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Protein

Gonadotropin-releasing hormone receptor

Gene

GNRHR

Organism
Ovis aries (Sheep)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Gonadotropin-releasing hormone receptor
Short name:
GnRH receptor
Short name:
GnRH-R
Gene namesi
Name:GNRHR
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
Proteomesi
  • UP000002356 Componenti: Chromosome 6

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3838ExtracellularSequence analysisAdd
BLAST
Transmembranei39 – 5820Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini59 – 7719CytoplasmicSequence analysisAdd
BLAST
Transmembranei78 – 9720Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini98 – 11518ExtracellularSequence analysisAdd
BLAST
Transmembranei116 – 13722Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini138 – 16427CytoplasmicSequence analysisAdd
BLAST
Transmembranei165 – 18420Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini185 – 21228ExtracellularSequence analysisAdd
BLAST
Transmembranei213 – 23220Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini233 – 28149CytoplasmicSequence analysisAdd
BLAST
Transmembranei282 – 30019Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini301 – 3066ExtracellularSequence analysis
Transmembranei307 – 32620Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini327 – 3282CytoplasmicSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 328328Gonadotropin-releasing hormone receptorPRO_0000069492Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi18 – 181N-linked (GlcNAc...)Sequence analysis
Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence analysis
Disulfide bondi114 ↔ 196PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliP32237.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000119156.
HOVERGENiHBG009082.
KOiK04280.
OMAiVAWIMAG.
OrthoDBiEOG091G0ZDG.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001658. GphnRH_fam_rcpt.
IPR027982. GphnRH_rcpt.
[Graphical view]
PANTHERiPTHR24241:SF22. PTHR24241:SF22. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00529. GNADOTRPHINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32237-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANGDSPDQN ENHCSAINSS ILLTPGSLPT LTLSGKIRVT VTFFLFLLST
60 70 80 90 100
IFNTSFLLKL QNWTQRKEKR KKLSKMKVLL KHLTLANLLE TLIVMPLDGM
110 120 130 140 150
WNITVQWYAG ELLCKVLSYL KLFSMYAPAF MMVVISLDRS LAITRPLAVK
160 170 180 190 200
SNSKLGQFMI GLAWLLSSIF AGPQLYIFGM IHLADDSGQT EGFSQCVTHC
210 220 230 240 250
SFPQWWHQAF YNFFTFSCLF IIPLLIMLIC NAKIIFTLTR VLHQDPHKLQ
260 270 280 290 300
LNQSKNNIPQ ARLRTLKMTV AFATSFTVCW TPYYVLGIWY WFDPDMVNRV
310 320
SDPVNHFFFL FAFLNPCFDP LIYGYFSL
Length:328
Mass (Da):37,685
Last modified:October 1, 1993 - v1
Checksum:i0618374F33ECC6FE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti8 – 81D → N in CAA50978 (PubMed:8224516).Curated
Sequence conflicti27 – 271S → R in CAA50978 (PubMed:8224516).Curated
Sequence conflicti64 – 641T → A in CAA50978 (PubMed:8224516).Curated
Sequence conflicti312 – 3121A → G in CAA50978 (PubMed:8224516).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L22215 mRNA. Translation: AAC37336.1.
X72088 mRNA. Translation: CAA50978.1.
L42937 Genomic DNA. Translation: AAB38515.1.
AH004943 Genomic DNA. Translation: AAB41939.1.
PIRiJN0882.
RefSeqiNP_001009397.1. NM_001009397.1.
UniGeneiOar.486.

Genome annotation databases

EnsembliENSOART00000008195; ENSOARP00000008075; ENSOARG00000007526.
GeneIDi443413.
KEGGioas:443413.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L22215 mRNA. Translation: AAC37336.1.
X72088 mRNA. Translation: CAA50978.1.
L42937 Genomic DNA. Translation: AAB38515.1.
AH004943 Genomic DNA. Translation: AAB41939.1.
PIRiJN0882.
RefSeqiNP_001009397.1. NM_001009397.1.
UniGeneiOar.486.

3D structure databases

ProteinModelPortaliP32237.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSOART00000008195; ENSOARP00000008075; ENSOARG00000007526.
GeneIDi443413.
KEGGioas:443413.

Organism-specific databases

CTDi2798.

Phylogenomic databases

GeneTreeiENSGT00760000119156.
HOVERGENiHBG009082.
KOiK04280.
OMAiVAWIMAG.
OrthoDBiEOG091G0ZDG.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001658. GphnRH_fam_rcpt.
IPR027982. GphnRH_rcpt.
[Graphical view]
PANTHERiPTHR24241:SF22. PTHR24241:SF22. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00529. GNADOTRPHINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGNRHR_SHEEP
AccessioniPrimary (citable) accession number: P32237
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: September 7, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.