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P32247

- BRS3_HUMAN

UniProt

P32247 - BRS3_HUMAN

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Protein

Bombesin receptor subtype-3

Gene

BRS3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

  1. bombesin receptor activity Source: ProtInc

GO - Biological processi

  1. adult feeding behavior Source: ProtInc
  2. glucose metabolic process Source: ProtInc
  3. regulation of blood pressure Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Bombesin receptor subtype-3
Short name:
BRS-3
Gene namesi
Name:BRS3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:1113. BRS3.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: ProtInc
  2. neuronal cell body Source: Ensembl
  3. neuron projection Source: Ensembl
  4. plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25427.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 399399Bombesin receptor subtype-3PRO_0000069196Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi10 – 101N-linked (GlcNAc...)Sequence Analysis
Glycosylationi18 – 181N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi120 ↔ 203PROSITE-ProRule annotation
Lipidationi347 – 3471S-palmitoyl cysteineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP32247.
PeptideAtlasiP32247.
PRIDEiP32247.

PTM databases

PhosphoSiteiP32247.

Expressioni

Tissue specificityi

In germ cells in testis. Lung carcinoma cells.

Gene expression databases

BgeeiP32247.
CleanExiHS_BRS3.
GenevestigatoriP32247.

Organism-specific databases

HPAiHPA003626.

Interactioni

Subunit structurei

Interacts with C6orf89.1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000359682.

Structurei

3D structure databases

ProteinModelPortaliP32247.
SMRiP32247. Positions 50-342.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4141ExtracellularSequence AnalysisAdd
BLAST
Topological domaini64 – 8219CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini104 – 12118ExtracellularSequence AnalysisAdd
BLAST
Topological domaini144 – 16320CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini185 – 22036ExtracellularSequence AnalysisAdd
BLAST
Topological domaini242 – 27231CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini294 – 31320ExtracellularSequence AnalysisAdd
BLAST
Topological domaini334 – 39966CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei42 – 6322Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei83 – 10321Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei122 – 14322Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei164 – 18421Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei221 – 24121Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei273 – 29321Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei314 – 33320Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG260553.
GeneTreeiENSGT00760000119177.
HOGENOMiHOG000230781.
HOVERGENiHBG004898.
InParanoidiP32247.
KOiK04170.
OMAiSKTFQKH.
OrthoDBiEOG73V6KG.
PhylomeDBiP32247.
TreeFamiTF331292.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR001560. Bombesin_rcpt_3.
IPR001556. Bombsn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00637. BOMBESIN3R.
PR00358. BOMBESINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32247-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAQRQPHSPN QTLISITNDT ESSSSVVSND NTNKGWSGDN SPGIEALCAI
60 70 80 90 100
YITYAVIISV GILGNAILIK VFFKTKSMQT VPNIFITSLA FGDLLLLLTC
110 120 130 140 150
VPVDATHYLA EGWLFGRIGC KVLSFIRLTS VGVSVFTLTI LSADRYKAVV
160 170 180 190 200
KPLERQPSNA ILKTCVKAGC VWIVSMIFAL PEAIFSNVYT FRDPNKNMTF
210 220 230 240 250
ESCTSYPVSK KLLQEIHSLL CFLVFYIIPL SIISVYYSLI ARTLYKSTLN
260 270 280 290 300
IPTEEQSHAR KQIESRKRIA RTVLVLVALF ALCWLPNHLL YLYHSFTSQT
310 320 330 340 350
YVDPSAMHFI FTIFSRVLAF SNSCVNPFAL YWLSKSFQKH FKAQLFCCKA
360 370 380 390
ERPEPPVADT SLTTLAVMGT VPGTGSIQMS EISVTSFTGC SVKQAEDRF
Length:399
Mass (Da):44,411
Last modified:October 1, 1993 - v1
Checksum:i979C93E962A3A28A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti53 – 531T → P.
Corresponds to variant rs5232 [ dbSNP | Ensembl ].
VAR_011844
Natural varianti162 – 1621L → Q.
Corresponds to variant rs5234 [ dbSNP | Ensembl ].
VAR_011845

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L08893 mRNA. Translation: AAA35604.1.
X76498 Genomic DNA. Translation: CAA54031.1.
AY585193 mRNA. Translation: AAT79496.1.
Z97632 Genomic DNA. Translation: CAB10731.1.
CCDSiCCDS14656.1.
PIRiA46632.
RefSeqiNP_001718.1. NM_001727.1.
XP_005262521.1. XM_005262464.1.
XP_005262522.1. XM_005262465.1.
UniGeneiHs.121484.

Genome annotation databases

EnsembliENST00000370648; ENSP00000359682; ENSG00000102239.
GeneIDi680.
KEGGihsa:680.
UCSCiuc004ezv.1. human.

Polymorphism databases

DMDMi416726.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L08893 mRNA. Translation: AAA35604.1 .
X76498 Genomic DNA. Translation: CAA54031.1 .
AY585193 mRNA. Translation: AAT79496.1 .
Z97632 Genomic DNA. Translation: CAB10731.1 .
CCDSi CCDS14656.1.
PIRi A46632.
RefSeqi NP_001718.1. NM_001727.1.
XP_005262521.1. XM_005262464.1.
XP_005262522.1. XM_005262465.1.
UniGenei Hs.121484.

3D structure databases

ProteinModelPortali P32247.
SMRi P32247. Positions 50-342.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000359682.

Chemistry

BindingDBi P32247.
ChEMBLi CHEMBL4080.
GuidetoPHARMACOLOGYi 40.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P32247.

Polymorphism databases

DMDMi 416726.

Proteomic databases

PaxDbi P32247.
PeptideAtlasi P32247.
PRIDEi P32247.

Protocols and materials databases

DNASUi 680.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000370648 ; ENSP00000359682 ; ENSG00000102239 .
GeneIDi 680.
KEGGi hsa:680.
UCSCi uc004ezv.1. human.

Organism-specific databases

CTDi 680.
GeneCardsi GC0XP135570.
HGNCi HGNC:1113. BRS3.
HPAi HPA003626.
MIMi 300107. gene.
neXtProti NX_P32247.
PharmGKBi PA25427.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG260553.
GeneTreei ENSGT00760000119177.
HOGENOMi HOG000230781.
HOVERGENi HBG004898.
InParanoidi P32247.
KOi K04170.
OMAi SKTFQKH.
OrthoDBi EOG73V6KG.
PhylomeDBi P32247.
TreeFami TF331292.

Enzyme and pathway databases

Reactomei REACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.

Miscellaneous databases

GeneWikii Bombesin-like_receptor_3.
GenomeRNAii 680.
NextBioi 2798.
PROi P32247.
SOURCEi Search...

Gene expression databases

Bgeei P32247.
CleanExi HS_BRS3.
Genevestigatori P32247.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR001560. Bombesin_rcpt_3.
IPR001556. Bombsn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00637. BOMBESIN3R.
PR00358. BOMBESINR.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells."
    Fathi Z., Corjay M.H., Shapira H., Wada E., Benya R., Jensen R., Viallet J., Sausville E.A., Battey J.F.
    J. Biol. Chem. 268:5979-5984(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Organization and chromosomal localization of the gene for the human bombesin receptor subtype expressed in pregnant uterus."
    Gorbulev V., Akhundova A., Grzeschik K.H., Fahrenholz F.
    FEBS Lett. 340:260-264(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Uterus.
  3. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Kopatz S.A., Aronstam R.S., Sharma S.V.
    Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Cloning of a novel protein interacting with BRS-3 and its effects in wound repair of bronchial epithelial cells."
    Liu H.J., Tan Y.R., Li M.L., Liu C., Xiang Y., Qin X.Q.
    PLoS ONE 6:E23072-E23072(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH C6ORF89.

Entry informationi

Entry nameiBRS3_HUMAN
AccessioniPrimary (citable) accession number: P32247
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: October 29, 2014
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3