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Protein

Cholecystokinin receptor type A

Gene

CCKAR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

  • cholecystokinin receptor activity Source: GO_Central
  • peptide binding Source: GO_Central
  • peptide hormone binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-416476 G alpha (q) signalling events
SignaLinkiP32238
SIGNORiP32238

Names & Taxonomyi

Protein namesi
Recommended name:
Cholecystokinin receptor type A
Short name:
CCK-A receptor
Short name:
CCK-AR
Alternative name(s):
Cholecystokinin-1 receptor
Short name:
CCK1-R
Gene namesi
Name:CCKAR
Synonyms:CCKRA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000163394.5
HGNCiHGNC:1570 CCKAR
MIMi118444 gene
neXtProtiNX_P32238

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 41ExtracellularSequence analysisAdd BLAST41
Transmembranei42 – 67Helical; Name=1Sequence analysisAdd BLAST26
Topological domaini68 – 77CytoplasmicSequence analysis10
Transmembranei78 – 104Helical; Name=2Sequence analysisAdd BLAST27
Topological domaini105 – 115ExtracellularSequence analysisAdd BLAST11
Transmembranei116 – 137Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini138 – 157CytoplasmicSequence analysisAdd BLAST20
Transmembranei158 – 178Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini179 – 210ExtracellularSequence analysisAdd BLAST32
Transmembranei211 – 234Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini235 – 313CytoplasmicSequence analysisAdd BLAST79
Transmembranei314 – 334Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini335 – 349ExtracellularSequence analysisAdd BLAST15
Transmembranei350 – 373Helical; Name=7Sequence analysisAdd BLAST24
Topological domaini374 – 428CytoplasmicSequence analysisAdd BLAST55

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi886
OpenTargetsiENSG00000163394
PharmGKBiPA26142

Chemistry databases

ChEMBLiCHEMBL1901
DrugBankiDB00403 Ceruletide
DB04856 Dexloxiglumide
DB04867 Lintitript
GuidetoPHARMACOLOGYi76

Polymorphism and mutation databases

BioMutaiCCKAR
DMDMi416772

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000692231 – 428Cholecystokinin receptor type AAdd BLAST428

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi10N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi18 ↔ 29PROSITE-ProRule annotation
Glycosylationi24N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi114 ↔ 196PROSITE-ProRule annotation
Glycosylationi190N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi387S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

MaxQBiP32238
PaxDbiP32238
PeptideAtlasiP32238
PRIDEiP32238

PTM databases

iPTMnetiP32238
PhosphoSitePlusiP32238

Expressioni

Gene expression databases

BgeeiENSG00000163394
CleanExiHS_CCKAR
GenevisibleiP32238 HS

Interactioni

Protein-protein interaction databases

BioGridi107328, 1 interactor
IntActiP32238, 1 interactor
MINTiP32238
STRINGi9606.ENSP00000295589

Chemistry databases

BindingDBiP32238

Structurei

Secondary structure

1428
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni5 – 11Combined sources7
Beta strandi13 – 15Combined sources3
Beta strandi21 – 25Combined sources5
Helixi39 – 44Combined sources6
Turni330 – 334Combined sources5
Helixi335 – 339Combined sources5
Beta strandi346 – 350Combined sources5
Helixi352 – 355Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1D6GNMR-A1-47[»]
1HZNNMR-A329-357[»]
1PB2model-A1-381[»]
ProteinModelPortaliP32238
SMRiP32238
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP32238

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00860000133695
HOGENOMiHOG000294067
HOVERGENiHBG036927
InParanoidiP32238
KOiK04194
OMAiYSYSHMS
OrthoDBiEOG091G084J
PhylomeDBiP32238
TreeFamiTF315303

Family and domain databases

Gene3Di4.10.670.10, 1 hit
InterProiView protein in InterPro
IPR009126 Cholcskin_rcpt
IPR000596 Cholcy_rcpt_A
IPR015276 CholecystokininA_recpt_N
IPR036472 CholecystokininA_recpt_N_sf
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PF09193 CholecysA-Rec_N, 1 hit
PRINTSiPR01822 CCYSTOKININR
PR00524 CCYSTOKNINAR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P32238-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVVDSLLVN GSNITPPCEL GLENETLFCL DQPRPSKEWQ PAVQILLYSL
60 70 80 90 100
IFLLSVLGNT LVITVLIRNK RMRTVTNIFL LSLAVSDLML CLFCMPFNLI
110 120 130 140 150
PNLLKDFIFG SAVCKTTTYF MGTSVSVSTF NLVAISLERY GAICKPLQSR
160 170 180 190 200
VWQTKSHALK VIAATWCLSF TIMTPYPIYS NLVPFTKNNN QTANMCRFLL
210 220 230 240 250
PNDVMQQSWH TFLLLILFLI PGIVMMVAYG LISLELYQGI KFEASQKKSA
260 270 280 290 300
KERKPSTTSS GKYEDSDGCY LQKTRPPRKL ELRQLSTGSS SRANRIRSNS
310 320 330 340 350
SAANLMAKKR VIRMLIVIVV LFFLCWMPIF SANAWRAYDT ASAERRLSGT
360 370 380 390 400
PISFILLLSY TSSCVNPIIY CFMNKRFRLG FMATFPCCPN PGPPGARGEV
410 420
GEEEEGGTTG ASLSRFSYSH MSASVPPQ
Length:428
Mass (Da):47,841
Last modified:October 1, 1993 - v1
Checksum:iA6E8FABDA805E610
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13605 mRNA Translation: AAA35659.1
L19315 mRNA Translation: AAA02819.1
U23430
, U23427, U23428, U23429 Genomic DNA Translation: AAA91123.1
D85606 Genomic DNA Translation: BAA90879.1
AY322549 mRNA Translation: AAP84362.1
AK313978 mRNA Translation: BAG36692.1
CH471069 Genomic DNA Translation: EAW92850.1
BC074987 mRNA Translation: AAH74987.1
CCDSiCCDS3438.1
PIRiJN0692
RefSeqiNP_000721.1, NM_000730.2
UniGeneiHs.129

Genome annotation databases

EnsembliENST00000295589; ENSP00000295589; ENSG00000163394
GeneIDi886
KEGGihsa:886
UCSCiuc003gse.2 human

Similar proteinsi

Entry informationi

Entry nameiCCKAR_HUMAN
AccessioniPrimary (citable) accession number: P32238
Secondary accession number(s): B2R9Z5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: April 25, 2018
This is version 180 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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