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Protein

Gonadotropin-releasing hormone receptor

Gene

GNRHR

Organism
Ovis aries (Sheep)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Gonadotropin-releasing hormone receptor
Short name:
GnRH receptor
Short name:
GnRH-R
Gene namesi
Name:GNRHR
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
Proteomesi
  • UP000002356 Componenti: Chromosome 6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 38ExtracellularSequence analysisAdd BLAST38
Transmembranei39 – 58Helical; Name=1Sequence analysisAdd BLAST20
Topological domaini59 – 77CytoplasmicSequence analysisAdd BLAST19
Transmembranei78 – 97Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini98 – 115ExtracellularSequence analysisAdd BLAST18
Transmembranei116 – 137Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini138 – 164CytoplasmicSequence analysisAdd BLAST27
Transmembranei165 – 184Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini185 – 212ExtracellularSequence analysisAdd BLAST28
Transmembranei213 – 232Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini233 – 281CytoplasmicSequence analysisAdd BLAST49
Transmembranei282 – 300Helical; Name=6Sequence analysisAdd BLAST19
Topological domaini301 – 306ExtracellularSequence analysis6
Transmembranei307 – 326Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini327 – 328CytoplasmicSequence analysis2

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000694921 – 328Gonadotropin-releasing hormone receptorAdd BLAST328

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi18N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi102N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi114 ↔ 196PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliP32237
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000119156
HOVERGENiHBG009082
KOiK04280
OMAiMEMESDL
OrthoDBiEOG091G0ZDG

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001658 GphnRH_fam_rcpt
IPR027982 GphnRH_rcpt
PANTHERiPTHR24241:SF22 PTHR24241:SF22, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00529 GNADOTRPHINR
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P32237-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANGDSPDQN ENHCSAINSS ILLTPGSLPT LTLSGKIRVT VTFFLFLLST
60 70 80 90 100
IFNTSFLLKL QNWTQRKEKR KKLSKMKVLL KHLTLANLLE TLIVMPLDGM
110 120 130 140 150
WNITVQWYAG ELLCKVLSYL KLFSMYAPAF MMVVISLDRS LAITRPLAVK
160 170 180 190 200
SNSKLGQFMI GLAWLLSSIF AGPQLYIFGM IHLADDSGQT EGFSQCVTHC
210 220 230 240 250
SFPQWWHQAF YNFFTFSCLF IIPLLIMLIC NAKIIFTLTR VLHQDPHKLQ
260 270 280 290 300
LNQSKNNIPQ ARLRTLKMTV AFATSFTVCW TPYYVLGIWY WFDPDMVNRV
310 320
SDPVNHFFFL FAFLNPCFDP LIYGYFSL
Length:328
Mass (Da):37,685
Last modified:October 1, 1993 - v1
Checksum:i0618374F33ECC6FE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8D → N in CAA50978 (PubMed:8224516).Curated1
Sequence conflicti27S → R in CAA50978 (PubMed:8224516).Curated1
Sequence conflicti64T → A in CAA50978 (PubMed:8224516).Curated1
Sequence conflicti312A → G in CAA50978 (PubMed:8224516).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L22215 mRNA Translation: AAC37336.1
X72088 mRNA Translation: CAA50978.1
L42937 Genomic DNA Translation: AAB38515.1
AH004943 Genomic DNA Translation: AAB41939.1
PIRiJN0882
RefSeqiNP_001009397.1, NM_001009397.1
UniGeneiOar.486

Genome annotation databases

EnsembliENSOART00000008195; ENSOARP00000008075; ENSOARG00000007526
GeneIDi443413
KEGGioas:443413

Similar proteinsi

Entry informationi

Entry nameiGNRHR_SHEEP
AccessioniPrimary (citable) accession number: P32237
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: March 28, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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