ID VIPR1_HUMAN Reviewed; 457 AA. AC P32241; A5JUT9; B3KPV1; B4DEB5; B4DGI4; F5H1F5; G3V0I1; Q15871; Q6P2M6; DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1993, sequence version 1. DT 24-JAN-2024, entry version 206. DE RecName: Full=Vasoactive intestinal polypeptide receptor 1; DE Short=VIP-R-1; DE AltName: Full=Pituitary adenylate cyclase-activating polypeptide type II receptor; DE Short=PACAP type II receptor; DE Short=PACAP-R-2; DE Short=PACAP-R2; DE AltName: Full=VPAC1; DE Flags: Precursor; GN Name=VIPR1; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM SHORT). RC TISSUE=Intestine; RX PubMed=8390245; DOI=10.1006/bbrc.1993.1658; RA Sreedharan S.P., Patel D.R., Huang J.-X., Goetzl E.J.; RT "Cloning and functional expression of a human neuroendocrine vasoactive RT intestinal peptide receptor."; RL Biochem. Biophys. Res. Commun. 193:546-553(1993). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS SHORT AND LONG), AND ALTERNATIVE RP SPLICING. RC TISSUE=Intestine; RX PubMed=8179610; DOI=10.1006/bbrc.1994.1517; RA Couvineau A., Rouyer-Fessard C., Darmoul D., Maoret J.J., Carrero I., RA Ogier-Denis E., Laburthe M.; RT "Human intestinal VIP receptor: cloning and functional expression of two RT cDNA encoding proteins with different N-terminal domains."; RL Biochem. Biophys. Res. Commun. 200:769-776(1994). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT). RC TISSUE=Lung; RA Martin A.L., Kaighin V.A., Aronstam R.S.; RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS SHORT; 3; 4 AND 5). RC TISSUE=Brain, Cerebellum, Lung, and Prostate; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16641997; DOI=10.1038/nature04728; RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.; RT "The DNA sequence, annotation and analysis of human chromosome 3."; RL Nature 440:1194-1198(2006). RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [8] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SHORT), AND VARIANT RP MET-341. RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [9] RP NUCLEOTIDE SEQUENCE [MRNA] OF 33-457. RC TISSUE=Liver; RX PubMed=7917790; DOI=10.1016/0898-6568(94)90037-x; RA Gagnon A.W., Aiyar N., Elshourbagy N.A.; RT "Molecular cloning and functional characterization of a human liver RT vasoactive intestinal peptide receptor."; RL Cell. Signal. 6:321-333(1994). RN [10] RP INTERACTION WITH VIP. RX PubMed=7818527; DOI=10.1006/bbrc.1995.1034; RA Couvineau A., Gaudin P., Maoret J.J., Rouyer-Fessard C., Nicole P., RA Laburthe M.; RT "Highly conserved aspartate 68, tryptophan 73 and glycine 109 in the N- RT terminal extracellular domain of the human VIP receptor are essential for RT its ability to bind VIP."; RL Biochem. Biophys. Res. Commun. 206:246-252(1995). RN [11] RP FUNCTION, AND TISSUE SPECIFICITY. RX PubMed=8926282; DOI=10.1007/bf01540969; RA Xia M., Sreedharan S.P., Goetzl E.J.; RT "Predominant expression of type II vasoactive intestinal peptide receptors RT by human T lymphoblastoma cells: transduction of both Ca2+ and cyclic AMP RT signals."; RL J. Clin. Immunol. 16:21-30(1996). RN [12] RP DISULFIDE BOND. RX PubMed=9928020; DOI=10.1111/j.1749-6632.1998.tb11186.x; RA Knudsen S.M., Tams J.W., Wulff B.S., Fahrenkrug J.; RT "Importance of conserved cysteines in the extracellular loops of human RT PACAP/VIP1 receptor for ligand binding and stimulation of cAMP RT production."; RL Ann. N. Y. Acad. Sci. 865:259-265(1998). RN [13] RP X-RAY CRYSTALLOGRAPHY (1.47 ANGSTROMS) OF 400-408 IN COMPLEX WITH MHC. RX PubMed=14734527; DOI=10.1084/jem.20031690; RA Hulsmeyer M., Fiorillo M.T., Bettosini F., Sorrentino R., Saenger W., RA Ziegler A., Uchanska-Ziegler B.; RT "Dual, HLA-B27 subtype-dependent conformation of a self-peptide."; RL J. Exp. Med. 199:271-281(2004). RN [14] RP X-RAY CRYSTALLOGRAPHY (1.86 ANGSTROMS) OF 400-408 IN COMPLEX WITH MHC. RX PubMed=18650441; DOI=10.1074/jbc.m802818200; RA Beltrami A., Rossmann M., Fiorillo M.T., Paladini F., Sorrentino R., RA Saenger W., Kumar P., Ziegler A., Uchanska-Ziegler B.; RT "Citrullination-dependent differential presentation of a self-peptide by RT HLA-B27 subtypes."; RL J. Biol. Chem. 283:27189-27199(2008). CC -!- FUNCTION: This is a receptor for VIP. The activity of this receptor is CC mediated by G proteins which activate adenylyl cyclase. The affinity is CC VIP = PACAP-27 > PACAP-38. {ECO:0000269|PubMed:8926282}. CC -!- INTERACTION: CC P32241; Q9NQX1-2: PRDM5; NbExp=3; IntAct=EBI-3917984, EBI-12859340; CC P32241; PRO_0000011460 [P01282]: VIP; NbExp=2; IntAct=EBI-3917984, EBI-6656819; CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=5; CC Name=Short; Synonyms=hIVR8; CC IsoId=P32241-1; Sequence=Displayed; CC Name=Long; Synonyms=hIVR5; CC IsoId=P32241-2; Sequence=VSP_002010; CC Name=3; CC IsoId=P32241-3; Sequence=VSP_045143; CC Name=4; CC IsoId=P32241-4; Sequence=VSP_047271, VSP_047273; CC Name=5; CC IsoId=P32241-5; Sequence=VSP_047272; CC -!- TISSUE SPECIFICITY: In lung, HT-29 colonic epithelial cells, Raji B- CC lymphoblasts. Lesser extent in brain, heart, kidney, liver and CC placenta. Not expressed in CD4+ or CD8+ T-cells. Expressed in the T- CC cell lines HARRIS, HuT 78, Jurkat and SUP-T1, but not in the T-cell CC lines Peer, MOLT-4, HSB and YT. {ECO:0000269|PubMed:8926282}. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family. CC {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; L13288; AAA36805.1; -; mRNA. DR EMBL; U11087; AAB60362.1; -; Genomic_DNA. DR EMBL; U11079; AAB60362.1; JOINED; Genomic_DNA. DR EMBL; U11080; AAB60362.1; JOINED; Genomic_DNA. DR EMBL; U11081; AAB60362.1; JOINED; Genomic_DNA. DR EMBL; U11083; AAB60362.1; JOINED; Genomic_DNA. DR EMBL; U11084; AAB60362.1; JOINED; Genomic_DNA. DR EMBL; U11085; AAB60362.1; JOINED; Genomic_DNA. DR EMBL; U11086; AAB60362.1; JOINED; Genomic_DNA. DR EMBL; X75299; CAA53046.1; -; mRNA. DR EMBL; X77777; CAA54814.1; -; mRNA. DR EMBL; AB065669; BAC05895.1; -; Genomic_DNA. DR EMBL; EF577396; ABQ52416.1; -; mRNA. DR EMBL; AK314334; BAG36980.1; -; mRNA. DR EMBL; AK293548; BAG57026.1; -; mRNA. DR EMBL; AK294609; BAG57795.1; -; mRNA. DR EMBL; AK056819; BAG51813.1; -; mRNA. DR EMBL; AC092047; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471055; EAW64649.1; -; Genomic_DNA. DR EMBL; CH471055; EAW64650.1; -; Genomic_DNA. DR EMBL; BC064424; AAH64424.1; -; mRNA. DR EMBL; L20295; AAA36802.1; -; mRNA. DR CCDS; CCDS2698.1; -. [P32241-1] DR CCDS; CCDS58827.1; -. [P32241-4] DR CCDS; CCDS58828.1; -. [P32241-5] DR CCDS; CCDS58829.1; -. [P32241-3] DR PIR; JC2194; JC2194. DR PIR; JC2195; JC2195. DR RefSeq; NP_001238811.1; NM_001251882.1. [P32241-5] DR RefSeq; NP_001238812.1; NM_001251883.1. [P32241-3] DR RefSeq; NP_001238813.1; NM_001251884.1. [P32241-4] DR RefSeq; NP_001238814.1; NM_001251885.1. DR RefSeq; NP_004615.2; NM_004624.3. [P32241-1] DR RefSeq; XP_005265495.1; XM_005265438.3. DR RefSeq; XP_011532381.1; XM_011534079.1. DR PDB; 1OF2; X-ray; 2.20 A; C=400-408. DR PDB; 1OGT; X-ray; 1.47 A; C=400-408. DR PDB; 3B3I; X-ray; 1.86 A; C=400-408. DR PDB; 3B6S; X-ray; 1.80 A; C=400-408. DR PDB; 3DTX; X-ray; 2.10 A; C=400-408. DR PDB; 3HCV; X-ray; 1.95 A; C=400-408. DR PDB; 5DEF; X-ray; 1.60 A; C=400-408. DR PDB; 5DEG; X-ray; 1.83 A; C=400-408. DR PDB; 5IB1; X-ray; 1.91 A; C=400-408. DR PDB; 5IB2; X-ray; 1.44 A; C=400-408. DR PDB; 5IB3; X-ray; 1.91 A; C=400-408. DR PDB; 5IB4; X-ray; 1.95 A; C=400-408. DR PDB; 5IB5; X-ray; 2.49 A; C/F=400-408. DR PDB; 6VN7; EM; 3.20 A; R=31-437. DR PDB; 7ALO; X-ray; 1.80 A; C/F=400-408. DR PDB; 8E3Y; EM; 2.30 A; R=28-457. DR PDB; 8E3Z; EM; 2.70 A; R=28-457. DR PDBsum; 1OF2; -. DR PDBsum; 1OGT; -. DR PDBsum; 3B3I; -. DR PDBsum; 3B6S; -. DR PDBsum; 3DTX; -. DR PDBsum; 3HCV; -. DR PDBsum; 5DEF; -. DR PDBsum; 5DEG; -. DR PDBsum; 5IB1; -. DR PDBsum; 5IB2; -. DR PDBsum; 5IB3; -. DR PDBsum; 5IB4; -. DR PDBsum; 5IB5; -. DR PDBsum; 6VN7; -. DR PDBsum; 7ALO; -. DR PDBsum; 8E3Y; -. DR PDBsum; 8E3Z; -. DR AlphaFoldDB; P32241; -. DR EMDB; EMD-21249; -. DR SMR; P32241; -. DR BioGRID; 113274; 245. DR IntAct; P32241; 27. DR MINT; P32241; -. DR STRING; 9606.ENSP00000327246; -. DR BindingDB; P32241; -. DR ChEMBL; CHEMBL5144; -. DR DrugCentral; P32241; -. DR GuidetoPHARMACOLOGY; 371; -. DR TCDB; 9.A.14.4.9; the g-protein-coupled receptor (gpcr) family. DR GlyCosmos; P32241; 4 sites, No reported glycans. DR GlyGen; P32241; 4 sites. DR iPTMnet; P32241; -. DR PhosphoSitePlus; P32241; -. DR SwissPalm; P32241; -. DR BioMuta; VIPR1; -. DR DMDM; 418253; -. DR jPOST; P32241; -. DR MassIVE; P32241; -. DR PaxDb; 9606-ENSP00000327246; -. DR PeptideAtlas; P32241; -. DR ProteomicsDB; 25640; -. DR ProteomicsDB; 32204; -. DR ProteomicsDB; 3938; -. DR ProteomicsDB; 54848; -. [P32241-1] DR ProteomicsDB; 54849; -. [P32241-2] DR ABCD; P32241; 2 sequenced antibodies. DR Antibodypedia; 12331; 507 antibodies from 37 providers. DR DNASU; 7433; -. DR Ensembl; ENST00000325123.5; ENSP00000327246.4; ENSG00000114812.13. [P32241-1] DR Ensembl; ENST00000433647.5; ENSP00000394950.1; ENSG00000114812.13. [P32241-5] DR Ensembl; ENST00000438259.6; ENSP00000415371.2; ENSG00000114812.13. [P32241-3] DR Ensembl; ENST00000543411.5; ENSP00000445701.1; ENSG00000114812.13. [P32241-4] DR GeneID; 7433; -. DR KEGG; hsa:7433; -. DR MANE-Select; ENST00000325123.5; ENSP00000327246.4; NM_004624.4; NP_004615.2. DR UCSC; uc003clf.3; human. [P32241-1] DR AGR; HGNC:12694; -. DR CTD; 7433; -. DR DisGeNET; 7433; -. DR GeneCards; VIPR1; -. DR HGNC; HGNC:12694; VIPR1. DR HPA; ENSG00000114812; Tissue enhanced (lung). DR MIM; 192321; gene. DR neXtProt; NX_P32241; -. DR OpenTargets; ENSG00000114812; -. DR PharmGKB; PA37313; -. DR VEuPathDB; HostDB:ENSG00000114812; -. DR eggNOG; KOG4564; Eukaryota. DR GeneTree; ENSGT00940000156402; -. DR HOGENOM; CLU_1124194_0_0_1; -. DR InParanoid; P32241; -. DR OMA; SKSQHPW; -. DR OrthoDB; 4209391at2759; -. DR PhylomeDB; P32241; -. DR TreeFam; TF315710; -. DR PathwayCommons; P32241; -. DR Reactome; R-HSA-418555; G alpha (s) signalling events. DR Reactome; R-HSA-420092; Glucagon-type ligand receptors. DR SignaLink; P32241; -. DR SIGNOR; P32241; -. DR BioGRID-ORCS; 7433; 10 hits in 1147 CRISPR screens. DR ChiTaRS; VIPR1; human. DR EvolutionaryTrace; P32241; -. DR GeneWiki; VIPR1; -. DR GenomeRNAi; 7433; -. DR Pharos; P32241; Tchem. DR PRO; PR:P32241; -. DR Proteomes; UP000005640; Chromosome 3. DR RNAct; P32241; Protein. DR Bgee; ENSG00000114812; Expressed in right lung and 142 other cell types or tissues. DR ExpressionAtlas; P32241; baseline and differential. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0043235; C:receptor complex; IDA:MGI. DR GO; GO:0008528; F:G protein-coupled peptide receptor activity; IBA:GO_Central. DR GO; GO:0017046; F:peptide hormone binding; IPI:GO_Central. DR GO; GO:0004999; F:vasoactive intestinal polypeptide receptor activity; IDA:GO_Central. DR GO; GO:0007188; P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway; IBA:GO_Central. DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro. DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; TAS:ProtInc. DR GO; GO:0007187; P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; IDA:GO_Central. DR GO; GO:0008284; P:positive regulation of cell population proliferation; TAS:ProtInc. DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1. DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1. DR InterPro; IPR017981; GPCR_2-like_7TM. DR InterPro; IPR036445; GPCR_2_extracell_dom_sf. DR InterPro; IPR001879; GPCR_2_extracellular_dom. DR InterPro; IPR000832; GPCR_2_secretin-like. DR InterPro; IPR017983; GPCR_2_secretin-like_CS. DR InterPro; IPR001571; GPCR_2_VIP_rcpt. DR InterPro; IPR001771; GPCR_2_VIP_rcpt_1. DR PANTHER; PTHR45620; PDF RECEPTOR-LIKE PROTEIN-RELATED; 1. DR PANTHER; PTHR45620:SF24; VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR 1; 1. DR Pfam; PF00002; 7tm_2; 1. DR Pfam; PF02793; HRM; 1. DR PRINTS; PR00249; GPCRSECRETIN. DR PRINTS; PR00491; VASOACTVEIPR. DR PRINTS; PR01154; VIP1RECEPTOR. DR SMART; SM00008; HormR; 1. DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1. DR SUPFAM; SSF111418; Hormone receptor domain; 1. DR PROSITE; PS00649; G_PROTEIN_RECEP_F2_1; 1. DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1. DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1. DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1. DR Genevisible; P32241; HS. PE 1: Evidence at protein level; KW 3D-structure; Alternative splicing; Cell membrane; Disulfide bond; KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor; KW Reference proteome; Signal; Transducer; Transmembrane; Transmembrane helix. FT SIGNAL 1..30 FT /evidence="ECO:0000255" FT CHAIN 31..457 FT /note="Vasoactive intestinal polypeptide receptor 1" FT /id="PRO_0000012855" FT TOPO_DOM 31..142 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 143..167 FT /note="Helical; Name=1" FT /evidence="ECO:0000255" FT TOPO_DOM 168..174 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 175..194 FT /note="Helical; Name=2" FT /evidence="ECO:0000255" FT TOPO_DOM 195..216 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 217..240 FT /note="Helical; Name=3" FT /evidence="ECO:0000255" FT TOPO_DOM 241..254 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 255..276 FT /note="Helical; Name=4" FT /evidence="ECO:0000255" FT TOPO_DOM 277..292 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 293..316 FT /note="Helical; Name=5" FT /evidence="ECO:0000255" FT TOPO_DOM 317..341 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 342..361 FT /note="Helical; Name=6" FT /evidence="ECO:0000255" FT TOPO_DOM 362..373 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 374..393 FT /note="Helical; Name=7" FT /evidence="ECO:0000255" FT TOPO_DOM 394..457 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT CARBOHYD 58 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 69 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 100 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 290 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT DISULFID 50..72 FT /evidence="ECO:0000250" FT DISULFID 63..105 FT /evidence="ECO:0000250" FT DISULFID 86..122 FT /evidence="ECO:0000250" FT DISULFID 215..285 FT /evidence="ECO:0000269|PubMed:9928020" FT VAR_SEQ 1..263 FT /note="MRPPSPLPARWLCVLAGALAWALGPAGGQAARLQEECDYVQMIEVQHKQCLE FT EAQLENETIGCSKMWDNLTCWPATPRGQVVVLACPLIFKLFSSIQGRNVSRSCTDEGWT FT HLEPGPYPIACGLDDKAASLDEQQTMFYGSVKTGYTIGYGLSLATLLVATAILSLFRKL FT HCTRNYIHMHLFISFILRAAAVFIKDLALFDSGESDQCSEGSVGCKAAMVFFQYCVMAN FT FFWLLVEGLYLYTLLAVSFFSERKYFWGYILIGW -> MTRQRVWMRWAVRQPWSFSNI FT VSWLTSSGCWWRASTCTPCLPSPSSLSGSTSG (in isoform 3)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_045143" FT VAR_SEQ 1..61 FT /note="MRPPSPLPARWLCVLAGALAWALGPAGGQAARLQEECDYVQMIEVQHKQCLE FT EAQLENETI -> MRAGRRPRLGPWAG (in isoform 4)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_047271" FT VAR_SEQ 1..41 FT /note="Missing (in isoform 5)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_047272" FT VAR_SEQ 1..32 FT /note="MRPPSPLPARWLCVLAGALAWALGPAGGQAAR -> MPPPPLLSLRRLGGGW FT SAVTRLVVAAAGARSRGGRGGSRGAGGGGRGGVARRRRLELRAARSLLGSS (in FT isoform Long)" FT /evidence="ECO:0000303|PubMed:8179610" FT /id="VSP_002010" FT VAR_SEQ 134 FT /note="Missing (in isoform 4)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_047273" FT VARIANT 341 FT /note="R -> M (in dbSNP:rs17855906)" FT /evidence="ECO:0000269|PubMed:15489334" FT /id="VAR_055041" FT VARIANT 445 FT /note="R -> L (in dbSNP:rs3733055)" FT /id="VAR_020021" FT CONFLICT 80 FT /note="Q -> R (in Ref. 5; BAG57795)" FT /evidence="ECO:0000305" FT CONFLICT 284 FT /note="G -> GLLR (in Ref. 2; CAA54814/CAA53046)" FT /evidence="ECO:0000305" FT CONFLICT 320 FT /note="L -> F (in Ref. 5; BAG51813)" FT /evidence="ECO:0000305" FT CONFLICT 369 FT /note="K -> R (in Ref. 5; BAG57795)" FT /evidence="ECO:0000305" FT HELIX 130..166 FT /evidence="ECO:0007829|PDB:6VN7" FT HELIX 173..200 FT /evidence="ECO:0007829|PDB:6VN7" FT HELIX 213..245 FT /evidence="ECO:0007829|PDB:6VN7" FT HELIX 251..280 FT /evidence="ECO:0007829|PDB:6VN7" FT STRAND 284..286 FT /evidence="ECO:0007829|PDB:6VN7" FT HELIX 291..294 FT /evidence="ECO:0007829|PDB:6VN7" FT TURN 295..298 FT /evidence="ECO:0007829|PDB:6VN7" FT HELIX 299..323 FT /evidence="ECO:0007829|PDB:6VN7" FT HELIX 336..344 FT /evidence="ECO:0007829|PDB:6VN7" FT HELIX 347..350 FT /evidence="ECO:0007829|PDB:6VN7" FT HELIX 352..356 FT /evidence="ECO:0007829|PDB:6VN7" FT STRAND 357..359 FT /evidence="ECO:0007829|PDB:6VN7" FT TURN 362..364 FT /evidence="ECO:0007829|PDB:6VN7" FT HELIX 366..388 FT /evidence="ECO:0007829|PDB:6VN7" FT HELIX 393..408 FT /evidence="ECO:0007829|PDB:6VN7" SQ SEQUENCE 457 AA; 51547 MW; DAA40CF5BEC47D7D CRC64; MRPPSPLPAR WLCVLAGALA WALGPAGGQA ARLQEECDYV QMIEVQHKQC LEEAQLENET IGCSKMWDNL TCWPATPRGQ VVVLACPLIF KLFSSIQGRN VSRSCTDEGW THLEPGPYPI ACGLDDKAAS LDEQQTMFYG SVKTGYTIGY GLSLATLLVA TAILSLFRKL HCTRNYIHMH LFISFILRAA AVFIKDLALF DSGESDQCSE GSVGCKAAMV FFQYCVMANF FWLLVEGLYL YTLLAVSFFS ERKYFWGYIL IGWGVPSTFT MVWTIARIHF EDYGCWDTIN SSLWWIIKGP ILTSILVNFI LFICIIRILL QKLRPPDIRK SDSSPYSRLA RSTLLLIPLF GVHYIMFAFF PDNFKPEVKM VFELVVGSFQ GFVVAILYCF LNGEVQAELR RKWRRWHLQG VLGWNPKYRH PSGGSNGATC STQVSMLTRV SPGARRSSSF QAEVSLV //