Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P32238

- CCKAR_HUMAN

UniProt

P32238 - CCKAR_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Cholecystokinin receptor type A

Gene

CCKAR

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

  1. cholecystokinin receptor activity Source: ProtInc

GO - Biological processi

  1. axonogenesis Source: Ensembl
  2. cholecystokinin signaling pathway Source: GOC
  3. digestion Source: ProtInc
  4. feeding behavior Source: ProtInc
  5. forebrain development Source: Ensembl
  6. neuron migration Source: Ensembl
  7. phospholipase C-activating G-protein coupled receptor signaling pathway Source: ProtInc
  8. positive regulation of cytosolic calcium ion concentration Source: ProtInc
  9. response to nutrient Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.
SignaLinkiP32238.

Names & Taxonomyi

Protein namesi
Recommended name:
Cholecystokinin receptor type A
Short name:
CCK-A receptor
Short name:
CCK-AR
Alternative name(s):
Cholecystokinin-1 receptor
Short name:
CCK1-R
Gene namesi
Name:CCKAR
Synonyms:CCKRA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:1570. CCKAR.

Subcellular locationi

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26142.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 428428Cholecystokinin receptor type APRO_0000069223Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi10 – 101N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi18 ↔ 29PROSITE-ProRule annotation
Glycosylationi24 – 241N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi114 ↔ 196PROSITE-ProRule annotation
Glycosylationi190 – 1901N-linked (GlcNAc...)Sequence Analysis
Lipidationi387 – 3871S-palmitoyl cysteineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

MaxQBiP32238.
PRIDEiP32238.

PTM databases

PhosphoSiteiP32238.

Expressioni

Gene expression databases

BgeeiP32238.
CleanExiHS_CCKAR.
GenevestigatoriP32238.

Organism-specific databases

HPAiCAB005619.

Interactioni

Protein-protein interaction databases

BioGridi107328. 1 interaction.
IntActiP32238. 1 interaction.
MINTiMINT-3012991.
STRINGi9606.ENSP00000295589.

Structurei

Secondary structure

1
428
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni5 – 117
Beta strandi13 – 153
Beta strandi21 – 255
Helixi39 – 446
Turni330 – 3345
Helixi335 – 3395
Beta strandi346 – 3505
Helixi352 – 3554

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1D6GNMR-A1-47[»]
1HZNNMR-A329-357[»]
1PB2model-A1-381[»]
ProteinModelPortaliP32238.
SMRiP32238. Positions 1-389.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP32238.

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4141ExtracellularSequence AnalysisAdd
BLAST
Topological domaini68 – 7710CytoplasmicSequence Analysis
Topological domaini105 – 11511ExtracellularSequence AnalysisAdd
BLAST
Topological domaini138 – 15720CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini179 – 21032ExtracellularSequence AnalysisAdd
BLAST
Topological domaini235 – 31379CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini335 – 34915ExtracellularSequence AnalysisAdd
BLAST
Topological domaini374 – 42855CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei42 – 6726Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei78 – 10427Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei116 – 13722Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei158 – 17821Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei211 – 23424Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei314 – 33421Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei350 – 37324Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG238659.
GeneTreeiENSGT00730000110635.
HOGENOMiHOG000294067.
HOVERGENiHBG036927.
InParanoidiP32238.
KOiK04194.
OMAiYSYSHMS.
OrthoDBiEOG7QVM36.
PhylomeDBiP32238.
TreeFamiTF315303.

Family and domain databases

Gene3Di1.20.1070.10. 2 hits.
4.10.670.10. 1 hit.
InterProiIPR009126. Cholcskin_rcpt.
IPR000596. Cholcy_rcpt_A.
IPR015276. CholecystokininA_recpt_N.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF09193. CholecysA-Rec_N. 1 hit.
[Graphical view]
PRINTSiPR01822. CCYSTOKININR.
PR00524. CCYSTOKNINAR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32238-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDVVDSLLVN GSNITPPCEL GLENETLFCL DQPRPSKEWQ PAVQILLYSL
60 70 80 90 100
IFLLSVLGNT LVITVLIRNK RMRTVTNIFL LSLAVSDLML CLFCMPFNLI
110 120 130 140 150
PNLLKDFIFG SAVCKTTTYF MGTSVSVSTF NLVAISLERY GAICKPLQSR
160 170 180 190 200
VWQTKSHALK VIAATWCLSF TIMTPYPIYS NLVPFTKNNN QTANMCRFLL
210 220 230 240 250
PNDVMQQSWH TFLLLILFLI PGIVMMVAYG LISLELYQGI KFEASQKKSA
260 270 280 290 300
KERKPSTTSS GKYEDSDGCY LQKTRPPRKL ELRQLSTGSS SRANRIRSNS
310 320 330 340 350
SAANLMAKKR VIRMLIVIVV LFFLCWMPIF SANAWRAYDT ASAERRLSGT
360 370 380 390 400
PISFILLLSY TSSCVNPIIY CFMNKRFRLG FMATFPCCPN PGPPGARGEV
410 420
GEEEEGGTTG ASLSRFSYSH MSASVPPQ
Length:428
Mass (Da):47,841
Last modified:October 1, 1993 - v1
Checksum:iA6E8FABDA805E610
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L13605 mRNA. Translation: AAA35659.1.
L19315 mRNA. Translation: AAA02819.1.
U23430
, U23427, U23428, U23429 Genomic DNA. Translation: AAA91123.1.
D85606 Genomic DNA. Translation: BAA90879.1.
AY322549 mRNA. Translation: AAP84362.1.
AK313978 mRNA. Translation: BAG36692.1.
CH471069 Genomic DNA. Translation: EAW92850.1.
BC074987 mRNA. Translation: AAH74987.1.
CCDSiCCDS3438.1.
PIRiJN0692.
RefSeqiNP_000721.1. NM_000730.2.
UniGeneiHs.129.

Genome annotation databases

EnsembliENST00000295589; ENSP00000295589; ENSG00000163394.
GeneIDi886.
KEGGihsa:886.
UCSCiuc003gse.1. human.

Polymorphism databases

DMDMi416772.

Cross-referencesi

Web resourcesi

Wikipedia

Cholecystokinin receptor entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L13605 mRNA. Translation: AAA35659.1 .
L19315 mRNA. Translation: AAA02819.1 .
U23430
, U23427 , U23428 , U23429 Genomic DNA. Translation: AAA91123.1 .
D85606 Genomic DNA. Translation: BAA90879.1 .
AY322549 mRNA. Translation: AAP84362.1 .
AK313978 mRNA. Translation: BAG36692.1 .
CH471069 Genomic DNA. Translation: EAW92850.1 .
BC074987 mRNA. Translation: AAH74987.1 .
CCDSi CCDS3438.1.
PIRi JN0692.
RefSeqi NP_000721.1. NM_000730.2.
UniGenei Hs.129.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1D6G NMR - A 1-47 [» ]
1HZN NMR - A 329-357 [» ]
1PB2 model - A 1-381 [» ]
ProteinModelPortali P32238.
SMRi P32238. Positions 1-389.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107328. 1 interaction.
IntActi P32238. 1 interaction.
MINTi MINT-3012991.
STRINGi 9606.ENSP00000295589.

Chemistry

BindingDBi P32238.
ChEMBLi CHEMBL1901.
DrugBanki DB00403. Ceruletide.
GuidetoPHARMACOLOGYi 76.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P32238.

Polymorphism databases

DMDMi 416772.

Proteomic databases

MaxQBi P32238.
PRIDEi P32238.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000295589 ; ENSP00000295589 ; ENSG00000163394 .
GeneIDi 886.
KEGGi hsa:886.
UCSCi uc003gse.1. human.

Organism-specific databases

CTDi 886.
GeneCardsi GC04M026483.
H-InvDB HIX0163965.
HGNCi HGNC:1570. CCKAR.
HPAi CAB005619.
MIMi 118444. gene.
neXtProti NX_P32238.
PharmGKBi PA26142.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG238659.
GeneTreei ENSGT00730000110635.
HOGENOMi HOG000294067.
HOVERGENi HBG036927.
InParanoidi P32238.
KOi K04194.
OMAi YSYSHMS.
OrthoDBi EOG7QVM36.
PhylomeDBi P32238.
TreeFami TF315303.

Enzyme and pathway databases

Reactomei REACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.
SignaLinki P32238.

Miscellaneous databases

EvolutionaryTracei P32238.
GeneWikii Cholecystokinin_A_receptor.
GenomeRNAii 886.
NextBioi 3662.
PROi P32238.
SOURCEi Search...

Gene expression databases

Bgeei P32238.
CleanExi HS_CCKAR.
Genevestigatori P32238.

Family and domain databases

Gene3Di 1.20.1070.10. 2 hits.
4.10.670.10. 1 hit.
InterProi IPR009126. Cholcskin_rcpt.
IPR000596. Cholcy_rcpt_A.
IPR015276. CholecystokininA_recpt_N.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
PF09193. CholecysA-Rec_N. 1 hit.
[Graphical view ]
PRINTSi PR01822. CCYSTOKININR.
PR00524. CCYSTOKNINAR.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and functional expression of the human gallbladder cholecystokinin A receptor."
    Ulrich C.D., Ferber I., Holicky E., Hadac E., Buell G., Miller L.J.
    Biochem. Biophys. Res. Commun. 193:204-211(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Gall bladder.
  2. "Molecular cloning, functional expression and chromosomal localization of the human cholecystokinin type A receptor."
    Wank S.A., de Weerth A., Pisegna J.R., Huppi K.
    Biochem. Biophys. Res. Commun. 194:811-818(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Abnormal processing of the human cholecystokinin receptor gene in association with gallstones and obesity."
    Miller L.J., Holicky E.L., Ulrich C.D., Wieben E.D.
    Gastroenterology 109:1375-1380(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Gene structure of human cholecystokinin (CCK) type-A receptor: body fat content is related to CCK type-A receptor gene promoter polymorphism."
    Funakoshi A., Miyasaka K., Matsumoto H., Yamamori S., Takiguchi S., Kataoka K., Takata Y., Matsusue K., Kono A., Shimokata H.
    FEBS Lett. 466:264-266(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Peripheral blood leukocyte.
  5. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Kopatz S.A., Aronstam R.S., Sharma S.V.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Stomach.
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thalamus.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  9. "Molecular complex of cholecystokinin-8 and N-terminus of the cholecystokinin A receptor by NMR spectroscopy."
    Pellegrini M., Mierke D.F.
    Biochemistry 38:14775-14783(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 1-47 IN COMPLEX WITH CCK.
  10. "Intermolecular interactions between cholecystokinin-8 and the third extracellular loop of the cholecystokinin A receptor."
    Giragossian C., Mierke D.F.
    Biochemistry 40:3804-3809(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 329-357 IN COMPLEX WITH CCK.

Entry informationi

Entry nameiCCKAR_HUMAN
AccessioniPrimary (citable) accession number: P32238
Secondary accession number(s): B2R9Z5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: October 29, 2014
This is version 152 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3