P32239 (GASR_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Gastrin/cholecystokinin type B receptor
Short name=CCK-B receptor
Short name=CCK-BR

Alternative name(s):
Cholecystokinin-2 receptor
Short name=CCK2-R

Gene names

Name:	CCKBR
Synonyms:	CCKRB

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	447 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Ref.3 Ref.5 Ref.6 Ref.8 Ref.9 Ref.17 Isoform 2 is constitutively activated and may regulate cancer cell proliferation via a gastrin-independent mechanism. Ref.3 Ref.5 Ref.6 Ref.8 Ref.9 Ref.17
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Isoform 1 is expressed in brain, pancreas, stomach, the colon cancer cell line LoVo and the T-lymphoblastoma Jurkat, but not in heart, placenta, liver, lung, skeletal muscle, kidney or the stomach cancer cell line AGS. Expressed at high levels in the small cell lung cancer cell line NCI-H510, at lower levels in NCI-H345, NCI-H69 and GLC-28 cell lines, not expressed in GLC-19 cell line. Within the stomach, expressed at high levels in the mucosa of the gastric fundus and at low levels in the antrum and duodenum. Isoform 2 is present in pancreatic cancer cells and colorectal cancer cells, but not in normal pancreas or colonic mucosa. Isoform 3 is expressed in brain, pancreas, stomach, the stomach cancer cell line AGS and the colon cancer cell line LoVo. Ref.3 Ref.5 Ref.6 Ref.7 Ref.8 Ref.10
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Lipoprotein Palmitate
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell proliferation Traceable author statement PubMed 10400698. Source: ProtInc digestion Traceable author statement Ref.2. Source: ProtInc elevation of cytosolic calcium ion concentration Inferred from direct assay Ref.8. Source: UniProtKB feeding behavior Traceable author statement Ref.2. Source: ProtInc phospholipase C-activating G-protein coupled receptor signaling pathway Traceable author statement PubMed 8455720. Source: ProtInc positive regulation of cell proliferation Inferred from direct assay Ref.8. Source: UniProtKB sensory perception Traceable author statement Ref.2. Source: ProtInc
Cellular_component	integral to plasma membrane Inferred by curator Ref.8. Source: UniProtKB
Molecular_function	1-phosphatidylinositol-3-kinase regulator activity Traceable author statement PubMed 10400698. Source: ProtInc gastrin receptor activity Inferred from direct assay Ref.8. Source: UniProtKB phosphatidylinositol phospholipase C activity Traceable author statement Ref.2. Source: ProtInc type B gastrin/cholecystokinin receptor binding Inferred from direct assay Ref.1PubMed 8185642. Source: NTNU_SB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P32239-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P32239-2)

Also known as: CCK-C; CCK-BRi4sv;

The sequence of this isoform differs from the canonical sequence as follows:
     271-271: G → GGAGPREQNLGEAELWRATGPAGVGGTEMKVRVRRKLEMELSWERRSGGDWAGDWGDSPFSLTAHPLCSG

Isoform 3 (identifier: P32239-3)

Also known as: DeltaCCK-B;

The sequence of this isoform differs from the canonical sequence as follows:
     1-66: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 447

447

Gastrin/cholecystokinin type B receptor

PRO_0000069474

Regions

Topological domain

1 – 57

57

Extracellular Potential

Transmembrane

58 – 79

22

Helical; Name=1; Potential

Topological domain

80 – 87

8

Cytoplasmic Potential

Transmembrane

88 – 109

22

Helical; Name=2; Potential

Topological domain

110 – 131

22

Extracellular Potential

Transmembrane

132 – 150

19

Helical; Name=3; Potential

Topological domain

151 – 170

20

Cytoplasmic Potential

Transmembrane

171 – 189

19

Helical; Name=4; Potential

Topological domain

190 – 219

30

Extracellular Potential

Transmembrane

220 – 242

23

Helical; Name=5; Potential

Topological domain

243 – 333

91

Cytoplasmic Potential

Transmembrane

334 – 355

22

Helical; Name=6; Potential

Topological domain

356 – 373

18

Extracellular Potential

Transmembrane

374 – 394

21

Helical; Name=7; Potential

Topological domain

395 – 447

53

Cytoplasmic Potential

Amino acid modifications

Lipidation

408

1

S-palmitoyl cysteine By similarity

Glycosylation

7

1

N-linked (GlcNAc...) Potential

Glycosylation

30

1

N-linked (GlcNAc...) Potential

Glycosylation

36

1

N-linked (GlcNAc...) Potential

Disulfide bond

127 ↔ 205

By similarity

Natural variations

Alternative sequence

1 – 66

66

Missing in isoform 3.

VSP_033444

Alternative sequence

271

1

G → GGAGPREQNLGEAELWRATG PAGVGGTEMKVRVRRKLEME LSWERRSGGDWAGDWGDSPF SLTAHPLCSG in isoform 2.

VSP_033445

Natural variant

37

1

L → F.
Corresponds to variant rs1805000 [ dbSNP | Ensembl ].

VAR_014684

Natural variant

77

1

V → G.
Corresponds to variant rs35816985 [ dbSNP | Ensembl ].

VAR_049388

Natural variant

125

1

V → I.
Corresponds to variant rs1805002 [ dbSNP | Ensembl ].

VAR_014685

Natural variant

215

1

R → H.
Corresponds to variant rs1805004 [ dbSNP | Ensembl ].

VAR_014686

Natural variant

319

1

R → Q.
Corresponds to variant rs1805001 [ dbSNP | Ensembl ].

VAR_014687

Experimental info

Sequence conflict

64

1

I → T in AAF67174. Ref.8

Sequence conflict

93

1

L → F in AAC27510. Ref.16

Sequence conflict

96

1

L → M in AAC27510. Ref.16

Sequence conflict

116

1

L → I in AAC27510. Ref.16

Sequence conflict

171

1

A → P in AAA91831. Ref.11

Sequence conflict

227

1

F → S in BAF84753. Ref.12

Sequence conflict

249

1

L → V in AAA91831. Ref.11

Sequence conflict

288

1

E → K in AAB30766. Ref.5

Secondary structure

1

.

.

.

.

.

.

.

447

Helix Strand Turn

Details...

Helix

353 – 358

6

Helix

363 – 368

6

Helix

372 – 378

7

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 1993. Version 1. Checksum: BAEEFAD4C1F85915	FASTA	447	48,419
	10 20 30 40 50 60 MELLKLNRSV QGTGPGPGAS LCRPGAPLLN SSSVGNLSCE PPRIRGAGTR ELELAIRITL 70 80 90 100 110 120 YAVIFLMSVG GNMLIIVVLG LSRRLRTVTN AFLLSLAVSD LLLAVACMPF TLLPNLMGTF 130 140 150 160 170 180 IFGTVICKAV SYLMGVSVSV STLSLVAIAL ERYSAICRPL QARVWQTRSH AARVIVATWL 190 200 210 220 230 240 LSGLLMVPYP VYTVVQPVGP RVLQCVHRWP SARVRQTWSV LLLLLLFFIP GVVMAVAYGL 250 260 270 280 290 300 ISRELYLGLR FDGDSDSDSQ SRVRNQGGLP GAVHQNGRCR PETGAVGEDS DGCYVQLPRS 310 320 330 340 350 360 RPALELTALT APGPGSGSRP TQAKLLAKKR VVRMLLVIVV LFFLCWLPVY SANTWRAFDG 370 380 390 400 410 420 PGAHRALSGA PISFIHLLSY ASACVNPLVY CFMHRRFRQA CLETCARCCP RPPRARPRAL 430 440 PDEDPPTPSI ASLSRLSYTT ISTLGPG
	Isoform 2 (CCK-C) (CCK-BRi4sv) [UniParc]. Checksum: 9B27DDCAE3A67CC7	FASTA	516	55,869
	10 20 30 40 50 60 MELLKLNRSV QGTGPGPGAS LCRPGAPLLN SSSVGNLSCE PPRIRGAGTR ELELAIRITL 70 80 90 100 110 120 YAVIFLMSVG GNMLIIVVLG LSRRLRTVTN AFLLSLAVSD LLLAVACMPF TLLPNLMGTF 130 140 150 160 170 180 IFGTVICKAV SYLMGVSVSV STLSLVAIAL ERYSAICRPL QARVWQTRSH AARVIVATWL 190 200 210 220 230 240 LSGLLMVPYP VYTVVQPVGP RVLQCVHRWP SARVRQTWSV LLLLLLFFIP GVVMAVAYGL 250 260 270 280 290 300 ISRELYLGLR FDGDSDSDSQ SRVRNQGGLP GGAGPREQNL GEAELWRATG PAGVGGTEMK 310 320 330 340 350 360 VRVRRKLEME LSWERRSGGD WAGDWGDSPF SLTAHPLCSG AVHQNGRCRP ETGAVGEDSD 370 380 390 400 410 420 GCYVQLPRSR PALELTALTA PGPGSGSRPT QAKLLAKKRV VRMLLVIVVL FFLCWLPVYS 430 440 450 460 470 480 ANTWRAFDGP GAHRALSGAP ISFIHLLSYA SACVNPLVYC FMHRRFRQAC LETCARCCPR 490 500 510 PPRARPRALP DEDPPTPSIA SLSRLSYTTI STLGPG
	Isoform 3 (DeltaCCK-B) [UniParc]. Checksum: 2DF92F7D8A27773B	FASTA	381	41,504
	10 20 30 40 50 60 MSVGGNMLII VVLGLSRRLR TVTNAFLLSL AVSDLLLAVA CMPFTLLPNL MGTFIFGTVI 70 80 90 100 110 120 CKAVSYLMGV SVSVSTLSLV AIALERYSAI CRPLQARVWQ TRSHAARVIV ATWLLSGLLM 130 140 150 160 170 180 VPYPVYTVVQ PVGPRVLQCV HRWPSARVRQ TWSVLLLLLL FFIPGVVMAV AYGLISRELY 190 200 210 220 230 240 LGLRFDGDSD SDSQSRVRNQ GGLPGAVHQN GRCRPETGAV GEDSDGCYVQ LPRSRPALEL 250 260 270 280 290 300 TALTAPGPGS GSRPTQAKLL AKKRVVRMLL VIVVLFFLCW LPVYSANTWR AFDGPGAHRA 310 320 330 340 350 360 LSGAPISFIH LLSYASACVN PLVYCFMHRR FRQACLETCA RCCPRPPRAR PRALPDEDPP 370 380 TPSIASLSRL SYTTISTLGP G

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of the human brain and gastric cholecystokinin receptor: structure, functional expression and chromosomal localization." Pisegna J.R., de Weerth A., Huppi K., Wank S.A. Biochem. Biophys. Res. Commun. 189:296-303(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Brain.
[2]	"The human brain cholecystokinin-B/gastrin receptor. Cloning and characterization." Lee Y.-M., Beinborn M., McBride E.W., Lu M., Kolakowski L.F. Jr., Kopin A.S. J. Biol. Chem. 268:8164-8169(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Brain.
[3]	"Functional characterization of a human brain cholecystokinin-B receptor. A trophic effect of cholecystokinin and gastrin." Ito M., Matsui T., Taniguchi T., Tsukamoto T., Murayama T., Arima N., Nakata H., Chiba T., Chihara K. J. Biol. Chem. 268:18300-18305(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY. Tissue: Brain.
[4]	"The human gastrin/cholecystokinin type B receptor gene: alternative splice donor site in exon 4 generates two variant mRNAs." Song I., Brown D.R., Wiltshire R.N., Gantz I., Trent J.M., Yamada T. Proc. Natl. Acad. Sci. U.S.A. 90:9085-9089(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Placenta.
[5]	"Cholecystokinin stimulates Ca2+ mobilization and clonal growth in small cell lung cancer through CCKA and CCKB/gastrin receptors." Herget T., Sethi T., Wu S.V., Walsh J.H., Rozengurt E. Ann. N. Y. Acad. Sci. 713:283-297(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY. Tissue: Fetal brain.
[6]	"Functional characterization of two cholecystokinin-B/gastrin receptor isoforms: a preferential splice donor site in the human receptor gene." Ito M., Iwata N., Taniguchi T., Murayama T., Chihara K., Matsui T. Cell Growth Differ. 5:1127-1135(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, ALTERNATIVE SPLICING, TISSUE SPECIFICITY. Tissue: Lung fibroblast.
[7]	"A truncated isoform of human CCK-B/gastrin receptor generated by alternative usage of a novel exon." Miyake A. Biochem. Biophys. Res. Commun. 208:230-237(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY. Tissue: Stomach.
[8]	"Human colorectal cancers express a constitutively active cholecystokinin-B/gastrin receptor that stimulates cell growth." Hellmich M.R., Rui X.-L., Hellmich H.L., Fleming R.Y.D., Evers B.M., Townsend C.M. Jr. J. Biol. Chem. 275:32122-32128(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION (ISOFORM 2), TISSUE SPECIFICITY. Tissue: Colon cancer.
[9]	"Identification of CCK-B/gastrin receptor splice variants in human peripheral blood mononuclear cells." Schmitz F., Schrader H., Otte J.-M., Schmitz H., Stueber E., Herzig K.-H., Schmidt W.E. Regul. Pept. 101:25-33(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, ALTERNATIVE SPLICING. Tissue: Peripheral blood.
[10]	"Characterization of the CCK-C (cancer) receptor in human pancreatic cancer." Smith J.P., Verderame M.F., McLaughlin P., Martenis M., Ballard E., Zagon I.S. Int. J. Mol. Med. 10:689-694(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY. Tissue: Pancreatic cancer.
[11]	"Cloning and expression of the human temporal cortex cholecystokinin B receptor." Tate S.N., Gray J., Denyer J., Stolz M., Foord S., Lee M.G. Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Temporal cortex.
[12]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Stomach.
[13]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Kopatz S.A., Aronstam R.S., Sharma S.V. Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[14]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[15]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Placenta.
[16]	"An 84-kilobase physical map and repeat polymorphisms of the gastrin/cholecystokinin brain receptor region at the junction of chromosome segments 11p15.4 and 15.5." O'Briant K.C., Ali S.Y., Weier H.-U.G., Bepler G. Chromosome Res. 6:415-418(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 52-447.
[17]	"CCKA and CCKB receptors are expressed in small cell lung cancer lines and mediate Ca2+ mobilization and clonal growth." Sethi T., Herget T., Wu S.V., Walsh J.H., Rozengurt E. Cancer Res. 53:5208-5213(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 244-333 (ISOFORMS 1/3), FUNCTION. Tissue: Fetal brain.
[18]	"Localization of the human cholecystokinin-B/gastrin receptor gene (CCKBR) to chromosome 11p15.5-->p15.4 by fluorescence in situ hybridization." Zimonjic D.B., Popescu N.C., Matsui T., Ito M., Chihara K. Cytogenet. Cell Genet. 65:184-185(1994) [PubMed] [Europe PMC] [Abstract] Cited for: CHROMOSOMAL LOCATION.
[19]	"Intermolecular interactions between cholecystokinin-8 and the third extracellular loop of the cholecystokinin-2 receptor." Giragossian C., Mierke D.F. Biochemistry 41:4560-4566(2002) [PubMed] [Europe PMC] [Abstract] Cited for: STRUCTURE BY NMR OF 352-379.
+	Additional computationally mapped references.

Web resources

Wikipedia

Cholecystokinin receptor entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

L04473 mRNA. Translation: AAA35660.1.
L08112 mRNA. Translation: AAA35657.1.
D13305 mRNA. Translation: BAA02564.1.
L10822 Genomic DNA. Translation: AAC37528.1.
S70057 mRNA. Translation: AAB30766.2.
D21219 Genomic DNA. Translation: BAA04759.2.
AF239668 mRNA. Translation: AAF67174.1.
AY029770 mRNA. Translation: AAK38351.1.
AF441129 mRNA. Translation: AAN32829.1.
L07746 mRNA. Translation: AAA91831.1.
AK292064 mRNA. Translation: BAF84753.1.
AY322551 mRNA. Translation: AAP84364.1.
BT006789 mRNA. Translation: AAP35435.1.
BC000740 mRNA. Translation: AAH00740.1.
AH006311 Genomic DNA. Translation: AAC27510.1.

IPI

IPI00027667.
IPI00893039.
IPI00893152.

PIR

A47430.
I65231.

RefSeq

NP_795344.1. NM_176875.3.

UniGene

Hs.203.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1L4T	NMR	-	A	352-379	[»]

ProteinModelPortal

P32239.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-229N.

IntAct

P32239. 5 interactions.

MINT

MINT-3013054.

STRING

9606.ENSP00000335544.

Protein family/group databases

GPCRDB

Search...

PTM databases

PhosphoSite

P32239.

Polymorphism databases

DMDM

417029.

Proteomic databases

PaxDb

P32239.

PRIDE

P32239.

Protocols and materials databases

DNASU

887.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000334619; ENSP00000335544; ENSG00000110148.
ENST00000525462; ENSP00000435534; ENSG00000110148.

GeneID

887.

KEGG

hsa:887.

UCSC

uc001mcp.3. human.
uc001mcs.3. human.

Organism-specific databases

CTD

887.

GeneCards

GC11P006280.

HGNC

HGNC:1571. CCKBR.

HPA

HPA041976.

MIM

118445. gene.

neXtProt

NX_P32239.

PharmGKB

PA26143.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG238659.

HOVERGEN

HBG036927.

InParanoid

P32239.

KO

K04195.

OMA

WRAFDGP.

OrthoDB

EOG43N7D1.

PhylomeDB

P32239.

Enzyme and pathway databases

Reactome

REACT_111102. Signal Transduction.

Gene expression databases

ArrayExpress

P32239.

Bgee

P32239.

CleanEx

HS_CCKBR.

Genevestigator

P32239.

GermOnline

ENSG00000110148. Homo sapiens.

Family and domain databases

InterPro

IPR009126. Cholcskin_rcpt.
IPR000314. Gastrin_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]

Pfam

PF00001. 7tm_1. 1 hit.
[Graphical view]

PRINTS

PR01822. CCYSTOKININR.
PR00527. GASTRINR.
PR00237. GPCRRHODOPSN.

PROSITE

PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

BindingDB

P32239.

ChEMBL

CHEMBL298.

DrugBank

DB00183. Pentagastrin.

EvolutionaryTrace

P32239.

GenomeRNAi

887.

NextBio

3666.

SOURCE

Search...

Entry information

Entry name

GASR_HUMAN

Accession

Primary (citable) accession number: P32239
Secondary accession number(s): A8K7P9 , O75824, Q16144, Q92492, Q96LC6, Q9NYK7, Q9UBV1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
Last sequence update:	October 1, 1993
Last modified:	May 1, 2013
This is version 136 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.