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P32246

- CCR1_HUMAN

UniProt

P32246 - CCR1_HUMAN

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Protein
C-C chemokine receptor type 1
Gene
CCR1, CMKBR1, CMKR1, SCYAR1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation.

GO - Molecular functioni

  1. C-C chemokine binding Source: UniProtKB
  2. C-C chemokine receptor activity Source: UniProtKB
  3. chemokine (C-C motif) ligand 5 binding Source: UniProtKB
  4. chemokine (C-C motif) ligand 7 binding Source: UniProtKB
  5. chemokine receptor activity Source: UniProtKB
  6. phosphatidylinositol phospholipase C activity Source: UniProtKB
  7. protein binding Source: UniProtKB

GO - Biological processi

  1. G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
  2. calcium ion transport Source: UniProtKB
  3. cell adhesion Source: ProtInc
  4. cell surface receptor signaling pathway Source: ProtInc
  5. cell-cell signaling Source: UniProtKB
  6. cellular calcium ion homeostasis Source: UniProtKB
  7. chemokine-mediated signaling pathway Source: UniProtKB
  8. chemotaxis Source: UniProtKB
  9. cytokine-mediated signaling pathway Source: UniProtKB
  10. dendritic cell chemotaxis Source: BHF-UCL
  11. exocytosis Source: UniProtKB
  12. immune response Source: UniProtKB
  13. inflammatory response Source: ProtInc
  14. metabolic process Source: GOC
  15. negative regulation of bone mineralization Source: UniProtKB
  16. negative regulation of gene expression Source: UniProtKB
  17. positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
  18. positive regulation of calcium ion transport Source: UniProtKB
  19. positive regulation of cytosolic calcium ion concentration Source: UniProtKB
  20. positive regulation of monocyte chemotaxis Source: UniProtKB
  21. positive regulation of osteoclast differentiation Source: UniProtKB
  22. response to wounding Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_15344. Chemokine receptors bind chemokines.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C chemokine receptor type 1
Short name:
C-C CKR-1
Short name:
CC-CKR-1
Short name:
CCR-1
Short name:
CCR1
Alternative name(s):
HM145
LD78 receptor
Macrophage inflammatory protein 1-alpha receptor
Short name:
MIP-1alpha-R
RANTES-R
CD_antigen: CD191
Gene namesi
Name:CCR1
Synonyms:CMKBR1, CMKR1, SCYAR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:1602. CCR1.

Subcellular locationi

Cell membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434Extracellular Reviewed prediction
Add
BLAST
Transmembranei35 – 6026Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini61 – 644Cytoplasmic Reviewed prediction
Transmembranei65 – 9127Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini92 – 10716Extracellular Reviewed prediction
Add
BLAST
Transmembranei108 – 12922Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini130 – 14617Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei147 – 17125Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini172 – 19726Extracellular Reviewed prediction
Add
BLAST
Transmembranei198 – 22326Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini224 – 23916Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei240 – 26425Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini265 – 28117Extracellular Reviewed prediction
Add
BLAST
Transmembranei282 – 30524Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini306 – 35550Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. external side of plasma membrane Source: UniProtKB
  2. integral component of plasma membrane Source: ProtInc
  3. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26166.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 355355C-C chemokine receptor type 1
PRO_0000069228Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi106 ↔ 183 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP32246.
PRIDEiP32246.

PTM databases

PhosphoSiteiP32246.

Expressioni

Tissue specificityi

Widely expressed in different hematopoietic cells.

Inductioni

Up-regulated by CREB3.1 Publication

Gene expression databases

ArrayExpressiP32246.
BgeeiP32246.
CleanExiHS_CCR1.
GenevestigatoriP32246.

Interactioni

Subunit structurei

Interacts with CREB3.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CREB3O43889-27EBI-608322,EBI-625022
PLP2Q049413EBI-608322,EBI-608347

Protein-protein interaction databases

BioGridi107635. 4 interactions.
DIPiDIP-5832N.
IntActiP32246. 3 interactions.
MINTiMINT-140567.
STRINGi9606.ENSP00000296140.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Y5Dmodel-A1-355[»]
ProteinModelPortaliP32246.
SMRiP32246. Positions 2-317.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG148353.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP32246.
KOiK04176.
OMAiFWIDYKL.
OrthoDBiEOG738051.
PhylomeDBiP32246.
TreeFamiTF330966.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR002236. Chemokine_CCR1.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01106. CHEMOKINER1.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32246-1 [UniParc]FASTAAdd to Basket

