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Protein

Antithrombin-III

Gene

SERPINC1

Organism
Ovis aries (Sheep)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei82HeparinBy similarity1
Binding sitei162HeparinBy similarity1
Binding sitei178HeparinBy similarity1
Sitei426 – 427Reactive bond2

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Keywords - Biological processi

Blood coagulation, Hemostasis

Keywords - Ligandi

Heparin-binding

Protein family/group databases

MEROPSiI04.018.

Names & Taxonomyi

Protein namesi
Recommended name:
Antithrombin-III
Short name:
ATIII
Alternative name(s):
Serpin C1
Gene namesi
Name:SERPINC1
Synonyms:AT3
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
Proteomesi
  • UP000002356 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32By similarityAdd BLAST32
ChainiPRO_000003249233 – 465Antithrombin-IIIAdd BLAST433

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi41 ↔ 161By similarity
Disulfide bondi54 ↔ 128By similarity
Modified residuei64PhosphothreonineBy similarity1
Modified residuei69PhosphoserineBy similarity1
Glycosylationi129N-linked (GlcNAc...)Sequence analysis1
Glycosylationi168N-linked (GlcNAc...)Sequence analysis1
Glycosylationi188N-linked (GlcNAc...)Sequence analysis1
Glycosylationi225N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi280 ↔ 463By similarity

Post-translational modificationi

Phosphorylated by FAM20C in the extracellular medium.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiP32262.

Expressioni

Tissue specificityi

Plasma.

Interactioni

Subunit structurei

Forms protease inhibiting heterodimer with TMPRSS7.By similarity

Structurei

3D structure databases

ProteinModelPortaliP32262.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG005957.
KOiK03911.

Family and domain databases

CDDicd02045. antithrombin-III_like. 1 hit.
InterProiIPR033829. Antithrombin_domain.
IPR015555. AT-III.
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PTHR11461:SF53. PTHR11461:SF53. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P32262-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISNGIGTVT TGKRSMCLFP LLLIGLWGCV TCHRSPVEDI CTAKPRDIPV
60 70 80 90 100
NPMCIYRSPE KKATEGEGSE QKIPGATNRR VWELSKANSH FATAFYQHLA
110 120 130 140 150
DSKNNNDNIF LSPLSISTAF AMTKLGACNN TLKQLMEVFK FDTISEKTSD
160 170 180 190 200
QIHFFFAKLN CRLYRKANKS SELVSANRLF GDKSITFNET YQDISEVVYG
210 220 230 240 250
AKLQPLDFKG NAEQSRLTIN QWISNKTEGR ITDVIPPQAI DEFTVLVLVN
260 270 280 290 300
TIYFKGLWKS KFSPENTKKE LFYKADGESC SVPMMYQEGK FRYRRVAEGT
310 320 330 340 350
QVLELPFKGD DITMVLILPK LEKPLAKVER ELTPDMLQEW LDELTETLLV
360 370 380 390 400
VHMPHFRIED SFSVKEQLQD MGLEDLFSPE KSRLPGIVAE GRNDLYVSDA
410 420 430 440 450
FHKAFLEVNE EGSEAAASTV ISIAGRSLNL NRVTFQANRP FLVLIREVAL
460
NTIIFMGRVA NPCVN
Length:465
Mass (Da):52,499
Last modified:October 1, 1993 - v1
Checksum:iE075EFAE51D5F118
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68287 mRNA. Translation: CAA48347.1.
PIRiS28219.
RefSeqiNP_001009393.1. NM_001009393.1.
UniGeneiOar.420.

Genome annotation databases

GeneIDi443407.
KEGGioas:443407.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68287 mRNA. Translation: CAA48347.1.
PIRiS28219.
RefSeqiNP_001009393.1. NM_001009393.1.
UniGeneiOar.420.

3D structure databases

ProteinModelPortaliP32262.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiI04.018.

Proteomic databases

PRIDEiP32262.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi443407.
KEGGioas:443407.

Organism-specific databases

CTDi462.

Phylogenomic databases

HOVERGENiHBG005957.
KOiK03911.

Family and domain databases

CDDicd02045. antithrombin-III_like. 1 hit.
InterProiIPR033829. Antithrombin_domain.
IPR015555. AT-III.
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PTHR11461:SF53. PTHR11461:SF53. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANT3_SHEEP
AccessioniPrimary (citable) accession number: P32262
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: November 30, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.