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Protein

C-C chemokine receptor type 7

Gene

CCR7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions.

GO - Molecular functioni

  • C-C chemokine receptor activity Source: BHF-UCL
  • C-C motif chemokine 19 receptor activity Source: UniProtKB
  • C-C motif chemokine 21 receptor activity Source: UniProtKB
  • chemokine (C-C motif) ligand 19 binding Source: BHF-UCL
  • chemokine (C-C motif) ligand 21 binding Source: BHF-UCL
  • G-protein coupled receptor activity Source: BHF-UCL

GO - Biological processi

  • activation of GTPase activity Source: BHF-UCL
  • cellular response to cytokine stimulus Source: BHF-UCL
  • dendritic cell chemotaxis Source: BHF-UCL
  • establishment of T cell polarity Source: BHF-UCL
  • G-protein coupled receptor signaling pathway Source: BHF-UCL
  • homeostasis of number of cells Source: Ensembl
  • immune response Source: Ensembl
  • inflammatory response Source: BHF-UCL
  • interleukin-12 secretion Source: BHF-UCL
  • lymphocyte migration into lymph node Source: BHF-UCL
  • mature conventional dendritic cell differentiation Source: BHF-UCL
  • myeloid dendritic cell chemotaxis Source: BHF-UCL
  • negative regulation of leukocyte apoptotic process Source: BHF-UCL
  • negative thymic T cell selection Source: Ensembl
  • positive regulation of actin filament polymerization Source: BHF-UCL
  • positive regulation of cell adhesion Source: BHF-UCL
  • positive regulation of cell-matrix adhesion Source: BHF-UCL
  • positive regulation of cell motility Source: BHF-UCL
  • positive regulation of cytosolic calcium ion concentration Source: ProtInc
  • positive regulation of dendritic cell antigen processing and presentation Source: BHF-UCL
  • positive regulation of dendritic cell chemotaxis Source: BHF-UCL
  • positive regulation of ERK1 and ERK2 cascade Source: BHF-UCL
  • positive regulation of filopodium assembly Source: BHF-UCL
  • positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation Source: BHF-UCL
  • positive regulation of humoral immune response Source: BHF-UCL
  • positive regulation of hypersensitivity Source: BHF-UCL
  • positive regulation of I-kappaB kinase/NF-kappaB signaling Source: BHF-UCL
  • positive regulation of immunological synapse formation Source: BHF-UCL
  • positive regulation of interleukin-12 production Source: BHF-UCL
  • positive regulation of JNK cascade Source: BHF-UCL
  • positive regulation of neutrophil chemotaxis Source: BHF-UCL
  • positive regulation of phosphatidylinositol 3-kinase activity Source: BHF-UCL
  • positive regulation of protein kinase activity Source: BHF-UCL
  • positive regulation of protein kinase B signaling Source: BHF-UCL
  • positive regulation of pseudopodium assembly Source: BHF-UCL
  • positive regulation of T cell costimulation Source: BHF-UCL
  • positive regulation of T cell receptor signaling pathway Source: Ensembl
  • regulation of dendritic cell dendrite assembly Source: BHF-UCL
  • regulation of interferon-gamma production Source: BHF-UCL
  • regulation of interleukin-1 beta secretion Source: BHF-UCL
  • release of sequestered calcium ion into cytosol Source: BHF-UCL
  • response to lipopolysaccharide Source: Ensembl
  • response to nitric oxide Source: BHF-UCL
  • response to prostaglandin E Source: BHF-UCL
  • ruffle organization Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000126353-MONOMER.
ReactomeiR-HSA-380108. Chemokine receptors bind chemokines.
R-HSA-418594. G alpha (i) signalling events.
SIGNORiP32248.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C chemokine receptor type 7
Short name:
C-C CKR-7
Short name:
CC-CKR-7
Short name:
CCR-7
Alternative name(s):
BLR2
CDw197
Epstein-Barr virus-induced G-protein coupled receptor 1
Short name:
EBI1
Short name:
EBV-induced G-protein coupled receptor 1
MIP-3 beta receptor
CD_antigen: CD197
Gene namesi
Name:CCR7
Synonyms:CMKBR7, EBI1, EVI1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:1608. CCR7.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 59ExtracellularSequence analysisAdd BLAST35
Transmembranei60 – 86Helical; Name=1Sequence analysisAdd BLAST27
Topological domaini87 – 95CytoplasmicSequence analysis9
Transmembranei96 – 116Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini117 – 130ExtracellularSequence analysisAdd BLAST14
Transmembranei131 – 152Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini153 – 170CytoplasmicSequence analysisAdd BLAST18
Transmembranei171 – 191Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini192 – 219ExtracellularSequence analysisAdd BLAST28
Transmembranei220 – 247Helical; Name=5Sequence analysisAdd BLAST28
Topological domaini248 – 263CytoplasmicSequence analysisAdd BLAST16
Transmembranei264 – 289Helical; Name=6Sequence analysisAdd BLAST26
Topological domaini290 – 313ExtracellularSequence analysisAdd BLAST24
Transmembranei314 – 331Helical; Name=7Sequence analysisAdd BLAST18
Topological domaini332 – 378CytoplasmicSequence analysisAdd BLAST47

GO - Cellular componenti

  • cell surface Source: UniProtKB
  • external side of plasma membrane Source: Ensembl
  • integral component of membrane Source: UniProtKB-KW
  • intracellular Source: BHF-UCL
  • plasma membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi1236.
OpenTargetsiENSG00000126353.
PharmGKBiPA26172.

Chemistry databases

ChEMBLiCHEMBL4594.
GuidetoPHARMACOLOGYi64.

Polymorphism and mutation databases

BioMutaiCCR7.
DMDMi1352335.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000001273525 – 378C-C chemokine receptor type 7Add BLAST354

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi36N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi129 ↔ 210PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP32248.
PaxDbiP32248.
PeptideAtlasiP32248.
PRIDEiP32248.

PTM databases

iPTMnetiP32248.
PhosphoSitePlusiP32248.

Expressioni

Tissue specificityi

Expressed in various lymphoid tissues and activated B- and T-lymphocytes, strongly up-regulated in B-cells infected with Epstein-Barr virus and T-cells infected with herpesvirus 6 or 7.

Inductioni

By Epstein-Barr virus (EBV).

Gene expression databases

BgeeiENSG00000126353.
CleanExiHS_CCR7.
HS_EVI1.
ExpressionAtlasiP32248. baseline and differential.
GenevisibleiP32248. HS.

Organism-specific databases

HPAiCAB003796.

Interactioni

GO - Molecular functioni

  • chemokine (C-C motif) ligand 19 binding Source: BHF-UCL
  • chemokine (C-C motif) ligand 21 binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi107641. 2 interactors.
DIPiDIP-5855N.
IntActiP32248. 3 interactors.
MINTiMINT-1524010.
STRINGi9606.ENSP00000246657.

Chemistry databases

BindingDBiP32248.

Structurei

3D structure databases

ProteinModelPortaliP32248.
SMRiP32248.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IMBE. Eukaryota.
ENOG4110ZGY. LUCA.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP32248.
KOiK04182.
OMAiVMLTYIY.
OrthoDBiEOG091G0BDV.
PhylomeDBiP32248.
TreeFamiTF330966.

Family and domain databases

InterProiIPR001718. Chemokine_CCR7.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR00641. CHEMOKINER7.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P32248-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLGKPMKSV LVVALLVIFQ VCLCQDEVTD DYIGDNTTVD YTLFESLCSK
60 70 80 90 100
KDVRNFKAWF LPIMYSIICF VGLLGNGLVV LTYIYFKRLK TMTDTYLLNL
110 120 130 140 150
AVADILFLLT LPFWAYSAAK SWVFGVHFCK LIFAIYKMSF FSGMLLLLCI
160 170 180 190 200
SIDRYVAIVQ AVSAHRHRAR VLLISKLSCV GIWILATVLS IPELLYSDLQ
210 220 230 240 250
RSSSEQAMRC SLITEHVEAF ITIQVAQMVI GFLVPLLAMS FCYLVIIRTL
260 270 280 290 300
LQARNFERNK AIKVIIAVVV VFIVFQLPYN GVVLAQTVAN FNITSSTCEL
310 320 330 340 350
SKQLNIAYDV TYSLACVRCC VNPFLYAFIG VKFRNDLFKL FKDLGCLSQE
360 370
QLRQWSSCRH IRRSSMSVEA ETTTTFSP
Length:378
Mass (Da):42,874
Last modified:February 1, 1996 - v2
Checksum:iD4CB4213841A1BD4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti182 – 183IW → SA in AAA58615 (PubMed:8383238).Curated2
Sequence conflicti337L → I in AAA58615 (PubMed:8383238).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0493837M → V.Corresponds to variant rs45521932dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08176 mRNA. Translation: AAA58615.1.
L31584, L31582, L31583 Genomic DNA. Translation: AAA74230.1.
L31581 mRNA. Translation: AAA74231.1.
AY587876 mRNA. Translation: AAT52232.1.
BC035343 mRNA. Translation: AAH35343.1.
CCDSiCCDS11369.1.
PIRiA45680.
B55735.
RefSeqiNP_001288643.1. NM_001301714.1.
NP_001288645.1. NM_001301716.1.
NP_001288646.1. NM_001301717.1.
NP_001288647.1. NM_001301718.1.
NP_001829.1. NM_001838.3.
UniGeneiHs.370036.

Genome annotation databases

EnsembliENST00000246657; ENSP00000246657; ENSG00000126353.
GeneIDi1236.
KEGGihsa:1236.
UCSCiuc002huw.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

CC chemokine receptors entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08176 mRNA. Translation: AAA58615.1.
L31584, L31582, L31583 Genomic DNA. Translation: AAA74230.1.
L31581 mRNA. Translation: AAA74231.1.
AY587876 mRNA. Translation: AAT52232.1.
BC035343 mRNA. Translation: AAH35343.1.
CCDSiCCDS11369.1.
PIRiA45680.
B55735.
RefSeqiNP_001288643.1. NM_001301714.1.
NP_001288645.1. NM_001301716.1.
NP_001288646.1. NM_001301717.1.
NP_001288647.1. NM_001301718.1.
NP_001829.1. NM_001838.3.
UniGeneiHs.370036.

3D structure databases

ProteinModelPortaliP32248.
SMRiP32248.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107641. 2 interactors.
DIPiDIP-5855N.
IntActiP32248. 3 interactors.
MINTiMINT-1524010.
STRINGi9606.ENSP00000246657.

Chemistry databases

BindingDBiP32248.
ChEMBLiCHEMBL4594.
GuidetoPHARMACOLOGYi64.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP32248.
PhosphoSitePlusiP32248.

Polymorphism and mutation databases

BioMutaiCCR7.
DMDMi1352335.

Proteomic databases

MaxQBiP32248.
PaxDbiP32248.
PeptideAtlasiP32248.
PRIDEiP32248.

Protocols and materials databases

DNASUi1236.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000246657; ENSP00000246657; ENSG00000126353.
GeneIDi1236.
KEGGihsa:1236.
UCSCiuc002huw.4. human.

Organism-specific databases

CTDi1236.
DisGeNETi1236.
GeneCardsiCCR7.
HGNCiHGNC:1608. CCR7.
HPAiCAB003796.
MIMi600242. gene.
neXtProtiNX_P32248.
OpenTargetsiENSG00000126353.
PharmGKBiPA26172.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IMBE. Eukaryota.
ENOG4110ZGY. LUCA.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP32248.
KOiK04182.
OMAiVMLTYIY.
OrthoDBiEOG091G0BDV.
PhylomeDBiP32248.
TreeFamiTF330966.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000126353-MONOMER.
ReactomeiR-HSA-380108. Chemokine receptors bind chemokines.
R-HSA-418594. G alpha (i) signalling events.
SIGNORiP32248.

Miscellaneous databases

GeneWikiiC-C_chemokine_receptor_type_7.
GenomeRNAii1236.
PROiP32248.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000126353.
CleanExiHS_CCR7.
HS_EVI1.
ExpressionAtlasiP32248. baseline and differential.
GenevisibleiP32248. HS.

Family and domain databases

InterProiIPR001718. Chemokine_CCR7.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR00641. CHEMOKINER7.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCR7_HUMAN
AccessioniPrimary (citable) accession number: P32248
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: February 1, 1996
Last modified: November 2, 2016
This is version 163 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.