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Protein

Homeobox protein OTX1

Gene

OTX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi38 – 97HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein OTX1
Alternative name(s):
Orthodenticle homolog 1
Gene namesi
Name:OTX1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000115507.9.
HGNCiHGNC:8521. OTX1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi5013.
OpenTargetsiENSG00000115507.
PharmGKBiPA32848.

Polymorphism and mutation databases

BioMutaiOTX1.
DMDMi417425.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000492071 – 354Homeobox protein OTX1Add BLAST354

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki344Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiP32242.
MaxQBiP32242.
PaxDbiP32242.
PeptideAtlasiP32242.
PRIDEiP32242.

PTM databases

iPTMnetiP32242.
PhosphoSitePlusiP32242.

Expressioni

Tissue specificityi

Expressed in brain. Detected in the anterior part of the neural fetal retina (at protein level).1 Publication

Developmental stagei

Embryo.

Gene expression databases

BgeeiENSG00000115507.
CleanExiHS_OTX1.
ExpressionAtlasiP32242. baseline and differential.
GenevisibleiP32242. HS.

Organism-specific databases

HPAiCAB012341.
HPA052122.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ADAMTSL4Q6UY14-34EBI-740446,EBI-10173507
AKR7LQ8NHP1-24EBI-740446,EBI-12816993
ALPPP051874EBI-740446,EBI-1211484
CHIC2Q9UKJ53EBI-740446,EBI-741528
CHRDQ9H2X03EBI-740446,EBI-947551
COL8A1P276584EBI-740446,EBI-747133
COMPP497475EBI-740446,EBI-2531022
CYSRT1A8MQ034EBI-740446,EBI-3867333
FBLN5Q9UBX53EBI-740446,EBI-947897
GRNP2879910EBI-740446,EBI-747754
INTS11Q5TA454EBI-740446,EBI-748258
KCNK16Q96T553EBI-740446,EBI-10294109
KPRPQ5T7494EBI-740446,EBI-10981970
KRT81Q145339EBI-740446,EBI-739648
KRT85P783864EBI-740446,EBI-1049371
KRTAP10-11P604125EBI-740446,EBI-10217483
KRTAP10-5P603705EBI-740446,EBI-10172150
KRTAP10-7P60409-24EBI-740446,EBI-10695388
KRTAP10-8P604109EBI-740446,EBI-10171774
KRTAP10-9P604118EBI-740446,EBI-10172052
KRTAP12-2P599915EBI-740446,EBI-10176379
KRTAP12-3P603286EBI-740446,EBI-11953334
KRTAP12-4P603297EBI-740446,EBI-10176396
KRTAP26-1Q6PEX33EBI-740446,EBI-3957672
KRTAP3-2Q9BYR75EBI-740446,EBI-751260
KRTAP3-3Q9BYR65EBI-740446,EBI-3957694
KRTAP4-11Q9BYQ65EBI-740446,EBI-10302392
KRTAP4-12Q9BQ666EBI-740446,EBI-739863
KRTAP4-2Q9BYR53EBI-740446,EBI-10172511
KRTAP4-7Q9BYR03EBI-740446,EBI-10302547
KRTAP5-6Q6L8G95EBI-740446,EBI-10250562
KRTAP5-9P263719EBI-740446,EBI-3958099
KRTAP9-2Q9BYQ47EBI-740446,EBI-1044640
KRTAP9-3Q9BYQ36EBI-740446,EBI-1043191
KRTAP9-4Q9BYQ25EBI-740446,EBI-10185730
KRTAP9-8Q9BYQ04EBI-740446,EBI-11958364
LCE1BQ5T7P33EBI-740446,EBI-10245913
LCE2AQ5TA793EBI-740446,EBI-10246607
LCE2CQ5TA814EBI-740446,EBI-11973993
LCE2DQ5TA823EBI-740446,EBI-10246750
LCE4AQ5TA783EBI-740446,EBI-10246358
LOC642947Q6ZP954EBI-740446,EBI-12813431
MDFIQ997507EBI-740446,EBI-724076
NOTCH2NLQ7Z3S94EBI-740446,EBI-945833
POU2AF1Q166334EBI-740446,EBI-943588
RBPMSQ930624EBI-740446,EBI-740322
RGS17Q9UGC65EBI-740446,EBI-3918154
RGS20O760814EBI-740446,EBI-1052678
SLC15A2Q163484EBI-740446,EBI-12806032
SMARCC1Q929223EBI-740446,EBI-355653
SPRY1O436093EBI-740446,EBI-3866665
SPRY2O435974EBI-740446,EBI-742487
TNS2Q63HR26EBI-740446,EBI-949753
TP73-AS1Q9UF724EBI-740446,EBI-11976343
VWC2LB2RUY74EBI-740446,EBI-11747707

Protein-protein interaction databases

BioGridi111053. 41 interactors.
IntActiP32242. 122 interactors.
MINTiMINT-1437362.
STRINGi9606.ENSP00000282549.

Structurei

3D structure databases

ProteinModelPortaliP32242.
SMRiP32242.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi275 – 301His-richAdd BLAST27

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG2251. Eukaryota.
ENOG4111XIJ. LUCA.
GeneTreeiENSGT00900000140776.
HOVERGENiHBG004028.
InParanoidiP32242.
KOiK09326.
OMAiPPYGVNG.
OrthoDBiEOG091G0K9K.
PhylomeDBiP32242.
TreeFamiTF351179.

Family and domain databases

CDDicd00086. homeodomain. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like_sf.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR003026. Otx1_TF.
IPR003025. Otx_TF.
IPR013851. Otx_TF_C.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PF03529. TF_Otx. 1 hit.
PRINTSiPR01256. OTX1HOMEOBOX.
PR01255. OTXHOMEOBOX.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P32242-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSYLKQPPY GMNGLGLAGP AMDLLHPSVG YPATPRKQRR ERTTFTRSQL
60 70 80 90 100
DVLEALFAKT RYPDIFMREE VALKINLPES RVQVWFKNRR AKCRQQQQSG
110 120 130 140 150
SGTKSRPAKK KSSPVRESSG SESSGQFTPP AVSSSASSSS SASSSSANPA
160 170 180 190 200
AAAAAGLGGN PVAAASSLST PAASSIWSPA SISPGSAPAS VSVPEPLAAP
210 220 230 240 250
SNTSCMQRSV AAGAATAAAS YPMSYGQGGS YGQGYPTPSS SYFGGVDCSS
260 270 280 290 300
YLAPMHSHHH PHQLSPMAPS SMAGHHHHHP HAHHPLSQSS GHHHHHHHHH
310 320 330 340 350
HQGYGGSGLA FNSADCLDYK EPGAAAASSA WKLNFNSPDC LDYKDQASWR

FQVL
Length:354
Mass (Da):37,327
Last modified:October 1, 1993 - v1
Checksum:iE32C1E47464BDDAA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095680 mRNA. Translation: BAG53106.1.
AC009501 Genomic DNA. Translation: AAY24357.1.
CH471053 Genomic DNA. Translation: EAW99967.1.
BC007621 mRNA. Translation: AAH07621.1.
CCDSiCCDS1873.1.
PIRiS39406.
RefSeqiNP_001186699.1. NM_001199770.1.
NP_055377.1. NM_014562.3.
UniGeneiHs.734360.

Genome annotation databases

EnsembliENST00000282549; ENSP00000282549; ENSG00000115507.
ENST00000366671; ENSP00000355631; ENSG00000115507.
GeneIDi5013.
KEGGihsa:5013.
UCSCiuc002scd.4. human.

Similar proteinsi

Entry informationi

Entry nameiOTX1_HUMAN
AccessioniPrimary (citable) accession number: P32242
Secondary accession number(s): A6NHA2, B3KTJ4, Q53TG6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: November 22, 2017
This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families