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P32238

- CCKAR_HUMAN

UniProt

P32238 - CCKAR_HUMAN

Protein

Cholecystokinin receptor type A

Gene

CCKAR

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 151 (01 Oct 2014)
      Sequence version 1 (01 Oct 1993)
      Previous versions | rss
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    Functioni

    Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

    GO - Molecular functioni

    1. cholecystokinin receptor activity Source: ProtInc

    GO - Biological processi

    1. axonogenesis Source: Ensembl
    2. cholecystokinin signaling pathway Source: GOC
    3. digestion Source: ProtInc
    4. feeding behavior Source: ProtInc
    5. forebrain development Source: Ensembl
    6. neuron migration Source: Ensembl
    7. phospholipase C-activating G-protein coupled receptor signaling pathway Source: ProtInc
    8. positive regulation of cytosolic calcium ion concentration Source: ProtInc
    9. response to nutrient Source: ProtInc

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_14819. Peptide ligand-binding receptors.
    REACT_18283. G alpha (q) signalling events.
    SignaLinkiP32238.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cholecystokinin receptor type A
    Short name:
    CCK-A receptor
    Short name:
    CCK-AR
    Alternative name(s):
    Cholecystokinin-1 receptor
    Short name:
    CCK1-R
    Gene namesi
    Name:CCKAR
    Synonyms:CCKRA
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:1570. CCKAR.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26142.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 428428Cholecystokinin receptor type APRO_0000069223Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi10 – 101N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi18 ↔ 29PROSITE-ProRule annotation
    Glycosylationi24 – 241N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi114 ↔ 196PROSITE-ProRule annotation
    Glycosylationi190 – 1901N-linked (GlcNAc...)Sequence Analysis
    Lipidationi387 – 3871S-palmitoyl cysteineBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    MaxQBiP32238.
    PRIDEiP32238.

    PTM databases

    PhosphoSiteiP32238.

    Expressioni

    Gene expression databases

    BgeeiP32238.
    CleanExiHS_CCKAR.
    GenevestigatoriP32238.

    Organism-specific databases

    HPAiCAB005619.

    Interactioni

    Protein-protein interaction databases

    BioGridi107328. 1 interaction.
    IntActiP32238. 1 interaction.
    MINTiMINT-3012991.
    STRINGi9606.ENSP00000295589.

    Structurei

    Secondary structure

    1
    428
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni5 – 117
    Beta strandi13 – 153
    Beta strandi21 – 255
    Helixi39 – 446
    Turni330 – 3345
    Helixi335 – 3395
    Beta strandi346 – 3505
    Helixi352 – 3554

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1D6GNMR-A1-47[»]
    1HZNNMR-A329-357[»]
    1PB2model-A1-381[»]
    ProteinModelPortaliP32238.
    SMRiP32238. Positions 1-389.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP32238.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4141ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini68 – 7710CytoplasmicSequence Analysis
    Topological domaini105 – 11511ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini138 – 15720CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini179 – 21032ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini235 – 31379CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini335 – 34915ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini374 – 42855CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei42 – 6726Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei78 – 10427Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei116 – 13722Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei158 – 17821Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei211 – 23424Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei314 – 33421Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei350 – 37324Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG238659.
    HOGENOMiHOG000294067.
    HOVERGENiHBG036927.
    InParanoidiP32238.
    KOiK04194.
    OMAiYSYSHMS.
    OrthoDBiEOG7QVM36.
    PhylomeDBiP32238.
    TreeFamiTF315303.

    Family and domain databases

    Gene3Di1.20.1070.10. 2 hits.
    4.10.670.10. 1 hit.
    InterProiIPR009126. Cholcskin_rcpt.
    IPR000596. Cholcy_rcpt_A.
    IPR015276. CholecystokininA_recpt_N.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    PF09193. CholecysA-Rec_N. 1 hit.
    [Graphical view]
    PRINTSiPR01822. CCYSTOKININR.
    PR00524. CCYSTOKNINAR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P32238-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDVVDSLLVN GSNITPPCEL GLENETLFCL DQPRPSKEWQ PAVQILLYSL    50
    IFLLSVLGNT LVITVLIRNK RMRTVTNIFL LSLAVSDLML CLFCMPFNLI 100
    PNLLKDFIFG SAVCKTTTYF MGTSVSVSTF NLVAISLERY GAICKPLQSR 150
    VWQTKSHALK VIAATWCLSF TIMTPYPIYS NLVPFTKNNN QTANMCRFLL 200
    PNDVMQQSWH TFLLLILFLI PGIVMMVAYG LISLELYQGI KFEASQKKSA 250
    KERKPSTTSS GKYEDSDGCY LQKTRPPRKL ELRQLSTGSS SRANRIRSNS 300
    SAANLMAKKR VIRMLIVIVV LFFLCWMPIF SANAWRAYDT ASAERRLSGT 350
    PISFILLLSY TSSCVNPIIY CFMNKRFRLG FMATFPCCPN PGPPGARGEV 400
    GEEEEGGTTG ASLSRFSYSH MSASVPPQ 428
    Length:428
    Mass (Da):47,841
    Last modified:October 1, 1993 - v1
    Checksum:iA6E8FABDA805E610
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L13605 mRNA. Translation: AAA35659.1.
    L19315 mRNA. Translation: AAA02819.1.
    U23430
    , U23427, U23428, U23429 Genomic DNA. Translation: AAA91123.1.
    D85606 Genomic DNA. Translation: BAA90879.1.
    AY322549 mRNA. Translation: AAP84362.1.
    AK313978 mRNA. Translation: BAG36692.1.
    CH471069 Genomic DNA. Translation: EAW92850.1.
    BC074987 mRNA. Translation: AAH74987.1.
    CCDSiCCDS3438.1.
    PIRiJN0692.
    RefSeqiNP_000721.1. NM_000730.2.
    UniGeneiHs.129.

    Genome annotation databases

    EnsembliENST00000295589; ENSP00000295589; ENSG00000163394.
    GeneIDi886.
    KEGGihsa:886.
    UCSCiuc003gse.1. human.

    Polymorphism databases

    DMDMi416772.

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Cholecystokinin receptor entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L13605 mRNA. Translation: AAA35659.1 .
    L19315 mRNA. Translation: AAA02819.1 .
    U23430
    , U23427 , U23428 , U23429 Genomic DNA. Translation: AAA91123.1 .
    D85606 Genomic DNA. Translation: BAA90879.1 .
    AY322549 mRNA. Translation: AAP84362.1 .
    AK313978 mRNA. Translation: BAG36692.1 .
    CH471069 Genomic DNA. Translation: EAW92850.1 .
    BC074987 mRNA. Translation: AAH74987.1 .
    CCDSi CCDS3438.1.
    PIRi JN0692.
    RefSeqi NP_000721.1. NM_000730.2.
    UniGenei Hs.129.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1D6G NMR - A 1-47 [» ]
    1HZN NMR - A 329-357 [» ]
    1PB2 model - A 1-381 [» ]
    ProteinModelPortali P32238.
    SMRi P32238. Positions 1-389.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107328. 1 interaction.
    IntActi P32238. 1 interaction.
    MINTi MINT-3012991.
    STRINGi 9606.ENSP00000295589.

    Chemistry

    BindingDBi P32238.
    ChEMBLi CHEMBL1901.
    DrugBanki DB00403. Ceruletide.
    GuidetoPHARMACOLOGYi 76.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P32238.

    Polymorphism databases

    DMDMi 416772.

    Proteomic databases

    MaxQBi P32238.
    PRIDEi P32238.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000295589 ; ENSP00000295589 ; ENSG00000163394 .
    GeneIDi 886.
    KEGGi hsa:886.
    UCSCi uc003gse.1. human.

    Organism-specific databases

    CTDi 886.
    GeneCardsi GC04M026483.
    H-InvDB HIX0163965.
    HGNCi HGNC:1570. CCKAR.
    HPAi CAB005619.
    MIMi 118444. gene.
    neXtProti NX_P32238.
    PharmGKBi PA26142.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG238659.
    HOGENOMi HOG000294067.
    HOVERGENi HBG036927.
    InParanoidi P32238.
    KOi K04194.
    OMAi YSYSHMS.
    OrthoDBi EOG7QVM36.
    PhylomeDBi P32238.
    TreeFami TF315303.

    Enzyme and pathway databases

    Reactomei REACT_14819. Peptide ligand-binding receptors.
    REACT_18283. G alpha (q) signalling events.
    SignaLinki P32238.

    Miscellaneous databases

    EvolutionaryTracei P32238.
    GeneWikii Cholecystokinin_A_receptor.
    GenomeRNAii 886.
    NextBioi 3662.
    PROi P32238.
    SOURCEi Search...

    Gene expression databases

    Bgeei P32238.
    CleanExi HS_CCKAR.
    Genevestigatori P32238.

    Family and domain databases

    Gene3Di 1.20.1070.10. 2 hits.
    4.10.670.10. 1 hit.
    InterProi IPR009126. Cholcskin_rcpt.
    IPR000596. Cholcy_rcpt_A.
    IPR015276. CholecystokininA_recpt_N.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    PF09193. CholecysA-Rec_N. 1 hit.
    [Graphical view ]
    PRINTSi PR01822. CCYSTOKININR.
    PR00524. CCYSTOKNINAR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and functional expression of the human gallbladder cholecystokinin A receptor."
      Ulrich C.D., Ferber I., Holicky E., Hadac E., Buell G., Miller L.J.
      Biochem. Biophys. Res. Commun. 193:204-211(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Gall bladder.
    2. "Molecular cloning, functional expression and chromosomal localization of the human cholecystokinin type A receptor."
      Wank S.A., de Weerth A., Pisegna J.R., Huppi K.
      Biochem. Biophys. Res. Commun. 194:811-818(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Abnormal processing of the human cholecystokinin receptor gene in association with gallstones and obesity."
      Miller L.J., Holicky E.L., Ulrich C.D., Wieben E.D.
      Gastroenterology 109:1375-1380(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Gene structure of human cholecystokinin (CCK) type-A receptor: body fat content is related to CCK type-A receptor gene promoter polymorphism."
      Funakoshi A., Miyasaka K., Matsumoto H., Yamamori S., Takiguchi S., Kataoka K., Takata Y., Matsusue K., Kono A., Shimokata H.
      FEBS Lett. 466:264-266(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Peripheral blood leukocyte.
    5. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Kopatz S.A., Aronstam R.S., Sharma S.V.
      Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Stomach.
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Thalamus.
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    9. "Molecular complex of cholecystokinin-8 and N-terminus of the cholecystokinin A receptor by NMR spectroscopy."
      Pellegrini M., Mierke D.F.
      Biochemistry 38:14775-14783(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 1-47 IN COMPLEX WITH CCK.
    10. "Intermolecular interactions between cholecystokinin-8 and the third extracellular loop of the cholecystokinin A receptor."
      Giragossian C., Mierke D.F.
      Biochemistry 40:3804-3809(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 329-357 IN COMPLEX WITH CCK.

    Entry informationi

    Entry nameiCCKAR_HUMAN
    AccessioniPrimary (citable) accession number: P32238
    Secondary accession number(s): B2R9Z5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: October 1, 1993
    Last modified: October 1, 2014
    This is version 151 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3