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P32261

- ANT3_MOUSE

UniProt

P32261 - ANT3_MOUSE

Protein

Antithrombin-III

Gene

Serpinc1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 1 (01 Oct 1993)
      Previous versions | rss
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    Functioni

    Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei82 – 821HeparinBy similarity
    Binding sitei162 – 1621HeparinBy similarity
    Binding sitei178 – 1781HeparinBy similarity
    Sitei426 – 4272Reactive bond

    GO - Molecular functioni

    1. heparin binding Source: UniProtKB-KW
    2. serine-type endopeptidase inhibitor activity Source: RefGenome

    GO - Biological processi

    1. blood coagulation Source: UniProtKB-KW
    2. negative regulation of endopeptidase activity Source: RefGenome
    3. negative regulation of inflammatory response Source: Ensembl
    4. regulation of blood coagulation, intrinsic pathway Source: InterPro
    5. regulation of proteolysis Source: RefGenome
    6. response to nutrient Source: Ensembl

    Keywords - Molecular functioni

    Protease inhibitor, Serine protease inhibitor

    Keywords - Biological processi

    Blood coagulation, Hemostasis

    Keywords - Ligandi

    Heparin-binding

    Protein family/group databases

    MEROPSiI04.018.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Antithrombin-III
    Short name:
    ATIII
    Alternative name(s):
    Serpin C1
    Gene namesi
    Name:Serpinc1
    Synonyms:At3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:88095. Serpinc1.

    Subcellular locationi

    Secretedextracellular space By similarity

    GO - Cellular componenti

    1. extracellular region Source: RefGenome
    2. extracellular space Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3232By similarityAdd
    BLAST
    Chaini33 – 465433Antithrombin-IIIPRO_0000032490Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi41 ↔ 161By similarity
    Disulfide bondi54 ↔ 128By similarity
    Glycosylationi129 – 1291N-linked (GlcNAc...)1 Publication
    Glycosylationi168 – 1681N-linked (GlcNAc...)1 Publication
    Glycosylationi188 – 1881N-linked (GlcNAc...)2 Publications
    Glycosylationi225 – 2251N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi280 ↔ 463By similarity

    Post-translational modificationi

    Phosphorylation sites are present in the extracellular medium.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiP32261.
    PaxDbiP32261.
    PRIDEiP32261.

    PTM databases

    PhosphoSiteiP32261.

    Expressioni

    Tissue specificityi

    Plasma.

    Gene expression databases

    BgeeiP32261.
    GenevestigatoriP32261.

    Interactioni

    Subunit structurei

    Forms protease inhibiting heterodimer with TMPRSS7.By similarity

    Protein-protein interaction databases

    IntActiP32261. 3 interactions.
    MINTiMINT-1846278.
    STRINGi10090.ENSMUSP00000068971.

    Structurei

    3D structure databases

    ProteinModelPortaliP32261.
    SMRiP32261. Positions 39-464.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the serpin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG4826.
    HOGENOMiHOG000238519.
    HOVERGENiHBG005957.
    InParanoidiP32261.
    KOiK03911.
    OMAiKADGESC.
    OrthoDBiEOG7327PB.
    PhylomeDBiP32261.
    TreeFamiTF343094.

    Family and domain databases

    InterProiIPR015555. AT-III.
    IPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view]
    PANTHERiPTHR11461. PTHR11461. 1 hit.
    PTHR11461:SF53. PTHR11461:SF53. 1 hit.
    PfamiPF00079. Serpin. 1 hit.
    [Graphical view]
    SMARTiSM00093. SERPIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF56574. SSF56574. 1 hit.
    PROSITEiPS00284. SERPIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P32261-1 [UniParc]FASTAAdd to Basket

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    MYSPGAGSGA AGERKLCLLS LLLIGALGCA ICHGNPVDDI CIAKPRDIPV    50
    NPLCIYRSPG KKATEEDGSE QKVPEATNRR VWELSKANSR FATNFYQHLA 100
    DSKNDNDNIF LSPLSISTAF AMTKLGACND TLKQLMEVFK FDTISEKTSD 150
    QIHFFFAKLN CRLYRKANKS SDLVSANRLF GDKSLTFNES YQDVSEVVYG 200
    AKLQPLDFKE NPEQSRVTIN NWVANKTEGR IKDVIPQGAI NELTALVLVN 250
    TIYFKGLWKS KFSPENTRKE PFYKVDGQSC PVPMMYQEGK FKYRRVAEGT 300
    QVLELPFKGD DITMVLILPK PEKSLAKVEQ ELTPELLQEW LDELSETMLV 350
    VHMPRFRTED GFSLKEQLQD MGLIDLFSPE KSQLPGIVAG GRDDLYVSDA 400
    FHKAFLEVNE EGSEAAASTS VVITGRSLNP NRVTFKANRP FLVLIREVAL 450
    NTIIFMGRVA NPCVN 465
    Length:465
    Mass (Da):52,004
    Last modified:October 1, 1993 - v1
    Checksum:i5CE087E98874E35D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S47225 mRNA. Translation: AAB23965.1.
    BC019447 mRNA. Translation: AAH19447.1.
    BC033377 mRNA. Translation: AAH33377.1.
    CCDSiCCDS15411.1.
    RefSeqiNP_543120.1. NM_080844.4.
    XP_006496689.1. XM_006496626.1.
    UniGeneiMm.260770.

    Genome annotation databases

    EnsembliENSMUST00000064725; ENSMUSP00000068971; ENSMUSG00000026715.
    GeneIDi11905.
    KEGGimmu:11905.
    UCSCiuc007dem.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S47225 mRNA. Translation: AAB23965.1 .
    BC019447 mRNA. Translation: AAH19447.1 .
    BC033377 mRNA. Translation: AAH33377.1 .
    CCDSi CCDS15411.1.
    RefSeqi NP_543120.1. NM_080844.4.
    XP_006496689.1. XM_006496626.1.
    UniGenei Mm.260770.

    3D structure databases

    ProteinModelPortali P32261.
    SMRi P32261. Positions 39-464.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P32261. 3 interactions.
    MINTi MINT-1846278.
    STRINGi 10090.ENSMUSP00000068971.

    Protein family/group databases

    MEROPSi I04.018.

    PTM databases

    PhosphoSitei P32261.

    Proteomic databases

    MaxQBi P32261.
    PaxDbi P32261.
    PRIDEi P32261.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000064725 ; ENSMUSP00000068971 ; ENSMUSG00000026715 .
    GeneIDi 11905.
    KEGGi mmu:11905.
    UCSCi uc007dem.2. mouse.

    Organism-specific databases

    CTDi 462.
    MGIi MGI:88095. Serpinc1.

    Phylogenomic databases

    eggNOGi COG4826.
    HOGENOMi HOG000238519.
    HOVERGENi HBG005957.
    InParanoidi P32261.
    KOi K03911.
    OMAi KADGESC.
    OrthoDBi EOG7327PB.
    PhylomeDBi P32261.
    TreeFami TF343094.

    Miscellaneous databases

    NextBioi 279953.
    PROi P32261.
    SOURCEi Search...

    Gene expression databases

    Bgeei P32261.
    Genevestigatori P32261.

    Family and domain databases

    InterProi IPR015555. AT-III.
    IPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view ]
    PANTHERi PTHR11461. PTHR11461. 1 hit.
    PTHR11461:SF53. PTHR11461:SF53. 1 hit.
    Pfami PF00079. Serpin. 1 hit.
    [Graphical view ]
    SMARTi SM00093. SERPIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56574. SSF56574. 1 hit.
    PROSITEi PS00284. SERPIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and cell-free expression of mouse antithrombin III."
      Wu J.K., Sheffield W.P., Blajchman M.A.
      Thromb. Haemost. 68:291-296(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Liver.
    3. "Proteome-wide characterization of N-glycosylation events by diagonal chromatography."
      Ghesquiere B., Van Damme J., Martens L., Vandekerckhove J., Gevaert K.
      J. Proteome Res. 5:2438-2447(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-188.
      Strain: C57BL/6.
      Tissue: Plasma.
    4. "Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides."
      Bernhard O.K., Kapp E.A., Simpson R.J.
      J. Proteome Res. 6:987-995(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-129; ASN-168 AND ASN-188.
      Strain: C57BL/6.
      Tissue: Plasma.

    Entry informationi

    Entry nameiANT3_MOUSE
    AccessioniPrimary (citable) accession number: P32261
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: October 1, 1993
    Last modified: October 1, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3