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Protein

Cholecystokinin receptor type A

Gene

CCKAR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

  • cholecystokinin receptor activity Source: ProtInc

GO - Biological processi

  • axonogenesis Source: Ensembl
  • digestion Source: ProtInc
  • feeding behavior Source: ProtInc
  • forebrain development Source: Ensembl
  • neuron migration Source: Ensembl
  • phospholipase C-activating G-protein coupled receptor signaling pathway Source: ProtInc
  • positive regulation of cytosolic calcium ion concentration Source: ProtInc
  • regulation of hormone secretion Source: GO_Central
  • response to nutrient Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163394-MONOMER.
ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-416476. G alpha (q) signalling events.
SignaLinkiP32238.
SIGNORiP32238.

Names & Taxonomyi

Protein namesi
Recommended name:
Cholecystokinin receptor type A
Short name:
CCK-A receptor
Short name:
CCK-AR
Alternative name(s):
Cholecystokinin-1 receptor
Short name:
CCK1-R
Gene namesi
Name:CCKAR
Synonyms:CCKRA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:1570. CCKAR.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 41ExtracellularSequence analysisAdd BLAST41
Transmembranei42 – 67Helical; Name=1Sequence analysisAdd BLAST26
Topological domaini68 – 77CytoplasmicSequence analysis10
Transmembranei78 – 104Helical; Name=2Sequence analysisAdd BLAST27
Topological domaini105 – 115ExtracellularSequence analysisAdd BLAST11
Transmembranei116 – 137Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini138 – 157CytoplasmicSequence analysisAdd BLAST20
Transmembranei158 – 178Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini179 – 210ExtracellularSequence analysisAdd BLAST32
Transmembranei211 – 234Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini235 – 313CytoplasmicSequence analysisAdd BLAST79
Transmembranei314 – 334Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini335 – 349ExtracellularSequence analysisAdd BLAST15
Transmembranei350 – 373Helical; Name=7Sequence analysisAdd BLAST24
Topological domaini374 – 428CytoplasmicSequence analysisAdd BLAST55

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi886.
OpenTargetsiENSG00000163394.
PharmGKBiPA26142.

Chemistry databases

ChEMBLiCHEMBL1901.
DrugBankiDB00403. Ceruletide.
GuidetoPHARMACOLOGYi76.

Polymorphism and mutation databases

BioMutaiCCKAR.
DMDMi416772.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000692231 – 428Cholecystokinin receptor type AAdd BLAST428

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi10N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi18 ↔ 29PROSITE-ProRule annotation
Glycosylationi24N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi114 ↔ 196PROSITE-ProRule annotation
Glycosylationi190N-linked (GlcNAc...)Sequence analysis1
Lipidationi387S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

MaxQBiP32238.
PaxDbiP32238.
PeptideAtlasiP32238.
PRIDEiP32238.

PTM databases

iPTMnetiP32238.
PhosphoSitePlusiP32238.

Expressioni

Gene expression databases

BgeeiENSG00000163394.
CleanExiHS_CCKAR.
GenevisibleiP32238. HS.

Organism-specific databases

HPAiCAB005619.

Interactioni

Protein-protein interaction databases

BioGridi107328. 1 interactor.
IntActiP32238. 1 interactor.
MINTiMINT-3012991.
STRINGi9606.ENSP00000295589.

Chemistry databases

BindingDBiP32238.

Structurei

Secondary structure

1428
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni5 – 11Combined sources7
Beta strandi13 – 15Combined sources3
Beta strandi21 – 25Combined sources5
Helixi39 – 44Combined sources6
Turni330 – 334Combined sources5
Helixi335 – 339Combined sources5
Beta strandi346 – 350Combined sources5
Helixi352 – 355Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1D6GNMR-A1-47[»]
1HZNNMR-A329-357[»]
1PB2model-A1-381[»]
ProteinModelPortaliP32238.
SMRiP32238.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP32238.

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00860000133695.
HOGENOMiHOG000294067.
HOVERGENiHBG036927.
InParanoidiP32238.
KOiK04194.
OMAiYSYSHMS.
OrthoDBiEOG091G084J.
PhylomeDBiP32238.
TreeFamiTF315303.