« Hide

METPNTTEDY DTTTEFDYGD ATPCQKVNER AFGAQLLPPL YSLVFVIGLV    50
GNILVVLVLV QYKRLKNMTS IYLLNLAISD LLFLFTLPFW IDYKLKDDWV 100
FGDAMCKILS GFYYTGLYSE IFFIILLTID RYLAIVHAVF ALRARTVTFG 150
VITSIIIWAL AILASMPGLY FSKTQWEFTH HTCSLHFPHE SLREWKLFQA 200
LKLNLFGLVL PLLVMIICYT GIIKILLRRP NEKKSKAVRL IFVIMIIFFL 250
FWTPYNLTIL ISVFQDFLFT HECEQSRHLD LAVQVTEVIA YTHCCVNPVI 300
YAFVGERFRK YLRQLFHRRV AVHLVKWLPF LSVDRLERVS STSPSTGEHE 350
LSAGF 355
Length:355
Mass (Da):41,173
Last modified:October 1, 1993 - v1
Checksum:iB2C100FFED275985
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti337 – 3371E → D in BAA01723. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L09230 mRNA. Translation: AAA58408.1.
L10918 mRNA. Translation: AAA36543.1.
D10925 mRNA. Translation: BAA01723.1.
BC051306 mRNA. Translation: AAH51306.2.
BC064991 mRNA. Translation: AAH64991.1.
CCDSiCCDS2737.1.
PIRiA45177.
RefSeqiNP_001286.1. NM_001295.2.
UniGeneiHs.301921.

Genome annotation databases

EnsembliENST00000296140; ENSP00000296140; ENSG00000163823.
GeneIDi1230.
KEGGihsa:1230.
UCSCiuc003cph.1. human.

Polymorphism databases

DMDMi416802.

Cross-referencesi

Web resourcesi

Wikipedia

CC chemokine receptors entry

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L09230 mRNA. Translation: AAA58408.1 .
L10918 mRNA. Translation: AAA36543.1 .
D10925 mRNA. Translation: BAA01723.1 .
BC051306 mRNA. Translation: AAH51306.2 .
BC064991 mRNA. Translation: AAH64991.1 .
CCDSi CCDS2737.1.
PIRi A45177.
RefSeqi NP_001286.1. NM_001295.2.
UniGenei Hs.301921.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1Y5D model - A 1-355 [» ]
ProteinModelPortali P32246.
SMRi P32246. Positions 2-317.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107635. 4 interactions.
DIPi DIP-5832N.
IntActi P32246. 3 interactions.
MINTi MINT-140567.
STRINGi 9606.ENSP00000296140.

Chemistry

BindingDBi P32246.
ChEMBLi CHEMBL2413.
GuidetoPHARMACOLOGYi 58.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P32246.

Polymorphism databases

DMDMi 416802.

Proteomic databases

PaxDbi P32246.
PRIDEi P32246.

Protocols and materials databases

DNASUi 1230.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000296140 ; ENSP00000296140 ; ENSG00000163823 .
GeneIDi 1230.
KEGGi hsa:1230.
UCSCi uc003cph.1. human.

Organism-specific databases

CTDi 1230.
GeneCardsi GC03M046218.
HGNCi HGNC:1602. CCR1.
MIMi 601159. gene.
neXtProti NX_P32246.
PharmGKBi PA26166.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG148353.
HOGENOMi HOG000234122.
HOVERGENi HBG106917.
InParanoidi P32246.
KOi K04176.
OMAi FWIDYKL.
OrthoDBi EOG738051.
PhylomeDBi P32246.
TreeFami TF330966.

Enzyme and pathway databases

Reactomei REACT_15344. Chemokine receptors bind chemokines.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikii CCR1.
GenomeRNAii 1230.
NextBioi 5015.
PROi P32246.
SOURCEi Search...

Gene expression databases

ArrayExpressi P32246.
Bgeei P32246.
CleanExi HS_CCR1.
Genevestigatori P32246.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR002236. Chemokine_CCR1.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24227. PTHR24227. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00657. CCCHEMOKINER.
PR01106. CHEMOKINER1.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor."
    Neote K., Digregorio D., Mak J.Y., Horuk R., Schall T.J.
    Cell 72:415-425(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Structure and functional expression of the human macrophage inflammatory protein 1 alpha/RANTES receptor."
    Gao J.-L., Kuhns D., Tiffany H.L., McDermott D., Li X., Francke U., Murphy P.M.
    J. Exp. Med. 177:1421-1427(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors."
    Nomura H., Nielsen B.W., Matsushima K.
    Int. Immunol. 5:1239-1249(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Monocyte.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Blood.
  5. "Human LZIP binds to CCR1 and differentially affects the chemotactic activities of CCR1-dependent chemokines."
    Ko J., Jang S.W., Kim Y.S., Kim I.S., Sung H.J., Kim H.-H., Park J.Y., Lee Y.H., Kim J., Na D.S.
    FASEB J. 18:890-892(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CREB3.
  6. "Human LZIP induces monocyte CC chemokine receptor 2 expression leading to enhancement of monocyte chemoattractant protein 1/CCL2-induced cell migration."
    Sung H.J., Kim Y.S., Kang H., Ko J.
    Exp. Mol. Med. 40:332-338(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INDUCTION.

Entry informationi

Entry nameiCCR1_HUMAN
AccessioniPrimary (citable) accession number: P32246
Secondary accession number(s): Q86VA9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: September 3, 2014
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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