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P32247 (BRS3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 128. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bombesin receptor subtype-3

Short name=BRS-3
Gene names
Name:BRS3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length399 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Subunit structure

Interacts with C6orf89. Ref.5

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

In germ cells in testis. Lung carcinoma cells.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 399399Bombesin receptor subtype-3
PRO_0000069196

Regions

Topological domain1 – 4141Extracellular Potential
Transmembrane42 – 6322Helical; Name=1; Potential
Topological domain64 – 8219Cytoplasmic Potential
Transmembrane83 – 10321Helical; Name=2; Potential
Topological domain104 – 12118Extracellular Potential
Transmembrane122 – 14322Helical; Name=3; Potential
Topological domain144 – 16320Cytoplasmic Potential
Transmembrane164 – 18421Helical; Name=4; Potential
Topological domain185 – 22036Extracellular Potential
Transmembrane221 – 24121Helical; Name=5; Potential
Topological domain242 – 27231Cytoplasmic Potential
Transmembrane273 – 29321Helical; Name=6; Potential
Topological domain294 – 31320Extracellular Potential
Transmembrane314 – 33320Helical; Name=7; Potential
Topological domain334 – 39966Cytoplasmic Potential

Amino acid modifications

Lipidation3471S-palmitoyl cysteine By similarity
Glycosylation101N-linked (GlcNAc...) Potential
Glycosylation181N-linked (GlcNAc...) Potential
Disulfide bond120 ↔ 203 By similarity

Natural variations

Natural variant531T → P.
Corresponds to variant rs5232 [ dbSNP | Ensembl ].
VAR_011844
Natural variant1621L → Q.
Corresponds to variant rs5234 [ dbSNP | Ensembl ].
VAR_011845

Sequences

Sequence LengthMass (Da)Tools
P32247 [UniParc].

Last modified October 1, 1993. Version 1.
Checksum: 979C93E962A3A28A

FASTA39944,411
        10         20         30         40         50         60 
MAQRQPHSPN QTLISITNDT ESSSSVVSND NTNKGWSGDN SPGIEALCAI YITYAVIISV 

        70         80         90        100        110        120 
GILGNAILIK VFFKTKSMQT VPNIFITSLA FGDLLLLLTC VPVDATHYLA EGWLFGRIGC 

       130        140        150        160        170        180 
KVLSFIRLTS VGVSVFTLTI LSADRYKAVV KPLERQPSNA ILKTCVKAGC VWIVSMIFAL 

       190        200        210        220        230        240 
PEAIFSNVYT FRDPNKNMTF ESCTSYPVSK KLLQEIHSLL CFLVFYIIPL SIISVYYSLI 

       250        260        270        280        290        300 
ARTLYKSTLN IPTEEQSHAR KQIESRKRIA RTVLVLVALF ALCWLPNHLL YLYHSFTSQT 

       310        320        330        340        350        360 
YVDPSAMHFI FTIFSRVLAF SNSCVNPFAL YWLSKSFQKH FKAQLFCCKA ERPEPPVADT 

       370        380        390 
SLTTLAVMGT VPGTGSIQMS EISVTSFTGC SVKQAEDRF 

« Hide

References

« Hide 'large scale' references
[1]"BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells."
Fathi Z., Corjay M.H., Shapira H., Wada E., Benya R., Jensen R., Viallet J., Sausville E.A., Battey J.F.
J. Biol. Chem. 268:5979-5984(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Organization and chromosomal localization of the gene for the human bombesin receptor subtype expressed in pregnant uterus."
Gorbulev V., Akhundova A., Grzeschik K.H., Fahrenholz F.
FEBS Lett. 340:260-264(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Uterus.
[3]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Kopatz S.A., Aronstam R.S., Sharma S.V.
Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[4]"The DNA sequence of the human X chromosome."
Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. expand/collapse author list , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"Cloning of a novel protein interacting with BRS-3 and its effects in wound repair of bronchial epithelial cells."
Liu H.J., Tan Y.R., Li M.L., Liu C., Xiang Y., Qin X.Q.
PLoS ONE 6:E23072-E23072(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH C6ORF89.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L08893 mRNA. Translation: AAA35604.1.
X76498 Genomic DNA. Translation: CAA54031.1.
AY585193 mRNA. Translation: AAT79496.1.
Z97632 Genomic DNA. Translation: CAB10731.1.
CCDSCCDS14656.1.
PIRA46632.
RefSeqNP_001718.1. NM_001727.1.
XP_005262521.1. XM_005262464.1.
XP_005262522.1. XM_005262465.1.
UniGeneHs.121484.

3D structure databases

ProteinModelPortalP32247.
SMRP32247. Positions 50-342.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000359682.

Chemistry

BindingDBP32247.
ChEMBLCHEMBL4080.
GuidetoPHARMACOLOGY40.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP32247.

Polymorphism databases

DMDM416726.

Proteomic databases

PaxDbP32247.
PeptideAtlasP32247.
PRIDEP32247.

Protocols and materials databases

DNASU680.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000370648; ENSP00000359682; ENSG00000102239.
GeneID680.
KEGGhsa:680.
UCSCuc004ezv.1. human.

Organism-specific databases

CTD680.
GeneCardsGC0XP135570.
HGNCHGNC:1113. BRS3.
HPAHPA003626.
MIM300107. gene.
neXtProtNX_P32247.
PharmGKBPA25427.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG260553.
HOGENOMHOG000230781.
HOVERGENHBG004898.
InParanoidP32247.
KOK04170.
OMASKTFQKH.
OrthoDBEOG73V6KG.
PhylomeDBP32247.
TreeFamTF331292.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeP32247.
CleanExHS_BRS3.
GenevestigatorP32247.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR001560. Bombesin_rcpt_3.
IPR001556. Bombsn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00637. BOMBESIN3R.
PR00358. BOMBESINR.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiBombesin-like_receptor_3.
GenomeRNAi680.
NextBio2798.
PROP32247.
SOURCESearch...

Entry information

Entry nameBRS3_HUMAN
AccessionPrimary (citable) accession number: P32247
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: July 9, 2014
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries