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P32238 (CCKAR_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 146. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cholecystokinin receptor type A

Short name=CCK-A receptor
Short name=CCK-AR
Alternative name(s):
Cholecystokinin-1 receptor
Short name=CCK1-R
Gene names
Name:CCKAR
Synonyms:CCKRA
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length428 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 428428Cholecystokinin receptor type A
PRO_0000069223

Regions

Topological domain1 – 4141Extracellular Potential
Transmembrane42 – 6726Helical; Name=1; Potential
Topological domain68 – 7710Cytoplasmic Potential
Transmembrane78 – 10427Helical; Name=2; Potential
Topological domain105 – 11511Extracellular Potential
Transmembrane116 – 13722Helical; Name=3; Potential
Topological domain138 – 15720Cytoplasmic Potential
Transmembrane158 – 17821Helical; Name=4; Potential
Topological domain179 – 21032Extracellular Potential
Transmembrane211 – 23424Helical; Name=5; Potential
Topological domain235 – 31379Cytoplasmic Potential
Transmembrane314 – 33421Helical; Name=6; Potential
Topological domain335 – 34915Extracellular Potential
Transmembrane350 – 37324Helical; Name=7; Potential
Topological domain374 – 42855Cytoplasmic Potential

Amino acid modifications

Lipidation3871S-palmitoyl cysteine By similarity
Glycosylation101N-linked (GlcNAc...) Potential
Glycosylation241N-linked (GlcNAc...) Potential
Glycosylation1901N-linked (GlcNAc...) Potential
Disulfide bond18 ↔ 29 By similarity
Disulfide bond114 ↔ 196 By similarity

Secondary structure

................ 428
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P32238 [UniParc].

Last modified October 1, 1993. Version 1.
Checksum: A6E8FABDA805E610

FASTA42847,841
        10         20         30         40         50         60 
MDVVDSLLVN GSNITPPCEL GLENETLFCL DQPRPSKEWQ PAVQILLYSL IFLLSVLGNT 

        70         80         90        100        110        120 
LVITVLIRNK RMRTVTNIFL LSLAVSDLML CLFCMPFNLI PNLLKDFIFG SAVCKTTTYF 

       130        140        150        160        170        180 
MGTSVSVSTF NLVAISLERY GAICKPLQSR VWQTKSHALK VIAATWCLSF TIMTPYPIYS 

       190        200        210        220        230        240 
NLVPFTKNNN QTANMCRFLL PNDVMQQSWH TFLLLILFLI PGIVMMVAYG LISLELYQGI 

       250        260        270        280        290        300 
KFEASQKKSA KERKPSTTSS GKYEDSDGCY LQKTRPPRKL ELRQLSTGSS SRANRIRSNS 

       310        320        330        340        350        360 
SAANLMAKKR VIRMLIVIVV LFFLCWMPIF SANAWRAYDT ASAERRLSGT PISFILLLSY 

       370        380        390        400        410        420 
TSSCVNPIIY CFMNKRFRLG FMATFPCCPN PGPPGARGEV GEEEEGGTTG ASLSRFSYSH 


