Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

C-C chemokine receptor type 1

Gene

CCR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation.

GO - Molecular functioni

  • C-C chemokine binding Source: UniProtKB
  • C-C chemokine receptor activity Source: UniProtKB
  • chemokine (C-C motif) ligand 5 binding Source: UniProtKB
  • chemokine (C-C motif) ligand 7 binding Source: UniProtKB
  • chemokine receptor activity Source: UniProtKB
  • phosphatidylinositol phospholipase C activity Source: UniProtKB

GO - Biological processi

  • calcium ion transport Source: UniProtKB
  • cell adhesion Source: ProtInc
  • cell-cell signaling Source: UniProtKB
  • cell surface receptor signaling pathway Source: ProtInc
  • cellular calcium ion homeostasis Source: UniProtKB
  • chemokine-mediated signaling pathway Source: UniProtKB
  • chemotaxis Source: UniProtKB
  • cytokine-mediated signaling pathway Source: UniProtKB
  • dendritic cell chemotaxis Source: BHF-UCL
  • exocytosis Source: UniProtKB
  • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
  • immune response Source: UniProtKB
  • inflammatory response Source: ProtInc
  • metabolic process Source: GOC
  • negative regulation of bone mineralization Source: UniProtKB
  • negative regulation of gene expression Source: UniProtKB
  • positive regulation of calcium ion transport Source: UniProtKB
  • positive regulation of cell migration Source: CACAO
  • positive regulation of cytosolic calcium ion concentration Source: UniProtKB
  • positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
  • positive regulation of monocyte chemotaxis Source: UniProtKB
  • positive regulation of osteoclast differentiation Source: UniProtKB
  • response to wounding Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_15344. Chemokine receptors bind chemokines.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C chemokine receptor type 1
Short name:
C-C CKR-1
Short name:
CC-CKR-1
Short name:
CCR-1
Short name:
CCR1
Alternative name(s):
HM145
LD78 receptor
Macrophage inflammatory protein 1-alpha receptor
Short name:
MIP-1alpha-R
RANTES-R
CD_antigen: CD191
Gene namesi
Name:CCR1
Synonyms:CMKBR1, CMKR1, SCYAR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:1602. CCR1.

Subcellular locationi

  • Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434ExtracellularSequence AnalysisAdd
BLAST
Transmembranei35 – 6026Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini61 – 644CytoplasmicSequence Analysis
Transmembranei65 – 9127Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini92 – 10716ExtracellularSequence AnalysisAdd
BLAST
Transmembranei108 – 12922Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini130 – 14617CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei147 – 17125Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini172 – 19726ExtracellularSequence AnalysisAdd
BLAST
Transmembranei198 – 22326Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini224 – 23916CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei240 – 26425Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini265 – 28117ExtracellularSequence AnalysisAdd
BLAST
Transmembranei282 – 30524Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini306 – 35550CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • cytosol Source: GOC
  • external side of plasma membrane Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26166.

Polymorphism and mutation databases

BioMutaiCCR1.
DMDMi416802.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 355355C-C chemokine receptor type 1PRO_0000069228Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi106 ↔ 183PROSITE-ProRule annotation
Modified residuei340 – 3401PhosphoserineBy similarity
Modified residuei341 – 3411PhosphoserineBy similarity
Modified residuei345 – 3451PhosphoserineBy similarity
Modified residuei352 – 3521PhosphoserineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP32246.
PRIDEiP32246.

PTM databases

PhosphoSiteiP32246.

Expressioni

Tissue specificityi

Widely expressed in different hematopoietic cells.

Inductioni

Up-regulated by CREB3.1 Publication

Gene expression databases

BgeeiP32246.
CleanExiHS_CCR1.
ExpressionAtlasiP32246. baseline and differential.
GenevisibleiP32246. HS.

Interactioni

Subunit structurei

Interacts with CREB3.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CREB3O43889-27EBI-608322,EBI-625022
PLP2Q049413EBI-608322,EBI-608347

Protein-protein interaction databases

BioGridi107635. 12 interactions.
DIPiDIP-5832N.
IntActiP32246. 3 interactions.
MINTiMINT-140567.
STRINGi9606.ENSP00000296140.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Y5Dmodel-A1-355[»]
ProteinModelPortaliP32246.
SMRiP32246. Positions 23-317.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG148353.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP32246.
KOiK04176.
OMAiFWIDYKL.
OrthoDBiEOG738051.
PhylomeDBiP32246.
TreeFamiTF330966.

