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P32248

- CCR7_HUMAN

UniProt

P32248 - CCR7_HUMAN

Protein

C-C chemokine receptor type 7

Gene

CCR7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 145 (01 Oct 2014)
      Sequence version 2 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions.

    GO - Molecular functioni

    1. C-C chemokine receptor activity Source: BHF-UCL
    2. C-C motif chemokine 19 receptor activity Source: UniProtKB
    3. C-C motif chemokine 21 receptor activity Source: UniProtKB
    4. chemokine (C-C motif) ligand 19 binding Source: BHF-UCL
    5. chemokine (C-C motif) ligand 21 binding Source: BHF-UCL
    6. G-protein coupled receptor activity Source: BHF-UCL

    GO - Biological processi

    1. activation of Rho GTPase activity Source: BHF-UCL
    2. cellular response to cytokine stimulus Source: BHF-UCL
    3. chemokine (C-C motif) ligand 19 signaling pathway Source: GOC
    4. chemokine (C-C motif) ligand 21 signaling pathway Source: GOC
    5. chemokine-mediated signaling pathway Source: GOC
    6. dendritic cell chemotaxis Source: BHF-UCL
    7. establishment of T cell polarity Source: BHF-UCL
    8. G-protein coupled receptor signaling pathway Source: BHF-UCL
    9. immune response Source: Ensembl
    10. inflammatory response Source: BHF-UCL
    11. interleukin-12 secretion Source: BHF-UCL
    12. lymphocyte migration into lymph node Source: BHF-UCL
    13. mature dendritic cell differentiation Source: BHF-UCL
    14. myeloid dendritic cell chemotaxis Source: BHF-UCL
    15. negative regulation of leukocyte apoptotic process Source: BHF-UCL
    16. negative thymic T cell selection Source: Ensembl
    17. positive regulation of actin filament polymerization Source: BHF-UCL
    18. positive regulation of cell adhesion Source: BHF-UCL
    19. positive regulation of cell-matrix adhesion Source: BHF-UCL
    20. positive regulation of cell motility Source: BHF-UCL
    21. positive regulation of cytosolic calcium ion concentration Source: ProtInc
    22. positive regulation of dendritic cell antigen processing and presentation Source: BHF-UCL
    23. positive regulation of dendritic cell chemotaxis Source: BHF-UCL
    24. positive regulation of ERK1 and ERK2 cascade Source: BHF-UCL
    25. positive regulation of filopodium assembly Source: BHF-UCL
    26. positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation Source: BHF-UCL
    27. positive regulation of humoral immune response Source: BHF-UCL
    28. positive regulation of hypersensitivity Source: BHF-UCL
    29. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: BHF-UCL
    30. positive regulation of immunological synapse formation Source: BHF-UCL
    31. positive regulation of interleukin-12 production Source: BHF-UCL
    32. positive regulation of JNK cascade Source: BHF-UCL
    33. positive regulation of neutrophil chemotaxis Source: BHF-UCL
    34. positive regulation of phosphatidylinositol 3-kinase activity Source: BHF-UCL
    35. positive regulation of protein kinase activity Source: BHF-UCL
    36. positive regulation of protein kinase B signaling Source: BHF-UCL
    37. positive regulation of pseudopodium assembly Source: BHF-UCL
    38. positive regulation of T cell costimulation Source: BHF-UCL
    39. positive regulation of T cell receptor signaling pathway Source: Ensembl
    40. regulation of dendritic cell dendrite assembly Source: BHF-UCL
    41. regulation of interferon-gamma production Source: BHF-UCL
    42. regulation of interleukin-1 beta secretion Source: BHF-UCL
    43. release of sequestered calcium ion into cytosol Source: BHF-UCL
    44. response to lipopolysaccharide Source: Ensembl
    45. response to nitric oxide Source: BHF-UCL
    46. response to prostaglandin E Source: BHF-UCL
    47. ruffle organization Source: BHF-UCL

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_15344. Chemokine receptors bind chemokines.
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C chemokine receptor type 7
    Short name:
    C-C CKR-7
    Short name:
    CC-CKR-7
    Short name:
    CCR-7
    Alternative name(s):
    BLR2
    CDw197
    Epstein-Barr virus-induced G-protein coupled receptor 1
    Short name:
    EBI1
    Short name:
    EBV-induced G-protein coupled receptor 1
    MIP-3 beta receptor
    CD_antigen: CD197
    Gene namesi
    Name:CCR7
    Synonyms:CMKBR7, EBI1, EVI1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:1608. CCR7.

