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P32247

- BRS3_HUMAN

UniProt

P32247 - BRS3_HUMAN

Protein

Bombesin receptor subtype-3

Gene

BRS3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 1 (01 Oct 1993)
      Previous versions | rss
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    Functioni

    Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

    GO - Molecular functioni

    1. bombesin receptor activity Source: ProtInc

    GO - Biological processi

    1. adult feeding behavior Source: ProtInc
    2. glucose metabolic process Source: ProtInc
    3. regulation of blood pressure Source: ProtInc

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_14819. Peptide ligand-binding receptors.
    REACT_18283. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bombesin receptor subtype-3
    Short name:
    BRS-3
    Gene namesi
    Name:BRS3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:1113. BRS3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: ProtInc
    2. neuronal cell body Source: Ensembl
    3. neuron projection Source: Ensembl
    4. plasma membrane Source: ProtInc

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25427.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 399399Bombesin receptor subtype-3PRO_0000069196Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi10 – 101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi18 – 181N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi120 ↔ 203PROSITE-ProRule annotation
    Lipidationi347 – 3471S-palmitoyl cysteineBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiP32247.
    PeptideAtlasiP32247.
    PRIDEiP32247.

    PTM databases

    PhosphoSiteiP32247.

    Expressioni

    Tissue specificityi

    In germ cells in testis. Lung carcinoma cells.

    Gene expression databases

    BgeeiP32247.
    CleanExiHS_BRS3.
    GenevestigatoriP32247.

    Organism-specific databases

    HPAiHPA003626.

    Interactioni

    Subunit structurei

    Interacts with C6orf89.1 Publication

    Protein-protein interaction databases

    STRINGi9606.ENSP00000359682.

    Structurei

    3D structure databases

    ProteinModelPortaliP32247.
    SMRiP32247. Positions 50-342.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4141ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini64 – 8219CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini104 – 12118ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini144 – 16320CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini185 – 22036ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini242 – 27231CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini294 – 31320ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini334 – 39966CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei42 – 6322Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei83 – 10321Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei122 – 14322Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei164 – 18421Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei221 – 24121Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei273 – 29321Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei314 – 33320Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG260553.
    HOGENOMiHOG000230781.
    HOVERGENiHBG004898.
    InParanoidiP32247.
    KOiK04170.
    OMAiSKTFQKH.
    OrthoDBiEOG73V6KG.
    PhylomeDBiP32247.
    TreeFamiTF331292.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR001560. Bombesin_rcpt_3.
    IPR001556. Bombsn_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00637. BOMBESIN3R.
    PR00358. BOMBESINR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P32247-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQRQPHSPN QTLISITNDT ESSSSVVSND NTNKGWSGDN SPGIEALCAI    50
    YITYAVIISV GILGNAILIK VFFKTKSMQT VPNIFITSLA FGDLLLLLTC 100
    VPVDATHYLA EGWLFGRIGC KVLSFIRLTS VGVSVFTLTI LSADRYKAVV 150
    KPLERQPSNA ILKTCVKAGC VWIVSMIFAL PEAIFSNVYT FRDPNKNMTF 200
    ESCTSYPVSK KLLQEIHSLL CFLVFYIIPL SIISVYYSLI ARTLYKSTLN 250
    IPTEEQSHAR KQIESRKRIA RTVLVLVALF ALCWLPNHLL YLYHSFTSQT 300
    YVDPSAMHFI FTIFSRVLAF SNSCVNPFAL YWLSKSFQKH FKAQLFCCKA 350
    ERPEPPVADT SLTTLAVMGT VPGTGSIQMS EISVTSFTGC SVKQAEDRF 399
    Length:399
    Mass (Da):44,411
    Last modified:October 1, 1993 - v1
    Checksum:i979C93E962A3A28A
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti53 – 531T → P.
    Corresponds to variant rs5232 [ dbSNP | Ensembl ].
    VAR_011844
    Natural varianti162 – 1621L → Q.
    Corresponds to variant rs5234 [ dbSNP | Ensembl ].
    VAR_011845

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L08893 mRNA. Translation: AAA35604.1.
    X76498 Genomic DNA. Translation: CAA54031.1.
    AY585193 mRNA. Translation: AAT79496.1.
    Z97632 Genomic DNA. Translation: CAB10731.1.
    CCDSiCCDS14656.1.
    PIRiA46632.
    RefSeqiNP_001718.1. NM_001727.1.
    XP_005262521.1. XM_005262464.1.
    XP_005262522.1. XM_005262465.1.
    UniGeneiHs.121484.

    Genome annotation databases

    EnsembliENST00000370648; ENSP00000359682; ENSG00000102239.
    GeneIDi680.
    KEGGihsa:680.
    UCSCiuc004ezv.1. human.

    Polymorphism databases

    DMDMi416726.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L08893 mRNA. Translation: AAA35604.1 .
    X76498 Genomic DNA. Translation: CAA54031.1 .
    AY585193 mRNA. Translation: AAT79496.1 .
    Z97632 Genomic DNA. Translation: CAB10731.1 .
    CCDSi CCDS14656.1.
    PIRi A46632.
    RefSeqi NP_001718.1. NM_001727.1.
    XP_005262521.1. XM_005262464.1.
    XP_005262522.1. XM_005262465.1.
    UniGenei Hs.121484.

    3D structure databases

    ProteinModelPortali P32247.
    SMRi P32247. Positions 50-342.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000359682.

    Chemistry

    BindingDBi P32247.
    ChEMBLi CHEMBL4080.
    GuidetoPHARMACOLOGYi 40.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P32247.

    Polymorphism databases

    DMDMi 416726.

    Proteomic databases

    PaxDbi P32247.
    PeptideAtlasi P32247.
    PRIDEi P32247.

    Protocols and materials databases

    DNASUi 680.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000370648 ; ENSP00000359682 ; ENSG00000102239 .
    GeneIDi 680.
    KEGGi hsa:680.
    UCSCi uc004ezv.1. human.

    Organism-specific databases

    CTDi 680.
    GeneCardsi GC0XP135570.
    HGNCi HGNC:1113. BRS3.
    HPAi HPA003626.
    MIMi 300107. gene.
    neXtProti NX_P32247.
    PharmGKBi PA25427.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG260553.
    HOGENOMi HOG000230781.
    HOVERGENi HBG004898.
    InParanoidi P32247.
    KOi K04170.
    OMAi SKTFQKH.
    OrthoDBi EOG73V6KG.
    PhylomeDBi P32247.
    TreeFami TF331292.

    Enzyme and pathway databases

    Reactomei REACT_14819. Peptide ligand-binding receptors.
    REACT_18283. G alpha (q) signalling events.

    Miscellaneous databases

    GeneWikii Bombesin-like_receptor_3.
    GenomeRNAii 680.
    NextBioi 2798.
    PROi P32247.
    SOURCEi Search...

    Gene expression databases

    Bgeei P32247.
    CleanExi HS_BRS3.
    Genevestigatori P32247.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR001560. Bombesin_rcpt_3.
    IPR001556. Bombsn_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00637. BOMBESIN3R.
    PR00358. BOMBESINR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells."
      Fathi Z., Corjay M.H., Shapira H., Wada E., Benya R., Jensen R., Viallet J., Sausville E.A., Battey J.F.
      J. Biol. Chem. 268:5979-5984(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Organization and chromosomal localization of the gene for the human bombesin receptor subtype expressed in pregnant uterus."
      Gorbulev V., Akhundova A., Grzeschik K.H., Fahrenholz F.
      FEBS Lett. 340:260-264(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Uterus.
    3. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Kopatz S.A., Aronstam R.S., Sharma S.V.
      Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    4. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "Cloning of a novel protein interacting with BRS-3 and its effects in wound repair of bronchial epithelial cells."
      Liu H.J., Tan Y.R., Li M.L., Liu C., Xiang Y., Qin X.Q.
      PLoS ONE 6:E23072-E23072(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH C6ORF89.

    Entry informationi

    Entry nameiBRS3_HUMAN
    AccessioniPrimary (citable) accession number: P32247
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: October 1, 1993
    Last modified: October 1, 2014
    This is version 130 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3