Family and domain databases

Gene3Di4.10.670.10. 1 hit.
InterProiIPR009126. Cholcskin_rcpt.
IPR000596. Cholcy_rcpt_A.
IPR015276. CholecystokininA_recpt_N.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF09193. CholecysA-Rec_N. 1 hit.
[Graphical view]
PRINTSiPR01822. CCYSTOKININR.
PR00524. CCYSTOKNINAR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32238-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVVDSLLVN GSNITPPCEL GLENETLFCL DQPRPSKEWQ PAVQILLYSL
60 70 80 90 100
IFLLSVLGNT LVITVLIRNK RMRTVTNIFL LSLAVSDLML CLFCMPFNLI
110 120 130 140 150
PNLLKDFIFG SAVCKTTTYF MGTSVSVSTF NLVAISLERY GAICKPLQSR
160 170 180 190 200
VWQTKSHALK VIAATWCLSF TIMTPYPIYS NLVPFTKNNN QTANMCRFLL
210 220 230 240 250
PNDVMQQSWH TFLLLILFLI PGIVMMVAYG LISLELYQGI KFEASQKKSA
260 270 280 290 300
KERKPSTTSS GKYEDSDGCY LQKTRPPRKL ELRQLSTGSS SRANRIRSNS
310 320 330 340 350
SAANLMAKKR VIRMLIVIVV LFFLCWMPIF SANAWRAYDT ASAERRLSGT
360 370 380 390 400
PISFILLLSY TSSCVNPIIY CFMNKRFRLG FMATFPCCPN PGPPGARGEV
410 420
GEEEEGGTTG ASLSRFSYSH MSASVPPQ
Length:428
Mass (Da):47,841
Last modified:October 1, 1993 - v1
Checksum:iA6E8FABDA805E610
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13605 mRNA. Translation: AAA35659.1.
L19315 mRNA. Translation: AAA02819.1.
U23430
, U23427, U23428, U23429 Genomic DNA. Translation: AAA91123.1.
D85606 Genomic DNA. Translation: BAA90879.1.
AY322549 mRNA. Translation: AAP84362.1.
AK313978 mRNA. Translation: BAG36692.1.
CH471069 Genomic DNA. Translation: EAW92850.1.
BC074987 mRNA. Translation: AAH74987.1.
CCDSiCCDS3438.1.
PIRiJN0692.
RefSeqiNP_000721.1. NM_000730.2.
UniGeneiHs.129.

Genome annotation databases

EnsembliENST00000295589; ENSP00000295589; ENSG00000163394.
GeneIDi886.
KEGGihsa:886.
UCSCiuc003gse.2. human.

Cross-referencesi

Web resourcesi

Wikipedia

Cholecystokinin receptor entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13605 mRNA. Translation: AAA35659.1.
L19315 mRNA. Translation: AAA02819.1.
U23430
, U23427, U23428, U23429 Genomic DNA. Translation: AAA91123.1.
D85606 Genomic DNA. Translation: BAA90879.1.
AY322549 mRNA. Translation: AAP84362.1.
AK313978 mRNA. Translation: BAG36692.1.
CH471069 Genomic DNA. Translation: EAW92850.1.
BC074987 mRNA. Translation: AAH74987.1.
CCDSiCCDS3438.1.
PIRiJN0692.
RefSeqiNP_000721.1. NM_000730.2.
UniGeneiHs.129.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1D6GNMR-A1-47[»]
1HZNNMR-A329-357[»]
1PB2model-A1-381[»]
ProteinModelPortaliP32238.
SMRiP32238.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107328. 1 interactor.
IntActiP32238. 1 interactor.
MINTiMINT-3012991.
STRINGi9606.ENSP00000295589.

Chemistry databases

BindingDBiP32238.
ChEMBLiCHEMBL1901.
DrugBankiDB00403. Ceruletide.
GuidetoPHARMACOLOGYi76.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP32238.
PhosphoSitePlusiP32238.

Polymorphism and mutation databases

BioMutaiCCKAR.
DMDMi416772.

Proteomic databases

MaxQBiP32238.
PaxDbiP32238.
PeptideAtlasiP32238.
PRIDEiP32238.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295589; ENSP00000295589; ENSG00000163394.
GeneIDi886.
KEGGihsa:886.
UCSCiuc003gse.2. human.

Organism-specific databases

CTDi886.
DisGeNETi886.
GeneCardsiCCKAR.
H-InvDBHIX0163965.
HGNCiHGNC:1570. CCKAR.
HPAiCAB005619.
MIMi118444. gene.
neXtProtiNX_P32238.
OpenTargetsiENSG00000163394.
PharmGKBiPA26142.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00860000133695.
HOGENOMiHOG000294067.
HOVERGENiHBG036927.
InParanoidiP32238.
KOiK04194.
OMAiYSYSHMS.
OrthoDBiEOG091G084J.
PhylomeDBiP32238.
TreeFamiTF315303.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163394-MONOMER.
ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-416476. G alpha (q) signalling events.
SignaLinkiP32238.
SIGNORiP32238.

Miscellaneous databases

EvolutionaryTraceiP32238.
GeneWikiiCholecystokinin_A_receptor.
GenomeRNAii886.
PROiP32238.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163394.
CleanExiHS_CCKAR.
GenevisibleiP32238. HS.

Family and domain databases

Gene3Di4.10.670.10. 1 hit.
InterProiIPR009126. Cholcskin_rcpt.
IPR000596. Cholcy_rcpt_A.
IPR015276. CholecystokininA_recpt_N.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF09193. CholecysA-Rec_N. 1 hit.
[Graphical view]
PRINTSiPR01822. CCYSTOKININR.
PR00524. CCYSTOKNINAR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCKAR_HUMAN
AccessioniPrimary (citable) accession number: P32238
Secondary accession number(s): B2R9Z5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: November 30, 2016
This is version 171 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.