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P32248

- CCR7_HUMAN

UniProt

P32248 - CCR7_HUMAN

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Protein

C-C chemokine receptor type 7

Gene

CCR7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions.

GO - Molecular functioni

  1. C-C chemokine receptor activity Source: BHF-UCL
  2. C-C motif chemokine 19 receptor activity Source: UniProtKB
  3. C-C motif chemokine 21 receptor activity Source: UniProtKB
  4. chemokine (C-C motif) ligand 19 binding Source: BHF-UCL
  5. chemokine (C-C motif) ligand 21 binding Source: BHF-UCL
  6. G-protein coupled receptor activity Source: BHF-UCL

GO - Biological processi

  1. activation of Rho GTPase activity Source: BHF-UCL
  2. cellular response to cytokine stimulus Source: BHF-UCL
  3. chemokine (C-C motif) ligand 19 signaling pathway Source: GOC
  4. chemokine (C-C motif) ligand 21 signaling pathway Source: GOC
  5. chemokine-mediated signaling pathway Source: GOC
  6. dendritic cell chemotaxis Source: BHF-UCL
  7. establishment of T cell polarity Source: BHF-UCL
  8. G-protein coupled receptor signaling pathway Source: BHF-UCL
  9. immune response Source: Ensembl
  10. inflammatory response Source: BHF-UCL
  11. interleukin-12 secretion Source: BHF-UCL
  12. lymphocyte migration into lymph node Source: BHF-UCL
  13. mature dendritic cell differentiation Source: BHF-UCL
  14. myeloid dendritic cell chemotaxis Source: BHF-UCL
  15. negative regulation of leukocyte apoptotic process Source: BHF-UCL
  16. negative thymic T cell selection Source: Ensembl
  17. positive regulation of actin filament polymerization Source: BHF-UCL
  18. positive regulation of cell adhesion Source: BHF-UCL
  19. positive regulation of cell-matrix adhesion Source: BHF-UCL
  20. positive regulation of cell motility Source: BHF-UCL
  21. positive regulation of cytosolic calcium ion concentration Source: ProtInc
  22. positive regulation of dendritic cell antigen processing and presentation Source: BHF-UCL
  23. positive regulation of dendritic cell chemotaxis Source: BHF-UCL
  24. positive regulation of ERK1 and ERK2 cascade Source: BHF-UCL
  25. positive regulation of filopodium assembly Source: BHF-UCL
  26. positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation Source: BHF-UCL
  27. positive regulation of humoral immune response Source: BHF-UCL
  28. positive regulation of hypersensitivity Source: BHF-UCL
  29. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: BHF-UCL
  30. positive regulation of immunological synapse formation Source: BHF-UCL
  31. positive regulation of interleukin-12 production Source: BHF-UCL
  32. positive regulation of JNK cascade Source: BHF-UCL
  33. positive regulation of neutrophil chemotaxis Source: BHF-UCL
  34. positive regulation of phosphatidylinositol 3-kinase activity Source: BHF-UCL
  35. positive regulation of protein kinase activity Source: BHF-UCL
  36. positive regulation of protein kinase B signaling Source: BHF-UCL
  37. positive regulation of pseudopodium assembly Source: BHF-UCL
  38. positive regulation of T cell costimulation Source: BHF-UCL
  39. positive regulation of T cell receptor signaling pathway Source: Ensembl
  40. regulation of dendritic cell dendrite assembly Source: BHF-UCL
  41. regulation of interferon-gamma production Source: BHF-UCL
  42. regulation of interleukin-1 beta secretion Source: BHF-UCL
  43. release of sequestered calcium ion into cytosol Source: BHF-UCL
  44. response to lipopolysaccharide Source: Ensembl
  45. response to nitric oxide Source: BHF-UCL
  46. response to prostaglandin E Source: BHF-UCL
  47. ruffle organization Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_15344. Chemokine receptors bind chemokines.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C chemokine receptor type 7
Short name:
C-C CKR-7
Short name:
CC-CKR-7
Short name:
CCR-7
Alternative name(s):
BLR2
CDw197
Epstein-Barr virus-induced G-protein coupled receptor 1
Short name:
EBI1
Short name:
EBV-induced G-protein coupled receptor 1
MIP-3 beta receptor
CD_antigen: CD197
Gene namesi
Name:CCR7
Synonyms:CMKBR7, EBI1, EVI1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:1608. CCR7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 5935ExtracellularSequence AnalysisAdd
BLAST
Transmembranei60 – 8627Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini87 – 959CytoplasmicSequence Analysis
Transmembranei96 – 11621Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini117 – 13014ExtracellularSequence AnalysisAdd
BLAST
Transmembranei131 – 15222Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini153 – 17018CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei171 – 19121Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini192 – 21928ExtracellularSequence AnalysisAdd
BLAST
Transmembranei220 – 24728Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini248 – 26316CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei264 – 28926Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini290 – 31324ExtracellularSequence AnalysisAdd
BLAST
Transmembranei314 – 33118Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini332 – 37847CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: UniProtKB
  2. external side of plasma membrane Source: Ensembl
  3. integral component of membrane Source: UniProtKB-KW
  4. intracellular Source: BHF-UCL
  5. plasma membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26172.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 378354C-C chemokine receptor type 7PRO_0000012735Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi36 – 361N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi129 ↔ 210PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP32248.
PaxDbiP32248.
PRIDEiP32248.

PTM databases

PhosphoSiteiP32248.

Expressioni

Tissue specificityi

Expressed in various lymphoid tissues and activated B- and T-lymphocytes, strongly up-regulated in B-cells infected with Epstein-Barr virus and T-cells infected with herpesvirus 6 or 7.

Inductioni

By Epstein-Barr virus (EBV).

Gene expression databases

BgeeiP32248.
CleanExiHS_CCR7.
HS_EVI1.
ExpressionAtlasiP32248. baseline and differential.
GenevestigatoriP32248.

Organism-specific databases

HPAiCAB003796.

Interactioni

Protein-protein interaction databases

BioGridi107641. 2 interactions.
DIPiDIP-5855N.
IntActiP32248. 3 interactions.
MINTiMINT-1524010.
STRINGi9606.ENSP00000246657.

Structurei

3D structure databases

ProteinModelPortaliP32248.
SMRiP32248. Positions 52-341.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG149643.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP32248.
KOiK04182.
OMAiCFKKDVR.
OrthoDBiEOG79CXZN.
PhylomeDBiP32248.
TreeFamiTF330966.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR001718. Chemokine_CCR7.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PTHR24227:SF29. PTHR24227:SF29. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR00641. CHEMOKINER7.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P32248-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDLGKPMKSV LVVALLVIFQ VCLCQDEVTD DYIGDNTTVD YTLFESLCSK
60 70 80 90 100
KDVRNFKAWF LPIMYSIICF VGLLGNGLVV LTYIYFKRLK TMTDTYLLNL
110 120 130 140 150
AVADILFLLT LPFWAYSAAK SWVFGVHFCK LIFAIYKMSF FSGMLLLLCI
160 170 180 190 200
SIDRYVAIVQ AVSAHRHRAR VLLISKLSCV GIWILATVLS IPELLYSDLQ
210 220 230 240 250
RSSSEQAMRC SLITEHVEAF ITIQVAQMVI GFLVPLLAMS FCYLVIIRTL
260 270 280 290 300
LQARNFERNK AIKVIIAVVV VFIVFQLPYN GVVLAQTVAN FNITSSTCEL
310 320 330 340 350
SKQLNIAYDV TYSLACVRCC VNPFLYAFIG VKFRNDLFKL FKDLGCLSQE
360 370
QLRQWSSCRH IRRSSMSVEA ETTTTFSP
Length:378
Mass (Da):42,874
Last modified:February 1, 1996 - v2
Checksum:iD4CB4213841A1BD4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti182 – 1832IW → SA in AAA58615. (PubMed:8383238)Curated
Sequence conflicti337 – 3371L → I in AAA58615. (PubMed:8383238)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti7 – 71M → V.
Corresponds to variant rs45521932 [ dbSNP | Ensembl ].
VAR_049383

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08176 mRNA. Translation: AAA58615.1.
L31584, L31582, L31583 Genomic DNA. Translation: AAA74230.1.
L31581 mRNA. Translation: AAA74231.1.
AY587876 mRNA. Translation: AAT52232.1.
BC035343 mRNA. Translation: AAH35343.1.
CCDSiCCDS11369.1.
PIRiA45680.
B55735.
RefSeqiNP_001829.1. NM_001838.3.
UniGeneiHs.370036.

Genome annotation databases

EnsembliENST00000246657; ENSP00000246657; ENSG00000126353.
GeneIDi1236.
KEGGihsa:1236.
UCSCiuc002huw.3. human.

Polymorphism databases

DMDMi1352335.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

CC chemokine receptors entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08176 mRNA. Translation: AAA58615.1 .
L31584 , L31582 , L31583 Genomic DNA. Translation: AAA74230.1 .
L31581 mRNA. Translation: AAA74231.1 .
AY587876 mRNA. Translation: AAT52232.1 .
BC035343 mRNA. Translation: AAH35343.1 .
CCDSi CCDS11369.1.
PIRi A45680.
B55735.
RefSeqi NP_001829.1. NM_001838.3.
UniGenei Hs.370036.

3D structure databases

ProteinModelPortali P32248.
SMRi P32248. Positions 52-341.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107641. 2 interactions.
DIPi DIP-5855N.
IntActi P32248. 3 interactions.
MINTi MINT-1524010.
STRINGi 9606.ENSP00000246657.

Chemistry

BindingDBi P32248.
ChEMBLi CHEMBL4594.
GuidetoPHARMACOLOGYi 64.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P32248.

Polymorphism databases

DMDMi 1352335.

Proteomic databases

MaxQBi P32248.
PaxDbi P32248.
PRIDEi P32248.

Protocols and materials databases

DNASUi 1236.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000246657 ; ENSP00000246657 ; ENSG00000126353 .
GeneIDi 1236.
KEGGi hsa:1236.
UCSCi uc002huw.3. human.

Organism-specific databases

CTDi 1236.
GeneCardsi GC17M038710.
HGNCi HGNC:1608. CCR7.
HPAi CAB003796.
MIMi 600242. gene.
neXtProti NX_P32248.
PharmGKBi PA26172.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG149643.
GeneTreei ENSGT00760000118785.
HOGENOMi HOG000234122.
HOVERGENi HBG106917.
InParanoidi P32248.
KOi K04182.
OMAi CFKKDVR.
OrthoDBi EOG79CXZN.
PhylomeDBi P32248.
TreeFami TF330966.

Enzyme and pathway databases

Reactomei REACT_15344. Chemokine receptors bind chemokines.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikii C-C_chemokine_receptor_type_7.
GenomeRNAii 1236.
NextBioi 5049.
PROi P32248.
SOURCEi Search...

Gene expression databases

Bgeei P32248.
CleanExi HS_CCR7.
HS_EVI1.
ExpressionAtlasi P32248. baseline and differential.
Genevestigatori P32248.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR001718. Chemokine_CCR7.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24227. PTHR24227. 1 hit.
PTHR24227:SF29. PTHR24227:SF29. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00657. CCCHEMOKINER.
PR00641. CHEMOKINER7.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors."
    Birkenbach M.P., Josefsen K., Yalamanchili R.R., Lenoir G.M., Kieff E.
    J. Virol. 67:2209-2220(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning of human and mouse EBI1, a lymphoid-specific G-protein-coupled receptor encoded on human chromosome 17q12-q21.2."
    Schweickart V.L., Raport C.J., Godiska R., Byers M.G., Eddy R.L. Jr., Shows T.B., Gray P.W.
    Genomics 23:643-650(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Tissue: Placenta.
  3. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Kopatz S.A., Aronstam R.S., Sharma S.V.
    Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiCCR7_HUMAN
AccessioniPrimary (citable) accession number: P32248
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: February 1, 1996
Last modified: October 29, 2014
This is version 146 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3