P32248 (CCR7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
C-C chemokine receptor type 7
Short name=C-C CKR-7
Short name=CC-CKR-7
Short name=CCR-7

Alternative name(s):
BLR2
CDw197
Epstein-Barr virus-induced G-protein coupled receptor 1
Short name=EBI1
Short name=EBV-induced G-protein coupled receptor 1
MIP-3 beta receptor
CD_antigen=CD197

Gene names

Name:	CCR7
Synonyms:	CMKBR7, EBI1, EVI1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	378 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Expressed in various lymphoid tissues and activated B- and T-lymphocytes, strongly up-regulated in B-cells infected with Epstein-Barr virus and T-cells infected with herpesvirus 6 or 7.
Induction	By Epstein-Barr virus (EBV).
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Signal Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	T cell costimulation Inferred from sequence or structural similarity. Source: BHF-UCL activation of Rho GTPase activity Inferred by curator. Source: BHF-UCL cell maturation Inferred from sequence or structural similarity. Source: BHF-UCL establishment of T cell polarity Inferred by curator. Source: BHF-UCL immunological synapse formation Inferred from sequence or structural similarity. Source: BHF-UCL inflammatory response Non-traceable author statement. Source: BHF-UCL interleukin-12 secretion Inferred from sequence or structural similarity. Source: BHF-UCL lymphocyte migration into lymph node Traceable author statement. Source: BHF-UCL myeloid dendritic cell chemotaxis Inferred by curator. Source: BHF-UCL negative regulation of leukocyte apoptosis Inferred by curator. Source: BHF-UCL positive regulation of ERK1 and ERK2 cascade Inferred by curator. Source: BHF-UCL positive regulation of I-kappaB kinase/NF-kappaB cascade Inferred by curator. Source: BHF-UCL positive regulation of JNK cascade Inferred by curator. Source: BHF-UCL positive regulation of actin filament polymerization Inferred by curator. Source: BHF-UCL positive regulation of cell-matrix adhesion Inferred by curator. Source: BHF-UCL positive regulation of dendritic cell antigen processing and presentation Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of filopodium assembly Inferred by curator. Source: BHF-UCL positive regulation of glycoprotein biosynthetic process Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of humoral immune response Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of hypersensitivity Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of interleukin-12 production Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of neutrophil chemotaxis Inferred from direct assay. Source: BHF-UCL positive regulation of phosphatidylinositol 3-kinase activity Inferred by curator. Source: BHF-UCL positive regulation of protein kinase B signaling cascade Inferred by curator. Source: BHF-UCL positive regulation of protein kinase activity Inferred by curator. Source: BHF-UCL positive regulation of pseudopodium assembly Inferred by curator. Source: BHF-UCL regulation of interferon-gamma production Inferred from sequence or structural similarity. Source: BHF-UCL regulation of interleukin-1 beta secretion Inferred from sequence or structural similarity. Source: BHF-UCL release of sequestered calcium ion into cytosol Inferred by curator. Source: BHF-UCL response to nitric oxide Inferred by curator. Source: BHF-UCL response to prostaglandin E stimulus Inferred by curator. Source: BHF-UCL ruffle organization Inferred by curator. Source: BHF-UCL
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW intracellular Inferred from direct assay. Source: BHF-UCL plasma membrane Inferred from direct assay. Source: BHF-UCL
Molecular function	C-C chemokine receptor activity Inferred from sequence or structural similarity. Source: BHF-UCL chemokine (C-C motif) ligand 19 binding Inferred from physical interaction. Source: BHF-UCL chemokine (C-C motif) ligand 21 binding Inferred from physical interaction. Source: BHF-UCL
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential
	Chain	25 – 378	354	C-C chemokine receptor type 7		PRO_0000012735
Regions
	Topological domain	25 – 59	35	Extracellular Potential
	Transmembrane	60 – 86	27	Helical; Name=1; Potential
	Topological domain	87 – 95	9	Cytoplasmic Potential
	Transmembrane	96 – 116	21	Helical; Name=2; Potential
	Topological domain	117 – 130	14	Extracellular Potential
	Transmembrane	131 – 152	22	Helical; Name=3; Potential
	Topological domain	153 – 170	18	Cytoplasmic Potential
	Transmembrane	171 – 191	21	Helical; Name=4; Potential
	Topological domain	192 – 219	28	Extracellular Potential
	Transmembrane	220 – 247	28	Helical; Name=5; Potential
	Topological domain	248 – 263	16	Cytoplasmic Potential
	Transmembrane	264 – 289	26	Helical; Name=6; Potential
	Topological domain	290 – 313	24	Extracellular Potential
	Transmembrane	314 – 331	18	Helical; Name=7; Potential
	Topological domain	332 – 378	47	Cytoplasmic Potential
Amino acid modifications
	Modified residue	151	1	Phosphoserine Ref.5
	Glycosylation	36	1	N-linked (GlcNAc...) Potential
	Disulfide bond	129 ↔ 210		By similarity
Natural variations
	Natural variant	7	1	M → V. Corresponds to variant rs45521932 [ dbSNP | Ensembl ].		VAR_049383
Experimental info
	Sequence conflict	182 – 183	2	IW → SA in AAA58615. Ref.1
	Sequence conflict	337	1	L → I in AAA58615. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P32248 [UniParc]. Last modified February 1, 1996. Version 2. Checksum: D4CB4213841A1BD4	FASTA	378	42,874
	10 20 30 40 50 60 MDLGKPMKSV LVVALLVIFQ VCLCQDEVTD DYIGDNTTVD YTLFESLCSK KDVRNFKAWF 70 80 90 100 110 120 LPIMYSIICF VGLLGNGLVV LTYIYFKRLK TMTDTYLLNL AVADILFLLT LPFWAYSAAK 130 140 150 160 170 180 SWVFGVHFCK LIFAIYKMSF FSGMLLLLCI SIDRYVAIVQ AVSAHRHRAR VLLISKLSCV 190 200 210 220 230 240 GIWILATVLS IPELLYSDLQ RSSSEQAMRC SLITEHVEAF ITIQVAQMVI GFLVPLLAMS 250 260 270 280 290 300 FCYLVIIRTL LQARNFERNK AIKVIIAVVV VFIVFQLPYN GVVLAQTVAN FNITSSTCEL 310 320 330 340 350 360 SKQLNIAYDV TYSLACVRCC VNPFLYAFIG VKFRNDLFKL FKDLGCLSQE QLRQWSSCRH 370 IRRSSMSVEA ETTTTFSP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors." Birkenbach M.P., Josefsen K., Yalamanchili R.R., Lenoir G.M., Kieff E. J. Virol. 67:2209-2220(1993) [PubMed: 8383238] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Cloning of human and mouse EBI1, a lymphoid-specific G-protein-coupled receptor encoded on human chromosome 17q12-q21.2." Schweickart V.L., Raport C.J., Godiska R., Byers M.G., Eddy R.L. Jr., Shows T.B., Gray P.W. Genomics 23:643-650(1994) [PubMed: 7851893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Tissue: Placenta.
[3]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Kopatz S.A., Aronstam R.S., Sharma S.V. Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[5]	"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column." Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y. Anal. Sci. 24:161-166(2008) [PubMed: 18187866] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-151, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Web resources

Wikipedia

CC chemokine receptors entry

Cross-references

Sequence databases
EMBL GenBank DDBJ	L08176 mRNA. Translation: AAA58615.1. L31584, L31582, L31583 Genomic DNA. Translation: AAA74230.1. L31581 mRNA. Translation: AAA74231.1. AY587876 mRNA. Translation: AAT52232.1. BC035343 mRNA. Translation: AAH35343.1.
IPI	IPI00027687.
PIR	A45680. B55735.
RefSeq	NP_001829.1. NM_001838.3.
UniGene	Hs.370036.
3D structure databases
ProteinModelPortal	P32248.
SMR	P32248. Positions 47-343.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-5855N.
IntAct	P32248. 1 interaction.
STRING	P32248.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P32248.
Polymorphism databases
DMDM	1352335.
Proteomic databases
PRIDE	P32248.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000246657; ENSP00000246657; ENSG00000126353.
GeneID	1236.
KEGG	hsa:1236.
UCSC	uc002huw.1. human.
Organism-specific databases
CTD	1236.
GeneCards	GC17M038710.
H-InvDB	HIX0027171.
HGNC	HGNC:1608. CCR7.
HPA	CAB003796.
MIM	600242. gene.
neXtProt	NX_P32248.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00590000082979.
HOGENOM	HBG715940.
HOVERGEN	HBG106917.
InParanoid	P32248.
OMA	GCLSQER.
OrthoDB	EOG43TZW4.
PhylomeDB	P32248.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	P32248.
Bgee	P32248.
CleanEx	HS_CCR7. HS_EVI1.
Genevestigator	P32248.
GermOnline	ENSG00000126353. Homo sapiens.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR001718. Chemokine_CCR7. IPR000355. Chemokine_rcpt. IPR017452. GPCR_Rhodpsn_supfam. [Graphical view]
KO	K04182.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00657. CCCHEMOKINER. PR00641. CHEMOKINER7. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	5049.
SOURCE	Search...

Entry information

Entry name

CCR7_HUMAN

Accession

Primary (citable) accession number: P32248

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
Last sequence update:	February 1, 1996
Last modified:	January 25, 2012
This is version 119 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.