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Protein

Melanocortin receptor 3

Gene

Mc3r

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase. Required for expression of anticipatory patterns of activity and wakefulness during periods of limited nutrient availability and for the normal regulation of circadian clock activity in the brain.By similarity

GO - Molecular functioni

  • melanocortin receptor activity Source: RGD
  • melanocyte-stimulating hormone receptor activity Source: Ensembl
  • neuropeptide binding Source: Ensembl
  • peptide hormone binding Source: RGD

GO - Biological processi

  • adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: RGD
  • circadian regulation of gene expression Source: UniProtKB
  • homoiothermy Source: RGD
  • locomotor rhythm Source: UniProtKB
  • positive regulation of cAMP biosynthetic process Source: Ensembl
  • regulation of blood pressure Source: RGD
  • regulation of feeding behavior Source: UniProtKB
  • regulation of heart rate Source: RGD
  • sodium ion homeostasis Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Biological rhythms

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.
R-RNO-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Melanocortin receptor 3
Short name:
MC3-R
Gene namesi
Name:Mc3r
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi3056. Mc3r.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 37ExtracellularSequence analysisAdd BLAST37
Transmembranei38 – 63Helical; Name=1Sequence analysisAdd BLAST26
Topological domaini64 – 75CytoplasmicSequence analysisAdd BLAST12
Transmembranei76 – 100Helical; Name=2Sequence analysisAdd BLAST25
Topological domaini101 – 118ExtracellularSequence analysisAdd BLAST18
Transmembranei119 – 140Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini141 – 160CytoplasmicSequence analysisAdd BLAST20
Transmembranei161 – 181Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini182 – 186ExtracellularSequence analysis5
Transmembranei187 – 210Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini211 – 245CytoplasmicSequence analysisAdd BLAST35
Transmembranei246 – 268Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini269 – 277ExtracellularSequence analysis9
Transmembranei278 – 301Helical; Name=7Sequence analysisAdd BLAST24
Topological domaini302 – 323CytoplasmicSequence analysisAdd BLAST22

GO - Cellular componenti

  • integral component of plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4023.
GuidetoPHARMACOLOGYi284.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000697201 – 323Melanocortin receptor 3Add BLAST323

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi2N-linked (GlcNAc...)Sequence analysis1
Glycosylationi16N-linked (GlcNAc...)Sequence analysis1
Glycosylationi28N-linked (GlcNAc...)Sequence analysis1
Lipidationi315S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP32244.
PRIDEiP32244.

Expressioni

Tissue specificityi

Brain.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005871.

Chemistry databases

BindingDBiP32244.

Structurei

3D structure databases

ProteinModelPortaliP32244.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00770000120529.
HOGENOMiHOG000246927.
HOVERGENiHBG108148.
InParanoidiP32244.
KOiK04201.
OMAiVHMFLFA.
OrthoDBiEOG091G0BVW.
TreeFamiTF332646.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002122. Mcort_3_rcpt.
IPR001908. Melancort_rcpt.
IPR001671. Melcrt_ACTH_rcpt.
[Graphical view]
PANTHERiPTHR22750:SF4. PTHR22750:SF4. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00534. MCRFAMILY.
PR00535. MELNOCORTINR.
PR01061. MELNOCORTN3R.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32244-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSSCCPSSS YPTLPNLSQH PAAPSASNRS GSGFCEQVFI KPEVFLALGI
60 70 80 90 100
VSLMENILVI LAVVRNGNLH SPMYFFLCSL AAADMLVSLS NSLETIMIVV
110 120 130 140 150
INSDSLTLED QFIQHMDNIF DSMICISLVA SICNLLAIAV DRYVTIFYAL
160 170 180 190 200
RYHSIMTVRK ALSLIVAIWV CCGICGVMFI VYSESKMVIV CLITMFFAMV
210 220 230 240 250
LLMGTLYIHM FLFARLHVQR IAALPPADGV APQQHSCMKG AVTITILLGV
260 270 280 290 300
FIFCWAPFFL HLVLIITCPT NPYCICYTAH FNTYLVLIMC NSVIDPLIYA
310 320
FRSLELRNTF KEILCGCNGM NVG
Length:323
Mass (Da):35,757
Last modified:July 11, 2012 - v2
Checksum:iF4E57B88E7A0A736
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti78C → L in CAA50005 (PubMed:8415620).Curated1
Sequence conflicti81 – 82AA → LQ in CAA50005 (PubMed:8415620).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70667 mRNA. Translation: CAA50005.1.
AY671938 mRNA. Translation: AAU87797.1.
CH474062 Genomic DNA. Translation: EDL85154.1.
PIRiA48254. S36636.
RefSeqiNP_001020441.3. NM_001025270.3.
UniGeneiRn.215838.

Genome annotation databases

EnsembliENSRNOT00000005871; ENSRNOP00000005871; ENSRNOG00000004451.
GeneIDi29310.
KEGGirno:29310.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70667 mRNA. Translation: CAA50005.1.
AY671938 mRNA. Translation: AAU87797.1.
CH474062 Genomic DNA. Translation: EDL85154.1.
PIRiA48254. S36636.
RefSeqiNP_001020441.3. NM_001025270.3.
UniGeneiRn.215838.

3D structure databases

ProteinModelPortaliP32244.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005871.

Chemistry databases

BindingDBiP32244.
ChEMBLiCHEMBL4023.
GuidetoPHARMACOLOGYi284.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiP32244.
PRIDEiP32244.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000005871; ENSRNOP00000005871; ENSRNOG00000004451.
GeneIDi29310.
KEGGirno:29310.

Organism-specific databases

CTDi4159.
RGDi3056. Mc3r.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00770000120529.
HOGENOMiHOG000246927.
HOVERGENiHBG108148.
InParanoidiP32244.
KOiK04201.
OMAiVHMFLFA.
OrthoDBiEOG091G0BVW.
TreeFamiTF332646.

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.
R-RNO-418555. G alpha (s) signalling events.

Miscellaneous databases

PROiP32244.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002122. Mcort_3_rcpt.
IPR001908. Melancort_rcpt.
IPR001671. Melcrt_ACTH_rcpt.
[Graphical view]
PANTHERiPTHR22750:SF4. PTHR22750:SF4. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00534. MCRFAMILY.
PR00535. MELNOCORTINR.
PR01061. MELNOCORTN3R.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMC3R_RAT
AccessioniPrimary (citable) accession number: P32244
Secondary accession number(s): Q4KXA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: July 11, 2012
Last modified: September 7, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.