MSASVPPQ 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and functional expression of the human gallbladder cholecystokinin A receptor."
Ulrich C.D., Ferber I., Holicky E., Hadac E., Buell G., Miller L.J.
Biochem. Biophys. Res. Commun. 193:204-211(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Gall bladder.
[2]"Molecular cloning, functional expression and chromosomal localization of the human cholecystokinin type A receptor."
Wank S.A., de Weerth A., Pisegna J.R., Huppi K.
Biochem. Biophys. Res. Commun. 194:811-818(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Abnormal processing of the human cholecystokinin receptor gene in association with gallstones and obesity."
Miller L.J., Holicky E.L., Ulrich C.D., Wieben E.D.
Gastroenterology 109:1375-1380(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"Gene structure of human cholecystokinin (CCK) type-A receptor: body fat content is related to CCK type-A receptor gene promoter polymorphism."
Funakoshi A., Miyasaka K., Matsumoto H., Yamamori S., Takiguchi S., Kataoka K., Takata Y., Matsusue K., Kono A., Shimokata H.
FEBS Lett. 466:264-266(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Peripheral blood leukocyte.
[5]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Kopatz S.A., Aronstam R.S., Sharma S.V.
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Stomach.
[6]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Thalamus.
[7]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[9]"Molecular complex of cholecystokinin-8 and N-terminus of the cholecystokinin A receptor by NMR spectroscopy."
Pellegrini M., Mierke D.F.
Biochemistry 38:14775-14783(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR OF 1-47 IN COMPLEX WITH CCK.
[10]"Intermolecular interactions between cholecystokinin-8 and the third extracellular loop of the cholecystokinin A receptor."
Giragossian C., Mierke D.F.
Biochemistry 40:3804-3809(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR OF 329-357 IN COMPLEX WITH CCK.
+Additional computationally mapped references.

Web resources

Wikipedia

Cholecystokinin receptor entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L13605 mRNA. Translation: AAA35659.1.
L19315 mRNA. Translation: AAA02819.1.
U23430 expand/collapse EMBL AC list , U23427, U23428, U23429 Genomic DNA. Translation: AAA91123.1.
D85606 Genomic DNA. Translation: BAA90879.1.
AY322549 mRNA. Translation: AAP84362.1.
AK313978 mRNA. Translation: BAG36692.1.
CH471069 Genomic DNA. Translation: EAW92850.1.
BC074987 mRNA. Translation: AAH74987.1.
PIRJN0692.
RefSeqNP_000721.1. NM_000730.2.
UniGeneHs.129.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1D6GNMR-A1-47[»]
1HZNNMR-A329-357[»]
1PB2model-A1-381[»]
ProteinModelPortalP32238.
SMRP32238. Positions 1-390.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107328. 1 interaction.
IntActP32238. 1 interaction.
MINTMINT-3012991.
STRING9606.ENSP00000295589.

Chemistry

BindingDBP32238.
ChEMBLCHEMBL1901.
DrugBankDB00403. Ceruletide.
GuidetoPHARMACOLOGY76.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP32238.

Polymorphism databases

DMDM416772.

Proteomic databases

PRIDEP32238.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000295589; ENSP00000295589; ENSG00000163394.
GeneID886.
KEGGhsa:886.
UCSCuc003gse.1. human.

Organism-specific databases

CTD886.
GeneCardsGC04M026483.
H-InvDBHIX0163965.
HGNCHGNC:1570. CCKAR.
HPACAB005619.
MIM118444. gene.
neXtProtNX_P32238.
PharmGKBPA26142.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG238659.
HOGENOMHOG000294067.
HOVERGENHBG036927.
InParanoidP32238.
KOK04194.
OMAYSYSHMS.
OrthoDBEOG7QVM36.
PhylomeDBP32238.
TreeFamTF315303.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.
SignaLinkP32238.

Gene expression databases

BgeeP32238.
CleanExHS_CCKAR.
GenevestigatorP32238.

Family and domain databases

Gene3D1.20.1070.10. 2 hits.
4.10.670.10. 1 hit.
InterProIPR009126. Cholcskin_rcpt.
IPR000596. Cholcy_rcpt_A.
IPR015276. CholecystokininA_recpt_N.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
PF09193. CholecysA-Rec_N. 1 hit.
[Graphical view]
PRINTSPR01822. CCYSTOKININR.
PR00524. CCYSTOKNINAR.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP32238.
GeneWikiCholecystokinin_A_receptor.
GenomeRNAi886.
NextBio3662.
PROP32238.
SOURCESearch...

Entry information

Entry nameCCKAR_HUMAN
AccessionPrimary (citable) accession number: P32238
Secondary accession number(s): B2R9Z5
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: April 16, 2014
This is version 146 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries