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Protein

GTP-binding protein 128up

Gene

128up

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Deformed (Dfd) is required to activate 1.28up in maxillary segment cells.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi71 – 78GTPPROSITE-ProRule annotation8
Nucleotide bindingi117 – 121GTPPROSITE-ProRule annotation5
Nucleotide bindingi248 – 251GTPPROSITE-ProRule annotation4

GO - Molecular functioni

  • GTP binding Source: FlyBase

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein 128up
Gene namesi
Name:128up
Synonyms:GTP-bp
ORF Names:CG8340
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0010339 128up

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002054301 – 368GTP-binding protein 128upAdd BLAST368

Proteomic databases

PaxDbiP32234
PRIDEiP32234

Expressioni

Tissue specificityi

Expressed in posterior-lateral epidermis of the maxillary lobe.1 Publication

Developmental stagei

Expressed in embryos and adults.1 Publication

Gene expression databases

BgeeiFBgn0010339
GenevisibleiP32234 DM

Interactioni

Protein-protein interaction databases

BioGridi62072, 4 interactors
IntActiP32234, 4 interactors
STRINGi7227.FBpp0087084

Structurei

3D structure databases

ProteinModelPortaliP32234
SMRiP32234
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini65 – 290OBG-type GPROSITE-ProRule annotationAdd BLAST226

Sequence similaritiesi

Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1487 Eukaryota
COG1163 LUCA
GeneTreeiENSGT00550000075013
InParanoidiP32234
OMAiSAKHPGQ
OrthoDBiEOG091G0A12
PhylomeDBiP32234

Family and domain databases

Gene3Di3.10.20.30, 1 hit
InterProiView protein in InterPro
IPR012675 Beta-grasp_dom_sf
IPR031167 G_OBG
IPR031662 GTP-binding_2
IPR006074 GTP1-OBG_CS
IPR006073 GTP_binding_domain
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR004095 TGS
IPR012676 TGS-like
PfamiView protein in Pfam
PF01926 MMR_HSR1, 1 hit
PF16897 MMR_HSR1_Xtn, 1 hit
PF02824 TGS, 1 hit
PRINTSiPR00326 GTP1OBG
SUPFAMiSSF52540 SSF52540, 1 hit
SSF81271 SSF81271, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51710 G_OBG, 1 hit
PS00905 GTP1_OBG, 1 hit

Sequencei

Sequence statusi: Complete.

P32234-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTILEKISA IESEMARTQK NKATSAHLGL LKAKLAKLRR ELISPKGGGG
60 70 80 90 100
GTGEAGFEVA KTGDARVGFV GFPSVGKSTL LSNLAGVYSE VAAYEFTTLT
110 120 130 140 150
TVPGCIKYKG AKIQLLDLPG IIEGAKDGKG RGRQVIAVAR TCNLIFMVLD
160 170 180 190 200
CLKPLGHKKL LEHELEGFGI RLNKKPPNIY YKRKDKGGIN LNSMVPQSEL
210 220 230 240 250
DTDLVKTILS EYKIHNADIT LRYDATSDDL IDVIEGNRIY IPCIYLLNKI
260 270 280 290 300
DQISIEELDV IYKIPHCVPI SAHHHWNFDD LLELMWEYLR LQRIYTKPKG
310 320 330 340 350
QLPDYNSPVV LHNERTSIED FCNKLHRSIA KEFKYALVWG SSVKHQPQKV
360
GIEHVLNDED VVQIVKKV
Length:368
Mass (Da):41,132
Last modified:March 29, 2005 - v2
Checksum:i5B38B09D0C0A92F2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2S → I in CAA50701 (PubMed:8121394).Curated1
Sequence conflicti34 – 35KL → NV in CAA50701 (PubMed:8121394).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71866 Genomic DNA Translation: CAA50701.1
AE013599 Genomic DNA Translation: AAF58591.1
AY069810 mRNA Translation: AAL39955.1
PIRiS42582
RefSeqiNP_536733.1, NM_080485.6
UniGeneiDm.7739

Genome annotation databases

EnsemblMetazoaiFBtr0087976; FBpp0087084; FBgn0010339
GeneIDi36288
KEGGidme:Dmel_CG8340

Similar proteinsi

Entry informationi

Entry namei128UP_DROME
AccessioniPrimary (citable) accession number: P32234
Secondary accession number(s): Q9V648
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: March 29, 2005
Last modified: March 28, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health