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P32246

- CCR1_HUMAN

UniProt

P32246 - CCR1_HUMAN

Protein

C-C chemokine receptor type 1

Gene

CCR1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 133 (01 Oct 2014)
      Sequence version 1 (01 Oct 1993)
      Previous versions | rss
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    Functioni

    Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation.

    GO - Molecular functioni

    1. C-C chemokine binding Source: UniProtKB
    2. C-C chemokine receptor activity Source: UniProtKB
    3. chemokine (C-C motif) ligand 5 binding Source: UniProtKB
    4. chemokine (C-C motif) ligand 7 binding Source: UniProtKB
    5. chemokine receptor activity Source: UniProtKB
    6. phosphatidylinositol phospholipase C activity Source: UniProtKB
    7. protein binding Source: UniProtKB

    GO - Biological processi

    1. calcium ion transport Source: UniProtKB
    2. cell adhesion Source: ProtInc
    3. cell-cell signaling Source: UniProtKB
    4. cell surface receptor signaling pathway Source: ProtInc
    5. cellular calcium ion homeostasis Source: UniProtKB
    6. chemokine-mediated signaling pathway Source: UniProtKB
    7. chemotaxis Source: UniProtKB
    8. cytokine-mediated signaling pathway Source: UniProtKB
    9. dendritic cell chemotaxis Source: BHF-UCL
    10. exocytosis Source: UniProtKB
    11. G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
    12. immune response Source: UniProtKB
    13. inflammatory response Source: ProtInc
    14. metabolic process Source: GOC
    15. negative regulation of bone mineralization Source: UniProtKB
    16. negative regulation of gene expression Source: UniProtKB
    17. positive regulation of calcium ion transport Source: UniProtKB
    18. positive regulation of cytosolic calcium ion concentration Source: UniProtKB
    19. positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
    20. positive regulation of monocyte chemotaxis Source: UniProtKB
    21. positive regulation of osteoclast differentiation Source: UniProtKB
    22. response to wounding Source: ProtInc

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_15344. Chemokine receptors bind chemokines.
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C chemokine receptor type 1
    Short name:
    C-C CKR-1
    Short name:
    CC-CKR-1
    Short name:
    CCR-1
    Short name:
    CCR1
    Alternative name(s):
    HM145
    LD78 receptor
    Macrophage inflammatory protein 1-alpha receptor
    Short name:
    MIP-1alpha-R
    RANTES-R
    CD_antigen: CD191
    Gene namesi
    Name:CCR1
    Synonyms:CMKBR1, CMKR1, SCYAR1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:1602. CCR1.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. external side of plasma membrane Source: UniProtKB
    2. integral component of plasma membrane Source: ProtInc
    3. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26166.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 355355C-C chemokine receptor type 1PRO_0000069228Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi106 ↔ 183PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP32246.
    PRIDEiP32246.

    PTM databases

    PhosphoSiteiP32246.

    Expressioni

    Tissue specificityi

    Widely expressed in different hematopoietic cells.

    Inductioni

    Up-regulated by CREB3.1 Publication

    Gene expression databases

    ArrayExpressiP32246.
    BgeeiP32246.
    CleanExiHS_CCR1.
    GenevestigatoriP32246.

    Interactioni

    Subunit structurei

    Interacts with CREB3.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CREB3O43889-27EBI-608322,EBI-625022
    PLP2Q049413EBI-608322,EBI-608347

    Protein-protein interaction databases

    BioGridi107635. 4 interactions.
    DIPiDIP-5832N.
    IntActiP32246. 3 interactions.
    MINTiMINT-140567.
    STRINGi9606.ENSP00000296140.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1Y5Dmodel-A1-355[»]
    ProteinModelPortaliP32246.
    SMRiP32246. Positions 2-317.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3434ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini61 – 644CytoplasmicSequence Analysis
    Topological domaini92 – 10716ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini130 – 14617CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini172 – 19726ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini224 – 23916CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini265 – 28117ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini306 – 35550CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei35 – 6026Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei65 – 9127Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei108 – 12922Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei147 – 17125Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei198 – 22326Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei240 – 26425Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei282 – 30524Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG148353.
    HOGENOMiHOG000234122.
    HOVERGENiHBG106917.
    InParanoidiP32246.
    KOiK04176.
    OMAiFWIDYKL.
    OrthoDBiEOG738051.
    PhylomeDBiP32246.
    TreeFamiTF330966.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR002236. Chemokine_CCR1.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24227. PTHR24227. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00657. CCCHEMOKINER.
    PR01106. CHEMOKINER1.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P32246-1 [UniParc]FASTAAdd to Basket

