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P32234

- 128UP_DROME

UniProt

P32234 - 128UP_DROME

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Protein

GTP-binding protein 128up

Gene

128up

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Deformed (Dfd) is required to activate 1.28up in maxillary segment cells.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi71 – 788GTPPROSITE-ProRule annotation
Nucleotide bindingi117 – 1215GTPPROSITE-ProRule annotation
Nucleotide bindingi248 – 2514GTPPROSITE-ProRule annotation

GO - Molecular functioni

  1. GTP binding Source: FlyBase
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein 128up
Gene namesi
Name:128up
Synonyms:GTP-bp
ORF Names:CG8340
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0010339. 128up.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 368368GTP-binding protein 128upPRO_0000205430Add
BLAST

Proteomic databases

PaxDbiP32234.

Expressioni

Tissue specificityi

Expressed in posterior-lateral epidermis of the maxillary lobe.1 Publication

Developmental stagei

Expressed in embryos and adults.1 Publication

Gene expression databases

BgeeiP32234.

Interactioni

Protein-protein interaction databases

BioGridi62072. 4 interactions.
IntActiP32234. 3 interactions.
MINTiMINT-843420.
STRINGi7227.FBpp0087084.

Structurei

3D structure databases

ProteinModelPortaliP32234.
SMRiP32234. Positions 2-367.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini65 – 290226OBG-type GPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.PROSITE-ProRule annotation
Contains 1 OBG-type G (guanine nucleotide-binding) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG1163.
GeneTreeiENSGT00550000075013.
InParanoidiP32234.
OMAiGNRIYIP.
OrthoDBiEOG7PZRXJ.
PhylomeDBiP32234.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR006074. GTP1-OBG_CS.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR004095. TGS.
IPR012676. TGS-like.
[Graphical view]
PfamiPF01926. MMR_HSR1. 1 hit.
PF02824. TGS. 1 hit.
[Graphical view]
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF81271. SSF81271. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51710. G_OBG. 1 hit.
PS00905. GTP1_OBG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32234-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTILEKISA IESEMARTQK NKATSAHLGL LKAKLAKLRR ELISPKGGGG
60 70 80 90 100
GTGEAGFEVA KTGDARVGFV GFPSVGKSTL LSNLAGVYSE VAAYEFTTLT
110 120 130 140 150
TVPGCIKYKG AKIQLLDLPG IIEGAKDGKG RGRQVIAVAR TCNLIFMVLD
160 170 180 190 200
CLKPLGHKKL LEHELEGFGI RLNKKPPNIY YKRKDKGGIN LNSMVPQSEL
210 220 230 240 250
DTDLVKTILS EYKIHNADIT LRYDATSDDL IDVIEGNRIY IPCIYLLNKI
260 270 280 290 300
DQISIEELDV IYKIPHCVPI SAHHHWNFDD LLELMWEYLR LQRIYTKPKG
310 320 330 340 350
QLPDYNSPVV LHNERTSIED FCNKLHRSIA KEFKYALVWG SSVKHQPQKV
360
GIEHVLNDED VVQIVKKV
Length:368
Mass (Da):41,132
Last modified:March 29, 2005 - v2
Checksum:i5B38B09D0C0A92F2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21S → I in CAA50701. (PubMed:8121394)Curated
Sequence conflicti34 – 352KL → NV in CAA50701. (PubMed:8121394)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X71866 Genomic DNA. Translation: CAA50701.1.
AE013599 Genomic DNA. Translation: AAF58591.1.
AY069810 mRNA. Translation: AAL39955.1.
PIRiS42582.
RefSeqiNP_536733.1. NM_080485.6.
UniGeneiDm.7739.

Genome annotation databases

EnsemblMetazoaiFBtr0087976; FBpp0087084; FBgn0010339.
GeneIDi36288.
KEGGidme:Dmel_CG8340.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X71866 Genomic DNA. Translation: CAA50701.1 .
AE013599 Genomic DNA. Translation: AAF58591.1 .
AY069810 mRNA. Translation: AAL39955.1 .
PIRi S42582.
RefSeqi NP_536733.1. NM_080485.6.
UniGenei Dm.7739.

3D structure databases

ProteinModelPortali P32234.
SMRi P32234. Positions 2-367.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 62072. 4 interactions.
IntActi P32234. 3 interactions.
MINTi MINT-843420.
STRINGi 7227.FBpp0087084.

Proteomic databases

PaxDbi P32234.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0087976 ; FBpp0087084 ; FBgn0010339 .
GeneIDi 36288.
KEGGi dme:Dmel_CG8340.

Organism-specific databases

CTDi 36288.
FlyBasei FBgn0010339. 128up.

Phylogenomic databases

eggNOGi COG1163.
GeneTreei ENSGT00550000075013.
InParanoidi P32234.
OMAi GNRIYIP.
OrthoDBi EOG7PZRXJ.
PhylomeDBi P32234.

Miscellaneous databases

GenomeRNAii 36288.
NextBioi 797758.
PROi P32234.

Gene expression databases

Bgeei P32234.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR006074. GTP1-OBG_CS.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR004095. TGS.
IPR012676. TGS-like.
[Graphical view ]
Pfami PF01926. MMR_HSR1. 1 hit.
PF02824. TGS. 1 hit.
[Graphical view ]
PRINTSi PR00326. GTP1OBG.
SUPFAMi SSF52540. SSF52540. 1 hit.
SSF81271. SSF81271. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51710. G_OBG. 1 hit.
PS00905. GTP1_OBG. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The gene upstream of DmRP128 codes for a novel GTP-binding protein of Drosophila melanogaster."
    Sommer K.A., Petersen G., Bautz E.K.F.
    Mol. Gen. Genet. 242:391-398(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Oregon-R.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Embryo.
  5. "Identification and characterization of a gene activated by the deformed homeoprotein."
    Mahaffey J.W., Jones D.F., Hickel J.A., Griswold C.M.
    Development 118:203-214(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

Entry informationi

Entry namei128UP_DROME
AccessioniPrimary (citable) accession number: P32234
Secondary accession number(s): Q9V648
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: March 29, 2005
Last modified: October 29, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3