Family and domain databases

InterProiIPR002236. Chemokine_CCR1.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01106. CHEMOKINER1.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32246-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METPNTTEDY DTTTEFDYGD ATPCQKVNER AFGAQLLPPL YSLVFVIGLV
60 70 80 90 100
GNILVVLVLV QYKRLKNMTS IYLLNLAISD LLFLFTLPFW IDYKLKDDWV
110 120 130 140 150
FGDAMCKILS GFYYTGLYSE IFFIILLTID RYLAIVHAVF ALRARTVTFG
160 170 180 190 200
VITSIIIWAL AILASMPGLY FSKTQWEFTH HTCSLHFPHE SLREWKLFQA
210 220 230 240 250
LKLNLFGLVL PLLVMIICYT GIIKILLRRP NEKKSKAVRL IFVIMIIFFL
260 270 280 290 300
FWTPYNLTIL ISVFQDFLFT HECEQSRHLD LAVQVTEVIA YTHCCVNPVI
310 320 330 340 350
YAFVGERFRK YLRQLFHRRV AVHLVKWLPF LSVDRLERVS STSPSTGEHE

LSAGF
Length:355
Mass (Da):41,173
Last modified:October 1, 1993 - v1
Checksum:iB2C100FFED275985
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti337 – 3371E → D in BAA01723 (PubMed:7505609).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L09230 mRNA. Translation: AAA58408.1.
L10918 mRNA. Translation: AAA36543.1.
D10925 mRNA. Translation: BAA01723.1.
BC051306 mRNA. Translation: AAH51306.2.
BC064991 mRNA. Translation: AAH64991.1.
CCDSiCCDS2737.1.
PIRiA45177.
RefSeqiNP_001286.1. NM_001295.2.
UniGeneiHs.301921.

Genome annotation databases

EnsembliENST00000296140; ENSP00000296140; ENSG00000163823.
GeneIDi1230.
KEGGihsa:1230.
UCSCiuc003cph.1. human.

Cross-referencesi

Web resourcesi

Wikipedia

CC chemokine receptors entry

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L09230 mRNA. Translation: AAA58408.1.
L10918 mRNA. Translation: AAA36543.1.
D10925 mRNA. Translation: BAA01723.1.
BC051306 mRNA. Translation: AAH51306.2.
BC064991 mRNA. Translation: AAH64991.1.
CCDSiCCDS2737.1.
PIRiA45177.
RefSeqiNP_001286.1. NM_001295.2.
UniGeneiHs.301921.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Y5Dmodel-A1-355[»]
ProteinModelPortaliP32246.
SMRiP32246. Positions 23-317.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107635. 12 interactions.
DIPiDIP-5832N.
IntActiP32246. 3 interactions.
MINTiMINT-140567.
STRINGi9606.ENSP00000296140.

Chemistry

BindingDBiP32246.
ChEMBLiCHEMBL2413.
GuidetoPHARMACOLOGYi58.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP32246.

Polymorphism and mutation databases

BioMutaiCCR1.
DMDMi416802.

Proteomic databases

PaxDbiP32246.
PRIDEiP32246.

Protocols and materials databases

DNASUi1230.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296140; ENSP00000296140; ENSG00000163823.
GeneIDi1230.
KEGGihsa:1230.
UCSCiuc003cph.1. human.

Organism-specific databases

CTDi1230.
GeneCardsiGC03M046218.
HGNCiHGNC:1602. CCR1.
MIMi601159. gene.
neXtProtiNX_P32246.
PharmGKBiPA26166.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG148353.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP32246.
KOiK04176.
OMAiFWIDYKL.
OrthoDBiEOG738051.
PhylomeDBiP32246.
TreeFamiTF330966.

Enzyme and pathway databases

ReactomeiREACT_15344. Chemokine receptors bind chemokines.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikiiCCR1.
GenomeRNAii1230.
NextBioi5015.
PROiP32246.
SOURCEiSearch...

Gene expression databases

BgeeiP32246.
CleanExiHS_CCR1.
ExpressionAtlasiP32246. baseline and differential.
GenevisibleiP32246. HS.

Family and domain databases

InterProiIPR002236. Chemokine_CCR1.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01106. CHEMOKINER1.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor."
    Neote K., Digregorio D., Mak J.Y., Horuk R., Schall T.J.
    Cell 72:415-425(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Structure and functional expression of the human macrophage inflammatory protein 1 alpha/RANTES receptor."
    Gao J.-L., Kuhns D., Tiffany H.L., McDermott D., Li X., Francke U., Murphy P.M.
    J. Exp. Med. 177:1421-1427(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors."
    Nomura H., Nielsen B.W., Matsushima K.
    Int. Immunol. 5:1239-1249(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Monocyte.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Blood.
  5. "Human LZIP binds to CCR1 and differentially affects the chemotactic activities of CCR1-dependent chemokines."
    Ko J., Jang S.W., Kim Y.S., Kim I.S., Sung H.J., Kim H.-H., Park J.Y., Lee Y.H., Kim J., Na D.S.
    FASEB J. 18:890-892(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CREB3.
  6. "Human LZIP induces monocyte CC chemokine receptor 2 expression leading to enhancement of monocyte chemoattractant protein 1/CCL2-induced cell migration."
    Sung H.J., Kim Y.S., Kang H., Ko J.
    Exp. Mol. Med. 40:332-338(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INDUCTION.

Entry informationi

Entry nameiCCR1_HUMAN
AccessioniPrimary (citable) accession number: P32246
Secondary accession number(s): Q86VA9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: July 22, 2015
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.