    « Hide

    METPNTTEDY DTTTEFDYGD ATPCQKVNER AFGAQLLPPL YSLVFVIGLV    50
    GNILVVLVLV QYKRLKNMTS IYLLNLAISD LLFLFTLPFW IDYKLKDDWV 100
    FGDAMCKILS GFYYTGLYSE IFFIILLTID RYLAIVHAVF ALRARTVTFG 150
    VITSIIIWAL AILASMPGLY FSKTQWEFTH HTCSLHFPHE SLREWKLFQA 200
    LKLNLFGLVL PLLVMIICYT GIIKILLRRP NEKKSKAVRL IFVIMIIFFL 250
    FWTPYNLTIL ISVFQDFLFT HECEQSRHLD LAVQVTEVIA YTHCCVNPVI 300
    YAFVGERFRK YLRQLFHRRV AVHLVKWLPF LSVDRLERVS STSPSTGEHE 350
    LSAGF 355
    Length:355
    Mass (Da):41,173
    Last modified:October 1, 1993 - v1
    Checksum:iB2C100FFED275985
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti337 – 3371E → D in BAA01723. (PubMed:7505609)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L09230 mRNA. Translation: AAA58408.1.
    L10918 mRNA. Translation: AAA36543.1.
    D10925 mRNA. Translation: BAA01723.1.
    BC051306 mRNA. Translation: AAH51306.2.
    BC064991 mRNA. Translation: AAH64991.1.
    CCDSiCCDS2737.1.
    PIRiA45177.
    RefSeqiNP_001286.1. NM_001295.2.
    UniGeneiHs.301921.

    Genome annotation databases

    EnsembliENST00000296140; ENSP00000296140; ENSG00000163823.
    GeneIDi1230.
    KEGGihsa:1230.
    UCSCiuc003cph.1. human.

    Polymorphism databases

    DMDMi416802.

    Cross-referencesi

    Web resourcesi

    Wikipedia

    CC chemokine receptors entry

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L09230 mRNA. Translation: AAA58408.1 .
    L10918 mRNA. Translation: AAA36543.1 .
    D10925 mRNA. Translation: BAA01723.1 .
    BC051306 mRNA. Translation: AAH51306.2 .
    BC064991 mRNA. Translation: AAH64991.1 .
    CCDSi CCDS2737.1.
    PIRi A45177.
    RefSeqi NP_001286.1. NM_001295.2.
    UniGenei Hs.301921.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1Y5D model - A 1-355 [» ]
    ProteinModelPortali P32246.
    SMRi P32246. Positions 2-317.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107635. 4 interactions.
    DIPi DIP-5832N.
    IntActi P32246. 3 interactions.
    MINTi MINT-140567.
    STRINGi 9606.ENSP00000296140.

    Chemistry

    BindingDBi P32246.
    ChEMBLi CHEMBL2413.
    GuidetoPHARMACOLOGYi 58.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P32246.

    Polymorphism databases

    DMDMi 416802.

    Proteomic databases

    PaxDbi P32246.
    PRIDEi P32246.

    Protocols and materials databases

    DNASUi 1230.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000296140 ; ENSP00000296140 ; ENSG00000163823 .
    GeneIDi 1230.
    KEGGi hsa:1230.
    UCSCi uc003cph.1. human.

    Organism-specific databases

    CTDi 1230.
    GeneCardsi GC03M046218.
    HGNCi HGNC:1602. CCR1.
    MIMi 601159. gene.
    neXtProti NX_P32246.
    PharmGKBi PA26166.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG148353.
    HOGENOMi HOG000234122.
    HOVERGENi HBG106917.
    InParanoidi P32246.
    KOi K04176.
    OMAi FWIDYKL.
    OrthoDBi EOG738051.
    PhylomeDBi P32246.
    TreeFami TF330966.

    Enzyme and pathway databases

    Reactomei REACT_15344. Chemokine receptors bind chemokines.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GeneWikii CCR1.
    GenomeRNAii 1230.
    NextBioi 5015.
    PROi P32246.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P32246.
    Bgeei P32246.
    CleanExi HS_CCR1.
    Genevestigatori P32246.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR002236. Chemokine_CCR1.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24227. PTHR24227. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00657. CCCHEMOKINER.
    PR01106. CHEMOKINER1.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor."
      Neote K., Digregorio D., Mak J.Y., Horuk R., Schall T.J.
      Cell 72:415-425(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Structure and functional expression of the human macrophage inflammatory protein 1 alpha/RANTES receptor."
      Gao J.-L., Kuhns D., Tiffany H.L., McDermott D., Li X., Francke U., Murphy P.M.
      J. Exp. Med. 177:1421-1427(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors."
      Nomura H., Nielsen B.W., Matsushima K.
      Int. Immunol. 5:1239-1249(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Monocyte.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Blood.
    5. "Human LZIP binds to CCR1 and differentially affects the chemotactic activities of CCR1-dependent chemokines."
      Ko J., Jang S.W., Kim Y.S., Kim I.S., Sung H.J., Kim H.-H., Park J.Y., Lee Y.H., Kim J., Na D.S.
      FASEB J. 18:890-892(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CREB3.
    6. "Human LZIP induces monocyte CC chemokine receptor 2 expression leading to enhancement of monocyte chemoattractant protein 1/CCL2-induced cell migration."
      Sung H.J., Kim Y.S., Kang H., Ko J.
      Exp. Mol. Med. 40:332-338(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, INDUCTION.

    Entry informationi

    Entry nameiCCR1_HUMAN
    AccessioniPrimary (citable) accession number: P32246
    Secondary accession number(s): Q86VA9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: October 1, 1993
    Last modified: October 1, 2014
    This is version 133 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    3. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3