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P32246 (CCR1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 129. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-C chemokine receptor type 1

Short name=C-C CKR-1
Short name=CC-CKR-1
Short name=CCR-1
Short name=CCR1
Alternative name(s):
HM145
LD78 receptor
Macrophage inflammatory protein 1-alpha receptor
Short name=MIP-1alpha-R
RANTES-R
CD_antigen=CD191
Gene names
Name:CCR1
Synonyms:CMKBR1, CMKR1, SCYAR1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length355 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation.

Subunit structure

Interacts with CREB3. Ref.5

Subcellular location

Cell membrane; Multi-pass membrane protein Ref.6.

Tissue specificity

Widely expressed in different hematopoietic cells.

Induction

Up-regulated by CREB3. Ref.6

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

Traceable author statement Ref.3. Source: ProtInc

calcium ion transport

Inferred from direct assay PubMed 10734056. Source: UniProtKB

cell adhesion

Traceable author statement PubMed 10910894. Source: ProtInc

cell surface receptor signaling pathway

Traceable author statement PubMed 10770925. Source: ProtInc

cell-cell signaling

Inferred from direct assay PubMed 10734056. Source: UniProtKB

cellular calcium ion homeostasis

Inferred from direct assay PubMed 10734056. Source: UniProtKB

chemokine-mediated signaling pathway

Inferred from direct assay PubMed 21403648. Source: UniProtKB

chemotaxis

Non-traceable author statement PubMed 15474493. Source: UniProtKB

cytokine-mediated signaling pathway

Non-traceable author statement PubMed 15474493. Source: UniProtKB

dendritic cell chemotaxis

Traceable author statement PubMed 16621978. Source: BHF-UCL

exocytosis

Inferred from direct assay PubMed 10734056. Source: UniProtKB

immune response

Inferred from direct assay PubMed 10734056. Source: UniProtKB

inflammatory response

Traceable author statement Ref.2. Source: ProtInc

metabolic process

Inferred from direct assay PubMed 10734056. Source: GOC

negative regulation of bone mineralization

Inferred from mutant phenotype PubMed 21403648. Source: UniProtKB

negative regulation of gene expression

Inferred from mutant phenotype PubMed 21403648. Source: UniProtKB

positive regulation of ERK1 and ERK2 cascade

Inferred from mutant phenotype PubMed 21403648. Source: UniProtKB

positive regulation of calcium ion transport

Inferred from direct assay PubMed 15764707. Source: UniProtKB

positive regulation of cytosolic calcium ion concentration

Inferred from direct assay PubMed 10734056. Source: UniProtKB

positive regulation of monocyte chemotaxis

Inferred from direct assay Ref.6. Source: UniProtKB

positive regulation of osteoclast differentiation

Inferred from mutant phenotype PubMed 21403648. Source: UniProtKB

response to wounding

Traceable author statement Ref.3. Source: ProtInc

   Cellular_componentexternal side of plasma membrane

Inferred from direct assay PubMed 10706735. Source: UniProtKB

integral component of plasma membrane

Traceable author statement Ref.3. Source: ProtInc

plasma membrane

Inferred from direct assay PubMed 10660125PubMed 15474493Ref.6. Source: UniProtKB

   Molecular_functionC-C chemokine binding

Inferred from physical interaction PubMed 10660125PubMed 15764707PubMed 7545673PubMed 8699119. Source: UniProtKB

C-C chemokine receptor activity

Inferred from direct assay PubMed 10734056. Source: UniProtKB

chemokine (C-C motif) ligand 5 binding

Inferred from physical interaction PubMed 10660125PubMed 10734056PubMed 7545673PubMed 8699119. Source: UniProtKB

chemokine (C-C motif) ligand 7 binding

Inferred from physical interaction PubMed 10660125PubMed 7545673. Source: UniProtKB

chemokine receptor activity

Inferred from direct assay PubMed 10660125. Source: UniProtKB

phosphatidylinositol phospholipase C activity

Inferred from direct assay PubMed 10734056. Source: UniProtKB

Complete GO annotation...

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 355355C-C chemokine receptor type 1
PRO_0000069228

Regions

Topological domain1 – 3434Extracellular Potential
Transmembrane35 – 6026Helical; Name=1; Potential
Topological domain61 – 644Cytoplasmic Potential
Transmembrane65 – 9127Helical; Name=2; Potential
Topological domain92 – 10716Extracellular Potential
Transmembrane108 – 12922Helical; Name=3; Potential
Topological domain130 – 14617Cytoplasmic Potential
Transmembrane147 – 17125Helical; Name=4; Potential
Topological domain172 – 19726Extracellular Potential
Transmembrane198 – 22326Helical; Name=5; Potential
Topological domain224 – 23916Cytoplasmic Potential
Transmembrane240 – 26425Helical; Name=6; Potential
Topological domain265 – 28117Extracellular Potential
Transmembrane282 – 30524Helical; Name=7; Potential
Topological domain306 – 35550Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Disulfide bond106 ↔ 183 By similarity

Experimental info

Sequence conflict3371E → D in BAA01723. Ref.3

Sequences

Sequence LengthMass (Da)Tools
P32246 [UniParc].

Last modified October 1, 1993. Version 1.
Checksum: B2C100FFED275985

FASTA35541,173
        10         20         30         40         50         60 
METPNTTEDY DTTTEFDYGD ATPCQKVNER AFGAQLLPPL YSLVFVIGLV GNILVVLVLV 

        70         80         90        100        110        120 
QYKRLKNMTS IYLLNLAISD LLFLFTLPFW IDYKLKDDWV FGDAMCKILS GFYYTGLYSE 

       130        140        150        160        170        180 
IFFIILLTID RYLAIVHAVF ALRARTVTFG VITSIIIWAL AILASMPGLY FSKTQWEFTH 

       190        200        210        220        230        240 
HTCSLHFPHE SLREWKLFQA LKLNLFGLVL PLLVMIICYT GIIKILLRRP NEKKSKAVRL 

       250        260        270        280        290        300 
IFVIMIIFFL FWTPYNLTIL ISVFQDFLFT HECEQSRHLD LAVQVTEVIA YTHCCVNPVI 

       310        320        330        340        350 
YAFVGERFRK YLRQLFHRRV AVHLVKWLPF LSVDRLERVS STSPSTGEHE LSAGF 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor."
Neote K., Digregorio D., Mak J.Y., Horuk R., Schall T.J.
Cell 72:415-425(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Structure and functional expression of the human macrophage inflammatory protein 1 alpha/RANTES receptor."
Gao J.-L., Kuhns D., Tiffany H.L., McDermott D., Li X., Francke U., Murphy P.M.
J. Exp. Med. 177:1421-1427(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors."
Nomura H., Nielsen B.W., Matsushima K.
Int. Immunol. 5:1239-1249(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Monocyte.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Blood.
[5]"Human LZIP binds to CCR1 and differentially affects the chemotactic activities of CCR1-dependent chemokines."
Ko J., Jang S.W., Kim Y.S., Kim I.S., Sung H.J., Kim H.-H., Park J.Y., Lee Y.H., Kim J., Na D.S.
FASEB J. 18:890-892(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH CREB3.
[6]"Human LZIP induces monocyte CC chemokine receptor 2 expression leading to enhancement of monocyte chemoattractant protein 1/CCL2-induced cell migration."
Sung H.J., Kim Y.S., Kang H., Ko J.
Exp. Mol. Med. 40:332-338(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, INDUCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L09230 mRNA. Translation: AAA58408.1.
L10918 mRNA. Translation: AAA36543.1.
D10925 mRNA. Translation: BAA01723.1.
BC051306 mRNA. Translation: AAH51306.2.
BC064991 mRNA. Translation: AAH64991.1.
PIRA45177.
RefSeqNP_001286.1. NM_001295.2.
UniGeneHs.301921.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1Y5Dmodel-A1-355[»]
ProteinModelPortalP32246.
SMRP32246. Positions 1-317.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107635. 4 interactions.
DIPDIP-5832N.
IntActP32246. 3 interactions.
MINTMINT-140567.
STRING9606.ENSP00000296140.

Chemistry

BindingDBP32246.
ChEMBLCHEMBL2413.
GuidetoPHARMACOLOGY58.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP32246.

Polymorphism databases

DMDM416802.

Proteomic databases

PaxDbP32246.
PRIDEP32246.

Protocols and materials databases

DNASU1230.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000296140; ENSP00000296140; ENSG00000163823.
GeneID1230.
KEGGhsa:1230.
UCSCuc003cph.1. human.

Organism-specific databases

CTD1230.
GeneCardsGC03M046218.
HGNCHGNC:1602. CCR1.
MIM601159. gene.
neXtProtNX_P32246.
PharmGKBPA26166.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG148353.
HOGENOMHOG000234122.
HOVERGENHBG106917.
InParanoidP32246.
KOK04176.
OMAFWIDYKL.
OrthoDBEOG738051.
PhylomeDBP32246.
TreeFamTF330966.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressP32246.
BgeeP32246.
CleanExHS_CCR1.
GenevestigatorP32246.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR002236. Chemokine_CCR1.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERPTHR24227. PTHR24227. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00657. CCCHEMOKINER.
PR01106. CHEMOKINER1.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiCCR1.
GenomeRNAi1230.
NextBio5015.
PROP32246.
SOURCESearch...

Entry information

Entry nameCCR1_HUMAN
AccessionPrimary (citable) accession number: P32246
Secondary accession number(s): Q86VA9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: April 16, 2014
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries