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Protein

Bombesin receptor subtype-3

Gene

BRS3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

  • bombesin receptor activity Source: ProtInc

GO - Biological processi

  • adult feeding behavior Source: ProtInc
  • glucose metabolic process Source: ProtInc
  • regulation of blood pressure Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000102239-MONOMER.
ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Bombesin receptor subtype-3
Short name:
BRS-3
Gene namesi
Name:BRS3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:1113. BRS3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 41ExtracellularSequence analysisAdd BLAST41
Transmembranei42 – 63Helical; Name=1Sequence analysisAdd BLAST22
Topological domaini64 – 82CytoplasmicSequence analysisAdd BLAST19
Transmembranei83 – 103Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini104 – 121ExtracellularSequence analysisAdd BLAST18
Transmembranei122 – 143Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini144 – 163CytoplasmicSequence analysisAdd BLAST20
Transmembranei164 – 184Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini185 – 220ExtracellularSequence analysisAdd BLAST36
Transmembranei221 – 241Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini242 – 272CytoplasmicSequence analysisAdd BLAST31
Transmembranei273 – 293Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini294 – 313ExtracellularSequence analysisAdd BLAST20
Transmembranei314 – 333Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini334 – 399CytoplasmicSequence analysisAdd BLAST66

GO - Cellular componenti

  • integral component of membrane Source: ProtInc
  • neuronal cell body Source: Ensembl
  • neuron projection Source: Ensembl
  • plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi680.
OpenTargetsiENSG00000102239.
PharmGKBiPA25427.

Chemistry databases

ChEMBLiCHEMBL4080.
GuidetoPHARMACOLOGYi40.

Polymorphism and mutation databases

BioMutaiBRS3.
DMDMi416726.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000691961 – 399Bombesin receptor subtype-3Add BLAST399

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi10N-linked (GlcNAc...)Sequence analysis1
Glycosylationi18N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi120 ↔ 203PROSITE-ProRule annotation
Lipidationi347S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP32247.
PeptideAtlasiP32247.
PRIDEiP32247.

PTM databases

iPTMnetiP32247.
PhosphoSitePlusiP32247.

Expressioni

Tissue specificityi

In germ cells in testis. Lung carcinoma cells.

Gene expression databases

BgeeiENSG00000102239.
CleanExiHS_BRS3.
GenevisibleiP32247. HS.

Organism-specific databases

HPAiHPA003626.

Interactioni

Subunit structurei

Interacts with C6orf89.1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000359682.

Chemistry databases

BindingDBiP32247.

Structurei

3D structure databases

ProteinModelPortaliP32247.
SMRiP32247.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119177.
HOGENOMiHOG000230781.
HOVERGENiHBG004898.
InParanoidiP32247.
KOiK04170.
OMAiMIWILAI.
OrthoDBiEOG091G085Y.
PhylomeDBiP32247.
TreeFamiTF331292.

Family and domain databases

InterProiIPR001560. Bombesin_rcpt_3.
IPR001556. Bombsn_rcpt-like.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00637. BOMBESIN3R.
PR00358. BOMBESINR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32247-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQRQPHSPN QTLISITNDT ESSSSVVSND NTNKGWSGDN SPGIEALCAI
60 70 80 90 100
YITYAVIISV GILGNAILIK VFFKTKSMQT VPNIFITSLA FGDLLLLLTC
110 120 130 140 150
VPVDATHYLA EGWLFGRIGC KVLSFIRLTS VGVSVFTLTI LSADRYKAVV
160 170 180 190 200
KPLERQPSNA ILKTCVKAGC VWIVSMIFAL PEAIFSNVYT FRDPNKNMTF
210 220 230 240 250
ESCTSYPVSK KLLQEIHSLL CFLVFYIIPL SIISVYYSLI ARTLYKSTLN
260 270 280 290 300
IPTEEQSHAR KQIESRKRIA RTVLVLVALF ALCWLPNHLL YLYHSFTSQT
310 320 330 340 350
YVDPSAMHFI FTIFSRVLAF SNSCVNPFAL YWLSKSFQKH FKAQLFCCKA
360 370 380 390
ERPEPPVADT SLTTLAVMGT VPGTGSIQMS EISVTSFTGC SVKQAEDRF
Length:399
Mass (Da):44,411
Last modified:October 1, 1993 - v1
Checksum:i979C93E962A3A28A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01184453T → P.Corresponds to variant rs5232dbSNPEnsembl.1
Natural variantiVAR_011845162L → Q.Corresponds to variant rs5234dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08893 mRNA. Translation: AAA35604.1.
X76498 Genomic DNA. Translation: CAA54031.1.
AY585193 mRNA. Translation: AAT79496.1.
Z97632 Genomic DNA. Translation: CAB10731.1.
CCDSiCCDS14656.1.
PIRiA46632.
RefSeqiNP_001718.1. NM_001727.1.
UniGeneiHs.121484.

Genome annotation databases

EnsembliENST00000370648; ENSP00000359682; ENSG00000102239.
GeneIDi680.
KEGGihsa:680.
UCSCiuc004ezv.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08893 mRNA. Translation: AAA35604.1.
X76498 Genomic DNA. Translation: CAA54031.1.
AY585193 mRNA. Translation: AAT79496.1.
Z97632 Genomic DNA. Translation: CAB10731.1.
CCDSiCCDS14656.1.
PIRiA46632.
RefSeqiNP_001718.1. NM_001727.1.
UniGeneiHs.121484.

3D structure databases

ProteinModelPortaliP32247.
SMRiP32247.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000359682.

Chemistry databases

BindingDBiP32247.
ChEMBLiCHEMBL4080.
GuidetoPHARMACOLOGYi40.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP32247.
PhosphoSitePlusiP32247.

Polymorphism and mutation databases

BioMutaiBRS3.
DMDMi416726.

Proteomic databases

PaxDbiP32247.
PeptideAtlasiP32247.
PRIDEiP32247.

Protocols and materials databases

DNASUi680.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370648; ENSP00000359682; ENSG00000102239.
GeneIDi680.
KEGGihsa:680.
UCSCiuc004ezv.2. human.

Organism-specific databases

CTDi680.
DisGeNETi680.
GeneCardsiBRS3.
HGNCiHGNC:1113. BRS3.
HPAiHPA003626.
MIMi300107. gene.
neXtProtiNX_P32247.
OpenTargetsiENSG00000102239.
PharmGKBiPA25427.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119177.
HOGENOMiHOG000230781.
HOVERGENiHBG004898.
InParanoidiP32247.
KOiK04170.
OMAiMIWILAI.
OrthoDBiEOG091G085Y.
PhylomeDBiP32247.
TreeFamiTF331292.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000102239-MONOMER.
ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-416476. G alpha (q) signalling events.

Miscellaneous databases

GeneWikiiBombesin-like_receptor_3.
GenomeRNAii680.
PROiP32247.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000102239.
CleanExiHS_BRS3.
GenevisibleiP32247. HS.

Family and domain databases

InterProiIPR001560. Bombesin_rcpt_3.
IPR001556. Bombsn_rcpt-like.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00637. BOMBESIN3R.
PR00358. BOMBESINR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBRS3_HUMAN
AccessioniPrimary (citable) accession number: P32247
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: November 30, 2016
This is version 148 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.