C-C chemokine receptor type 7 precursor

Contribute

Send feedback

Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot P32248 (CCR7_HUMAN)

Last modified November 3, 2009. Version 96. History...

Clusters with 100%, 90%, 50% identity |

Documents (7) |

Third-party data |

Customize display

text xml rdf/xml gff fasta

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein names

Recommended name:
    C-C chemokine receptor type 7
      Short name=C-C CKR-7
      Short name=CC-CKR-7
      Short name=CCR-7
Alternative name(s):
    MIP-3 beta receptor
    EBV-induced G-protein coupled receptor 1
      Short name=EBI1
    BLR2
    CDw197
    CD_antigen=CD197

Gene names

Name:	CCR7
Synonyms:	CMKBR7, EBI1, EVI1

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Hide | Top

Protein attributes

Sequence length	378 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

Hide | Top

General annotation (Comments)

Function	Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Expressed in various lymphoid tissues and activated B- and T-lymphocytes, strongly up-regulated in B-cells infected with Epstein-Barr virus and T-cells infected with herpesvirus 6 or 7.
Induction	By EBV.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Hide | Top

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Signal Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	G-protein coupled receptor protein signaling pathway Inferred from Experiment. Source: Reactome chemotaxis Traceable author statement. Source: ProtInc elevation of cytosolic calcium ion concentration Traceable author statement. Source: ProtInc inflammatory response Traceable author statement. Source: ProtInc
Cellular component	integral to plasma membrane Traceable author statement. Source: ProtInc
Molecular function	C-C chemokine receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Hide | Top

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 24

Potential

Chain

25 – 378

354

C-C chemokine receptor type 7

PRO_0000012735

Regions

Topological domain

25 – 59

Extracellular Potential

Transmembrane

60 – 86

1 Potential

Topological domain

87 – 95

Cytoplasmic Potential

Transmembrane

96 – 116

2 Potential

Topological domain

117 – 130

Extracellular Potential

Transmembrane

131 – 152

3 Potential

Topological domain

153 – 170

Cytoplasmic Potential

Transmembrane

171 – 191

4 Potential

Topological domain

192 – 219

Extracellular Potential

Transmembrane

220 – 247

5 Potential

Topological domain

248 – 263

Cytoplasmic Potential

Transmembrane

264 – 289

6 Potential

Topological domain

290 – 313

Extracellular Potential

Transmembrane

314 – 331

7 Potential

Topological domain

332 – 378

Cytoplasmic Potential

Amino acid modifications

Modified residue

151

Phosphoserine Ref.5

Glycosylation

N-linked (GlcNAc...) Potential

Disulfide bond

129 ↔ 210

By similarity

Natural variations

Natural variant

M → V: dbSNP rs45521932.

VAR_049383

Experimental info

Sequence conflict

182 – 183

IW → SA in AAA58615. Ref.1

Sequence conflict

337

L → I in AAA58615. Ref.1

Hide | Top

Sequences

Sequence

Length

Mass (Da)

Tools

P32248-1 [UniParc].

Last modified February 1, 1996. Version 2.
Checksum: D4CB4213841A1BD4
Show »

FASTA

378

42,874

        10         20         30         40         50         60 
MDLGKPMKSV LVVALLVIFQ VCLCQDEVTD DYIGDNTTVD YTLFESLCSK KDVRNFKAWF 

        70         80         90        100        110        120 
LPIMYSIICF VGLLGNGLVV LTYIYFKRLK TMTDTYLLNL AVADILFLLT LPFWAYSAAK 

       130        140        150        160        170        180 
SWVFGVHFCK LIFAIYKMSF FSGMLLLLCI SIDRYVAIVQ AVSAHRHRAR VLLISKLSCV 

       190        200        210        220        230        240 
GIWILATVLS IPELLYSDLQ RSSSEQAMRC SLITEHVEAF ITIQVAQMVI GFLVPLLAMS 

       250        260        270        280        290        300 
FCYLVIIRTL LQARNFERNK AIKVIIAVVV VFIVFQLPYN GVVLAQTVAN FNITSSTCEL 

       310        320        330        340        350        360 
SKQLNIAYDV TYSLACVRCC VNPFLYAFIG VKFRNDLFKL FKDLGCLSQE QLRQWSSCRH 

       370 
IRRSSMSVEA ETTTTFSP

« Hide

Hide | Top

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors." Birkenbach M.P., Josefsen K., Yalamanchili R.R., Lenoir G.M., Kieff E. J. Virol. 67:2209-2220(1993) [PubMed: 8383238] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Cloning of human and mouse EBI1, a lymphoid-specific G-protein-coupled receptor encoded on human chromosome 17q12-q21.2." Schweickart V.L., Raport C.J., Godiska R., Byers M.G., Eddy R.L. Jr., Shows T.B., Gray P.W. Genomics 23:643-650(1994) [PubMed: 7851893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Tissue: Placenta.
[3]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Kopatz S.A., Aronstam R.S., Sharma S.V. Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[5]	"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column." Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y. Anal. Sci. 24:161-166(2008) [PubMed: 18187866] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-151, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Hide | Top

Web resources

Wikipedia

CC chemokine receptors entry

Hide | Top

Cross-references

Sequence databases
	L08176 mRNA. Translation: AAA58615.1. L31584, L31582, L31583 Genomic DNA. Translation: AAA74230.1. L31581 mRNA. Translation: AAA74231.1. AY587876 mRNA. Translation: AAT52232.1. BC035343 mRNA. Translation: AAH35343.1.
IPI	IPI00027687.
PIR	A45680. B55735.
RefSeq	NP_001829.1.
UniGene	Hs.370036
3D structure databases
HSSP	HSSP built from PDB template 1DDD based on UniProtKB P34996.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:5855N.
STRING	P32248.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P32248.
Proteomic databases
PRIDE	P32248.
Genome annotation databases
Ensembl	ENST00000246657; ENSP00000246657; ENSG00000126353; Homo sapiens. [Genome view]
GeneID	1236.
KEGG	hsa:1236.
UCSC	uc002huw.1. human.
Organism-specific databases
CTD	1236.
GeneCards	GC17M035963.
H-InvDB	HIX0027171.
HGNC	HGNC:1608. CCR7.
HPA	CAB003796.
MIM	600242. gene.
PharmGKB	PA26172.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	P32248.
HOVERGEN	P32248.
OMA	GCLSQER.
Enzyme and pathway databases
Reactome	REACT_14797. Signaling by GPCR.
Gene expression databases
ArrayExpress	P32248.
Bgee	P32248.
CleanEx	HS_CCR7. HS_EVI1.
Genevestigator	P32248.
GermOnline	ENSG00000126353. Homo sapiens.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR001718. CC_7_rcpt. IPR000355. Chmkine_rcpt. IPR017452. GPCR_Rhodpsn_supfam. [Graphical view]
PANTHER	PTHR19264:SF209. CC_7_rcpt. 1 hit.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00657. CCCHEMOKINER. PR00641. CHEMOKINER7. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	5049.
SOURCE	Search...

Hide | Top

Entry information

Entry name

CCR7_HUMAN

Accession

Primary (citable) accession number: P32248

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
Last sequence update:	February 1, 1996
Last modified:	November 3, 2009
This is version 96 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Hide | Top