Antithrombin-III precursor - Mus musculus (Mouse)

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P32261 (ANT3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 109. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Antithrombin-III
Short name=ATIII

Alternative name(s):
Serpin C1

Gene names

Name:	Serpinc1
Synonyms:	At3

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	465 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin By similarity.
Subunit structure	Forms protease inhibiting heterodimer with TMPRSS7 By similarity.
Subcellular location	Secreted › extracellular space By similarity.
Tissue specificity	Plasma.
Post-translational modification	Phosphorylation sites are present in the extracellular medium By similarity.
Sequence similarities	Belongs to the serpin family.

Ontologies

Keywords
Biological process	Blood coagulation Hemostasis
Cellular component	Secreted
Domain	Signal
Ligand	Heparin-binding
Molecular function	Protease inhibitor Serine protease inhibitor
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	blood coagulation Inferred from electronic annotation. Source: UniProtKB-KW negative regulation of inflammatory response Inferred from electronic annotation. Source: Compara regulation of proteolysis Inferred from Biological aspect of Ancestor. Source: RefGenome response to nutrient Inferred from electronic annotation. Source: Compara
Cellular_component	extracellular region Inferred from Biological aspect of Ancestor. Source: RefGenome extracellular space Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	heparin binding Inferred from electronic annotation. Source: UniProtKB-KW serine-type endopeptidase inhibitor activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 32

By similarity

Chain

33 – 465

433

Antithrombin-III

PRO_0000032490

Sites

Binding site

Heparin By similarity

Binding site

162

Heparin By similarity

Binding site

178

Heparin By similarity

Site

426 – 427

Reactive bond

Amino acid modifications

Glycosylation

129

N-linked (GlcNAc...) Ref.4

Glycosylation

168

N-linked (GlcNAc...) Ref.4

Glycosylation

188

N-linked (GlcNAc...) Ref.3 Ref.4

Glycosylation

225

N-linked (GlcNAc...) Potential

Disulfide bond

41 ↔ 161

By similarity

Disulfide bond

54 ↔ 128

By similarity

Disulfide bond

280 ↔ 463

By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

P32261 [UniParc].

Last modified October 1, 1993. Version 1.
Checksum: 5CE087E98874E35D
Show »

FASTA

465

52,004

        10         20         30         40         50         60 
MYSPGAGSGA AGERKLCLLS LLLIGALGCA ICHGNPVDDI CIAKPRDIPV NPLCIYRSPG 

        70         80         90        100        110        120 
KKATEEDGSE QKVPEATNRR VWELSKANSR FATNFYQHLA DSKNDNDNIF LSPLSISTAF 

       130        140        150        160        170        180 
AMTKLGACND TLKQLMEVFK FDTISEKTSD QIHFFFAKLN CRLYRKANKS SDLVSANRLF 

       190        200        210        220        230        240 
GDKSLTFNES YQDVSEVVYG AKLQPLDFKE NPEQSRVTIN NWVANKTEGR IKDVIPQGAI 

       250        260        270        280        290        300 
NELTALVLVN TIYFKGLWKS KFSPENTRKE PFYKVDGQSC PVPMMYQEGK FKYRRVAEGT 

       310        320        330        340        350        360 
QVLELPFKGD DITMVLILPK PEKSLAKVEQ ELTPELLQEW LDELSETMLV VHMPRFRTED 

       370        380        390        400        410        420 
GFSLKEQLQD MGLIDLFSPE KSQLPGIVAG GRDDLYVSDA FHKAFLEVNE EGSEAAASTS 

       430        440        450        460 
VVITGRSLNP NRVTFKANRP FLVLIREVAL NTIIFMGRVA NPCVN

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and cell-free expression of mouse antithrombin III." Wu J.K., Sheffield W.P., Blajchman M.A. Thromb. Haemost. 68:291-296(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Liver.
[3]	"Proteome-wide characterization of N-glycosylation events by diagonal chromatography." Ghesquiere B., Van Damme J., Martens L., Vandekerckhove J., Gevaert K. J. Proteome Res. 5:2438-2447(2006) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-188, MASS SPECTROMETRY. Strain: C57BL/6. Tissue: Plasma.
[4]	"Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides." Bernhard O.K., Kapp E.A., Simpson R.J. J. Proteome Res. 6:987-995(2007) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-129; ASN-168 AND ASN-188, MASS SPECTROMETRY. Strain: C57BL/6. Tissue: Plasma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	S47225 mRNA. Translation: AAB23965.1. BC019447 mRNA. Translation: AAH19447.1. BC033377 mRNA. Translation: AAH33377.1.
IPI	IPI00136642.
RefSeq	NP_543120.1. NM_080844.4.
UniGene	Mm.260770.
3D structure databases
ProteinModelPortal	P32261.
SMR	P32261. Positions 39-464.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000068971.
Protein family/group databases
MEROPS	I04.018.
PTM databases
PhosphoSite	P32261.
Proteomic databases
PaxDb	P32261.
PRIDE	P32261.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000064725; ENSMUSP00000068971; ENSMUSG00000026715.
GeneID	11905.
KEGG	mmu:11905.
Organism-specific databases
CTD	462.
MGI	MGI:88095. Serpinc1.
Phylogenomic databases
eggNOG	COG4826.
HOGENOM	HOG000238519.
HOVERGEN	HBG005957.
InParanoid	P32261.
KO	K03911.
OMA	ACDNTLK.
OrthoDB	EOG4SF968.
Gene expression databases
ArrayExpress	P32261.
Bgee	P32261.
Genevestigator	P32261.
GermOnline	ENSMUSG00000026715. Mus musculus.
Family and domain databases
InterPro	IPR015555. AT-III. IPR023795. Protease_inhib_I4_serpin_CS. IPR023796. Serpin_dom. IPR000215. Serpin_fam. [Graphical view]
PANTHER	PTHR11461. PTHR11461. 1 hit. PTHR11461:SF53. PTHR11461:SF53. 1 hit.
Pfam	PF00079. Serpin. 1 hit. [Graphical view]
SMART	SM00093. SERPIN. 1 hit. [Graphical view]
SUPFAM	SSF56574. Prot_inh_serpin. 1 hit.
PROSITE	PS00284. SERPIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	279953.
SOURCE	Search...

Entry information

Entry name

ANT3_MOUSE

Accession

Primary (citable) accession number: P32261

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
Last sequence update:	October 1, 1993
Last modified:	April 3, 2013
This is version 109 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Sites

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents