 290 300 KFHIYNLGNP GFDEQRAVFY AAELCCGLED LQRERIVYRD LKPENILLDD RGHIRISDLG 310 320 330 340 350 360 LATEIPEGQR VRGRVGTVGY MAPEVVNNEK YTFSPDWWGL GCLIYEMIQG HSPFKKYKEK 370 380 390 400 410 420 VKWEEVDQRI KNDTEEYSEK FSEDAKSICR MLLTKNPSKR LGCRGEGAAG VKQHPVFKDI 430 440 450 460 470 480 NFRRLEANML EPPFCPDPHA VYCKDVLDIE QFSVVKGIYL DTADEDFYAR FATGCVSIPW 490 500 510 520 530 540 QNEMIESGCF KDINKSESEE ALPLDLDKNI HTPVSRPNRG FFYRLFRRGG CLTMVPSEKE VEPKQC
	Isoform 3 (GRK4-delta) (GRK4A) [UniParc]. Checksum: 6AF0953E8D1F7A06	FASTA	500	57,663
	10 20 30 40 50 60 MELENIVANS LLLKARQEKD YSSLCDKQPI GRRLFRQFCD TKPTLKRHIE FLDAVAEYEV 70 80 90 100 110 120 ADDEDRSDCG LSILDRFFND KLAAPLPEIP PDVVTECRLG LKEENPSKKA FEECTRVAHN 130 140 150 160 170 180 YLRGEPFEEY QESSYFSQFL QWKWLERQPV TKNTFRHYRV LGKGGFGEVC ACQVRATGKM 190 200 210 220 230 240 YACKKLQKKR IKKRKGEAMA LNEKRILEKV QSRFVVSLAY AYETKDALCL VLTIMNGGDL 250 260 270 280 290 300 KFHIYNLGNP GFDEQRAVFY AAELCCGLED LQRERIVYRD LKPENILLDD RGHIRISDLG 310 320 330 340 350 360 LATEIPEGQR VRGRVGTVGY MAPEVVNNEK YTFSPDWWGL GCLIYEMIQG HSPFKKYKEK 370 380 390 400 410 420 VKWEEVDQRI KNDTEEYSEK FSEDAKSICR MLLTKNPSKR LGCRGEGAAG VKQHPVFKDI 430 440 450 460 470 480 NFRRLEANML EPPFCPDPHA VYCKDVLDIE QFSVVKGIYL DTADEDFYAR FATGCVSIPW 490 500 QNEGCLTMVP SEKEVEPKQC
	Isoform 4 (GRK4-gamma) (GRK4B) [UniParc]. Checksum: 1DD49402FCB381E5	FASTA	532	61,216
	10 20 30 40 50 60 MELENIVANS LLLKARQGGY GKKSGRSKKW KEILTLPPVS QCSELRHSIE KDYSSLCDKQ 70 80 90 100 110 120 PIGRRLFRQF CDTKPTLKRH IEFLDAVAEY EVADDEDRSD CGLSILDRFF NDKLAAPLPE 130 140 150 160 170 180 IPPDVVTECR LGLKEENPSK KAFEECTRVA HNYLRGEPFE EYQESSYFSQ FLQWKWLERQ 190 200 210 220 230 240 PVTKNTFRHY RVLGKGGFGE VCACQVRATG KMYACKKLQK KRIKKRKGEA MALNEKRILE 250 260 270 280 290 300 KVQSRFVVSL AYAYETKDAL CLVLTIMNGG DLKFHIYNLG NPGFDEQRAV FYAAELCCGL 310 320 330 340 350 360 EDLQRERIVY RDLKPENILL DDRGHIRISD LGLATEIPEG QRVRGRVGTV GYMAPEVVNN 370 380 390 400 410 420 EKYTFSPDWW GLGCLIYEMI QGHSPFKKYK EKVKWEEVDQ RIKNDTEEYS EKFSEDAKSI 430 440 450 460 470 480 CRMLLTKNPS KRLGCRGEGA AGVKQHPVFK DINFRRLEAN MLEPPFCPDP HAVYCKDVLD 490 500 510 520 530 IEQFSVVKGI YLDTADEDFY ARFATGCVSI PWQNEGCLTM VPSEKEVEPK QC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel G protein-coupled receptor kinase gene cloned from 4p16.3." Ambrose C., James M., Barnes G., Lin C., Bates G., Altherr M., Duyao M., Groot N., Church D., Wasmuth J.J., Lehrach H., Housman D., Buckler A.J., Gusella J.F., McDonald M.E. Hum. Mol. Genet. 1:697-703(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 3), VARIANT ALA-486.
[2]	"G protein-coupled receptor kinase GRK4. Molecular analysis of the four isoforms and ultrastructural localization in spermatozoa and germinal cells." Sallese M., Mariggio S., Collodel G., Moretti E., Piomboni P., Baccetti B., de Blasi A. J. Biol. Chem. 272:10188-10195(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), VARIANT ALA-486. Tissue: Testis.
[3]	"Characterization of the G protein-coupled receptor kinase GRK4. Identification of four splice variants." Premont R.T., Macrae A.D., Stoffel R.H., Chung N., Pitcher J.A., Ambrose C., Inglese J., MacDonald M.E., Lefkowitz R.J. J. Biol. Chem. 271:6403-6410(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], ALTERNATIVE SPLICING, FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, PALMITOYLATION, VARIANT ALA-486. Tissue: Testis.
[4]	"Two isoforms of G protein-coupled receptor kinase 4 identified by molecular cloning." Sallese M., Lombardi M.S., de Blasi A. Biochem. Biophys. Res. Commun. 199:848-854(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANT ALA-486. Tissue: Brain.
[5]	Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Kidney.
[6]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-486.
[8]	"Amelioration of genetic hypertension by suppression of renal G protein-coupled receptor kinase type 4 expression." Sanada H., Yatabe J., Midorikawa S., Katoh T., Hashimoto S., Watanabe T., Xu J., Luo Y., Wang X., Zeng C., Armando I., Felder R.A., Jose P.A. Hypertension 47:1131-1139(2006) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[9]	"G protein-coupled receptor kinase 4 (GRK4) regulates the phosphorylation and function of the dopamine D3 receptor." Villar V.A.M., Jones J.E., Armando I., Palmes-Saloma C., Yu P., Pascua A.M., Keever L., Arnaldo F.B., Wang Z., Luo Y., Felder R.A., Jose P.A. J. Biol. Chem. 284:21425-21434(2009) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, ENZYME REGULATION, SUBCELLULAR LOCATION, INTERACTION WITH DRD3.
[10]	"Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R. Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] LEU-65; THR-116; VAL-142; ILE-247; GLN-383; PRO-425; ILE-473; ALA-486 AND THR-495.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L03718 Genomic DNA. Translation: AAB04045.1. X97879 mRNA. Translation: CAA66468.1. X97880 mRNA. Translation: CAA66469.1. X97881 mRNA. Translation: CAA66470.1. U33054 mRNA. Translation: AAC50406.1. U33055 mRNA. Translation: AAC50407.1. U33056 mRNA. Translation: AAC50408.1. U33168 , U33153, U33155, U33156, U33157, U33158, U33159, U33160, U33161, U33162, U33163, U33164, U33165, U33166, U33167 Genomic DNA. Translation: AAC50409.1. U33168 , U33153, U33154, U33155, U33156, U33157, U33158, U33159, U33160, U33161, U33162, U33163, U33164, U33165, U33166, U33167 Genomic DNA. Translation: AAC50410.1. U33168 , U33153, U33154, U33155, U33156, U33157, U33158, U33159, U33160, U33161, U33162, U33163, U33164, U33165, U33166 Genomic DNA. Translation: AAC50411.1. U33168 , U33153, U33155, U33156, U33157, U33158, U33159, U33160, U33161, U33162, U33163, U33164, U33165, U33166 Genomic DNA. Translation: AAC50412.1. AK223581 mRNA. Translation: BAD97301.1. X98118 mRNA. Translation: CAA66802.1. X75897 mRNA. Translation: CAA53506.1. Z68192 Genomic DNA. Translation: CAA92341.1. BC117320 mRNA. Translation: AAI17321.1.
IPI	IPI00180426. IPI00182614. IPI00217944. IPI00337306.
PIR	I54326. JC2127.
RefSeq	NP_001004056.1. NM_001004056.1. NP_001004057.1. NM_001004057.1. NP_892027.2. NM_182982.2.
UniGene	Hs.32959.
3D structure databases
ProteinModelPortal	P32298.
ModBase	Search...
Protein-protein interaction databases
IntAct	P32298. 2 interactions.
PTM databases
PhosphoSite	P32298.
Polymorphism databases
DMDM	143811400.
Proteomic databases
PaxDb	P32298.
PRIDE	P32298.
Protocols and materials databases
DNASU	2868.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000345167; ENSP00000264764; ENSG00000125388. ENST00000398051; ENSP00000381128; ENSG00000125388. ENST00000398052; ENSP00000381129; ENSG00000125388. ENST00000504933; ENSP00000427445; ENSG00000125388.
GeneID	2868.
KEGG	hsa:2868.
UCSC	uc003ggn.1. human. uc003ggo.1. human. uc003ggp.1. human. uc003ggq.1. human.
Organism-specific databases
CTD	2868.
GeneCards	GC04P002967.
HGNC	HGNC:4543. GRK4.
HPA	CAB004421.
MIM	137026. gene.
neXtProt	NX_P32298.
PharmGKB	PA28941.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0515.
HOVERGEN	HBG004532.
KO	K08291.
OMA	HSIEKDY.
OrthoDB	EOG4HHP24.
Enzyme and pathway databases
BRENDA	2.7.11.16. 2681.
Gene expression databases
ArrayExpress	P32298.
Bgee	P32298.
Genevestigator	P32298.
GermOnline	ENSG00000125388. Homo sapiens.
Family and domain databases
InterPro	IPR000961. AGC-kinase_C. IPR000239. GPCR_kinase. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR000342. Regulat_G_prot_signal. IPR016137. Regulat_G_prot_signal_superfam. IPR002290. Ser/Thr_dual-sp_kinase_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. PF00615. RGS. 1 hit. [Graphical view]
PRINTS	PR00717. GPCRKINASE.
SMART	SM00315. RGS. 1 hit. SM00133. S_TK_X. 1 hit. SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit. SSF48097. Regulat_G_prot_signal_superfam. 1 hit.
PROSITE	PS51285. AGC_KINASE_CTER. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. PS50132. RGS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P32298.
ChEMBL	CHEMBL5861.
GenomeRNAi	2868.
NextBio	11309.
SOURCE	Search...

Entry information

Entry name

GRK4_HUMAN

Accession

Primary (citable) accession number: P32298
Secondary accession number(s): O00641 , O00642, Q13293, Q13294, Q13295, Q14453, Q14725, Q15313, Q15314, Q15315, Q15316, Q17RH6, Q53EQ8

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
Last sequence update:	April 3, 2007
Last modified:	May 1, 2013
This is version 134 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.