    Subcellular locationi

    GO - Cellular componenti

    1. external side of plasma membrane Source: Ensembl
    2. integral component of membrane Source: UniProtKB-KW
    3. intracellular Source: BHF-UCL
    4. plasma membrane Source: BHF-UCL

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26172.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 378354C-C chemokine receptor type 7PRO_0000012735Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi36 – 361N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi129 ↔ 210PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiP32248.
    PaxDbiP32248.
    PRIDEiP32248.

    PTM databases

    PhosphoSiteiP32248.

    Expressioni

    Tissue specificityi

    Expressed in various lymphoid tissues and activated B- and T-lymphocytes, strongly up-regulated in B-cells infected with Epstein-Barr virus and T-cells infected with herpesvirus 6 or 7.

    Inductioni

    By Epstein-Barr virus (EBV).

    Gene expression databases

    ArrayExpressiP32248.
    BgeeiP32248.
    CleanExiHS_CCR7.
    HS_EVI1.
    GenevestigatoriP32248.

    Organism-specific databases

    HPAiCAB003796.

    Interactioni

    Protein-protein interaction databases

    BioGridi107641. 1 interaction.
    DIPiDIP-5855N.
    IntActiP32248. 3 interactions.
    MINTiMINT-1524010.
    STRINGi9606.ENSP00000246657.

    Structurei

    3D structure databases

    ProteinModelPortaliP32248.
    SMRiP32248. Positions 52-341.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini25 – 5935ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini87 – 959CytoplasmicSequence Analysis
    Topological domaini117 – 13014ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini153 – 17018CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini192 – 21928ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini248 – 26316CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini290 – 31324ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini332 – 37847CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei60 – 8627Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei96 – 11621Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei131 – 15222Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei171 – 19121Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei220 – 24728Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei264 – 28926Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei314 – 33118Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG149643.
    HOGENOMiHOG000234122.
    HOVERGENiHBG106917.
    InParanoidiP32248.
    KOiK04182.
    OMAiCFKKDVR.
    OrthoDBiEOG79CXZN.
    PhylomeDBiP32248.
    TreeFamiTF330966.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR001718. Chemokine_CCR7.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24227. PTHR24227. 1 hit.
    PTHR24227:SF29. PTHR24227:SF29. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00657. CCCHEMOKINER.
    PR00641. CHEMOKINER7.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P32248-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDLGKPMKSV LVVALLVIFQ VCLCQDEVTD DYIGDNTTVD YTLFESLCSK    50
    KDVRNFKAWF LPIMYSIICF VGLLGNGLVV LTYIYFKRLK TMTDTYLLNL 100
    AVADILFLLT LPFWAYSAAK SWVFGVHFCK LIFAIYKMSF FSGMLLLLCI 150
    SIDRYVAIVQ AVSAHRHRAR VLLISKLSCV GIWILATVLS IPELLYSDLQ 200
    RSSSEQAMRC SLITEHVEAF ITIQVAQMVI GFLVPLLAMS FCYLVIIRTL 250
    LQARNFERNK AIKVIIAVVV VFIVFQLPYN GVVLAQTVAN FNITSSTCEL 300
    SKQLNIAYDV TYSLACVRCC VNPFLYAFIG VKFRNDLFKL FKDLGCLSQE 350
    QLRQWSSCRH IRRSSMSVEA ETTTTFSP 378
    Length:378
    Mass (Da):42,874
    Last modified:February 1, 1996 - v2
    Checksum:iD4CB4213841A1BD4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti182 – 1832IW → SA in AAA58615. (PubMed:8383238)Curated
    Sequence conflicti337 – 3371L → I in AAA58615. (PubMed:8383238)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti7 – 71M → V.
    Corresponds to variant rs45521932 [ dbSNP | Ensembl ].
    VAR_049383

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L08176 mRNA. Translation: AAA58615.1.
    L31584, L31582, L31583 Genomic DNA. Translation: AAA74230.1.
    L31581 mRNA. Translation: AAA74231.1.
    AY587876 mRNA. Translation: AAT52232.1.
    BC035343 mRNA. Translation: AAH35343.1.
    CCDSiCCDS11369.1.
    PIRiA45680.
    B55735.
    RefSeqiNP_001829.1. NM_001838.3.
    UniGeneiHs.370036.

    Genome annotation databases

    EnsembliENST00000246657; ENSP00000246657; ENSG00000126353.
    GeneIDi1236.
    KEGGihsa:1236.
    UCSCiuc002huw.3. human.

    Polymorphism databases

    DMDMi1352335.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    CC chemokine receptors entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L08176 mRNA. Translation: AAA58615.1 .
    L31584 , L31582 , L31583 Genomic DNA. Translation: AAA74230.1 .
    L31581 mRNA. Translation: AAA74231.1 .
    AY587876 mRNA. Translation: AAT52232.1 .
    BC035343 mRNA. Translation: AAH35343.1 .
    CCDSi CCDS11369.1.
    PIRi A45680.
    B55735.
    RefSeqi NP_001829.1. NM_001838.3.
    UniGenei Hs.370036.

    3D structure databases

    ProteinModelPortali P32248.
    SMRi P32248. Positions 52-341.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107641. 1 interaction.
    DIPi DIP-5855N.
    IntActi P32248. 3 interactions.
    MINTi MINT-1524010.
    STRINGi 9606.ENSP00000246657.

    Chemistry

    BindingDBi P32248.
    ChEMBLi CHEMBL4594.
    GuidetoPHARMACOLOGYi 64.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P32248.

    Polymorphism databases

    DMDMi 1352335.

    Proteomic databases

    MaxQBi P32248.
    PaxDbi P32248.
    PRIDEi P32248.

    Protocols and materials databases

    DNASUi 1236.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000246657 ; ENSP00000246657 ; ENSG00000126353 .
    GeneIDi 1236.
    KEGGi hsa:1236.
    UCSCi uc002huw.3. human.

    Organism-specific databases

    CTDi 1236.
    GeneCardsi GC17M038710.
    HGNCi HGNC:1608. CCR7.
    HPAi CAB003796.
    MIMi 600242. gene.
    neXtProti NX_P32248.
    PharmGKBi PA26172.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG149643.
    HOGENOMi HOG000234122.
    HOVERGENi HBG106917.
    InParanoidi P32248.
    KOi K04182.
    OMAi CFKKDVR.
    OrthoDBi EOG79CXZN.
    PhylomeDBi P32248.
    TreeFami TF330966.

    Enzyme and pathway databases

    Reactomei REACT_15344. Chemokine receptors bind chemokines.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GeneWikii C-C_chemokine_receptor_type_7.
    GenomeRNAii 1236.
    NextBioi 5049.
    PROi P32248.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P32248.
    Bgeei P32248.
    CleanExi HS_CCR7.
    HS_EVI1.
    Genevestigatori P32248.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR001718. Chemokine_CCR7.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24227. PTHR24227. 1 hit.
    PTHR24227:SF29. PTHR24227:SF29. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00657. CCCHEMOKINER.
    PR00641. CHEMOKINER7.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors."
      Birkenbach M.P., Josefsen K., Yalamanchili R.R., Lenoir G.M., Kieff E.
      J. Virol. 67:2209-2220(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Cloning of human and mouse EBI1, a lymphoid-specific G-protein-coupled receptor encoded on human chromosome 17q12-q21.2."
      Schweickart V.L., Raport C.J., Godiska R., Byers M.G., Eddy R.L. Jr., Shows T.B., Gray P.W.
      Genomics 23:643-650(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Tissue: Placenta.
    3. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Kopatz S.A., Aronstam R.S., Sharma S.V.
      Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiCCR7_HUMAN
    AccessioniPrimary (citable) accession number: P32248
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 145 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    3. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    4. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    5. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    6. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3