Skip Header

 
Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot P32248 (CCR7_HUMAN)

Last modified November 3, 2009. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    C-C chemokine receptor type 7
      Short name=C-C CKR-7
      Short name=CC-CKR-7
      Short name=CCR-7
Alternative name(s):
    MIP-3 beta receptor
    EBV-induced G-protein coupled receptor 1
      Short name=EBI1
    BLR2
    CDw197
    CD_antigen=CD197
Gene names
Name: CCR7
Synonyms: CMKBR7, EBI1, EVI1
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length378 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in various lymphoid tissues and activated B- and T-lymphocytes, strongly up-regulated in B-cells infected with Epstein-Barr virus and T-cells infected with herpesvirus 6 or 7.

Induction

By EBV.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 378354C-C chemokine receptor type 7
PRO_0000012735

Regions

Topological domain25 – 5935Extracellular Potential
Transmembrane60 – 86271 Potential
Topological domain87 – 959Cytoplasmic Potential
Transmembrane96 – 116212 Potential
Topological domain117 – 13014Extracellular Potential
Transmembrane131 – 152223 Potential
Topological domain153 – 17018Cytoplasmic Potential
Transmembrane171 – 191214 Potential
Topological domain192 – 21928Extracellular Potential
Transmembrane220 – 247285 Potential
Topological domain248 – 26316Cytoplasmic Potential
Transmembrane264 – 289266 Potential
Topological domain290 – 31324Extracellular Potential
Transmembrane314 – 331187 Potential
Topological domain332 – 37847Cytoplasmic Potential

Amino acid modifications

Modified residue1511Phosphoserine Ref.5
Glycosylation361N-linked (GlcNAc...) Potential
Disulfide bond129 ↔ 210 By similarity

Natural variations

Natural variant71M → V: dbSNP rs45521932.
VAR_049383

Experimental info

Sequence conflict182 – 1832IW → SA in AAA58615. Ref.1
Sequence conflict3371L → I in AAA58615. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P32248-1 [UniParc].

Last modified February 1, 1996. Version 2.
Checksum: D4CB4213841A1BD4

FASTA37842,874
        10         20         30         40         50         60 
MDLGKPMKSV LVVALLVIFQ VCLCQDEVTD DYIGDNTTVD YTLFESLCSK KDVRNFKAWF 

        70         80         90        100        110        120 
LPIMYSIICF VGLLGNGLVV LTYIYFKRLK TMTDTYLLNL AVADILFLLT LPFWAYSAAK 

       130        140        150        160        170        180 
SWVFGVHFCK LIFAIYKMSF FSGMLLLLCI SIDRYVAIVQ AVSAHRHRAR VLLISKLSCV 

       190        200        210        220        230        240 
GIWILATVLS IPELLYSDLQ RSSSEQAMRC SLITEHVEAF ITIQVAQMVI GFLVPLLAMS 

       250        260        270        280        290        300 
FCYLVIIRTL LQARNFERNK AIKVIIAVVV VFIVFQLPYN GVVLAQTVAN FNITSSTCEL 

       310        320        330        340        350        360 
SKQLNIAYDV TYSLACVRCC VNPFLYAFIG VKFRNDLFKL FKDLGCLSQE QLRQWSSCRH 

       370 
IRRSSMSVEA ETTTTFSP 

« Hide

References

« Hide 'large scale' references
[1]"Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors."
Birkenbach M.P., Josefsen K., Yalamanchili R.R., Lenoir G.M., Kieff E.
J. Virol. 67:2209-2220(1993) [PubMed: 8383238] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Cloning of human and mouse EBI1, a lymphoid-specific G-protein-coupled receptor encoded on human chromosome 17q12-q21.2."
Schweickart V.L., Raport C.J., Godiska R., Byers M.G., Eddy R.L. Jr., Shows T.B., Gray P.W.
Genomics 23:643-650(1994) [PubMed: 7851893] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Tissue: Placenta.
[3]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Kopatz S.A., Aronstam R.S., Sharma S.V.
Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[5]"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column."
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.
Anal. Sci. 24:161-166(2008) [PubMed: 18187866] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-151, MASS SPECTROMETRY.
+Additional computationally mapped references.

Web resources

Wikipedia

CC chemokine receptors entry

Cross-references

Sequence databases

L08176 mRNA. Translation: AAA58615.1.
L31584, L31582, L31583 Genomic DNA. Translation: AAA74230.1.
L31581 mRNA. Translation: AAA74231.1.
AY587876 mRNA. Translation: AAT52232.1.
BC035343 mRNA. Translation: AAH35343.1.
IPIIPI00027687.
PIRA45680.
B55735.
RefSeqNP_001829.1.
UniGeneHs.370036

3D structure databases

HSSPHSSP built from PDB template 1DDD based on UniProtKB P34996.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP:5855N.
STRINGP32248.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP32248.

Proteomic databases

PRIDEP32248.

Genome annotation databases

EnsemblENST00000246657; ENSP00000246657; ENSG00000126353; Homo sapiens. [Genome view]
GeneID1236.
KEGGhsa:1236.
UCSCuc002huw.1. human.

Organism-specific databases

CTD1236.
GeneCardsGC17M035963.
H-InvDBHIX0027171.
HGNCHGNC:1608. CCR7.
HPACAB003796.
MIM600242. gene.
PharmGKBPA26172.
GenAtlasSearch...

Phylogenomic databases

HOGENOMP32248.
HOVERGENP32248.
OMAGCLSQER.

Enzyme and pathway databases

ReactomeREACT_14797. Signaling by GPCR.

Gene expression databases

ArrayExpressP32248.
BgeeP32248.
CleanExHS_CCR7.
HS_EVI1.
GenevestigatorP32248.
GermOnlineENSG00000126353. Homo sapiens.

Family and domain databases

InterProIPR000276. 7TM_GPCR_Rhodpsn.
IPR001718. CC_7_rcpt.
IPR000355. Chmkine_rcpt.
IPR017452. GPCR_Rhodpsn_supfam.
[Graphical view]
PANTHERPTHR19264:SF209. CC_7_rcpt. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00657. CCCHEMOKINER.
PR00641. CHEMOKINER7.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio5049.
SOURCESearch...

Entry information

Entry nameCCR7_HUMAN
AccessionPrimary (citable) accession number: P32248
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: February 1, 1996
Last modified: November 3, 2009
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents