##gff-version 3
P32243	UniProtKB	Chain	1	289	.	.	.	ID=PRO_0000049210;Note=Homeobox protein OTX2	
P32243	UniProtKB	DNA binding	38	97	.	.	.	Note=Homeobox;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00108	
P32243	UniProtKB	Region	93	143	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P32243	UniProtKB	Compositional bias	93	109	.	.	.	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P32243	UniProtKB	Compositional bias	120	143	.	.	.	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P32243	UniProtKB	Alternative sequence	32	32	.	.	.	ID=VSP_021006;Note=In isoform 2. P->PGPWASCPA;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:8101484;Dbxref=PMID:15489334,PMID:8101484	
P32243	UniProtKB	Natural variant	79	79	.	.	.	ID=VAR_073793;Note=In RDEOP. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25293953;Dbxref=dbSNP:rs786205224,PMID:25293953	
P32243	UniProtKB	Natural variant	89	89	.	.	.	ID=VAR_029354;Note=In MCOPS5. R->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15846561;Dbxref=dbSNP:rs104894464,PMID:15846561	
P32243	UniProtKB	Natural variant	90	90	.	.	.	ID=VAR_065952;Note=In MCOPS5%3B does not affect the expression or nuclear localization of the protein but inhibits its DNA-binding activity as well as its transactivation capability%3B the protein is non-functional. R->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20396904;Dbxref=PMID:20396904	
P32243	UniProtKB	Natural variant	133	133	.	.	.	ID=VAR_029355;Note=In MCOPS5. P->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15846561;Dbxref=dbSNP:rs376333965,PMID:15846561	
P32243	UniProtKB	Natural variant	134	134	.	.	.	ID=VAR_029356;Note=In MCOPS5. P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15846561;Dbxref=dbSNP:rs753783256,PMID:15846561	
P32243	UniProtKB	Natural variant	134	134	.	.	.	ID=VAR_078446;Note=In CPHD6%3B uncertain significance%3B loss of transcriptional activity%2C when tested on bicoid binding sites%3B decreases transactivation mediated by the wild-type protein%2C when tested on bicoid binding sites%3B no effect on DNA-binding. P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22715480;Dbxref=dbSNP:rs199761861,PMID:22715480	
P32243	UniProtKB	Natural variant	225	225	.	.	.	ID=VAR_065953;Note=In CPHD6%3B acts as a dominant inhibitor of the HESX1 gene. N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18728160;Dbxref=dbSNP:rs370761964,PMID:18728160