SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P32261

- ANT3_MOUSE

UniProt

P32261 - ANT3_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Antithrombin-III
Gene
Serpinc1, At3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei82 – 821Heparin By similarity
Binding sitei162 – 1621Heparin By similarity
Binding sitei178 – 1781Heparin By similarity
Sitei426 – 4272Reactive bond

GO - Molecular functioni

  1. heparin binding Source: UniProtKB-KW
  2. serine-type endopeptidase inhibitor activity Source: RefGenome

GO - Biological processi

  1. blood coagulation Source: UniProtKB-KW
  2. negative regulation of endopeptidase activity Source: RefGenome
  3. negative regulation of inflammatory response Source: Ensembl
  4. regulation of blood coagulation, intrinsic pathway Source: InterPro
  5. regulation of proteolysis Source: RefGenome
  6. response to nutrient Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Keywords - Biological processi

Blood coagulation, Hemostasis

Keywords - Ligandi

Heparin-binding

Protein family/group databases

MEROPSiI04.018.

Names & Taxonomyi

Protein namesi
Recommended name:
Antithrombin-III
Short name:
ATIII
Alternative name(s):
Serpin C1
Gene namesi
Name:Serpinc1
Synonyms:At3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:88095. Serpinc1.

Subcellular locationi

Secretedextracellular space By similarity

GO - Cellular componenti

  1. extracellular region Source: RefGenome
  2. extracellular space Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232 By similarity
Add
BLAST
Chaini33 – 465433Antithrombin-III
PRO_0000032490Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi41 ↔ 161 By similarity
Disulfide bondi54 ↔ 128 By similarity
Glycosylationi129 – 1291N-linked (GlcNAc...)1 Publication
Glycosylationi168 – 1681N-linked (GlcNAc...)1 Publication
Glycosylationi188 – 1881N-linked (GlcNAc...)2 Publications
Glycosylationi225 – 2251N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi280 ↔ 463 By similarity

Post-translational modificationi

Phosphorylation sites are present in the extracellular medium By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP32261.
PaxDbiP32261.
PRIDEiP32261.

PTM databases

PhosphoSiteiP32261.

Expressioni

Tissue specificityi

Plasma.

Gene expression databases

BgeeiP32261.
GenevestigatoriP32261.

Interactioni

Subunit structurei

Forms protease inhibiting heterodimer with TMPRSS7 By similarity.

Protein-protein interaction databases

IntActiP32261. 3 interactions.
MINTiMINT-1846278.
STRINGi10090.ENSMUSP00000068971.

Structurei

3D structure databases

ProteinModelPortaliP32261.
SMRiP32261. Positions 39-464.

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG4826.
HOGENOMiHOG000238519.
HOVERGENiHBG005957.
InParanoidiP32261.
KOiK03911.
OMAiKADGESC.
OrthoDBiEOG7327PB.
PhylomeDBiP32261.
TreeFamiTF343094.

Family and domain databases

InterProiIPR015555. AT-III.
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PTHR11461:SF53. PTHR11461:SF53. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P32261-1 [UniParc]FASTAAdd to Basket

« Hide

MYSPGAGSGA AGERKLCLLS LLLIGALGCA ICHGNPVDDI CIAKPRDIPV    50
NPLCIYRSPG KKATEEDGSE QKVPEATNRR VWELSKANSR FATNFYQHLA 100
DSKNDNDNIF LSPLSISTAF AMTKLGACND TLKQLMEVFK FDTISEKTSD 150
QIHFFFAKLN CRLYRKANKS SDLVSANRLF GDKSLTFNES YQDVSEVVYG 200
AKLQPLDFKE NPEQSRVTIN NWVANKTEGR IKDVIPQGAI NELTALVLVN 250
TIYFKGLWKS KFSPENTRKE PFYKVDGQSC PVPMMYQEGK FKYRRVAEGT 300
QVLELPFKGD DITMVLILPK PEKSLAKVEQ ELTPELLQEW LDELSETMLV 350
VHMPRFRTED GFSLKEQLQD MGLIDLFSPE KSQLPGIVAG GRDDLYVSDA 400
FHKAFLEVNE EGSEAAASTS VVITGRSLNP NRVTFKANRP FLVLIREVAL 450
NTIIFMGRVA NPCVN 465
Length:465
Mass (Da):52,004
Last modified:October 1, 1993 - v1
Checksum:i5CE087E98874E35D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S47225 mRNA. Translation: AAB23965.1.
BC019447 mRNA. Translation: AAH19447.1.
BC033377 mRNA. Translation: AAH33377.1.
CCDSiCCDS15411.1.
RefSeqiNP_543120.1. NM_080844.4.
XP_006496689.1. XM_006496626.1.
UniGeneiMm.260770.

Genome annotation databases

EnsembliENSMUST00000064725; ENSMUSP00000068971; ENSMUSG00000026715.
GeneIDi11905.
KEGGimmu:11905.
UCSCiuc007dem.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S47225 mRNA. Translation: AAB23965.1 .
BC019447 mRNA. Translation: AAH19447.1 .
BC033377 mRNA. Translation: AAH33377.1 .
CCDSi CCDS15411.1.
RefSeqi NP_543120.1. NM_080844.4.
XP_006496689.1. XM_006496626.1.
UniGenei Mm.260770.

3D structure databases

ProteinModelPortali P32261.
SMRi P32261. Positions 39-464.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P32261. 3 interactions.
MINTi MINT-1846278.
STRINGi 10090.ENSMUSP00000068971.

Protein family/group databases

MEROPSi I04.018.

PTM databases

PhosphoSitei P32261.

Proteomic databases

MaxQBi P32261.
PaxDbi P32261.
PRIDEi P32261.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000064725 ; ENSMUSP00000068971 ; ENSMUSG00000026715 .
GeneIDi 11905.
KEGGi mmu:11905.
UCSCi uc007dem.2. mouse.

Organism-specific databases

CTDi 462.
MGIi MGI:88095. Serpinc1.

Phylogenomic databases

eggNOGi COG4826.
HOGENOMi HOG000238519.
HOVERGENi HBG005957.
InParanoidi P32261.
KOi K03911.
OMAi KADGESC.
OrthoDBi EOG7327PB.
PhylomeDBi P32261.
TreeFami TF343094.

Miscellaneous databases

NextBioi 279953.
PROi P32261.
SOURCEi Search...

Gene expression databases

Bgeei P32261.
Genevestigatori P32261.

Family and domain databases

InterProi IPR015555. AT-III.
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view ]
PANTHERi PTHR11461. PTHR11461. 1 hit.
PTHR11461:SF53. PTHR11461:SF53. 1 hit.
Pfami PF00079. Serpin. 1 hit.
[Graphical view ]
SMARTi SM00093. SERPIN. 1 hit.
[Graphical view ]
SUPFAMi SSF56574. SSF56574. 1 hit.
PROSITEi PS00284. SERPIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and cell-free expression of mouse antithrombin III."
    Wu J.K., Sheffield W.P., Blajchman M.A.
    Thromb. Haemost. 68:291-296(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.
  3. "Proteome-wide characterization of N-glycosylation events by diagonal chromatography."
    Ghesquiere B., Van Damme J., Martens L., Vandekerckhove J., Gevaert K.
    J. Proteome Res. 5:2438-2447(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-188.
    Strain: C57BL/6.
    Tissue: Plasma.
  4. "Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides."
    Bernhard O.K., Kapp E.A., Simpson R.J.
    J. Proteome Res. 6:987-995(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-129; ASN-168 AND ASN-188.
    Strain: C57BL/6.
    Tissue: Plasma.

Entry informationi

Entry nameiANT3_MOUSE
AccessioniPrimary (citable) accession number: P32261
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: July 9, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi