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P32248 (CCR7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 143. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-C chemokine receptor type 7

Short name=C-C CKR-7
Short name=CC-CKR-7
Short name=CCR-7
Alternative name(s):
BLR2
CDw197
Epstein-Barr virus-induced G-protein coupled receptor 1
Short name=EBI1
Short name=EBV-induced G-protein coupled receptor 1
MIP-3 beta receptor
CD_antigen=CD197
Gene names
Name:CCR7
Synonyms:CMKBR7, EBI1, EVI1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length378 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in various lymphoid tissues and activated B- and T-lymphocytes, strongly up-regulated in B-cells infected with Epstein-Barr virus and T-cells infected with herpesvirus 6 or 7.

Induction

By Epstein-Barr virus (EBV).

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   Coding sequence diversityPolymorphism
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor signaling pathway

Traceable author statement PubMed 16621978. Source: BHF-UCL

activation of Rho GTPase activity

Inferred by curator PubMed 15778365. Source: BHF-UCL

chemokine (C-C motif) ligand 19 signaling pathway

Inferred from direct assay PubMed 9507024. Source: GOC

chemokine (C-C motif) ligand 21 signaling pathway

Inferred from direct assay PubMed 9507024. Source: GOC

chemokine-mediated signaling pathway

Inferred from sequence or structural similarity. Source: GOC

dendritic cell chemotaxis

Inferred by curator PubMed 15778365. Source: BHF-UCL

establishment of T cell polarity

Inferred by curator PubMed 12729902. Source: BHF-UCL

immune response

Inferred from electronic annotation. Source: Ensembl

inflammatory response

Non-traceable author statement PubMed 14592837. Source: BHF-UCL

interleukin-12 secretion

Inferred from sequence or structural similarity. Source: BHF-UCL

lymphocyte migration into lymph node

Traceable author statement PubMed 18379575. Source: BHF-UCL

mature dendritic cell differentiation

Inferred from sequence or structural similarity. Source: BHF-UCL

myeloid dendritic cell chemotaxis

Inferred by curator. Source: BHF-UCL

negative regulation of leukocyte apoptotic process

Inferred by curator PubMed 15059845. Source: BHF-UCL

negative thymic T cell selection

Inferred from electronic annotation. Source: Ensembl

positive regulation of ERK1 and ERK2 cascade

Inferred by curator PubMed 12729902PubMed 15778365. Source: BHF-UCL

positive regulation of I-kappaB kinase/NF-kappaB signaling

Inferred by curator PubMed 15059845. Source: BHF-UCL

positive regulation of JNK cascade

Inferred by curator PubMed 15778365. Source: BHF-UCL

positive regulation of T cell costimulation

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of T cell receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

positive regulation of actin filament polymerization

Inferred by curator PubMed 11242036. Source: BHF-UCL

positive regulation of cell adhesion

Inferred by curator PubMed 15569314. Source: BHF-UCL

positive regulation of cell motility

Inferred by curator PubMed 15778365. Source: BHF-UCL

positive regulation of cell-matrix adhesion

Inferred by curator PubMed 15569314. Source: BHF-UCL

positive regulation of cytosolic calcium ion concentration

Traceable author statement PubMed 9153236. Source: ProtInc

positive regulation of dendritic cell antigen processing and presentation

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of dendritic cell chemotaxis

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of filopodium assembly

Inferred by curator PubMed 15569314. Source: BHF-UCL

positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of humoral immune response

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of hypersensitivity

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of immunological synapse formation

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of interleukin-12 production

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of neutrophil chemotaxis

Inferred from direct assay PubMed 21051556. Source: BHF-UCL

positive regulation of phosphatidylinositol 3-kinase activity

Inferred by curator PubMed 15059845PubMed 15778365. Source: BHF-UCL

positive regulation of protein kinase B signaling

Inferred by curator PubMed 15059845PubMed 15778365. Source: BHF-UCL

positive regulation of protein kinase activity

Inferred by curator PubMed 14592837PubMed 15059845. Source: BHF-UCL

positive regulation of pseudopodium assembly

Inferred by curator PubMed 11242036. Source: BHF-UCL

regulation of dendritic cell dendrite assembly

Inferred from sequence or structural similarity. Source: BHF-UCL

regulation of interferon-gamma production

Inferred from sequence or structural similarity. Source: BHF-UCL

regulation of interleukin-1 beta secretion

Inferred from sequence or structural similarity. Source: BHF-UCL

release of sequestered calcium ion into cytosol

Inferred by curator PubMed 14592837. Source: BHF-UCL

response to lipopolysaccharide

Inferred from electronic annotation. Source: Ensembl

response to nitric oxide

Inferred by curator PubMed 16249377. Source: BHF-UCL

response to prostaglandin E

Inferred by curator PubMed 14592837. Source: BHF-UCL

ruffle organization

Inferred by curator PubMed 15569314. Source: BHF-UCL

   Cellular_componentexternal side of plasma membrane

Inferred from electronic annotation. Source: Ensembl

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

intracellular

Inferred from direct assay PubMed 21051556. Source: BHF-UCL

plasma membrane

Inferred from direct assay PubMed 21051556. Source: BHF-UCL

   Molecular_functionC-C chemokine receptor activity

Inferred from sequence or structural similarity. Source: BHF-UCL

C-C motif chemokine 19 receptor activity

Inferred from direct assay PubMed 9507024. Source: UniProtKB

C-C motif chemokine 21 receptor activity

Inferred from direct assay PubMed 9507024. Source: UniProtKB

G-protein coupled receptor activity

Traceable author statement PubMed 16621978. Source: BHF-UCL

chemokine (C-C motif) ligand 19 binding

Inferred from physical interaction PubMed 9507024. Source: BHF-UCL

chemokine (C-C motif) ligand 21 binding

Inferred from physical interaction PubMed 9507024. Source: BHF-UCL

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 378354C-C chemokine receptor type 7
PRO_0000012735

Regions

Topological domain25 – 5935Extracellular Potential
Transmembrane60 – 8627Helical; Name=1; Potential
Topological domain87 – 959Cytoplasmic Potential
Transmembrane96 – 11621Helical; Name=2; Potential
Topological domain117 – 13014Extracellular Potential
Transmembrane131 – 15222Helical; Name=3; Potential
Topological domain153 – 17018Cytoplasmic Potential
Transmembrane171 – 19121Helical; Name=4; Potential
Topological domain192 – 21928Extracellular Potential
Transmembrane220 – 24728Helical; Name=5; Potential
Topological domain248 – 26316Cytoplasmic Potential
Transmembrane264 – 28926Helical; Name=6; Potential
Topological domain290 – 31324Extracellular Potential
Transmembrane314 – 33118Helical; Name=7; Potential
Topological domain332 – 37847Cytoplasmic Potential

Amino acid modifications

Glycosylation361N-linked (GlcNAc...) Potential
Disulfide bond129 ↔ 210 By similarity

Natural variations

Natural variant71M → V.
Corresponds to variant rs45521932 [ dbSNP | Ensembl ].
VAR_049383

Experimental info

Sequence conflict182 – 1832IW → SA in AAA58615. Ref.1
Sequence conflict3371L → I in AAA58615. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P32248 [UniParc].

Last modified February 1, 1996. Version 2.
Checksum: D4CB4213841A1BD4

FASTA37842,874
        10         20         30         40         50         60 
MDLGKPMKSV LVVALLVIFQ VCLCQDEVTD DYIGDNTTVD YTLFESLCSK KDVRNFKAWF 

        70         80         90        100        110        120 
LPIMYSIICF VGLLGNGLVV LTYIYFKRLK TMTDTYLLNL AVADILFLLT LPFWAYSAAK 

       130        140        150        160        170        180 
SWVFGVHFCK LIFAIYKMSF FSGMLLLLCI SIDRYVAIVQ AVSAHRHRAR VLLISKLSCV 

       190        200        210        220        230        240 
GIWILATVLS IPELLYSDLQ RSSSEQAMRC SLITEHVEAF ITIQVAQMVI GFLVPLLAMS 

       250        260        270        280        290        300 
FCYLVIIRTL LQARNFERNK AIKVIIAVVV VFIVFQLPYN GVVLAQTVAN FNITSSTCEL 

       310        320        330        340        350        360 
SKQLNIAYDV TYSLACVRCC VNPFLYAFIG VKFRNDLFKL FKDLGCLSQE QLRQWSSCRH 

       370 
IRRSSMSVEA ETTTTFSP 

« Hide

References

« Hide 'large scale' references
[1]"Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors."
Birkenbach M.P., Josefsen K., Yalamanchili R.R., Lenoir G.M., Kieff E.
J. Virol. 67:2209-2220(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Cloning of human and mouse EBI1, a lymphoid-specific G-protein-coupled receptor encoded on human chromosome 17q12-q21.2."
Schweickart V.L., Raport C.J., Godiska R., Byers M.G., Eddy R.L. Jr., Shows T.B., Gray P.W.
Genomics 23:643-650(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Tissue: Placenta.
[3]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Kopatz S.A., Aronstam R.S., Sharma S.V.
Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Web resources

Wikipedia

CC chemokine receptors entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L08176 mRNA. Translation: AAA58615.1.
L31584, L31582, L31583 Genomic DNA. Translation: AAA74230.1.
L31581 mRNA. Translation: AAA74231.1.
AY587876 mRNA. Translation: AAT52232.1.
BC035343 mRNA. Translation: AAH35343.1.
CCDSCCDS11369.1.
PIRA45680.
B55735.
RefSeqNP_001829.1. NM_001838.3.
UniGeneHs.370036.

3D structure databases

ProteinModelPortalP32248.
SMRP32248. Positions 52-341.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107641. 1 interaction.
DIPDIP-5855N.
IntActP32248. 3 interactions.
MINTMINT-1524010.
STRING9606.ENSP00000246657.

Chemistry

BindingDBP32248.
ChEMBLCHEMBL4594.
GuidetoPHARMACOLOGY64.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP32248.

Polymorphism databases

DMDM1352335.

Proteomic databases

MaxQBP32248.
PaxDbP32248.
PRIDEP32248.

Protocols and materials databases

DNASU1236.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000246657; ENSP00000246657; ENSG00000126353.
GeneID1236.
KEGGhsa:1236.
UCSCuc002huw.3. human.

Organism-specific databases

CTD1236.
GeneCardsGC17M038710.
HGNCHGNC:1608. CCR7.
HPACAB003796.
MIM600242. gene.
neXtProtNX_P32248.
PharmGKBPA26172.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG149643.
HOGENOMHOG000234122.
HOVERGENHBG106917.
InParanoidP32248.
KOK04182.
OMACFKKDVR.
OrthoDBEOG79CXZN.
PhylomeDBP32248.
TreeFamTF330966.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressP32248.
BgeeP32248.
CleanExHS_CCR7.
HS_EVI1.
GenevestigatorP32248.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR001718. Chemokine_CCR7.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERPTHR24227. PTHR24227. 1 hit.
PTHR24227:SF29. PTHR24227:SF29. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00657. CCCHEMOKINER.
PR00641. CHEMOKINER7.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiC-C_chemokine_receptor_type_7.
GenomeRNAi1236.
NextBio5049.
PROP32248.
SOURCESearch...

Entry information

Entry nameCCR7_HUMAN
AccessionPrimary (citable) accession number: P32248
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: February 1, 1996
Last modified: July 9, 2014
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries