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P32234

- 128UP_DROME

UniProt

P32234 - 128UP_DROME

Protein

GTP-binding protein 128up

Gene

128up

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 2 (29 Mar 2005)
      Previous versions | rss
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    Functioni

    Deformed (Dfd) is required to activate 1.28up in maxillary segment cells.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi71 – 788GTPPROSITE-ProRule annotation
    Nucleotide bindingi117 – 1215GTPPROSITE-ProRule annotation
    Nucleotide bindingi248 – 2514GTPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. GTP binding Source: FlyBase

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP-binding protein 128up
    Gene namesi
    Name:128up
    Synonyms:GTP-bp
    ORF Names:CG8340
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 2R

    Organism-specific databases

    FlyBaseiFBgn0010339. 128up.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 368368GTP-binding protein 128upPRO_0000205430Add
    BLAST

    Proteomic databases

    PaxDbiP32234.

    Expressioni

    Tissue specificityi

    Expressed in posterior-lateral epidermis of the maxillary lobe.1 Publication

    Developmental stagei

    Expressed in embryos and adults.1 Publication

    Gene expression databases

    BgeeiP32234.

    Interactioni

    Protein-protein interaction databases

    BioGridi62072. 4 interactions.
    IntActiP32234. 3 interactions.
    MINTiMINT-843420.
    STRINGi7227.FBpp0087084.

    Structurei

    3D structure databases

    ProteinModelPortaliP32234.
    SMRiP32234. Positions 2-367.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini65 – 290226OBG-type GPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.PROSITE-ProRule annotation
    Contains 1 OBG-type G (guanine nucleotide-binding) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG1163.
    GeneTreeiENSGT00550000075013.
    InParanoidiP32234.
    OMAiGNRIYIP.
    OrthoDBiEOG7PZRXJ.
    PhylomeDBiP32234.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    InterProiIPR006074. GTP1-OBG_CS.
    IPR006073. GTP_binding_domain.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR004095. TGS.
    IPR012676. TGS-like.
    [Graphical view]
    PfamiPF01926. MMR_HSR1. 1 hit.
    PF02824. TGS. 1 hit.
    [Graphical view]
    PRINTSiPR00326. GTP1OBG.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    SSF81271. SSF81271. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51710. G_OBG. 1 hit.
    PS00905. GTP1_OBG. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P32234-1 [UniParc]FASTAAdd to Basket

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    MSTILEKISA IESEMARTQK NKATSAHLGL LKAKLAKLRR ELISPKGGGG    50
    GTGEAGFEVA KTGDARVGFV GFPSVGKSTL LSNLAGVYSE VAAYEFTTLT 100
    TVPGCIKYKG AKIQLLDLPG IIEGAKDGKG RGRQVIAVAR TCNLIFMVLD 150
    CLKPLGHKKL LEHELEGFGI RLNKKPPNIY YKRKDKGGIN LNSMVPQSEL 200
    DTDLVKTILS EYKIHNADIT LRYDATSDDL IDVIEGNRIY IPCIYLLNKI 250
    DQISIEELDV IYKIPHCVPI SAHHHWNFDD LLELMWEYLR LQRIYTKPKG 300
    QLPDYNSPVV LHNERTSIED FCNKLHRSIA KEFKYALVWG SSVKHQPQKV 350
    GIEHVLNDED VVQIVKKV 368
    Length:368
    Mass (Da):41,132
    Last modified:March 29, 2005 - v2
    Checksum:i5B38B09D0C0A92F2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti2 – 21S → I in CAA50701. (PubMed:8121394)Curated
    Sequence conflicti34 – 352KL → NV in CAA50701. (PubMed:8121394)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X71866 Genomic DNA. Translation: CAA50701.1.
    AE013599 Genomic DNA. Translation: AAF58591.1.
    AY069810 mRNA. Translation: AAL39955.1.
    PIRiS42582.
    RefSeqiNP_536733.1. NM_080485.5.
    UniGeneiDm.7739.

    Genome annotation databases

    EnsemblMetazoaiFBtr0087976; FBpp0087084; FBgn0010339.
    GeneIDi36288.
    KEGGidme:Dmel_CG8340.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X71866 Genomic DNA. Translation: CAA50701.1 .
    AE013599 Genomic DNA. Translation: AAF58591.1 .
    AY069810 mRNA. Translation: AAL39955.1 .
    PIRi S42582.
    RefSeqi NP_536733.1. NM_080485.5.
    UniGenei Dm.7739.

    3D structure databases

    ProteinModelPortali P32234.
    SMRi P32234. Positions 2-367.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 62072. 4 interactions.
    IntActi P32234. 3 interactions.
    MINTi MINT-843420.
    STRINGi 7227.FBpp0087084.

    Proteomic databases

    PaxDbi P32234.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0087976 ; FBpp0087084 ; FBgn0010339 .
    GeneIDi 36288.
    KEGGi dme:Dmel_CG8340.

    Organism-specific databases

    CTDi 36288.
    FlyBasei FBgn0010339. 128up.

    Phylogenomic databases

    eggNOGi COG1163.
    GeneTreei ENSGT00550000075013.
    InParanoidi P32234.
    OMAi GNRIYIP.
    OrthoDBi EOG7PZRXJ.
    PhylomeDBi P32234.

    Miscellaneous databases

    GenomeRNAii 36288.
    NextBioi 797758.
    PROi P32234.

    Gene expression databases

    Bgeei P32234.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    InterProi IPR006074. GTP1-OBG_CS.
    IPR006073. GTP_binding_domain.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR004095. TGS.
    IPR012676. TGS-like.
    [Graphical view ]
    Pfami PF01926. MMR_HSR1. 1 hit.
    PF02824. TGS. 1 hit.
    [Graphical view ]
    PRINTSi PR00326. GTP1OBG.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    SSF81271. SSF81271. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51710. G_OBG. 1 hit.
    PS00905. GTP1_OBG. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The gene upstream of DmRP128 codes for a novel GTP-binding protein of Drosophila melanogaster."
      Sommer K.A., Petersen G., Bautz E.K.F.
      Mol. Gen. Genet. 242:391-398(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Oregon-R.
    2. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    3. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Berkeley.
      Tissue: Embryo.
    5. "Identification and characterization of a gene activated by the deformed homeoprotein."
      Mahaffey J.W., Jones D.F., Hickel J.A., Griswold C.M.
      Development 118:203-214(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

    Entry informationi

    Entry namei128UP_DROME
    AccessioniPrimary (citable) accession number: P32234
    Secondary accession number(s): Q9V648
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: March 29, 2005
    Last modified: October 1, 2014
    This is version 101 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3