C-C chemokine receptor type 1 - Homo sapiens (Human)

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P32246 (CCR1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 119. History...

Clusters with 100%, 90%, 50% identity |

Documents (6) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
C-C chemokine receptor type 1
Short name=C-C CKR-1
Short name=CC-CKR-1
Short name=CCR-1
Short name=CCR1

Alternative name(s):
HM145
LD78 receptor
Macrophage inflammatory protein 1-alpha receptor
Short name=MIP-1alpha-R
RANTES-R
CD_antigen=CD191

Gene names

Name:	CCR1
Synonyms:	CMKBR1, CMKR1, SCYAR1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	355 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation.
Subunit structure	Interacts with CREB3. Ref.5
Subcellular location	Cell membrane; Multi-pass membrane protein Ref.6.
Tissue specificity	Widely expressed in different hematopoietic cells.
Induction	Up-regulated by CREB3. Ref.6
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Traceable author statement Ref.3. Source: ProtInc activation of MAPK activity Inferred from electronic annotation. Source: InterPro calcium ion transport Inferred from direct assay PubMed 10734056. Source: UniProtKB cell adhesion Traceable author statement PubMed 10910894. Source: ProtInc cell-cell signaling Inferred from direct assay PubMed 10734056. Source: UniProtKB dendritic cell chemotaxis Traceable author statement PubMed 16621978. Source: BHF-UCL elevation of cytosolic calcium ion concentration Inferred from direct assay PubMed 10734056. Source: UniProtKB exocytosis Inferred from direct assay PubMed 10734056. Source: UniProtKB immune response Inferred from direct assay PubMed 10734056. Source: UniProtKB inflammatory response Traceable author statement Ref.2. Source: ProtInc negative regulation of bone mineralization Inferred from mutant phenotype PubMed 21403648. Source: UniProtKB negative regulation of gene expression Inferred from mutant phenotype PubMed 21403648. Source: UniProtKB positive regulation of ERK1 and ERK2 cascade Inferred from mutant phenotype PubMed 21403648. Source: UniProtKB positive regulation of calcium ion transport Inferred from direct assay PubMed 15764707. Source: UniProtKB positive regulation of monocyte chemotaxis Inferred from direct assay Ref.6. Source: UniProtKB positive regulation of osteoclast differentiation Inferred from mutant phenotype PubMed 21403648. Source: UniProtKB
Cellular_component	external side of plasma membrane Inferred from direct assay PubMed 10706735. Source: UniProtKB integral to plasma membrane Traceable author statement Ref.3. Source: ProtInc
Molecular_function	C-C chemokine receptor activity Inferred from direct assay PubMed 10734056. Source: UniProtKB phosphatidylinositol phospholipase C activity Inferred from direct assay PubMed 10734056. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CREB3	O43889-2	7	EBI-608322,EBI-625022
PLP2	Q04941	3	EBI-608322,EBI-608347

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 355

355

C-C chemokine receptor type 1

PRO_0000069228

Regions

Topological domain

1 – 34

Extracellular Potential

Transmembrane

35 – 60

Helical; Name=1; Potential

Topological domain

61 – 64

Cytoplasmic Potential

Transmembrane

65 – 91

Helical; Name=2; Potential

Topological domain

92 – 107

Extracellular Potential

Transmembrane

108 – 129

Helical; Name=3; Potential

Topological domain

130 – 146

Cytoplasmic Potential

Transmembrane

147 – 171

Helical; Name=4; Potential

Topological domain

172 – 197

Extracellular Potential

Transmembrane

198 – 223

Helical; Name=5; Potential

Topological domain

224 – 239

Cytoplasmic Potential

Transmembrane

240 – 264

Helical; Name=6; Potential

Topological domain

265 – 281

Extracellular Potential

Transmembrane

282 – 305

Helical; Name=7; Potential

Topological domain

306 – 355

Cytoplasmic Potential

Amino acid modifications

Glycosylation

N-linked (GlcNAc...) Potential

Disulfide bond

106 ↔ 183

By similarity

Experimental info

Sequence conflict

337

E → D in BAA01723. Ref.3

Sequences

Sequence

Length

Mass (Da)

Tools

P32246 [UniParc].

Last modified October 1, 1993. Version 1.
Checksum: B2C100FFED275985
Show »

FASTA

355

41,173

        10         20         30         40         50         60 
METPNTTEDY DTTTEFDYGD ATPCQKVNER AFGAQLLPPL YSLVFVIGLV GNILVVLVLV 

        70         80         90        100        110        120 
QYKRLKNMTS IYLLNLAISD LLFLFTLPFW IDYKLKDDWV FGDAMCKILS GFYYTGLYSE 

       130        140        150        160        170        180 
IFFIILLTID RYLAIVHAVF ALRARTVTFG VITSIIIWAL AILASMPGLY FSKTQWEFTH 

       190        200        210        220        230        240 
HTCSLHFPHE SLREWKLFQA LKLNLFGLVL PLLVMIICYT GIIKILLRRP NEKKSKAVRL 

       250        260        270        280        290        300 
IFVIMIIFFL FWTPYNLTIL ISVFQDFLFT HECEQSRHLD LAVQVTEVIA YTHCCVNPVI 

       310        320        330        340        350 
YAFVGERFRK YLRQLFHRRV AVHLVKWLPF LSVDRLERVS STSPSTGEHE LSAGF

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor." Neote K., Digregorio D., Mak J.Y., Horuk R., Schall T.J. Cell 72:415-425(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Structure and functional expression of the human macrophage inflammatory protein 1 alpha/RANTES receptor." Gao J.-L., Kuhns D., Tiffany H.L., McDermott D., Li X., Francke U., Murphy P.M. J. Exp. Med. 177:1421-1427(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors." Nomura H., Nielsen B.W., Matsushima K. Int. Immunol. 5:1239-1249(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Monocyte.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Blood.
[5]	"Human LZIP binds to CCR1 and differentially affects the chemotactic activities of CCR1-dependent chemokines." Ko J., Jang S.W., Kim Y.S., Kim I.S., Sung H.J., Kim H.-H., Park J.Y., Lee Y.H., Kim J., Na D.S. FASEB J. 18:890-892(2004) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH CREB3.
[6]	"Human LZIP induces monocyte CC chemokine receptor 2 expression leading to enhancement of monocyte chemoattractant protein 1/CCL2-induced cell migration." Sung H.J., Kim Y.S., Kang H., Ko J. Exp. Mol. Med. 40:332-338(2008) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, INDUCTION.
+	Additional computationally mapped references.

Web resources

Wikipedia

CC chemokine receptors entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

L09230 mRNA. Translation: AAA58408.1.
L10918 mRNA. Translation: AAA36543.1.
D10925 mRNA. Translation: BAA01723.1.
BC051306 mRNA. Translation: AAH51306.2.
BC064991 mRNA. Translation: AAH64991.1.

IPI

IPI00027685.

PIR

A45177.

RefSeq

NP_001286.1. NM_001295.2.

UniGene

Hs.301921.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1Y5D	model	-	A	1-355	[»]

ProteinModelPortal

P32246.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-5832N.

IntAct

P32246. 3 interactions.

STRING

9606.ENSP00000296140.

Protein family/group databases

GPCRDB

Search...

PTM databases

PhosphoSite

P32246.

Polymorphism databases

DMDM

416802.

Proteomic databases

PaxDb

P32246.

PRIDE

P32246.

Protocols and materials databases

DNASU

1230.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000296140; ENSP00000296140; ENSG00000163823.

GeneID

1230.

KEGG

hsa:1230.

UCSC

uc003cph.1. human.

Organism-specific databases

CTD

1230.

GeneCards

GC03M046218.

HGNC

HGNC:1602. CCR1.

MIM

601159. gene.

neXtProt

NX_P32246.

PharmGKB

PA26166.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG148353.

HOGENOM

HOG000234122.

HOVERGEN

HBG106917.

InParanoid

P32246.

K04176.

OMA

FWIDYKL.

OrthoDB

EOG4S1T7D.

PhylomeDB

P32246.

Enzyme and pathway databases

Reactome

REACT_111102. Signal Transduction.

Gene expression databases

ArrayExpress

P32246.

Bgee

P32246.

CleanEx

HS_CCR1.

Genevestigator

P32246.

GermOnline

ENSG00000163823. Homo sapiens.

Family and domain databases

InterPro

IPR002236. Chemokine_CCR1.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]

Pfam

PF00001. 7tm_1. 1 hit.
[Graphical view]

PRINTS

PR00657. CCCHEMOKINER.
PR01106. CHEMOKINER1.
PR00237. GPCRRHODOPSN.

PROSITE

PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

BindingDB

P32246.

ChEMBL

CHEMBL2413.

GenomeRNAi

1230.

NextBio

5015.

SOURCE

Search...

Entry information

Entry name

CCR1_HUMAN

Accession

Primary (citable) accession number: P32246
Secondary accession number(s): Q86VA9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
Last sequence update:	October 1, 1993
Last modified:	May 1, 2013
This is version 119 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Web resources

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents